Dr Jordi Lopez Tremoleda

Experimental Models Manager

As a veterinarian with an extensive breath of knowledge on preclinical research, with a PhD in biomedical sciences, I manage the core unit to develop, validate and standardise experimental models for effective trauma translation.

The unit I lead brings together complex models of trauma, haemorrhage, shock, coagulopathy, spinal cord and brain injury to facilitate the full translation of experimental work into the clinics, ensuring animal welfare while providing a unique source of expertise and capability for trauma science.

I am also a Member of the Royal College of Veterinary Surgeons, London (MRCVS).

Research interests:

  • To bring together expertise on cutting edge experimental physiology, advanced interventional modelling and technologies such as bioengineering and imaging, to optimise and standardise trauma experimental models.
  • To develop an efficacious experimental model pathway to support the development of novel therapeutic.
  • To establish complex models integrating neurotrauma, haemorrhage, coagulopathy and organ dysfunction, while working at the interface of collaborative multidisciplinary research groups.

Current projects

  • Testing several therapeutic approached to improve the acute clinical management of acute traumatic coagulopathy in a fixed-pressure rodent model of traumatic hemorrhagic shock.
  • To development of a model incorporating trauma induced coagulopathy and uncontrolled haemorrhage to enable measurement of a translatable clinical endpoint.
  • Implementation of minimally invasive imaging technologies to validate and develop new safety and efficacy readouts for our preclinical trauma models (neuroinflammation, cardiovascular function and tissue perfusion).
  • Refinement of welfare assessment and pain management for interventional trauma models.

Other interests

With an MSc in Bioethics , I am very interested in regulatory and ethical aspects related to health and biotechnology issues, with a particular interest in animal welfare, to promote high standards for in vivo research. I am member of the LASA UK and involved in welfare animal research bodies.

Having extensively worked in preclinical imaging, we are very interested in the implementation of forefront imaging modalities in our models, to maximise their translational efficacy and to support the development of new clinical minimally invasive assessment methods and pioneer new biomarkers and biological sensors.

