Professor Chris Thiemermann

Professor of Pharmacology, Centre Lead for Translational Medicine & Therapeutics

Chris Thiemermann is the co-lead of the Organ Dysfunction and Protection Research Theme (together with Professor Karim Brohi) within the C4TS. Chris is Professor of Pharmacology and Centre Lead for Translational Medicine & Therapeutics at the William Harvey Research Institute (WHRI) and has 30 years’ experience in sepsis/traumatic shock research.

Supervision

(1) Role of IKK in the activation of NF-kB in sepsis, trauma and acute kidney injury; 

(2) Gender-differences in the response to sepsis and trauma; 

(3) Aging and response to tissue injury and shock; 

(4) Development of translatable interventions aimed at reducing the organ injury/dysfunction in trauma.

Research interests:

Chris has expertise in target discovery and evaluation of the efficacy of drugs in animal models of disease. His specific field of interest encompasses the pathophysiology of shock caused by trauma or sepsis, and reperfusion injury following ischemia (i.e. a restriction in blood supply to tissues, causing a shortage of oxygen and glucose needed to keep tissue alive). Hi research focuses upon the discovery of novel therapeutic targets and interventions that can be translated from the laboratory models of these diseases into the clinic for protection against associated organ injury.

Other research interests include the pathophysiology and treatment of (a) acute and chronic kidney disease and (b) acute myocardial infarction. Chris Thiemermann's lead role within the Organ Failure and Protection Research Theme aligns closely with his research at the William Harvey Research Institute (WHRI). To visit the WHRI's website click here.

Contact

email: c.thiemermann@qmul.ac.uk
Tel: +44 (0) 207 882 2121

  • Voisin M-B, Leoni G, Woodfin A et al. (2019). Neutrophil elastase plays a non-redundant role in remodeling the venular basement membrane and neutrophil diapedesis post-ischemia/reperfusion injury. J Pathol 248, (1) 88-102.
    10.1002/path.5234
  • SOLITO EGLE, PURVIS G, THIEMERMANN C (2019). Annexin-A1: therapeutic potential in microvascular disease. Frontiers in Immunology .
    10.3389/fimmu.2019.00938
  • Martin L, Derwall M, Al Zoubi S et al. (2019). Response. Chest 155, (3) 647-648.
    10.1016/j.chest.2018.10.018
  • Martin L, Derwall M, Al Zoubi S et al. (2019). The Septic Heart: Current Understanding of Molecular Mechanisms and Clinical Implications. Chest 155, (2) 427-437.
    10.1016/j.chest.2018.08.1037
  • Purvis GSD, Collino M, Loiola RA et al. (2019). Identification of AnnexinA1 as an Endogenous Regulator of RhoA, and Its Role in the Pathophysiology and Experimental Therapy of Type-2 Diabetes. Front Immunol 10571-.
    10.3389/fimmu.2019.00571
  • Zingarelli B, Coopersmith CM, Drechsler S et al. (2019). Part I: Minimum Quality Threshold in Preclinical Sepsis Studies (MQTiPSS) for Study Design and Humane Modeling Endpoints. Shock 51, (1) 10-22.
    10.1097/SHK.0000000000001243
  • Barry SP, Ounzain S, McCormick J et al. (2019). Retraction notice to "Enhanced IL-17 signalling following myocardial ischaemia/reperfusion injury" [Int. J. Cardiol. 163 (2013) 326-334]. Int J Cardiol 274404-.
    10.1016/j.ijcard.2018.10.031
  • Andrikopoulos P, Kieswich J, Pacheco S et al. (2019). The MEK Inhibitor Trametinib Ameliorates Kidney Fibrosis by Suppressing ERK1/2 and mTORC1 Signaling. J Am Soc Nephrol 30, (1) 33-49.
    10.1681/ASN.2018020209
  • Osuchowski MF, Hellman J, Huber-Lang M et al. (2019). The Response to the Letter to the Editor Titled: "Is Triple Self-plagiarism "OK" If Only Made Transparent?" by Volker R Jacobs, MD, MBA. Shock 51, (1) 140-141.
    10.1097/SHK.0000000000001294
  • Kieswich JE, Chen J, Alliouachene S et al. (2018). A novel model of reno-cardiac syndrome in the C57BL/ 6 mouse strain. BMC Nephrol 19, (1) 346-.
    10.1186/s12882-018-1155-3
  • Osuchowski MF, Ayala A, Bahrami S et al. (2018). Correction to: Minimum Quality Threshold in Pre-Clinical Sepsis Studies (MQTiPSS): an international expert consensus initiative for improvement of animal modeling in sepsis. Infection 46, (5) 745-747.
    10.1007/s15010-018-1197-2
  • Osuchowski MF, Ayala A, Bahrami S et al. (2018). Minimum Quality Threshold in Pre-Clinical Sepsis Studies (MQTiPSS): An International Expert Consensus Initiative for Improvement of Animal Modeling in Sepsis. Shock 50, (4) 377-380.
    10.1097/SHK.0000000000001212
  • Osuchowski MF, Ayala A, Bahrami S et al. (2018). Minimum Quality Threshold in Pre-Clinical Sepsis Studies (MQTiPSS): an international expert consensus initiative for improvement of animal modeling in sepsis. Infection 46, (5) 687-691.
    10.1007/s15010-018-1183-8
  • Osuchowski MF, Ayala A, Bahrami S et al. (2018). Minimum quality threshold in pre-clinical sepsis studies (MQTiPSS): an international expert consensus initiative for improvement of animal modeling in sepsis. Intensive Care Med Exp 6, (1) 26-.
    10.1186/s40635-018-0189-y
  • Chen J, Hamers AJP, Finsterbusch M et al. (2018). Endogenously generated arachidonate-derived ligands for TRPV1 induce cardiac protection in sepsis. FASEB J fj201701303R-fj201701303R.
    10.1096/fj.201701303R
  • Khan AI, Kapoor A, Chen J et al. (2018). The Antimalarial Drug Artesunate Attenuates Cardiac Injury in A Rodent Model of Myocardial Infarction. Shock 49, (6) 675-681.
    10.1097/SHK.0000000000000963
  • Busch D, Kapoor A, Rademann P et al. (2018). Delayed activation of PPAR-β/δ improves long-term survival in mouse sepsis: effects on organ inflammation and coagulation. Innate Immun 24, (4) 262-273.
    10.1177/1753425918771748
  • Zechendorf E, Vaßen P, Zhang J et al. (2018). Heparan Sulfate Induces Necroptosis in Murine Cardiomyocytes: A Medical-In silico Approach Combining In vitro Experiments and Machine Learning. Front Immunol 9393-393.
    10.3389/fimmu.2018.00393
  • Martin L, Thiemermann C (2018). Mitochondrial DNA in Acute Kidney Injury: Chicken or Egg?. Shock 49, (3) 352-353.
    10.1097/SHK.0000000000000966
  • Al Zoubi S, Chen J, Murphy C et al. (2018). Linagliptin Attenuates the Cardiac Dysfunction Associated With Experimental Sepsis in Mice With Pre-existing Type 2 Diabetes by Inhibiting NF-κB. Front Immunol 92996-.
    10.3389/fimmu.2018.02996
  • Aswani A, Manson J, Itagaki K et al. (2018). Scavenging Circulating Mitochondrial DNA as a Potential Therapeutic Option for Multiple Organ Dysfunction in Trauma Hemorrhage. Front Immunol 9891-.
    10.3389/fimmu.2018.00891
  • Tremoleda JL, Watts SA, Reynolds PS et al. (2017). Modeling Acute Traumatic Hemorrhagic Shock Injury: Challenges and Guidelines for Preclinical Studies. Shock 48, (6) 610-623.
    10.1097/SHK.0000000000000901
  • Purvis GSD, Chiazza F, Chen J et al. (2017). Annexin A1 attenuates microvascular complications through restoration of Akt signalling in a murine model of type 1 diabetes. Diabetologia .
    10.1007/s00125-017-4469-y
  • Briegel J, Möhnle P, Vogeser M et al. (2017). Relative Adrenal Insufficiency in Cardiogenic Shock: Is There a Need for Action?. Shock 48, (4) 498-499.
    10.1097/SHK.0000000000000870
  • Khan AI, Kapoor A, Che J et al. (2017). The Anti-Malarial Drug Artesunate Attenuates Cardiac Injury in a Rodent Model of Myocardial Infarction. Shock .
    10.1097/SHK.0000000000000963
  • Sordi R, Nandra KK, Chiazza F et al. (2017). Artesunate Protects Against the Organ Injury and Dysfunction Induced by Severe Hemorrhage and Resuscitation. Ann Surg 265, (2) 408-417.
    10.1097/SLA.0000000000001664
  • Johnson FL, Patel NSA, Purvis GSD et al. (2017). Inhibition of IκB Kinase at 24 Hours After Acute Kidney Injury Improves Recovery of Renal Function and Attenuates Fibrosis. J Am Heart Assoc 6, (7) .
    10.1161/JAHA.116.005092
  • Martin L, Derwall M, Thiemermann C et al. (2017). [Heart in sepsis : Molecular mechanisms, diagnosis and therapy of septic cardiomyopathy]. Anaesthesist 66, (7) 479-490.
    10.1007/s00101-017-0329-x
  • Martin L, Gombert A, Chen J et al. (2017). The β-d-Endoglucuronidase Heparanase Is a Danger Molecule That Drives Systemic Inflammation and Correlates with Clinical Course after Open and Endovascular Thoracoabdominal Aortic Aneurysm Repair: Lessons Learnt from Mice and Men. Front Immunol 8681-681.
    10.3389/fimmu.2017.00681
  • Yamada N, Martin L, Zechendorf E et al. (2017). A NOVEL SYNTHETIC, HOST-DEFENCE PEPTIDE PROTECTS AGAINST ORGAN INJURY/DYSFUNCTION IN A RAT-MODEL OF SEVERE HEMORRHAGIC SHOCK. SHOCK 47, (6) 116-117.
  • Martin L, Chen J, Zechendorf E et al. (2017). ROLE OF THE beta-D-ENDOGLUCURONIDASE HEPARANASE IN SEPTIC CARDIOMYOPATHY. SHOCK 47, (6) 129-129.
  • Osuchowski MF, Thiemermann C, Remick DG (2017). Sepsis-3 on the Block: What Does It Mean for Preclinical Sepsis Modeling?. Shock 47, (5) 658-660.
    10.1097/SHK.0000000000000775
  • Purvis GSD, Chiazza F, Collino M et al. (2017). Endogenous Annexin-A1 is a Protective Determinant in HFD-induced Insulin Resistance and Diabetic Nephropathy. FASEB JOURNAL 31.
  • Kalbitz M, Waller C, Huber-Lang M et al. (2017). Oxygen in the Heart: How Much is too Much?. Shock 47, (4) 531-532.
    10.1097/SHK.0000000000000760
  • Yamada N, Lukas M, Zechendorf E et al. (). Novel Synthetic, Host-defense Peptide Protects Against Organ Injury/Dysfunction in a Rat Model of Severe Hemorrhagic Shock. Annals of Surgery .
    10.1097/SLA.0000000000002186
  • Purvis GSD, Chiazza F, Solito E et al. (2017). Endogenous annexin-A1 is a protective determinant in high-fat diet (HFD)-induced insulin resistance and diabetic nephropathy. DIABETIC MEDICINE 3426-26.
    10.1111/dme.42_13304
  • Davenport RA, Guerreiro M, Frith D et al. (2017). Activated Protein C Drives the Hyperfibrinolysis of Acute Traumatic Coagulopathy. Anesthesiology 126, (1) 115-127.
    10.1097/ALN.0000000000001428
  • Chen J, Kieswich JE, Chiazza F et al. (2017). IκB Kinase Inhibitor Attenuates Sepsis-Induced Cardiac Dysfunction in CKD. Journal of the American Society of Nephrology : JASN 28, (1) 94-105.
    10.1681/ASN.2015060670
  • Martin L, Horst K, Chiazza F et al. (2016). The synthetic antimicrobial peptide 19-2.5 attenuates septic cardiomyopathy and prevents down-regulation of SERCA2 in polymicrobial sepsis. Sci Rep 637277-.
    10.1038/srep37277
  • Osuchowski MF, Thiemermann C, Remick DG (2016). SEPSIS-3 On the Block: What Does It Mean for Pre-Clinical Sepsis Modeling?. Shock .
    10.1097/SHK.0000000000000775
  • Yamada N, Martin L, Sordi R et al. (2016). A NOVEL SYNTHETIC PEPTIDE PROTECTS AGAINST ORGAN INJURY IN A RAT-MODEL OF SEVERE HAEMORRHAGIC SHOCK. SHOCK 46, (4) 34-35.
  • Chen J, Hamers AJP, Finsterbusch M et al. (2016). ACTIVATION OF TRPV1 BY 12(S)-HPETE AND 20-HETE RELEASES CGRP AND PROTECTS THE HEART AGAINST THE CARDIAC DYSFUNCTION CAUSED BY LPS. SHOCK 46, (4) 31-32.
  • Martin LB, Zechendorf E, Chen J et al. (2016). THE SYNTHETIC ANTIMICROBIAL PEPTIDE 19-2.5 ATTENUATES SEPTIC CARDIOMYOPATHY IN A MURINE MODEL OF POLYMICROBIAL SEPSIS. SHOCK 46, (4) 31-31.
  • Asfar P, Thiemermann C, Radermacher P (2016). Norepinephrine, the Intensivist's Swiss Army Knife for Circulatory Shock?. Shock 46, (1) 106-107.
    10.1097/SHK.0000000000000590
  • Coldewey SM, Benetti E, Collino M et al. (2016). Elevation of serum sphingosine-1-phosphate attenuates impaired cardiac function in experimental sepsis. Scientific Reports 627594-27594.
    10.1038/srep27594
  • Chen J, Thiemermann C (2016). Selenium and Niacin for Sepsis Therapy: The Sum Is Greater Than Its Parts. Crit Care Med 44, (6) 1256-1257.
    10.1097/CCM.0000000000001493
  • Sordi R, Chiazza F, Collino M et al. (2016). Neuronal Nitric Oxide Synthase is Involved in Vascular Hyporeactivity and Multiple Organ Dysfunction Associated with Hemorrhagic Shock. SHOCK 45, (5) 525-533.
    10.1097/SHK.0000000000000533
  • Gaffney VJ, Mota-Filipe H, Pinto RA et al. (2016). Chemical and biochemical characterization and in vivo safety evaluation of pharmaceuticals in drinking water. Environmental toxicology and chemistry / SETAC .
    10.1002/etc.3451
  • Chen J, Hamers AJP, Finsterbusch M et al. (2016). Activation of TRPV1 by 12(s)-HpETE and 20-HETE Releases CGRP and Protects the Heart Against the Cardiac Dysfunction Caused by LPS. FASEB JOURNAL 30.
  • Chiazza F, Couturier-Maillard A, Benetti E et al. (2016). Targeting the NLRP3 Inflammasome to Reduce Diet-Induced Metabolic Abnormalities in Mice. Mol Med 21, (1) 1025-1037.
    10.2119/molmed.2015.00104
  • Sordi R, Nandra KK, Chiazza F et al. (2016). Artesunate Protects Against the Organ Injury and Dysfunction Induced by Severe Hemorrhage and Resuscitation. Annals of surgery .
  • Sordi R, Nandra KK, Chiazza F et al. (2016). Artesunate Protects Against the Organ Injury and Dysfunction Induced by Severe Hemorrhage and Resuscitation. Ann Surg .
    10.1097/SLA.0000000000001664
  • Coldewey SM, Benetti E, Collino M et al. (2015). Enhanced sphingosine-1-phosphate levels ameliorate murine septic cardiomyopathy. Intensive Care Med Exp 3, (Suppl 1) A615-.
    10.1186/2197-425X-3-S1-A615
  • Coldewey SM, Benetti E, Collino M et al. (2015). ENHANCED SPHINGOSINE-1-PHOSPHATE LEVELS ATTENUATE CARDIAC DYSFUNCTION IN EXPERIMENTAL SEPTIC CARDIOMYOPATHY. SHOCK 4417-17.
  • Wall JM, Tremoleda JL, Thiemermann C et al. (2015). HEART FATTY ACID BINDING PROTEIN (H-FABP) IS A BIOMARKER OF TRAUMA-INDUCED SECONDARY CARDIAC INJURY IN A PRE-CLINICAL MODEL OF TRAUMA-HAEMORRHAGE. SHOCK 4421-22.
  • Chen J, Kieswich J, Chiazza F et al. (2015). THE CARDIAC DYSFUNCTION CAUSED BY SEPSIS IN ANIMALS WITH CHRONIC KIDNEY DISEASE IS ATTENUATED BY INHIBITING I kappa B KINASE. SHOCK 4416-16.
  • Johnson F, Patel N, Collino M et al. (2015). THE LATE INHIBITION OF INHIBITOR OF IKB KINASE ATTENUATES ACUTE KIDNEY INJURY AND THE SUBSEQUENT DEVELOPMENT OF FIBROSIS IN A RAT MODEL OF ISCHAEMIA REPERFUSION INJURY. SHOCK 4410-10.
  • Sordi R, Nandra KK, Chiazza F et al. (2015). TRAUMA ORGAN PROTECTION WITH ARTESUNATE (TOP-ART): PRECLINICAL EFFICACY OF AN ANTIMALARIAL DRUG WITH EXCELLENT SAFETY PROFILE AND PLANNED PHASE II RCT. SHOCK 441-1.
  • Hache G, Osuchowski M, Thiemermann C (2015). Does Insulin Protect the Brain in Mice and Man with Sepsis?. Shock 44, (3) 287-.
    10.1097/SHK.0000000000000423
  • Collino M, Thiemermann C, Cerami A et al. (2015). Flipping the molecular switch for innate protection and repair of tissues: Long-lasting effects of a non-erythropoietic small peptide engineered from erythropoietin. Pharmacol Ther 15132-40.
    10.1016/j.pharmthera.2015.02.005
  • Sordi R, Chiazza F, Johnson FL et al. (2015). Inhibition of IκB Kinase Attenuates the Organ Injury and Dysfunction Associated with Hemorrhagic Shock. Mol Med 21563-575.
    10.2119/molmed.2015.00049
  • Chen J, Kieswich J, Chiazza F et al. (2015). THE CARDIAC DYSFUNCTION CAUSED BY SEPSIS IN ANIMALS WITH CHRONIC KIDNEY DISEASE IS ATTENUATED BY INHIBITING I kappa B KINASE. SHOCK 43, (6) 92-93.
  • Lilley E, Armstrong R, Clark N et al. (2015). Refinement of animal models of sepsis and septic shock. Shock 43, (4) 304-316.
    10.1097/SHK.0000000000000318
  • Sand CA, Starr A, Wilder CDE et al. (2015). Quantification of microcirculatory blood flow: a sensitive and clinically relevant prognostic marker in murine models of sepsis. J Appl Physiol (1985) 118, (3) 344-354.
    10.1152/japplphysiol.00793.2014
  • Sordi R, Chiazza F, Patel NSA et al. (2015). 'Preconditioning' with low dose lipopolysaccharide aggravates the organ injury / dysfunction caused by hemorrhagic shock in rats. PLoS One 10, (4) e0122096-.
    10.1371/journal.pone.0122096
  • Madalli S, Beyrau M, Whiteford J et al. (2015). Sex-specific regulation of chemokine Cxcl5/6 controls neutrophil recruitment and tissue injury in acute inflammatory states. Biol Sex Differ 627-.
    10.1186/s13293-015-0047-5
  • Gobbetti T, Coldewey SM, Chen J et al. (2014). Nonredundant protective properties of FPR2/ALX in polymicrobial murine sepsis. Proc Natl Acad Sci U S A 111, (52) 18685-18690.
    10.1073/pnas.1410938111
  • Collino M, Benetti E, Rogazzo M et al. (2014). A non-erythropoietic peptide derivative of erythropoietin decreases susceptibility to diet-induced insulin resistance in mice. Br J Pharmacol 171, (24) 5802-5815.
    10.1111/bph.12888
  • Guerreiro M, Tremoleda JL, Frith D et al. (2014). Reduction of the natural Activated protein C pathway activity significantly prevents coagulopathy in a murine model of acute traumatic coagulopathy. Scand J Trauma Resusc Emerg Med 22, (1) 773-.
    10.1186/1757-7241-22-S1-O6
  • McCafferty K, Forbes S, Thiemermann C et al. (2014). The challenge of translating ischemic conditioning from animal models to humans: the role of comorbidities. Dis Model Mech 7, (12) 1321-1333.
    10.1242/dmm.016741
  • Roesner JP, Thiemermann C (2014). Mirror, mirror on the wall, is off-pump better than on-pump at all?. Shock 42, (2) 174-175.
    10.1097/SHK.0000000000000202
  • Osuchowski MF, Remick DG, Lederer JA et al. (2014). Abandon the mouse research ship? Not just yet!. Shock 41, (6) 463-475.
    10.1097/SHK.0000000000000153
  • Osuchowski MF, Radermacher P, Thiemermann C (2014). Caught between a rock and a hard place: seeking an optimal resuscitation strategy for hemorrhaging patients with lung injury. Shock 41, (6) 556-557.
    10.1097/SHK.0000000000000159
  • Chen J, Chiazza F, Collino M et al. (2014). GENDER DIMORPHISM OF THE CARDIAC DYSFUNCTION IN SEPSIS. SHOCK 4135-35.
  • Chen J, Kieswich J, Yaqoob MM et al. (2014). PRE-EXISTING CHRONIC KIDNEY DISEASE WORSENS MYOCARDIAL DYSFUNCTION CAUSED BY SEPSIS IN MICE. SHOCK 4140-41.
  • Guerreiro ML, Tremoleda JL, Thiemermann C et al. (2014). REDUCTION OF NATURAL ACTIVATED PROTEIN C PREVENTS COAGULOPATHY IN A PRECLINICAL ANIMAL MODEL OF ACUTE TRAUMATIC COAGULOPATHY. SHOCK 4151-51.
  • Radermacher P, Huber-Lang M, Knippschild U et al. (2014). The obesity paradox revisited: does increased body mass protect against circulatory shock?. Shock 41, (6) 554-555.
    10.1097/SHK.0000000000000166
  • Coldewey SM, Thiemermann C (2014). PLEIOTROPIC EFFECTS OF ATORVASTATIN IN EXPERIMENTAL SEPSIS: PRESERVATION OF beta(1)-ADRENORECEPTOR SIGNALING IN THE HEART. SHOCK 41, (5) 458-459.
    10.1097/SHK.0000000000000154
  • Chapagain A, Caton PW, Kieswich J et al. (2014). Elevated hepatic 11β-hydroxysteroid dehydrogenase type 1 induces insulin resistance in uremia. Proc Natl Acad Sci U S A 111, (10) 3817-3822.
    10.1073/pnas.1312436111
  • Jellestad L, Fink T, Pradarutti S et al. (2014). Inhibition of glycogen synthase kinase (GSK)-3-β improves liver microcirculation and hepatocellular function after hemorrhagic shock. Eur J Pharmacol 724175-184.
    10.1016/j.ejphar.2013.12.029
  • Chen J, Chiazza F, Collino M et al. (2014). Gender dimorphism of the cardiac dysfunction in murine sepsis: signalling mechanisms and age-dependency. PLoS One 9, (6) e100631-.
    10.1371/journal.pone.0100631
  • Clemens MG, Radermacher P, Thiemermann C (2014). Nutritional support in critically ill patients: enteral, parenteral, or not at all?. Shock 41, (1) 87-88.
    10.1097/SHK.0000000000000076
  • McCafferty K, Byrne CJ, Kieswich J et al. (2014). The effect of uraemia on the duration of arrhythmias in the context of cardioprotective ischaemic conditioning strategies. Heart Asia 6, (1) 76-82.
    10.1136/heartasia-2013-010432
  • Hafner S, Wepler M, McCook O et al. (2013). EFFECTS OF THE PPAR-beta/delta AGONIST GW0742 ON RENAL INFLAMMATION AND KIDNEY TISSUE INJURY DURING RESUSCITATED PORCINE SEPTIC SHOCK. SHOCK 4024-24.
  • Coldewey SM, Khan AI, Kapoor A et al. (2013). Erythropoietin attenuates acute kidney dysfunction in murine experimental sepsis by activation of the β-common receptor. Kidney Int 84, (3) 482-490.
    10.1038/ki.2013.118
  • Rocha J, Barateiro A, Fernandes A et al. (2013). GLYCOGEN SYNTHASE KINASE-3 INHIBITION REDUCES LIVER, NEUROMUSCULAR, AND LUNG INJURY CAUSED BY BURN INJURY IN THE RAT. SHOCK 4027-27.
  • Coldewey SM, Collino M, Rogazzo M et al. (2013). INHIBITION OF I kappa B KINASE-A NOVEL THERAPEUTIC APPROACH IN EXPERIMENTAL SEPSIS. SHOCK 4016-16.
  • Khan AI, Coldewey SM, Patel NSA et al. (2013). Erythropoietin attenuates cardiac dysfunction in experimental sepsis in mice via activation of the beta-common receptor. DISEASE MODELS & MECHANISMS 6, (4) 1021-1030.
    10.1242/dmm.011908
  • Coldewey SM, Rogazzo M, Collino M et al. (2013). Inhibition of IκB kinase reduces the multiple organ dysfunction caused by sepsis in the mouse. Dis Model Mech 6, (4) 1031-1042.
    10.1242/dmm.012435
  • Radermacher P, van Griensven M, Thiemermann C (2013). Humane end points in experimental models of septic shock: a must, not a superfluous nightmare for researchers!. Shock 39, (6) 541-542.
    10.1097/SHK.0b013e3182941ac7
  • Radermacher P, Thiemermann C (2013). Receptor-selective vasopressin analogs: a new push for "decatecholaminization"?. Shock 39, (6) 539-540.
    10.1097/SHK.0b013e3182951982
  • Khan AI, Coldewey SM, Patel NS et al. (2013). ERYTHROPOIETIN ATTENUATES CARDIAC DYSFUNCTION IN EXPERIMENTAL SEPSIS VIA ACTIVATION OF THE B-COMMON RECEPTOR. HEART 99.
    10.1136/heartjnl-2013-304019.233
  • Nandra KK, Collino M, Rogazzo M et al. (2013). Pharmacological preconditioning with erythropoietin attenuates the organ injury and dysfunction induced in a rat model of hemorrhagic shock. Dis Model Mech 6, (3) 701-709.
    10.1242/dmm.011353
  • Radermacher P, Huber-Lang M, Thiemermann C (2013). Catecholamines and the septic heart: opening Pandora's box?. Shock 39, (4) 404-405.
    10.1097/SHK.0b013e31828b247b
  • Bangash MN, Patel NSA, Benetti E et al. (2013). Dopexamine can attenuate the inflammatory response and protect against organ injury in the absence of significant effects on hemodynamics or regional microvascular flow. Crit Care 17, (2) R57-.
    10.1186/cc12585
  • Shintani Y, Kapoor A, Kaneko M et al. (2013). TLR9 mediates cellular protection by modulating energy metabolism in cardiomyocytes and neurons. Proc Natl Acad Sci U S A 110, (13) 5109-5114.
    10.1073/pnas.1219243110
  • Barry SP, Ounzain S, McCormick J et al. (2013). Enhanced IL-17 signalling following myocardial ischaemia/reperfusion injury (Retracted article. See vol. 274, pg. 404, 2019). INTERNATIONAL JOURNAL OF CARDIOLOGY 163, (3) 326-334.
    10.1016/j.ijcard.2011.08.849
  • Collino M, Benetti E, Rogazzo M et al. (2013). Reversal of the deleterious effects of chronic dietary HFCS-55 intake by PPAR-delta agonism correlates with impaired NLRP3 inflammasome activation. BIOCHEMICAL PHARMACOLOGY 85, (2) 257-264.
    10.1016/j.bcp.2012.10.014
  • Calzia E, Huber-Lang M, Ignatius A et al. (2012). MODELING TRAUMATIC-HEMORRHAGIC SHOCK-NOTHING IS SIMPLE AND EASY. SHOCK 38, (6) 685-686.
    10.1097/SHK.0b013e3182756a24
  • McCafferty K, Byrne CJ, Kieswich J et al. (2012). Response to letter regarding article, "ischemic conditioning protects the uremic heart in a rodent model of myocardial infarction". Circulation 126, (13) .