  • Yip PK, Chapman GE, Sillito RR et al. (2019). Studies on long term behavioural changes in group-housed rat models of brain and spinal cord injury using an automated home cage recording system. J Neurosci Methods 32149-63.
    10.1016/j.jneumeth.2019.04.005
  • Thau-Zuchman O, Gomes RN, Dyall SC et al. (2019). Brain Phospholipid Precursors Administered Post-Injury Reduce Tissue Damage and Improve Neurological Outcome in Experimental Traumatic Brain Injury. J Neurotrauma 36, (1) 25-42.
    10.1089/neu.2017.5579
  • Chan JMS, Monaco C, Wylezinska-Arridge M et al. (2018). Imaging vulnerable plaques by targeting inflammation in atherosclerosis using fluorescent-labeled dual-ligand microparticles of iron oxide and magnetic resonance imaging. J Vasc Surg 67, (5) 1571-1583.e3.
    10.1016/j.jvs.2017.04.046
  • Tremoleda JL, Macholl S, Sosabowski JK (2018). Anesthesia and Monitoring of Animals During MRI Studies. Methods Mol Biol 1718423-439.
    10.1007/978-1-4939-7531-0_25
  • Alvarez K, Lopez-Tremoleda J, Donnan R et al. (2018). Heart rate sensitive optical coherence angiography. Progress in Biomedical Optics and Imaging - Proceedings of SPIE 10493.
    10.1117/12.2317602
  • Lopez-Tremoleda J, Alvarez K, ADEN A et al. (2017). Heart-rate sensitive optical coherence angiography for measuring vascular changes due to posttraumatic brain injury in mice. Journal of Biomedical Optics 22, (12) 121710-121710.
    10.1117/1.JBO.22.12.121710
  • Tremoleda JL, Watts SA, Reynolds PS et al. (2017). Modeling Acute Traumatic Hemorrhagic Shock Injury: Challenges and Guidelines for Preclinical Studies. Shock 48, (6) 610-623.
    10.1097/SHK.0000000000000901
  • Venero JL, Yip PK, Carrillo-Jimenez A et al. (2017). Galectin-3 acts as an early alarmin orchestrating brain immune response and promoting neurodegeneration after traumatic brain injury. GLIA 65E504-E504.
  • Schrantee A, Tremoleda JL, Wylezinska-Arridge M et al. (2017). Repeated dexamphetamine treatment alters the dopaminergic system and increases the phMRI response to methylphenidate. PLoS One 12, (2) e0172776-e0172776.
    10.1371/journal.pone.0172776
  • Yip PK, Carrillo-Jimenez A, King P et al. (2017). Galectin-3 released in response to traumatic brain injury acts as an alarmin orchestrating brain immune response and promoting neurodegeneration. Scientific Reports 741689-41689.
    10.1038/srep41689
  • Pedrigi RM, Mehta VV, Bovens SM et al. (2016). Influence of shear stress magnitude and direction on atherosclerotic plaque composition. R Soc Open Sci 3, (10) 160588-.
    10.1098/rsos.160588
  • Tremoleda JL, Thau-Zuchman O, Davies M et al. (2016). In vivo PET imaging of the neuroinflammatory response in rat spinal cord injury using the TSPO tracer [(18)F]GE-180 and effect of docosahexaenoic acid. Eur J Nucl Med Mol Imaging 43, (9) 1710-1722.
    10.1007/s00259-016-3391-8
  • Luong L, Duckles H, Schenkel T et al. (2016). Heart rate reduction with ivabradine promotes shear stress-dependent anti-inflammatory mechanisms in arteries. Thromb Haemost 116, (1) 181-190.
    10.1160/TH16-03-0214
  • LOPEZ TREMOLEDA J (2016). In vivo PET imaging of the neuroinflammatory response in rat spinal cord injury using the TSPO tracer [18F]GE-180 and effect of docosahexaenoic acid. Eur J Nucl Med Mol Imaging .
    10.1007/s00259-016-3391-8
  • Thau-Zuchman O, Pallier PN, Davies M et al. (2016). A specific multi-nutrient intervention, designed to enhance synapse formation and function, improves functional outcome following traumatic brain injury. BRAIN INJURY 30, (5-6) 679-679.
  • Wall JM, Tremoleda JL, Thiemermann C et al. (2015). HEART FATTY ACID BINDING PROTEIN (H-FABP) IS A BIOMARKER OF TRAUMA-INDUCED SECONDARY CARDIAC INJURY IN A PRE-CLINICAL MODEL OF TRAUMA-HAEMORRHAGE. SHOCK 4421-22.
  • Tremoleda JL, Thau-Zuchman O, Davies M et al. (2015). IN VIVO IMAGING OF NEUROINFLAMMATION IN NEUROTRAUMA PRECLINICAL MODELS: POTENTIAL FOR CLINICAL TRANSLATION. SHOCK 4424-25.
  • Tremoleda JL, Thau-Zuchman O, Davies M et al. (2015). T-14: IN VIVO IMAGING OF NEUROINFLAMMATION IN NEUROTRAUMA PRECLINICAL MODELS: POTENTIAL FOR CLINICAL TRANSLATION. Shock 44 Suppl 224-25.
    10.1097/01.shk.0000472079.77136.27
  • Tremoleda JL, Sosabowski J (2015). Imaging technologies and basic considerations for welfare of laboratory rodents. LAB ANIMAL 44, (3) 101-109.
  • Tremoleda JL, Sosabowski J (2015). Imaging technologies and basic considerations for welfare of laboratory rodents. Lab Anim (NY) 44, (3) 97-105.
    10.1038/laban.665