    10.1161/CIRCULATIONAHA.112.130971
  • Patel NSA, Nandra KK, Thiemermann C (2012). Bench-to-bedside review: Erythropoietin and its derivatives as therapies in critical care. Crit Care 16, (4) 229-.
    10.1186/cc11315
  • Nandra KK, Takahashi K, Collino M et al. (2012). Acute treatment with bone marrow-derived mononuclear cells attenuates the organ injury/dysfunction induced by hemorrhagic shock in the rat. Shock 37, (6) 592-598.
    10.1097/SHK.0b013e31824e4c0d
  • Patel NSA, Kerr-Peterson HL, Brines M et al. (2012). Delayed administration of pyroglutamate helix B surface peptide (pHBSP), a novel nonerythropoietic analog of erythropoietin, attenuates acute kidney injury. Mol Med 18719-727.
    10.2119/molmed.2012.00093
  • Byrne CJ, McCafferty K, Kieswich J et al. (2012). Ischemic conditioning protects the uremic heart in a rodent model of myocardial infarction. Circulation 125, (10) 1256-1265.
    10.1161/CIRCULATIONAHA.111.055392
  • Khan AI, Coldewey SM, Kapoor A et al. (2012). ERYTHROPOIETIN ATTENUATES CARDIAC DYSFUNCTION IN EXPERIMENTAL SEPSIS VIA ACTIVATION OF THE BETA-COMMON RECEPTOR. SHOCK 3755-56.
    10.1242/dmm.011908
  • Coldewey SM, Khan AI, Rogazzo M et al. (2012). ERYTHROPOIETIN REDUCES THE ACUTE KIDNEY INJURY IN EXPERIMENTAL SEPSIS VIA ACTIVATION OF THE beta ETA-COMMON RECEPTOR. SHOCK 3752-52.
  • Frith D, Guerreiro M, Pearse R et al. (2012). EXPERIMENTAL ACUTE TRAUMATIC COAGULOPATHY IS ASSOCIATED WITH MODERATE IMPAIRMENT OF THROMBIN GENERATION AND DYSFIBRINOGENEMIA. SHOCK 3734-34.
  • McCook O, Georgieff M, Scheuerle A et al. (2012). Erythropoietin in the critically ill: do we ask the right questions?. CRITICAL CARE 16, (5) .
    10.1186/cc11430
  • Duvigneau J, Patel NS, Kerr-Peterson H et al. (2012). REMOTE EFFECTS OF KIDNEY ISCHEMIA/REPERFUSION INJURY ON THE LIVER INVOLVES ENDOPLASMIC RETICULUM STRESS. SHOCK 37119-119.
  • Nandra KK, Patel NS, Harwood S et al. (2012). THREE DAY PRE-TREATMENT WITH ERYTHROPOIETIN ATTENUATES THE ORGAN INJURY AND DYSFUNCTION INDUCED BY HEMORRHAGIC SHOCK IN THE RAT BY A MECHANISM INDEPENDENT OF ENDOTHELIAL PROGENITOR CELL MOBILISATION. SHOCK 3796-97.
  • Manson J, Thiemermann C, Brohi K (2012). Trauma alarmins as activators of damage-induced inflammation. Br J Surg 99 Suppl 112-20.
    10.1002/bjs.7717
  • Shintani Y, Kapoor A, Drexler H et al. (2011). A Novel Toll-Like Receptor 9 Signaling in Cardiomyocytes. CIRCULATION 124, (21) .
  • Madalli S, Bauer M, Thiemermann C et al. (2011). Differential Regulation of Neutrophil Mobilization and Integrin Expression in Females Protects Against Ischemia/Reperfusion-Induced Local and Remote Tissue Injury. CIRCULATION 124, (21) .
  • Patel NS, Collino M, Yaqoob MM et al. (2011). Erythropoietin in the intensive care unit: beyond treatment of anemia. Ann Intensive Care 140-.
    10.1186/2110-5820-1-40
  • Patel NSA, Nandra KK, Brines M et al. (2011). A nonerythropoietic peptide that mimics the 3D structure of erythropoietin reduces organ injury/dysfunction and inflammation in experimental hemorrhagic shock. Mol Med 17, (9-10) 883-892.
    10.2119/molmed.2011.00053
  • Wang YY, Ryg U, Dahle MK et al. (2011). Liver X Receptor Protects against Liver Injury in Sepsis Caused by Rodent Cecal Ligation and Puncture. SURG INFECT 12, (4) 283-289.
    10.1089/sur.2010.066
  • Frith D, Baptista ML, Cohen M et al. (2011). Experimental acute traumatic coagulopathy is due to systemic activation of protein c during hypoperfusion. JOURNAL OF THROMBOSIS AND HAEMOSTASIS 9481-481.
  • Manson J, Davenport R, Coates A et al. (2011). TRAUMATIC TISSUE DAMAGE: THE SEARCH FOR TRAUMA ALARMINS. INFLAMMATION RESEARCH 60160-160.
  • Maio R, Sepodes B, Patel NSA et al. (2011). Erythropoietin preserves the integrity and quality of organs for transplantation after cardiac death. Shock 35, (2) 126-133.
    10.1097/SHK.0b013e3181e83236
  • Kapoor A, Thiemermann C (2011). Niacin as a novel therapy for septic shock?. Crit Care Med 39, (2) 410-411.
    10.1097/CCM.0b013e318205c05e
  • Collino M, Benetti E, Miglio G et al. (2011). Peroxisome proliferator-activated receptor beta/delta agonism protects the kidney against ischemia/reperfusion injury in diabetic rats. FREE RADICAL BIO MED 50, (2) 345-353.
    10.1016/j.freeradbiomed.2010.10.710
  • Kapoor A, Thiemermann C (2011). Targeting CCR2 A Novel Therapeutic Strategy for Septic Shock?. AM J RESP CRIT CARE 183, (2) 150-151.
    10.1164/rccm.201009-1403ED
  • Kapoor A, Shintani Y, Collino M et al. (2011). BENEFICIAL ROLE OF PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR-BETA/DELTA IN SEPTIC SHOCK. SHOCK 3620-20.
  • Nandra K, Takahashi K, Collino M et al. (2011). BONE-MARROW DERIVED MONONUCLEAR CELLS PROTECT AGAINST MULTIPLE ORGAN FAILURE IN HEMORRHAGIC SHOCK THROUGH AN AKT DEPENDANT PATHWAY. SHOCK 3626-26.
  • Busch D, Kapoor A, Khadem A et al. (2011). DELAYED ACTIVATION OF PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR (PPAR)-BETA/DELTA IMPROVES LONG-TERM SURVIVAL IN THE MOUSE MODEL OF POLYMICROBIAL SEPSIS. SHOCK 3610-10.
  • Frith D, Baptista ML, Cohen MJ et al. (2011). EXPERIMENTAL ACUTE TRAUMATIC COAGULOPATHY: INITIATED BY HYPOPERFUSION, MODULATED BY THE PROTEIN C PATHWAY. SHOCK 3616-17.
  • Maio R, Sepodes B, Thiemermann C et al. (2011). OPPORTUNITIES TO ENHANCE ORGAN VIABILITY. SHOCK 363-3.
  • Kapoor A, Shintani Y, Collino M et al. (2010). Protective role of peroxisome proliferator-activated receptor-β/δ in septic shock. Am J Respir Crit Care Med 182, (12) 1506-1515.
    10.1164/rccm.201002-0240OC
  • Frith D, Stanworth S, Gaarder C et al. (2010). Acute traumatic coagulopathy is dependent upon injury load and shock. BRITISH JOURNAL OF SURGERY 9739-40.
  • Lovell MJ, Yasin M, Lee KL et al. (2010). Bone marrow mononuclear cells reduce myocardial reperfusion injury by activating the PI3K/Akt survival pathway. Atherosclerosis 213, (1) 67-76.
    10.1016/j.atherosclerosis.2010.07.045
  • Galuppo M, Di Paola R, Mazzon E et al. (2010). GW0742, a high affinity PPAR-β/δ agonist reduces lung inflammation induced by bleomycin instillation in mice. Int J Immunopathol Pharmacol 23, (4) 1033-1046.
    10.1177/039463201002300408
  • Frith D, Goslings JC, Gaarder C et al. (2010). Definition and drivers of acute traumatic coagulopathy: clinical and experimental investigations. J Thromb Haemost 8, (9) 1919-1925.
    10.1111/j.1538-7836.2010.03945.x
  • Kapoor A, Collino M, Castiglia S et al. (2010). Activation of peroxisome proliferator-activated receptor-beta/delta attenuates myocardial ischemia/reperfusion injury in the rat. Shock 34, (2) 117-124.
    10.1097/SHK.0b013e3181cd86d6
  • Barry SP, Lawrence KM, McCormick J et al. (2010). New targets of urocortin-mediated cardioprotection. J Mol Endocrinol 45, (2) 69-85.
    10.1677/JME-09-0148
  • Collino M, Aragno M, Castiglia S et al. (2010). Pioglitazone improves lipid and insulin levels in overweight rats on a high cholesterol and fructose diet by decreasing hepatic inflammation. BRIT J PHARMACOL 160, (8) 1892-1902.
    10.1111/j.1476-5381.2010.00671.x
  • Ghezzi P, Bernaudin M, Bianchi R et al. (2010). Erythropoietin: not just about erythropoiesis. Lancet 375, (9732) 2142-.
    10.1016/S0140-6736(10)60992-0
  • Rehberg S, Thiemermann C, Traber DL (2010). Increased inotropism following PARP inhibition in the setting of myocardial reperfusion injury: another piece in the jigsaw?. Shock 33, (6) 668-669.
    10.1097/SHK.0b013e3181c24e87
  • Paterniti I, Esposito E, Mazzon E et al. (2010). Evidence for the Role of Peroxisome Proliferator-Activated Receptor-beta/delta in the Development of Spinal Cord Injury. J PHARMACOL EXP THER 333, (2) 465-477.
    10.1124/jpet.110.165605
  • Rehberg S, Thiemermann C, Maybauer MO (2010). Role of chelatable iron versus myoglobin in oxidative stress after crush trauma. Shock 33, (5) 552-553.
    10.1097/SHK.0b013e3181c24fa7
  • Esposito E, Paterniti I, Mazzon E et al. (2010). Evidence for the role of PPAR-beta/delta in the development of spinal cord injury. FASEB JOURNAL 24.
  • Di Paola R, Crisafulli C, Mazzon E et al. (2010). GW0742, A HIGH-AFFINITY PPAR-beta/delta AGONIST, INHIBITS ACUTE LUNG INJURY IN MICE. SHOCK 33, (4) 426-435.
    10.1097/SHK.0b013e3181b8f2fb
  • Salem HK, Thiemermann C (2010). Mesenchymal stromal cells: current understanding and clinical status. Stem Cells 28, (3) 585-596.
    10.1002/stem.269
  • Galuppo M, Di Paola R, Mazzon E et al. (2010). Role of PPAR-delta in the development of zymosan-induced multiple organ failure: an experiment mice study. J INFLAMM-LOND 7.
    10.1186/1476-9255-7-12
  • Milsom AB, Patel NSA, Mazzon E et al. (2010). Role for endothelial nitric oxide synthase in nitrite-induced protection against renal ischemia-reperfusion injury in mice. NITRIC OXIDE-BIOL CH 22, (2) 141-148.
    10.1016/j.niox.2009.10.010
  • Kapoor A, Thiemermann C (2010). Hydrogen sulfide, neurogenic inflammation, and cardioprotection: A tale of rotten eggs and vanilloid receptors. CRIT CARE MED 38, (2) 728-730.
    10.1097/CCM.0b013e3181cab0ee
  • Kumar S, Allen DA, Kieswich JE et al. (2009). Dexamethasone ameliorates renal ischemia-reperfusion injury. J Am Soc Nephrol 20, (11) 2412-2425.
    10.1681/ASN.2008080868
  • Wang YY, Dahle MK, Steffensen KR et al. (2009). Liver X receptor agonist GW3965 dose-dependently regulates lps-mediated liver injury and modulates posttranscriptional TNF-alpha production and p38 mitogen-activated protein kinase activation in liver macrophages. Shock 32, (5) 548-553.
    10.1097/SHK.0b013e3181a47f85
  • Scheiermann C, Colom B, Meda P et al. (2009). Junctional adhesion molecule-C mediates leukocyte infiltration in response to ischemia reperfusion injury. Arterioscler Thromb Vasc Biol 29, (10) 1509-1515.
    10.1161/ATVBAHA.109.187559
  • Maio R, Figueiredo N, Santos I et al. (2009). STRATEGIES TO IMPROVE THE QUALITY OF ORGANS FROM DCD. TRANSPL INT 2243-43.
  • Milsom A, Patel N, Storey A et al. (2009). Role for endothelial nitric oxide synthase in nitrite-induced protection against renal ischaemia-reperfusion injury in mice. NITRIC OXIDE-BIOLOGY AND CHEMISTRY 20S39-S40.
    10.1016/j.niox.2009.10.010
  • Bianca RDD, Sorrentino R, Mitidieri E et al. (2009). RECOMBINANT HUMAN ERYTHROPOIETIN PREVENTS LIPOPOLYSACCHARIDE-INDUCED VASCULAR HYPOREACTIVITY IN THE RAT. SHOCK 31, (5) 529-534.
    10.1097/SAK.0b013e31818909c0
  • di Villa Bianca RD, Sorrentino R, Mitidieri E et al. (2009). Recombinant human erythropoietin prevents lipopolysaccharide-induced vascular hyporeactivity in the rat. Shock 31, (5) 529-534.
    10.1097/SHK.0b013e31818909c0
  • Ozuna H, Burke D, Wylie M et al. (2009). Alternative mRNA splicing of RAD5 on mouse tissues. FASEB JOURNAL 23.
  • Genilo EJ, Dutta S, Keating A (2009). Determining specificities and affinities between BH3 peptides and BcL-2 proteins using yeast surface display. FASEB JOURNAL 23.
  • Colom B, Scheiermann C, Woodfin A et al. (2009). Effect of soluble JAM-C on leukocyte transmigration in models of ischemia/reperfusion injury. FASEB JOURNAL 23.
  • Sepodes BM, Rocha JP, Eduardo-Figueira M et al. (2009). Effects of Glycogen Synthase Kinase-beta Inhibition in Ischemia-Reperfusion Injury of the Liver. FASEB JOURNAL 23.
  • Tripatara P, Patel NSA, Brancaleone V et al. (2009). Characterisation of cystathionine gamma-lyase/hydrogen sulphide pathway in ischaemia/reperfusion injury of the mouse kidney: an in vivo study. Eur J Pharmacol 606, (1-3) 205-209.
    10.1016/j.ejphar.2009.01.041
  • Sivarajah A, Collino M, Yasin M et al. (2009). Anti-apoptotic and anti-inflammatory effects of hydrogen sulfide in a rat model of regional myocardial I/R. Shock 31, (3) 267-274.
    10.1097/SHK.0b013e318180ff89
  • Patel NSA, di Paola R, Mazzon E et al. (2009). Peroxisome proliferator-activated receptor-alpha contributes to the resolution of inflammation after renal ischemia/reperfusion injury. J Pharmacol Exp Ther 328, (2) 635-643.
    10.1124/jpet.108.146191
  • Patel NSA, Brines M, Sepodes B et al. (2009). A TISSUE PROTECTIVE, BUT NON-HAEMATOPOIETIC, ANALOGUE OF ERYTHROPOIETIN FOR THE TREATMENT OF ACUTE KIDNEY INJURY. SHOCK 325-5.
  • Kapoor A, Collino M, Castiglia S et al. (2009). ACTIVATION OF PPAR-beta/delta ATTENUATES MYOCARDIAL ISCHEMIA/REPERFUSION INJURY IN THE RAT. SHOCK 3223-23.
  • Frith D, Chesebro B, Pittet JF et al. (2009). ACUTE TRAUMATIC COAGULOPATHY IS DRIVEN BY SYSTEMIC HYPOPERFUSION INDEPENDENT OF HYPOTENSION AND HAEMORRHAGE VOLUME. SHOCK 329-9.
  • Nandra KK, Patel NSA, Thiemermann C (2009). DAILY PRETREATMENT WITH ERYTHROPOIETIN ATTENUATES THE TISSUE INJURY CAUSED BY HAEMORRHAGIC SHOCK. SHOCK 3211-11.
  • Cuzzoerea S, Galuppo M, Di Paola R et al. (2009). GW0742, A HIGH AFFINITY PPAR-beta/delta AGONIST REDUCES THE DEVELOPMENT OF ZYMOSAN-INDUCED MULTIPLE ORGAN FAILURE IN MICE. SHOCK 3213-13.
  • Collino M, Aragno M, Castiglia S et al. (2009). Insulin Reduces Cerebral Ischemia/Reperfusion Injury in the Hippocampus of Diabetic Rats A Role for Glycogen Synthase Kinase-3 beta. DIABETES 58, (1) 235-242.
    10.2337/db08-0691
  • Kapoor A, Shintani Y, Collino M et al. (2009). PPAR-B/delta ACTIVATION ATTENUATES ORGAN INJURY/DYSFUNCTION AND INFLAMMATION CAUSED BY ENDOTOXIN. SHOCK 327-7.
  • Maio R, Figueiredo N, Santos I et al. (2009). PRE-TREATMENT OF THE DONOR WITH ERYTHROPOIETIN AND TREATMENT OF THE RECIPIENT WITH 5-AIQ IMPROVES THE QUALITY OF ORGANS FROM DONORS AFTER CARDIAC DEATH (DCD), IN EXPERIMENTAL KIDNEY TRANSPLANTATION. SHOCK 325-5.
  • Marques P, Rocha J, Pinto R et al. (2009). THE EFFECT OF LIPOPOLYSACCHARIDE PRECONDITIONING IN AN EXPERIMENTAL MODEL OF BURN INJURY IN THE RAT. SHOCK 326-6.
  • Marques P, Rocha J, Pinto R et al. (2009). THE EFFECT OF SIMVASTATTN PRE-TREATMENT IN AN EXPERIMENTAL MODEL OF BURN INJURY IN THE RAT. SHOCK 3219-19.
  • Davenport R, Coates A, Allard S et al. (2009). TRAUMA HAEMORRHAGE: EVOLVING ROLE OF ROTEM FOR PREDICTING TRANSFUSION REQUIREMENTS. SHOCK 3215-15.
  • Eltze T, Boer R, Wagner T et al. (2008). Imidazoquinolinone, Imidazopyridine, and Isoquinolindione Derivatives as Novel and Potent Inhibitors of the Poly(ADP-ribose) Polymerase (PARP): A Comparison with Standard PARP Inhibitors. MOL PHARMACOL 74, (6) 1587-1598.
    10.1124/mol.108.048751
  • Yasin M, Shintani Y, Collino M et al. (2008). Bone Marrow Mononuclear Cell Therapy upon Reperfusion Reduces Myocardial Infarct Size by Activating the PI3K/Akt Survival Pathway. CIRCULATION 118, (18) S380-S380.
  • Dugo L, Collin M, Allen DA et al. (2008). Inhibiting Glycogen Synthase Kinase 3β in Sepsis. 280128-142.
    10.1002/9780470059593.ch9
  • Tripatara P, Patel NSA, Collino M et al. (2008). Generation of endogenous hydrogen sulfide by cystathionine gamma-lyase limits renal ischemia/reperfusion injury and dysfunction. Lab Invest 88, (10) 1038-1048.
    10.1038/labinvest.2008.73
  • Collino M, Thiemermann C, Mastrocola R et al. (2008). Treatment with the glycogen synthase kinase-3 beta inhibitor, TDZD-8, affects transient cerebral ischemia/reperfusion injury in the rat hippocampus. SHOCK 30, (3) 299-307.
    10.1097/SHK.0b013e318164e762
  • Thiemermann C (2008). What's new in Shock, September 2008?. Shock 30, (3) 227-230.
    10.1097/SHK.0b013e318181002b
  • Brines M, Patel NSA, Villa P et al. (2008). Nonerythropoietic, tissue-protective peptides derived from the tertiary structure of erythropoietin. P NATL ACAD SCI USA 105, (31) 10925-10930.
    10.1073/pnas.0805594105
  • Todorovic Z, Nesic Z, Stojanovic R et al. (2008). Acute protective effects of simvastatin in the rat model of renal ischemia-reperfusion injury: It is never too late for the pretreatment. J PHARMACOL SCI 107, (4) 465-470.
    10.1254/jphs.SC0070374
  • Collino M, Patel NSA, Thiemermann C (2008). PPARs as new therapeutic targets for the treatment of cerebral ischemia/reperfusion injury. Ther Adv Cardiovasc Dis 2, (3) 179-197.
    10.1177/1753944708090924
  • Maio R, Figueiredo N, Santos I et al. (2008). Strategies to improve the quality of organs from DCD: Pre-treat the donor with erythropoietin and treat the recipient with 5-aminoisoquinolinone. AMERICAN JOURNAL OF TRANSPLANTATION 8303-303.
  • Figueiredo N, Maio R, Santos I et al. (2008). The effect of 5-aminoisoquinolinone during machine perfusion of kidneys recovered after cardiac death (Experimental study). AMERICAN JOURNAL OF TRANSPLANTATION 8498-498.
  • Myhre AE, Agren J, Dahle MK et al. (2008). Liver X receptor is a key regulator of cytokine release in human monocytes. Shock 29, (4) 468-474.
    10.1097/shk.0b013e31815073cb
  • Thiemermann C (2008). What's new in Shock, April 2008?. Shock 29, (4) 427-430.
    10.1097/SHK.0b013e31816c14e9
  • Murch O, Abdelrahman M, Kapoor A et al. (2008). Muramyl dipeptide enhances the response to endotoxin to cause multiple organ injury in the anesthetized rat. Shock 29, (3) 388-394.
    10.1097/shk.0b013e3181453e59
  • Thiemermann C (2008). What's new in shock, March 2008. Shock 29, (3) 311-314.
    10.1097/SHK.0b013e31816470a0
  • Murch O, Abdelrahman M, Collino M et al. (2008). Sphingosylphosphorylcholine reduces the organ injury/dysfunction and inflammation caused by endotoxemia in the rat. Crit Care Med 36, (2) 550-559.
    10.1097/01.CCM.0B013E3181620D2F
  • Wang JE, Wang YY, Dahle MK et al. (2008). Role of liver X receptor in experimental sepsis. SHOCK 29101-101.
  • Frith D, Chesebro B, Patel N et al. (2008). Towards a mouse model for acute coagulopathy of trauma/shock. SHOCK 296-6.
  • Cuzzocrea S, Malleo G, Genovese T et al. (2007). Effects of glycogen synthase kinase-3beta inhibition on the development of cerulein-induced acute pancreatitis in mice*. Crit Care Med .
    10.1097/01.CCM.0000295303.62996.9F
  • Ruud TE, Gundersen Y, Wang JE et al. (2007). Activation of cytokine synthesis by systemic infusions of lipopolysaccharide and peptidoglycan in a porcine model in vivo and in vitro. Surg Infect (Larchmt) 8, (5) 495-503.
    10.1089/sur.2006.083
  • Thiemermann C (2007). What's new in shock, October 2007?. SHOCK 28, (4) 371-374.
    10.1097/shk.0b13e3181814a54f8
  • Sexton A, McDonald M, Cayla C et al. (2007). 12-Lipoxygenase-derived eicosanoids protect against myocardial ischemia/reperfusion injury via activation of neuronal TRPV1. FASEB J 21, (11) 2695-2703.
    10.1096/fj.06-7828com
  • Bao Z, Lim SH, Liao WP et al. (2007). Glycogen synthase kinase-3 beta inhibition attenuates asthma in mice. AM J RESP CRIT CARE 176, (5) 431-438.
    10.1164/rccm.200609-1292OC
  • Cuzzocrea S, Genovese T, Mazzon E et al. (2007). Glycogen synthase kinase-3 beta inhibition attenuates the development of bleomycin-induced lung injury. INT J IMMUNOPATH PH 20, (3) 619-630.
    10.1177/039463200702000320
  • Bao Z, Lim S, Lin Y et al. (2007). Anti-inflammatory effects of GSK-3B inhibitor TDZD-8 in a mouse model of asthma. INFLAMM RES 56S416-S416.
  • Dugo L, Abdelrahman M, Murch O et al. (2007). Glycogen synthase kinase-3beta inhibitors protect against the organ injury and dysfunction caused by hemorrhage and resuscitation. INFLAMM RES 56S387-S387.
  • Albuszies G, Vogt J, Wachter U et al. (2007). The effect of iNOS deletion on hepatic gluconeogenesis in hyperdynamic murine septic shock. INTENS CARE MED 33, (6) 1094-1101.
    10.1007/s00134-007-0638-7
  • Thiemermann C (2007). What's new in Shock, June 2007. SHOCK 27, (6) 593-596.
    10.1097/shk.0b013e3180546b6b
  • Patel NSA, Cuzzocrea S, Collino M et al. (2007). The role of cycloxygenase-2 in the rodent kidney following ischaemia/reperfusion injury in vivo. Eur J Pharmacol 562, (1-2) 148-154.
    10.1016/j.ejphar.2007.01.079
  • Hadley JS, Wang JE, Michaels LC et al. (2007). Alterations in inflammatory capacity and TLR expression on monocytes and neutrophils after cardiopulmonary bypass. Shock 27, (5) 466-473.
    10.1097/01.shk.0000245033.69977.c5
  • Maio RF, Figueiredo NL, Sepodes BN et al. (2007). Donor pre-treatment with erythropoietin - A way to improve the quality of organs from donation after cardiac death (experimental study). AMERICAN JOURNAL OF TRANSPLANTATION 7251-251.
  • Cuzzocrea S, Mazzon E, Esposito E et al. (2007). Glycogen synthase kinase-3 beta inhibition attenuates the development of ischaemia/reperfusion injury of the gut. INTENS CARE MED 33, (5) 880-893.
    10.1007/s00134-007-0595-1
  • Figueiredo NL, Maio RF, Sepodes BN et al. (2007). The effect of donor pre-treatment with erythropoietin in machine perfusion parameters (Experimental study). AMERICAN JOURNAL OF TRANSPLANTATION 7508-508.
  • Thiemermann C (2007). What's new in Shock, May 2007?. SHOCK 27, (5) 457-460.
    10.1097/shk.0b013e31804854ca
  • Whittle BJ, Varga C, Berko A et al. (2007). Attenuation of indomethacin-induced rat intestinal lesions, TNF alpha-production and iNOS activity by Tdzd-8, an inhibitor of glycogen synthase kinase-3p. GASTROENTEROLOGY 132, (4) A564-A564.
  • Cartwright N, Murch O, McMaster SK et al. (2007). Selective NOD1 agonists cause shock and organ injury/dysfunction in vivo. Am J Respir Crit Care Med 175, (6) 595-603.
    10.1164/rccm.200608-1103OC
  • Sivarajah A, Collino M, Yasin M et al. (2007). Hydrogen sulfide in disease. INFLAMM RES 56S261-S261.
  • Thiemermann C (2007). Inhibitors of glycogen-synthase kinase 3beta. INFLAMM RES 56S260-S260.
  • Dugo L, Collin M, Thiemermann C (2007). Glycogen synthase kinase 3beta as a target for the therapy of shock and inflammation. Shock 27, (2) 113-123.
    10.1097/01.shk.0000238059.23837.68
  • Tripatara P, Patel NSA, Webb A et al. (2007). Nitrite-derived nitric oxide protects the rat kidney against ischemia/reperfusion injury in vivo: role for xanthine oxidoreductase. J Am Soc Nephrol 18, (2) 570-580.
    10.1681/ASN.2006050450
  • Thiemermann C (2007). Beneficial effects of erythropoietin in preclinical models of shock and organ failure. Crit Care 11, (3) 132-.
    10.1186/cc5912
  • Cuzzocrea S, Di Paola R, Mazzon E et al. (2007). Glycogen synthase kinase 3 beta inhibition reduces the development of nonseptic shock induced by zymosan in mice. SHOCK 27, (1) 97-107.
    10.1097/01.shk.0000235084.56100.71
  • Dugo L, Collin M, Allen DA et al. (2007). Inhibiting glycogen synthase kinase 3beta in sepsis. Novartis Found Symp 280128-142.