  • Guerreiro M, Tremoleda JL, Frith D et al. (2014). Reduction of the natural Activated protein C pathway activity significantly prevents coagulopathy in a murine model of acute traumatic coagulopathy. Scand J Trauma Resusc Emerg Med 22, (1) 773-.
    10.1186/1757-7241-22-S1-O6
  • Guerreiro ML, Tremoleda JL, Thiemermann C et al. (2014). REDUCTION OF NATURAL ACTIVATED PROTEIN C PREVENTS COAGULOPATHY IN A PRECLINICAL ANIMAL MODEL OF ACUTE TRAUMATIC COAGULOPATHY. SHOCK 4151-51.
  • Chan JMS, Monaco C, Wylezinska-Arridge M et al. (2014). Imaging of the vulnerable carotid plaque: biological targeting of inflammation in atherosclerosis using iron oxide particles and MRI. Eur J Vasc Endovasc Surg 47, (5) 462-469.
    10.1016/j.ejvs.2014.01.017
  • Cuhlmann S, Gsell W, Van der Heiden K et al. (2014). In vivo mapping of vascular inflammation using the translocator protein tracer 18F-FEDAA1106. Mol Imaging 13.
    10.2310/7290.2014.00014
  • Lopez-Tremoleda J, Gsell W (2013). The use of contrast agents to enhance soft-tissue imaging using micro-CT in laboratory rodents. Animal Technology and Welfare 12, (1) 59-62.
  • Stasiuk GJ, Smith H, Wylezinska-Arridge M et al. (2013). Gd3+ cFLFLFK conjugate for MRI: a targeted contrast agent for FPR1 in inflammation. Chem Commun (Camb) 49, (6) 564-566.
    10.1039/c2cc37460a
  • Cristante E, McArthur S, Mauro C et al. (2013). Identification of an essential endogenous regulator of blood-brain barrier integrity, and its pathological and therapeutic implications. Proc Natl Acad Sci U S A 110, (3) 832-841.
    10.1073/pnas.1209362110
  • Tremoleda JL, Khan NS, Mann V et al. (2012). Assessment of a preclinical model for studying the survival and engraftment of human stem cell derived osteogenic cell populations following orthotopic implantation. J Musculoskelet Neuronal Interact 12, (4) 241-253.
  • Van Doormaal MA, Kazakidi A, Wylezinska M et al. (2012). Haemodynamics in the mouse aortic arch computed from MRI-derived velocities at the aortic root. J R Soc Interface 9, (76) 2834-2844.
    10.1098/rsif.2012.0295
  • Tremoleda JL, Kerton A, Gsell W (2012). Anaesthesia and physiological monitoring during in vivo imaging of laboratory rodents: considerations on experimental outcomes and animal welfare. EJNMMI Res 2, (1) 44-.
    10.1186/2191-219X-2-44
  • Seyfried F, Lannoo M, Gsell W et al. (2012). Roux-en-Y gastric bypass in mice--surgical technique and characterisation. Obes Surg 22, (7) 1117-1125.
    10.1007/s11695-012-0661-9
  • Bouet V, Klomp A, Freret T et al. (2012). Age-dependent effects of chronic fluoxetine treatment on the serotonergic system one week following treatment. Psychopharmacology (Berl) 221, (2) 329-339.
    10.1007/s00213-011-2580-1
  • Stuckey DJ, Tremoleda JL, Mcsweeney S et al. (2012). Systematic evaluation of 2D versus M-mode echocardiography in mice, compared to ex vivo and in vivo MRI. CARDIOVASCULAR RESEARCH 93S90-S90.
  • Klomp A, Tremoleda JL, Wylezinska M et al. (2012). Lasting effects of chronic fluoxetine treatment on the late developing rat brain: age-dependent changes in the serotonergic neurotransmitter system assessed by pharmacological MRI. Neuroimage 59, (1) 218-226.
    10.1016/j.neuroimage.2011.07.082
  • Gsell W, Cuhlmann S, Van der Heiden K et al. (2011). (18)FEDAA is a more specific probe than (18)FDG for imaging vascular inflammation. EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING 38S210-S210.
  • Tremoleda JL, Khalil M, Gsell W et al. (2011). The use of micro-computed tomography to study bone changes in a preclinical model of Osteoarthritis. EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING 38S418-S418.
  • Song W, Dyer E, Stuckey DJ et al. (2011). Molecular mechanism of the E99K mutation in cardiac actin (ACTC Gene) that causes apical hypertrophy in man and mouse. J Biol Chem 286, (31) 27582-27593.
    10.1074/jbc.M111.252320
  • Tremoleda JL, Khalil M, Gompels LL et al. (2011). Imaging technologies for preclinical models of bone and joint disorders. EJNMMI Res 1, (1) 11-.
    10.1186/2191-219X-1-11
  • Cuhlmann S, Van der Heiden K, Saliba D et al. (2011). Disturbed blood flow induces RelA expression via c-Jun N-terminal kinase 1: a novel mode of NF-κB regulation that promotes arterial inflammation. Circ Res 108, (8) 950-959.
    10.1161/CIRCRESAHA.110.233841
  • Kazakidi A, Wylezinska M, Bohraus Y et al. (2010). NUMERICAL MODELLING OF BLOOD FLOW IN THE MOUSE AORTIC ARCH USING INFLOW VELOCITIES OBTAINED BY PHASE-CONTRAST MRI. PROCEEDINGS OF THE ASME SUMMER BIOENGINEERING CONFERENCE, 2010 555-556.

 

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