  • Murch O, Collin M, Hinds CJ et al. (2007). Lipoproteins in inflammation and sepsis. I. Basic science. Intensive Care Med 33, (1) 13-24.
    10.1007/s00134-006-0432-y
  • Murch O, Collin M, Thiemermann C (2007). Lysophosphatidic acid reduces the organ injury caused by endotoxemia-a role for G-protein-coupled receptors and peroxisome proliferator-activated receptor-gamma. Shock 27, (1) 48-54.
    10.1097/01.shk.0000235086.63723.7e
  • Nesic Z, Todorovic Z, Stojanovic R et al. (2006). Single-dose intravenous simvastatin treatment attenuates renal injury in an experimental model of ischemia-reperfusion in the rat. J PHARMACOL SCI 102, (4) 413-417.
    10.1254/jphs.SCE06002X
  • Collino M, Aragno M, Mastrocola R et al. (2006). Oxidative stress and inflammatory response evoked by transient cerebral ischemia/reperfusion: Effects of the PPAR-alpha agonist WY14643 (vol 41, pg 579, 2006). FREE RADICAL BIO MED 41, (10) 1619-1619.
    10.1016/j.freeradbiomed.2006.09.013
  • Cuzzocrea S, Crisafulli C, Mazzon E et al. (2006). Inhibition of glycogen synthase kinase-3 beta attenuates the development of carrageenan-induced lung injury in mice. BRIT J PHARMACOL 149, (6) 687-702.
    10.1038/sj.bjp.0706902
  • Sepodes B, Maio R, Pinto R et al. (2006). Recombinant human erythropoietin protects the liver from hepatic ischemia-reperfusion injury in the rat. TRANSPLANT INT 19, (11) 919-926.
    10.1111/j.1432-2277.2006.00366.x
  • Sepodes B, Abdelrahman M, Rocha J et al. (2006). A glycogen synthase kinase-3 inhibitor (TDZD-8) attenuates the liver and neuromuscular injury caused by burn in the rat. SHOCK 2620-20.
    10.1097/00024382-200610001-00064
  • McCormick J, Barry SP, Sivarajah A et al. (2006). Free radical scavenging inhibits STAT phosphorylation following in vivo ischemia/reperfusion injury. FASEB J 20, (12) 2115-+.
    10.1096/fj.06-6188fje
  • Cuzzocrea S, Di Paola R, Mazzon E et al. (2006). Glycogen synthase kinase-3 beta inhibition reduces the development of non-septic shock induced by zymosan in mice. SHOCK 266-7.
    10.1097/00024382-200610001-00019
  • Sepodes B, Rocha J, Abdelrahman M et al. (2006). Inhibition of endogenous hydrogen sulphide formation protects the liver from hepatic ischemia-reperfusion injury in the rat. SHOCK 2615-16.
    10.1097/00024382-200610001-00049
  • Ruud TE, Gundersen Y, Wang JE et al. (2006). Systemic petidoglycan (PegG) stimulates proinflammatory responses in synergy with lipopolysaccharide (LPS) in an in vivo and in vitro porcine model. SHOCK 2632-32.
    10.1097/00024382-200610001-00099
  • Albuszies G, Vogt J, Radermacher P et al. (2006). The role of iNOS for hepatic glucose production in murine septic shock. SHOCK 263-4.
    10.1097/00024382-200610001-00010
  • Thiemermann C (2006). What's new in Shock, October 2006?. SHOCK 26, (4) 319-321.
    10.1097/0.1shk.0000235129.05235.14
  • Thiemermann C (2006). What's new in Shock, September 2006?. SHOCK 26, (3) 223-225.
    10.1097/01.shk.0000235136.12858.b7
  • Collino M, Aragno M, Mastrocola R et al. (2006). Oxidative stress and inflammatory response evoked by transient cerebral ischemia/reperfusion: Effects of the PPAR-alpha agonist WY14643. FREE RADICAL BIO MED 41, (4) 579-589.
    10.1016/j.freeradbiomed.2006.04.030
  • Sivarajah A, McDonald MC, Thiemermann C (2006). The production of hydrogen sulfide limits myocardial ischemia and reperfusion injury and contributes to the cardioprotective effects of preconditioning with endotoxin, but not ischemia in the rat. Shock 26, (2) 154-161.
    10.1097/01.shk.0000225722.56681.64
  • Bao Z, Lim SH, Thiemermann C et al. (2006). Anti-inflammatory effects of glycogen synthase kinase-3 beta inhibitor in a mouse asthma model. ACTA PHARMACOL SIN 27270-270.
  • Agren J, Thiemermann C, Foster SJ et al. (2006). Cytokine responses to CpG DNA in human leukocytes. SCAND J IMMUNOL 64, (1) 61-68.
    10.1111/j.1365-3083.2006.01779.x
  • Cuzzocrea S, Genovese T, Mazzon E et al. (2006). Glycogen synthase kinase-3 beta inhibition reduces secondary damage in experimental spinal cord trauma. J PHARMACOL EXP THER 318, (1) 79-89.
    10.1124/jpet.106.102863
  • Abdelrahman M, Dugo L, Murch O et al. (2006). Glycogen synthase kinase-3-beta inhibitors attenuate the organ injury/dysfunction caused by hemorrhagic shock. ACTA PHARMACOL SIN 27161-161.
  • Sepodes B, Abdelrahman M, Pinto R et al. (2006). Glycogen synthase kinase-3b inhibitor, TDZD-8, attenuates the liver injury caused by ischemia-reperfusion in the rat. ACTA PHARMACOL SIN 27278-278.
  • THIEMERMANN C, Muia C, Di Paola R et al. (2006). Glycogen synthase kinase-3beta inhibition attenuates the degree of arthritis caused by type II collagen in the mouse. Clin. Immunol 120, (1) 57-67.
    10.1016/j.clim.2006.03.005
  • Murch O, Collin M, Sepodes B et al. (2006). Lysophosphatidylcholine reduces the organ injury and dysfunction in rodent models of gram-negative and gram-positive shock. Br J Pharmacol 148, (6) 769-777.
    10.1038/sj.bjp.0706788
  • Thiemermann C (2006). Poly (ADP-ribose) polymerase (PARP) inhibitors for the treatment of Ischemia-Reperfusion injury. ACTA PHARMACOL SIN 2737-37.
  • Bar-Or D, McDonald MC, Thiemermann C (2006). Reduction of infarct size in a rat model of regional myocardial ischemia and reperfusion by the synthetic peptide DAHK. CRIT CARE MED 34, (7) 1955-1959.
    10.1097/01.CCM.0000220493.10289.03
  • Thiemermann C (2006). The spice of life: Curcumin reduces the mortality associated with experimental sepsis. CRIT CARE MED 34, (7) 2009-2011.
    10.1097/01.CCM.0000226836.72913.C4
  • Wang YY, Dahle MK, Collins JL et al. (2006). Activation of liver x receptor by synthetic agonist t0901317 reduces the liver injury caused by lipopolysaccharide in the rat: A novel principle for treatment of sepsis and shock. SHOCK 2572-72.
    10.1097/00024382-200606001-00217
  • Myhre AE, Lyngstadaas SP, Dahle MK et al. (2006). Anti-inflammatory properties of enamel matrix derivative in human blood. J PERIODONTAL RES 41, (3) 208-213.
    10.1111/j.1600-0765.2005.00863.x
  • Patel NSA, Tripatara P, Thiemermann C (2006). Inhibition of hydrogen sulfide synthesis protects the rat kidney in vivo against ischemia-reperfusion injury. SHOCK 2537-37.
    10.1097/00024382-200606001-00110
  • Murch O, Wray J, Collin M et al. (2006). Lysophosphatidic acid reduces the organ injury caused by endotoxemia via activation of G-protein-coupled receptors, but not peroxisome proliferator-activated receptor gamma. SHOCK 2572-72.
    10.1097/00024382-200606001-00218
  • Lovell M, McDonald M, Sivarajah A et al. (2006). Bone marrow mononuclear cells home to the heart in the acute setting of myocardial infarction with no adverse effects on cardiac function. HEART 92A70-A71.
  • Dugo L, Abdelrahman M, Murch O et al. (2006). Glycogen synthase kinase-3beta inhibitors protect against the organ injury and dysfunction caused by hemorrhage and resuscitation. Shock 25, (5) 485-491.
    10.1097/01.shk.0000209545.29671.31
  • Dugo L, Collin M, Allen DA et al. (2006). Insulin reduces the multiple organ injury and dysfunction caused by coadministration of lipopolysaccharide and peptidoglycan independently of blood glucose: role of glycogen synthase kinase-3beta inhibition. Crit Care Med 34, (5) 1489-1496.
    10.1097/01.CCM.0000215457.83953.E3
  • Lovell M, McDonald M, Sivarajah A et al. (2006). Localisation of bone marrow mononuclear cells administered during acute myocardial infarction; The effects of time in culture. HEART 92A69-A70.
  • Thiemermann C (2006). What's new in SHOCK, May 2006?. SHOCK 25, (5) 429-431.
    10.1097/01.shk.0000215323.29736.cl
  • Thiemermann C, Yaqoob MM (2006). Cardio-renal interface in translational and clinical research. CURR OPIN PHARMACOL 6, (2) 121-124.
    10.1016/j.coph.2006.02.001
  • Cuzzocrea S, Di Paola R, Mazzon E et al. (2006). Erythropoietin reduces the development of nonseptic shock induced by zymosan in mice. CRIT CARE MED 34, (4) 1168-1177.
    10.1097/01.CCM.0000207346.56477.E8
  • Whittle BJ, Varga C, Berko A et al. (2006). Modulation of rat colonic TNF-alpha, iNOS and acute colitis through down-regulation of NF-kappa B by glycogen synthase kinase-3 beta inhibition. GASTROENTEROLOGY 130, (4) A551-A551.
  • Sharples EJ, Thiemermann C, Yaqoob MM (2006). Novel applications of recombinant erythropoietin. Curr Opin Pharmacol 6, (2) 184-189.
    10.1016/j.coph.2006.01.003
  • Collin M, Murch O, Thiemermann C (2006). Peroxisome proliferator-activated receptor-gamma antagonists GW9662 and T0070907 reduce the protective effects of lipopolysaccharide preconditioning against organ failure caused by endotoxemia. CRIT CARE MED 34, (4) 1131-1138.
    10.1097/01.CCM.0000206472.63040.60
  • Collin M, Murch O, Thiemermann C (2006). Peroxisome proliferator-activated receptor-gamma antagonists GW9662 and T0070907 reduce the protective effects of lipopolysaccharide preconditioning against organ failure caused by endotoxemia. Crit Care Med 34, (4) 1131-1138.
    10.1097/01.CCM.0000206472.63040.6D
  • Goddard A, McDonald M, Thiemermann C et al. (2006). Identification of an endogenous cardioprotective pathway involving 12-lipoxygenase (12-LOX), C-fibers and the non-selective cation channel TRPV1. FASEB JOURNAL 20, (4) A230-A230.
  • Myhre AE, Aasen AO, Thiemermann C et al. (2006). Peptidoglycan - An endotoxin in its own right?. SHOCK 25, (3) 227-235.
    10.1097/01.shk.0000191378.55274.37
  • Whittle BJR, Varga C, Pósa A et al. (2006). Reduction of experimental colitis in the rat by inhibitors of glycogen synthase kinase-3beta. Br J Pharmacol 147, (5) 575-582.
    10.1038/sj.bjp.0706509
  • Wang YY, Dahle MK, Agren J et al. (2006). Activation of the liver X receptor protects against hepatic injury in endotoxemia by suppressing Kupffer cell activation. SHOCK 25, (2) 141-146.
    10.1097/01.shk.0000191377.78144.d9
  • Barth E, Radermacher P, Thiemermann C et al. (2006). Role of inducible nitric oxide synthase in the reduced responsiveness of the myocardium to catecholamines in a hyperdynamic, murine model of septic shock. CRIT CARE MED 34, (2) 307-313.
    10.1097/01.CCM.0000199070.46812.21
  • Collino M, Aragno M, Mastrocola R et al. (2006). Modulation of the oxidative stress and inflammatory response by PPAR-gamma agonists in the hippocampus of rats exposed to cerebral ischemia/reperfusion. EUR J PHARMACOL 530, (1-2) 70-80.
    10.1016/j.ejphar.2005.11.049
  • THIEMERMANN C, Gallicchio M, Danni O et al. (2006). Modulation of the oxidative stress and inflammatory response by PPAR-gamma agonists in the hippocampus of rats exposed to cerebral ischemia/reperfusion. Eur J Pharmacol 530, (1-2) 70-70.
  • Wang YY, Dahle MK, Aasen AO et al. (2005). Activation of the liver X receptor by GW3965 protects against hepatic injury in endotoxemia. CRITICAL CARE MEDICINE 33, (12) A138-A138.
    10.1097/00003246-200512002-00489
  • Collin M, Thiemermann C (2005). Hydrogen sulfide and sulfite: Novel mediators in the pathophysiology of shock and inflammation. SHOCK 24, (6) 595-596.
    10.1097/01.shk.0000188328.59770.25
  • Sharples EJ, Thiemermann C, Yaqoob MM (2005). Mechanisms of disease: Cell death in acute renal failure and emerging evidence for a protective role of erythropoietin. Nat Clin Pract Nephrol 1, (2) 87-97.
    10.1038/ncpneph0042
  • Hadley JS, Wang JE, Foster SJ et al. (2005). Peptidoglycan of Staphylococcus aureus upregulates monocyte expression of CD14, Toll-like receptor 2 (TLR2), and TLR4 in human blood: possible implications for priming of lipopolysaccharide signaling. Infect Immun 73, (11) 7613-7619.
    10.1128/IAI.73.11.7613-7619.2005
  • Collin M, Anuar FBM, Murch O et al. (2005). Inhibition of endogenous hydrogen sulfide formation reduces the organ injury caused by endotoxemia. Br J Pharmacol 146, (4) 498-505.
    10.1038/sj.bjp.0706367
  • Dugo L, Collin M, Allen DA et al. (2005). GSK-3beta inhibitors attenuate the organ injury/dysfunction caused by endotoxemia in the rat. Crit Care Med 33, (9) 1903-1912.
    10.1097/01.CCM.0000178350.21839.44
  • Wang YY, Myhre AE, Pettersen SJ et al. (2005). Peptidoglycan of Staphylococcus aureus induces enhanced levels of matrix metalloproteinase-9 in human blood originating from neutrophils. Shock 24, (3) 214-218.
    10.1097/01.shk.0000174935.13786.6c
  • Collino M, Patel NSA, Lawrence KM et al. (2005). The selective PPARgamma antagonist GW9662 reverses the protection of LPS in a model of renal ischemia-reperfusion. Kidney Int 68, (2) 529-536.
    10.1111/j.1523-1755.2005.00430.x
  • Collin M, Murch O, Thiemermann C (2005). Lysophosphatidylcholine reduces the multiple organ injury and dysfunction caused by endotoxemia in the rat. SHOCK 2341-41.
  • Sivarajah A, McDonald MC, Thiemermann C (2005). The cardioprotective effects of endotoxin are abolished by the PPAR-g antagonist GW9662. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY 38, (6) 1068-1068.
  • Sivarajah A, McDonald MC, Thiemermann C (2005). The cardioprotective effects of endotoxin but not ischemia are abolished by the PPAR-gamma antagonist GW9662. SHOCK 2331-31.
  • Patel NSA, Collino M, Collin M et al. (2005). The selective PPAR gamma antagonist GW9662 abolished the protection afforded by lpspretreatment in a rat model of renal ischemia/reperfusion injury. SHOCK 2330-31.
  • Genovese T, Mazzon E, Di Paola R et al. (2005). Inhibitors of poly(ADP-ribose) polymerase modulate signal transduction pathways and the development of bleomycin-induced lung injury. J PHARMACOL EXP THER 313, (2) 529-538.
    10.1124/jpet.104.080705
  • Sivarajah A, McDonald MC, Thiemermann C (2005). The cardioprotective effects of preconditioning with endotoxin, but not ischemia, are abolished by a peroxisome proliferator-activated receptor-gamma antagonist. J Pharmacol Exp Ther 313, (2) 896-901.
    10.1124/jpet.104.080598
  • Chatterjee PK, Todorovic Z, Sivarajah A et al. (2005). Inhibitors of calpain activation (PD150606 and E-64) and renal ischemia-reperfusion injury. Biochem Pharmacol 69, (7) 1121-1131.
    10.1016/j.bcp.2005.01.003
  • Abdelrahman M, Sivarajah A, Thiemermann C (2005). Beneficial effects of PPAR-gamma ligands in ischemia-reperfusion injury, inflammation and shock. Cardiovasc Res 65, (4) 772-781.
    10.1016/j.cardiores.2004.12.008
  • Patel NSA, Chatterjee PK, Di Paola R et al. (2005). Endogenous interleukin-6 enhances the renal injury, dysfunction, and inflammation caused by ischemia/reperfusion. J Pharmacol Exp Ther 312, (3) 1170-1178.
    10.1124/jpet.104.078659
  • Cuzzocrea S, Mazzon E, di Paola R et al. (2005). Erythropoietin reduces the degree of arthritis caused by type II collagen in the mouse. Arthritis Rheum 52, (3) 940-950.
    10.1002/art.20875
  • Patel NSA, Cortes U, Di Poala R et al. (2005). Mice lacking the 110-kD isoform of poly(ADP-ribose) glycohydrolase are protected against renal ischemia/reperfusion injury. J Am Soc Nephrol 16, (3) 712-719.
    10.1681/ASN.2004080677
  • Genovese T, Cuzzocrea S, Di Paola R et al. (2005). Effect of rosiglitazone and 15-deoxy-Delta(12,14)-prostaglandin J(2) on bleomycin-induced lung injury. EUR RESPIR J 25, (2) 225-234.
    10.1183/09031936.05.00049704
  • Abdelrahman M, Mazzon E, Bauer M et al. (2005). Inhibitors of NADPH oxidase reduce the organ injury in hemorrhagic shock. Shock 23, (2) 107-114.
    10.1097/01.shk.0000151028.15377.f7
  • Genovese T, Mazzon E, Muia C et al. (2005). Inhibitors of poly(ADP-ribose) polymerase modulate signal transduction pathways and secondary damage in experimental spinal cord trauma. J PHARMACOL EXP THER 312, (2) 449-457.
    10.1124/jpet.104.076711
  • Di Paola R, Mazzon E, Patel NSA et al. (2005). Beneficial effects of GW274150 treatment on the development of experimental colitis induced by dinitrobenzene sulfonic acid. EUR J PHARMACOL 507, (1-3) 281-289.
    10.1016/j.ejphar.2004.11.041
  • Dugo L, Collin M, Cuzzocrea S et al. (2005). 15d-PGJ(2) reduces the multiple organ failure caused by wall-fragments of Gram-positive and Gram-negative bacteria. SHOCK 2342-42.
  • Di Paola R, Genovese T, Caputi AP et al. (2005). Beneficial effects of 5-aminoisoquinolinone, a novel, potent, water-soluble, inhibitor of the of poly (ADP-ribose) polymerase, in a rat model of splanchnic artery occlusion and reperfusion. SHOCK 2313-14.
  • Barth E, Radermacher P, Thiemermann C et al. (2005). Effetcs of selective iNOS inhibition with GW274150 on catecholamine reactivity during hyperdynamic murine septic shock. SHOCK 2357-57.
  • Abdelrahman M, Bauer M, Bauer I et al. (2005). Inhibitors of NADPH oxidase reduce the organ injury in hemorrhagic shock. SHOCK 2353-53.
    10.1097/01.shk.0000151028.15377.f7
  • Genovese T, Mazzon E, Muia C et al. (2005). Inhibitors of poly (ADP-ribose) polymerase modulate signal transduction pathways and secondary damage in experimental spinal cord trauma. SHOCK 2319-19.
  • Patel NSA, Cortes U, Di Poala R et al. (2005). Mice lacking the 110 KDa isoform of poly(ADP-ribose) glycohydrolase are protected against renal ischemia-reperfusion injury. SHOCK 2340-40.
  • Klouche K, Delbosc S, Abdelrahman M et al. (2005). Oxidative stress tissular production precedes organ dysfunction during animal septic shock. SHOCK 2351-51.
  • WHITTLE BJR, Thiemermann C, Collin M et al. (2005). Reduction of Experimental Colitis in the Rat by Inhibitors of Glycogen Synthase Kinase-3b. J Pharmacol 147575-582.
    10.1038/sj.bjp.0706509
  • Cuzzocrea S, Dugo L, Patel NSA et al. (2005). Rosiglitazont and 15-deoxy-Delta(12,14)-prostaglandin J(2), ligands of the peroxisome proliferator-activated receptor-gamma (PPAR-gamma), reduce ischaemia/reperfusion injury of the gut. SHOCK 2341-42.
  • Agren J, Foster SJ, Thiemermann C et al. (2005). Synthetic CpG- and GpC oligonucleotides enhance the TNF alpha release induced by peptidoglycan but not by lipopolysaccharide. SHOCK 2322-22.
  • Sivarajah A, McDonald MC, Thiemermann C (2005). The cardioprotective effects of preconditioning with endotoxin, but not ischemia, are abolished by a PPAR-gamma antagonist. SHOCK 2341-41.
  • Hadley JS, Wang JE, Michaels LC et al. (2005). The effect of cardiopulmonary bypass (CPB) on monocyte receptor expression and ex vivo cytokine production. SHOCK 2372-72.
  • Sepodes B, Pinto R, McDonald M et al. (2005). Tyrphostin AG126 reduces ischemia-reperfusion injury of the liver in the rat. SHOCK 2339-39.
  • Cuzzocrea S, Mazzon E, Di Paola R et al. (2004). 5-Aminoisoquinolinone reduces colon injury by experimental colitis. N-S ARCH PHARMACOL 370, (6) 464-473.
    10.1007/s00210-004-1002-x
  • Cuzzocrea S, Mazzon E, Di Paola R et al. (2004). Erythropoietin reduces the development of experimental inflammatory bowel disease. J PHARMACOL EXP THER 311, (3) 1272-1280.
    10.1124/jpet.104.073197
  • Hauser B, Radermacher P, Thiemermann C et al. (2004). Nitric oxide, bacteria, and host defense in sepsis: Who needs what?. SHOCK 22, (6) 588-590.
    10.1097/00024382-200412000-00016
  • Abdelrahman M, Collin M, Thiemermann C (2004). The peroxisome proliferator-activated receptor-gamma ligand 15-deoxyDelta12,14 prostaglandin J2 reduces the organ injury in hemorrhagic shock. Shock 22, (6) 555-561.
    10.1097/01.shk.0000144132.13900.24
  • Collin M, Rossi A, Cuzzocrea S et al. (2004). Reduction of the multiple organ injury and dysfunction caused by endotoxemia in 5-lipoxygenase knockout mice and by the 5-lipoxygenase inhibitor zileuton. J Leukoc Biol 76, (5) 961-970.
    10.1189/jlb.0604338
  • Chatterjee PK, Todorovic Z, Sivarajah A et al. (2004). Differential effects of caspase inhibitors on the renal dysfunction and injury caused by ischemia-reperfusion of the rat kidney. Eur J Pharmacol 503, (1-3) 173-183.
    10.1016/j.ejphar.2004.09.025
  • Petrilli V, Herceg Z, Hassa PO et al. (2004). Noncleavable poly(ADP-ribose) polymerase-1 regulates the inflammatbn response in mice. J CLIN INVEST 114, (8) 1072-1081.
    10.1172/JCI200421854
  • Wang JE, Pettersen S, Stuestol JF et al. (2004). Peptidoglycan of S-aureus causes increased levels of matrix metalloproteinases in the rat. SHOCK 22, (4) 376-379.
    10.1097/01.shk.0000140299.48063.89
  • Dugo L, Collin M, Cuzzocrea S et al. (2004). 15d-prostaglandin J2 reduces multiple organ failure caused by wall-fragment of Gram-positive and Gram-negative bacteria. Eur J Pharmacol 498, (1-3) 295-301.
    10.1016/j.ejphar.2004.07.074
  • Patel NSA, Sharples EJ, Cuzzocrea S et al. (2004). Pretreatment with EPO reduces the injury and dysfunction caused by ischemia/reperfusion in the mouse kidney in vivo. Kidney Int 66, (3) 983-989.
    10.1111/j.1523-1755.2004.00847.x
  • Patel NSA, Collin M, Thiemermann C (2004). Urocortin does not reduce the renal injury and dysfunction caused by experimental ischaemia/reperfusion. Eur J Pharmacol 496, (1-3) 175-180.
    10.1016/j.ejphar.2004.06.008
  • Sharples EJ, Patel N, Brown P et al. (2004). Erythropoietin protects the kidney against the injury and dysfunction caused by ischemia-reperfusion. J Am Soc Nephrol 15, (8) 2115-2124.
    10.1097/01.ASN.0000135059.67385.5D
  • Patel NSA, Cuzzocrea S, Chatterjee PK et al. (2004). Reduction of renal ischemia-reperfusion injury in 5-lipoxygenase knockout mice and by the 5-lipoxygenase inhibitor zileuton. Mol Pharmacol 66, (2) 220-227.
    10.1124/mol.66.2.220
  • Cuzzocrea S, Pisano B, Dugo L et al. (2004). Tempol reduces the activation of nuclear factor-kappa B in acute inflammation. FREE RADICAL RES 38, (8) 813-819.
    10.1080/10715760410001710829
  • Cuzzocrea S, Genovese T, Di Paola R et al. (2004). Effect of rosiglitazone and 15-deoxy-Delta 12,14-prostaglandin J2 on bleomycin-induced lung injury. FUNDAMENTAL & CLINICAL PHARMACOLOGY 1890-90.
  • Abdelrahman M, Sharples EJ, McDonald MC et al. (2004). Erythropoietin attenuates the tissue injury associated with hemorrhagic shock and myocardial ischemia. Shock 22, (1) 63-69.
    10.1097/01.shk.0000126869.21260.9d
  • Thiemermann C (2004). Inhibition of the activation of nuclear factor kappa B to reduce myocardial reperfusion injury and infarct size. CARDIOVASC RES 63, (1) 8-10.
    10.1016/j.cardiores.2004.04.023
  • Thiemermann C (2004). Ligands of the peroxisome proliferator-activated receptor-gamma and heart failure. Br J Pharmacol 142, (6) 1049-1051.
    10.1038/sj.bjp.0705898
  • Cuzzocrea S, Mazzon E, Dugo L et al. (2004). Rosiglitazone, a ligand of the peroxisome proliferator-activated receptor-gamma (PPAR-gamma), reduce the evolution of murine type II collagen-induced arthritis. FUNDAMENTAL & CLINICAL PHARMACOLOGY 1890-90.
  • Sepodes B, Pinto R, McDonald M et al. (2004). The effect of haemoglobin pretreatment on the liver ischaemia/reperfusion injury. FUNDAMENTAL & CLINICAL PHARMACOLOGY 18124-124.
  • Cuzzocrea S, Pisano B, Dugo L et al. (2004). Rosiglitazone, a ligand of the peroxisome proliferator-activated receptor-gamma, reduces acute pancreatitis induced by cerulein. INTENS CARE MED 30, (5) 951-956.
    10.1007/s00134-004-2180-1
  • Sepodes B, Maio R, Pinto R et al. (2004). Tempol, an intracelullar free radical scavenger, reduces liver injury in hepatic ischemia-reperfusion in the rat. TRANSPLANTATION PROCEEDINGS 36, (4) 849-853.
    10.1016/j.transproceed.2004.03.050
  • Cuzzocrea S, Dugo L, Patel NSA et al. (2004). High-density lipoproteins reduce the intestinal damage associated with ischemia/reperfusion and colitis. SHOCK 21, (4) 342-351.
    10.1097/01.shk.0000117327.45.192.eb
  • Chatterjee PK, Patel NSA, Kvale EO et al. (2004). EUK-134 reduces renal dysfunction and injury caused by oxidative and nitrosative stress of the kidney. Am J Nephrol 24, (2) 165-177.
    10.1159/000076547
  • Wu AH, Hinds CJ, Thiemermann C (2004). High-density lipoproteins in sepsis and septic shock: Metabolism, actions, and therapeutic applications. SHOCK 21, (3) 210-221.
    10.1097/01.shk.0000111661.09279.82
  • Myhre AE, Stuestol JF, Dahle MK et al. (2004). Organ injury and cytokine release caused by peptidoglycan are dependent on the structural integrity of the glycan chain. INFECT IMMUN 72, (3) 1311-1317.
    10.1128/IAI.72.3.1311-1317.2004
  • Al-Ghamdi SS, Chatterjee PK, Raftery MJ et al. (2004). Role of cytochrome P4502E1 activation in proximal tubular cell injury induced by hydrogen peroxide. Ren Fail 26, (2) 103-110.
    10.1081/jdi-120038483
  • Collin M, Patel NSA, Dugo L et al. (2004). Role of peroxisome proliferator-activated receptor-gamma in the protection afforded by 15-deoxy Delta(12,14) prostaglandin J(2) against the multiple organ failure caused by endotoxin. CRIT CARE MED 32, (3) 826-831.
    10.1097/01.CCM.0000114821.25573.E7
  • Collin M, Abdelrahman M, Thiemermann C (2004). Endogenous ligands of PPAR-gamma reduce the liver injury in haemorrhagic shock. Eur J Pharmacol 486, (2) 233-235.
    10.1016/j.ejphar.2003.12.032
  • Chatterjee PK, Patel NSA, Cuzzocrea S et al. (2004). The cyclopentenone prostaglandin 15-deoxy-Delta(12,14)-prostaglandin J2 ameliorates ischemic acute renal failure. Cardiovasc Res 61, (3) 630-643.
    10.1016/j.cardiores.2003.10.024
  • Chatterjee PK, Chatterjee BE, Pedersen H et al. (2004). 5-Aminoisoquinolinone reduces renal injury and dysfunction caused by experimental ischemia/reperfusion. Kidney Int 65, (2) 499-509.
    10.1111/j.1523-1755.2004.00415.x
  • Wang JE, Dahle MK, Yndestad A et al. (2004). Peptidoglycan of Staphylococcus aureus causes inflammation and organ injury in the rat. CRIT CARE MED 32, (2) 546-552.
    10.1097/01.CCM.0000109775.22138.8F
  • Cuzzocrea S, Pisano B, Dugo L et al. (2004). Rosiglitazone, a ligand of the peroxisome proliferator-activated receptor-gamma, reduces the development of nonseptic shock induced by zymosan in mice. CRIT CARE MED 32, (2) 457-466.
    10.1097/01.CCM.0000109446.38675.61
  • THIEMERMANN C, Cuzzocrea S, Genovese T et al. (2004). Benefical effects of 5-aminoisoquinolinone, a novel, potent, water-soluable, inhibitor of poly (ADP-ribose) polymerase, in a rat model of splanchnic artery occulsion and reperfusion. European Journal of Pharmacology 492203-210.
    10.1016/j.ejphar.2004.03.033
  • Marzocco S, Di Paola R, Autore G et al. (2004). Calpain inhibitor I reduces intestinal ischemia-reperfusion injury in the rat. SHOCK 21, (1) 38-44.
    10.1097/01.shk.0000095056.62263.b2
  • Hadley JS, Wang JE, Foster SJ et al. (2004). Cytokine responses to combined administration of lipopolysaccharide (LPS) and peptidoglycan (PepG). SHOCK 2150-50.
    10.1097/00024382-200403001-00197
  • Sepodes B, Pinto R, McDonald MC et al. (2004). Effect of recombinant human erythropoietin in a rat model of ischemia-reperfusion injury of the liver. SHOCK 2187-87.
    10.1097/00024382-200403001-00346
  • Thiemermann C (2004). Ligands of the peroxisome proliferator-activated receptor-gamma and heart failure. Br J Pharmacol 141, (1) 1-3.
    10.1038/sj.bjp.0705586
  • Hadley JS, Wang JE, Foster SJ et al. (2004). Monocyte cell surface receptor upregulation in response to stimulation with lipopolysaccharide and peptidoglycan. SHOCK 2121-21.
    10.1097/00024382-200403001-00084
  • Wang JE, Dahle MK, Aasen AO et al. (2004). Peptidoglycan causes local and systemic inflammation in the rat. SHOCK 21148-148.
    10.1097/00024382-200403001-00591
  • THIEMERMANN C, Salvemini D, Cuzzocrea S (2004). Potential therapeutic effect of antioxidant therapy in shock and inflammation. Curr. Medicinal Chemistry 111147-1162.
    10.2174/0929867043365396
  • Cuzzocrea S, Pisano B, Dugo L et al. (2004). Rosiglitazone, a ligand of the peroxisome proliferator-activated receptor-gamma, reduces acute inflammation. EUR J PHARMACOL 483, (1) 79-93.
    10.1016/j.ejphar.2003.10.056
  • Chatterjee PK, di Villa Bianca RD, Sivarajah A et al. (2003). Pyrrolidine dithiocarbamate reduces renal dysfunction and injury caused by ischemia/reperfusion of the rat kidney. Eur J Pharmacol 482, (1-3) 271-280.
    10.1016/j.ejphar.2003.09.071
  • Keller T, Pleskova M, McDonald MC et al. (2003). Identification of manganese superoxide dismutase as a NO-regulated gene in rat glomerular mesangial cells by 2D gel electrophoresis. NITRIC OXIDE-BIOL CH 9, (4) 183-193.
    10.1016/j.niox.2004.01.003
  • McDonald MC, Dhadly P, Cockerill GW et al. (2003). Reconstituted high-density lipoprotein attenuates organ injury and adhesion molecule expression in a rodent model of endotoxic shock. Shock 20, (6) 551-557.
    10.1097/01.shk.0000097249.97298.a3
  • Cuzzocrea S, Mazzon E, Dugo L et al. (2003). Reduction in the evolution of murine type II collagen-induced arthritis by treatment with rosiglitazone, a ligand of the peroxisome proliferator-activated receptor gamma. ARTHRITIS RHEUM 48, (12) 3544-3556.
    10.1002/art.11351
  • Sharples EJ, Patel N, Brown P et al. (2003). Erythropoietin protects the kidney against the injury and dysfunction caused by ischemia-reperfusion injury by the inhibition of the caspase cascade and apoptosis. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY 14273A-273A.
  • Wang JE, Dahle MK, McDonald M et al. (2003). Peptidoglycan and lipoteichoic acid in gram-positive bacterial sepsis: receptors, signal transduction, biological effects, and synergism. Shock 20, (5) 402-414.
    10.1097/01.shk.0000092268.01859.0d
  • Cuzzocrea S, Rossi A, Pisano B et al. (2003). Pyrrolidine dithiocarbamate attenuates the development of organ failure induced by zymosan in mice. INTENS CARE MED 29, (11) 2016-2025.
    10.1007/s00134-003-1887-8
  • Chatterjee PK, Patel NSA, Kvale EO et al. (2003). The tyrosine kinase inhibitor tyrphostin AG126 reduces renal ischemia/reperfusion injury in the rat. Kidney Int 64, (5) 1605-1619.
    10.1046/j.1523-1755.2003.00254.x
  • Chatterjee PK, Kvale EO, Patel NSA et al. (2003). GW274150 inhibits nitric oxide production by primary cultures of rat proximal tubular cells. Med Sci Monit 9, (10) BR357-BR362.
  • Muscoli C, Cuzzocrea S, Riley DP et al. (2003). On the selectivity of superoxide dismutase mimetics and its importance in pharmacological studies. BRIT J PHARMACOL 140, (3) 445-460.
    10.1038/sj.bjp.0705430
  • Cuzzocrea S, Pisano B, Dugo L et al. (2003). Rosiglitazone and 15-deoxy-Delta(12,14)-prostaglandin J(2), ligands of the peroxisome proliferator-activated receptor-gamma (PPAR-gamma), reduce ischaemia/reperfusion injury of the gut. BRIT J PHARMACOL 140, (2) 366-376.
    10.1038/sj.bjp.0705419
  • McDonald M, Abdelrahman M, Cuzzocrea S et al. (2003). Tyrphostin reduces the organ injury in haemorrhagic shock: role of inducible nitric oxide synthase. Resuscitation 58, (3) 349-361.
    10.1016/S0300-9572(03)00156-4
  • Collin M, Thiemermann C (2003). The PPAR-gamma ligand 15-deoxy(delta12,14) prostaglandin J2 reduces the liver injury in endotoxic shock. Eur J Pharmacol 476, (3) 257-258.
    10.1016/S0014-2999(03)02179-4
  • Wang Y, Chang CF, Morales M et al. (2003). Diadenosine tetraphosphate protects against injuries induced by ischemia and 6-hydroxydopamine in rat brain. J NEUROSCI 23, (21) 7958-7965.
    10.1523/jneurosci.23-21-07958.2003
  • Sivarajah A, Chatterjee PK, Patel NSA et al. (2003). Agonists of peroxisome-proliferator activated receptor-gamma reduce renal ischemia/reperfusion injury. Am J Nephrol 23, (4) 267-276.
    10.1159/000072088
  • Thiemermann C, Patel NSA, Kvale EO et al. (2003). High density lipoprotein (HDL) reduces renal ischemia/reperfusion injury. J Am Soc Nephrol 14, (7) 1833-1843.
    10.1097/01.asn.0000075552.97794.8c
  • Wayman NS, Ellis BL, Thiemermann C (2003). Simvastatin reduces infarct size in a model of acute myocardial ischemia and reperfusion in the rat. Med Sci Monit 9, (5) BR155-BR159.
  • McDonald MC, d'Emmanuele di Villa Bianca R, Wayman NS et al. (2003). A superoxide dismutase mimetic with catalase activity (EUK-8) reduces the organ injury in endotoxic shock. Eur J Pharmacol 466, (1-2) 181-189.
    10.1016/S0014-2999(03)01538-3
  • Sivarajah A, Chatterjee PK, Todorovic Z et al. (2003). Agonists of peroxisome proliferator activated receptor-alpha (clofibrate and WY14643) reduce ischaemia/reperfusion injury of the rat kidney. BRITISH JOURNAL OF PHARMACOLOGY 138U47-U47.
  • Chatterjee PK, Sivarajah A, Todorovic Z et al. (2003). PPAR-gamma agonists (rosiglitazone and ciglitazone) reduce renal dysfunction and injury caused by ischaemia/reperfusion of the rat kidney. BRITISH JOURNAL OF PHARMACOLOGY 138U19-U19.
  • Dugo L, Pisano B, Wayman N et al. (2003). PPAR-gamma ligands attenuate the development of intestinal ischemia/reperfusion. BRITISH JOURNAL OF PHARMACOLOGY 138U20-U20.
  • Cuzzocrea S, Dugo L, Di Paola R et al. (2003). Role of PPAR-gamma ligand rosiglitazone on the development of carrageenan-induced lung injury. BRITISH JOURNAL OF PHARMACOLOGY 138U20-U20.
  • Chatterjee PK, Patel NSA, Sivarajah A et al. (2003). GW274150, a potent and highly selective inhibitor of iNOS, reduces experimental renal ischemia/reperfusion injury. Kidney Int 63, (3) 853-865.
    10.1046/j.1523-1755.2003.00802.x
  • Thiemermann C (2003). Protein tyrosine kinase inhibitors as novel therapeutics for systemic inflammation, shock, and organ injury. CRIT CARE MED 31, (2) 652-653.
    10.1097/01.CCM.0000049942.70689.C2
  • Cuzzocrea S, Ianaro A, Wayman NS et al. (2003). The cyclopentenone prostaglandin 15-deoxy-Delta (12,14)-PGJ(2) attenuates the development of colon injury caused by dinitrobenzene sulphonic acid in the rat. BRIT J PHARMACOL 138, (4) 678-688.
    10.1038/sj.bjp.0705077
  • Chatterjee PK, Thiemermann C (2003). An in vivo model of ischemia/reperfusion and inflammation of the kidneys of the rat. Methods Mol Biol 225223-237.
    10.1385/1-59259-374-7:223
  • Øverland G, Morath S, Yndestad A et al. (2003). Lipoteichoic acid is a potent inducer of cytokine production in rat and human Kupffer cells in vitro. Surg Infect (Larchmt) 4, (2) 181-191.
    10.1089/109629603766956979
  • Thiemermann C (2003). Membrane-permeable radical scavengers (tempol) for shock, ischemia-reperfusion injury, and inflammation. Crit Care Med 31, (1 Suppl) S76-S84.
    10.1097/01.CCM.0000042475.97887.05
  • THIEMERMANN C, Chatterjee PK, McDonald MC et al. (2003). Models of coronary artery occlusion and reperfusion for the discovery of novel antiischemic and antiinflammatory drugs for the heart. Methods Mol. Biol. 225199-208.
    10.1385/1-59259-374-7:199
  • McDonald MC, Izumi M, Cuzzocrea S et al. (2002). A novel, potent and selective inhibitor of the activity of inducible nitric oxide synthase (GW274150) reduces the organ injury in hemorrhagic shock. J Physiol Pharmacol 53, (4 Pt 1) 555-569.
  • Sivarajah A, Chatterjee PK, Hattori Y et al. (2002). Agonists of peroxisome-proliferator activated receptor-alpha (clofibrate and WY14643) reduce renal ischemia/reperfusion injury in the rat. Med Sci Monit 8, (12) BR532-BR539.
  • Patel NSA, Chatterjee PK, Chatterjee BE et al. (2002). TEMPONE reduces renal dysfunction and injury mediated by oxidative stress of the rat kidney. FREE RADICAL BIO MED 33, (11) 1575-1589.
    10.1016/S0891-5849(02)01116-4
  • Mota-Filipe H, Sepodes B, McDonald MC et al. (2002). The novel PARP inhibitor 5-aminoisoquinolinone reduces the liver injury caused by ischemia and reperfusion in the rat. Med Sci Monit 8, (11) BR444-BR453.
  • Cuzzocrea S, Chatterjee PK, Mazzon E et al. (2002). Beneficial effects of GW274150, a novel, potent and selective inhibitor of NOS activity, in a rodent model of collagen-induced arthritis. EUR J PHARMACOL 453, (1) 119-129.
    10.1016/S0014-2999(02)02338-5
  • Cuzzocrea S, Chatterjee PK, Mazzon E et al. (2002). Effects of calpain inhibitor I on multiple organ failure induced by zymosan in the rat. CRIT CARE MED 30, (10) 2284-2294.
    10.1097/01.CCM.0000026736.79791.23
  • Chatterjee PK, Zacharowski K, Cuzzocrea S et al. (2002). Lipoteichoic acid from Staphylococcus aureus reduces renal ischemia/reperfusion injury. Kidney Int 62, (4) 1249-1263.
    10.1111/j.1523-1755.2002.kid580.x
  • Thiemermann C (2002). A vaccine to prevent infections with Staphylococcus aureus. Med Sci Monit 8, (9) LE35-LE36.
  • Chatterjee PK, Todorovic Z, Sivarajah A et al. (2002). Caspase and calpain inhibitors reduce the renal dysfunction caused by ischemia/reperfusion of the kidney of the rat. J AM SOC NEPHROL 13755A-755A.
  • Chatterjee PK, Patel NSA, Kvale EO et al. (2002). GW274150 reduces renal dysfunction caused by ischemia/reperfusion of the kidney of the rat. J AM SOC NEPHROL 13549A-549A.
  • Chatterjee PK, Sivarajah A, Todorovic Z et al. (2002). PPAR agonists reduce renal dysfunction caused by ischemia/reperfusion of the kidney of the rat: Comparison of PPAR alpha and PPAR gamma agonists. J AM SOC NEPHROL 13136A-136A.
  • Izumi M, McDonald MC, Sharpe MA et al. (2002). Superoxide dismutase mimetics with catalase activity reduce the organ injury in hemorrhagic shock. Shock 18, (3) 230-235.
    10.1097/00024382-200209000-00005
  • Cuzzocrea S, Chatterjee PK, Mazzon E et al. (2002). Role of induced nitric oxide in the initiation of the inflammatory response after postischemic injury. SHOCK 18, (2) 169-176.
    10.1097/00024382-200208000-00014
  • Millar CGM, Thiemermann C (2002). Carboxy-PTIO, a scavenger of nitric oxide, selectively inhibits the increase in medullary perfusion and improves renal function in endotoxemia. Shock 18, (1) 64-68.
    10.1097/00024382-200207000-00012
  • Thiemermann C (2002). Interactions between lipoteichoic acid and peptidoglycan from Staphylococcus aureus: a structural and functional analysis. Microbes Infect 4, (9) 927-935.
    10.1016/S1286-4579(02)01620-9
  • Wayman NS, Ellis BL, Thiemermann C (2002). Ligands of the peroxisome proliferator-activated receptor-PPAR-a reduce myocardial infarct size. Med Sci Monit 8, (7) BR243-BR247.
  • Wayman NS, Hattori Y, McDonald MC et al. (2002). Ligands of the peroxisome proliferator-activated receptors (PPAR-gamma and PPAR-alpha) reduce myocardial infarct size. FASEB J 16, (9) 1027-1040.
    10.1096/fj.01-0793com
  • Cuzzocrea S, Mazzon E, Dugo L et al. (2002). Absence of endogenous interleukin-6 enhances the inflammatory response during acute pancreatitis induced by cerulein in mice. CYTOKINE 18, (5) 274-285.
    10.1006/cyto.2002.0883
  • Dugo L, Chatterjee PK, Mazzon E et al. (2002). The tyrosine kinase inhibitor tyrphostin AG 126 reduces the multiple organ failure induced by zymosan in the rat. INTENS CARE MED 28, (6) 775-788.
    10.1007/s00134-002-1308-4
  • Thiemermann C (2002). Corticosteroids and cardioprotection. NAT MED 8, (5) 453-455.
    10.1038/nm0502-453
  • Thiemermann C (2002). Development of novel, water-soluble inhibitors of poly(adenosine 5 '-diphosphate ribose) synthetase activity for use in shock and ischemia-reperfusion injury. CRIT CARE MED 30, (5) 1163-1165.
    10.1097/00003246-200205000-00038
  • Cuzzocrea S, Mazzon E, Dugo L et al. (2002). Inducible nitric oxide synthase-deficient mice exhibit resistance to the acute pancreatitis induced by cerulein. SHOCK 17, (5) 416-422.
    10.1097/00024382-200205000-00013
  • Ellingsen E, Morath S, Flo T et al. (2002). Induction of cytokine production in human T cells and monocytes by highly purified lipoteichoic acid: involvement of Toll-like receptors and CD14. Med Sci Monit 8, (5) BR149-BR156.
  • Cuzzocrea S, Wayman NS, Mazzon E et al. (2002). The cyclopentenone prostaglandin 15-deoxy-Delta(12,14)-prostaglandin J(2) attenuates the development of acute and chronic inflammation. MOL PHARMACOL 61, (5) 997-1007.
    10.1124/mol.61.5.997
  • Thiemermann C, Cuzzocrea S (2002). Calpain inhibitor I and colonic inflammation induced by DNBS in the rat - Reply. GUT 50, (3) 441-441.
  • Izumi M, McDonald MC, Thiemermann C (2002). Effects of GW274150, a novel and potent inhibitor of the activity of inducible nitric oxide synthase on the multiple organ injury in haemorrhagic shock in the anaesthetised rat. BRIT J PHARMACOL 135.
  • Chatterjee PK, Patel NSA, Kvale EO et al. (2002). Inhibition of inducible nitric oxide synthase reduces renal ischemia/reperfusion injury. Kidney Int 61, (3) 862-871.
    10.1046/j.1523-1755.2002.00234.x
  • Patel NSA, Chatterjee PK, Kvale EO et al. (2002). The novel iNOS inhibitor GW274150 reduces renal dysfunction mediated by ischaemia/reperfusion of the rat and mouse kidney in vivo. BRIT J PHARMACOL 135.
  • Cuzzocrea S, Chatterjee PK, Mazzon E et al. (2002). Beneficial effects of GW274150, a novel, potent and selective inhibitor of iNOS activity, in a rodent model of collagen-induced arthritis. BRIT J PHARMACOL 135.
  • Sepodes B, Pinto R, McDonald MC et al. (2002). Dithiocarbamates attenuate the organ injury and dysfunction caused by endotoxin in the rat. BRIT J PHARMACOL 135.
  • Kvale EO, Patel NSA, Chatterjee PK et al. (2002). EUK-134 reduces oxidative stress-mediated injury and death of rat proximal tubular cells. BRIT J PHARMACOL 135.
  • Izumi M, McDonald MC, Sharpe MA et al. (2002). Effects of EUK-8, a superoxide dismutase mimetic with catalase activity, on the circulatory failure and multiple organ injury in haemorrhagic shock in the anaesthetised rat. BRIT J PHARMACOL 135.
  • Patel NSA, Kvale EO, Chatterjee PK et al. (2002). Effects of L-NIL and AE-ITU on the renal dysfunction mediated by ischaemia-reperfusion of rat kidneys in vivo. BRIT J PHARMACOL 135.
  • McDonald MC, Mota-Filipe H, Cockerill GW et al. (2002). Effects of human high-density lipoproteins (HDLs) on the multiple organ injury in haemorrhagic shock in the anaesthetised rat. BRIT J PHARMACOL 135.
  • Bianca RDD, Izumi M, McDonald MC et al. (2002). Pyrrolidine dithiocarbamate (PDTC) reduces the renal dysfunction associated with ischaemia-reperfusion of kidney of the rat in vivo. BRIT J PHARMACOL 135.
  • Chatterjee PK, Patel NSA, Kvale EO et al. (2002). The PPAR-gamma ligand 15d-PGJ(2) reduces renal dysfunction and injury mediated by ischaemia/reperfusion of the rat kidney. BRIT J PHARMACOL 135.
  • Kvale EO, Patel NSA, Chatterjee PK et al. (2002). The SOD mimetic EUK-134 reduces oxidative stress-mediated renal dysfunction in the rat in vivo. BRIT J PHARMACOL 135.
  • Wayman NS, McDonald MC, Hattori Y et al. (2002). The cyclopentenone prostaglandin 15d-PGJ(2) reduces the expression of iNOS and of monocyte chemoattractant protein-1 caused by ischaemia-reperfusion in the heart. BRIT J PHARMACOL 135.
  • Wayman NS, McDonald MC, Thiemermann C (2002). The peroxisome-proliferator activator receptor-gamma ligand pioglitazone reduces infarct size caused by myocardial ischaemia and reperfusion in the rat. BRIT J PHARMACOL 135.
  • Zacharowski K, Chatterjee PK, Thiemermann C (2002). Delayed preconditioning induced by lipoteichoic acid from B-subtilis and S-aureus is not blocked by administration of 5-hydroxydecanoate. SHOCK 17, (1) 19-22.
    10.1097/00024382-200201000-00004
  • THIEMERMANN C, McDonald MC, Serraino I et al. (2002). Effects of 5-aminoisoquinolinone, a water-soluble, potent inhibitor of the activity of poly (ADP-ribose) polymerase, in a rodent model of lung injury. Biochem. Pharmacol. 63293-304.
    10.1016/S0006-2952(01)00864-4
  • Cuzzocrea S, Chatterjee PK, Mazzon E et al. (2002). Pyrrolidine dithiocarbamate attenuates the development of acute and chronic inflammation. BRIT J PHARMACOL 135, (2) 496-510.
    10.1038/sj.bjp.0704463
  • Bianca RDDV, Wayman NS, McDonald MC et al. (2002). Superoxide dismutase mimetic with catalase activity, EUK-134, attenuates the multiple organ injury and dysfunction caused by endotoxin in the rat. Med Sci Monit 8, (1) BR1-BR7.
  • Wayman N, McDonald MC, Thompson AS et al. (2001). 5-aminoisoquinolinone, a potent inhibitor of poly (adenosine 5'-diphosphate ribose) polymerase, reduces myocardial infarct size. Eur J Pharmacol 430, (1) 93-100.
    10.1016/S0014-2999(01)01359-0
  • THIEMERMANN C, Miller NE, McDonald MC et al. (2001). High density lipoproteins reduce organ injury and organ dysfunction in a rat model of hemorrhagic shock. FASEB Journal 15, (11) 1941-1952.
    10.1096/fj.99-0645com
  • Cockerill GW, McDonald MC, Mota-Filipe H et al. (2001). High density lipoproteins reduce organ injury and organ dysfunction in a rat model of hemorrhagic shock. FASEB J 15, (11) 1941-1952.
    10.1096/fj.01-0075com
  • Wang JE, Jorgensen PF, Ellingsen A et al. (2001). Peptidoglycan primes for LPS-induced release of proinflammatory cytokines in whole human blood. SHOCK 16, (3) 178-182.
    10.1097/00024382-200116030-00002
  • Zacharowski K, Berkels R, Olbrich A et al. (2001). The selective guanylate cyclase inhibitor ODQ reduces multiple organ injury in rodent models of Gram-positive and Gram-negative shock. Crit Care Med 29, (8) 1599-1608.
    10.1097/00003246-200108000-00017
  • McDonald MC, Mota-Filipe H, Abdelrahman M et al. (2001). Discovery of 5-aminoisocoumarin as a novel inhibitor of the activity of poly (ADP-ribose) polymerase, which inhibits the multiple organ failure in haemorrhagic shock. FUNDAMENTAL & CLINICAL PHARMACOLOGY 15153-153.
  • Cuzzocrea S, Dugo L, Mazzon E et al. (2001). Inducible nitric oxide synthase regulate the initiation of the inflammatory response after postischemic injury. FUNDAMENTAL & CLINICAL PHARMACOLOGY 1588-88.
  • Thiemermann C, Wayman NS (2001). Menarini Academy Cardiovascular Research Awards in Basic Science 2001: ligands of the orphan receptor peroxisome-proliferator activator-gamma reduce myocardial infarct size. Med Sci Monit 7, (4) 787-789.
  • Sepodes B, Mota-Filipe H, Pinto R et al. (2001). Pretreatment of rats with hemoglobin reduces the multiple organ dysfunction associated with endotoxic shock. FUNDAMENTAL & CLINICAL PHARMACOLOGY 1585-85.
  • Wayman NS, McDonald MC, Thiemermann C (2001). Reduction of myocardial infarct size by ligands (15d-PGJ(2), ciglitazone and rosiglitazone) for the peroxisome-proliferator activator receptor-gamma (PPAR-gamma). FUNDAMENTAL & CLINICAL PHARMACOLOGY 1587-87.
  • Chatterjee PK, Patel N, Kvale E et al. (2001). The tyrosine kinase inhibitor Tyrphostin AG126 reduces the renal dysfunction associated with ischaemia/reperfusion of rat kidneys in vivo. FUNDAMENTAL & CLINICAL PHARMACOLOGY 1570-70.
  • Thiemermann C (2001). Aminoethyl-isothiourea in gram-positive shock: An inhibitor of inducible nitric oxide synthase or a jack-of-all-trades?. SHOCK 15, (6) 453-454.
    10.1097/00024382-200115060-00007
  • Chatterjee PK, Brown PAJ, Cuzzocrea S et al. (2001). Calpain inhibitor-1 reduces renal ischemia/reperfusion injury in the rat. KIDNEY INT 59, (6) 2073-2083.
    10.1046/j.1523-1755.2001.00722.x
  • Zacharowski K, Chatterjee PK, Thiemermann C (2001). Different wall fragments of gram-positive or negative bacteria induce delayed preconditioning in the rat heart in vivo. BRIT J PHARMACOL 133U6-U6.
  • Wayman NS, Thiemermann C (2001). Effects of 15-deoxy-D12, 14-prostaglandin J2 on the infarct size caused by myocardial ischaemia and reperfusion in the rat. BRIT J PHARMACOL 133U64-U64.
  • Wayman NS, McDonald MC, Threadgill MD et al. (2001). Effects of 5-aminoisoquinolinone regional myocardial ischaemia and reperfusion in the anaesthetised rat. BRIT J PHARMACOL 133.
  • Cuzzocrea S, McDonald MC, Mazzon E et al. (2001). Effects of 5-aminoisoquinolinone, a water-soluble, potent inhibitor of the activity of poly (ADP-ribose) polymerase on P-selectin and intercellular adhesion molecule-1 in lung injury. BRIT J PHARMACOL 133U24-U24.
  • Abdelrahman M, McDonald MC, Wayman NS et al. (2001). Effects of L-N-(L-iminoethyl)lysine (L-NIL) on the circulatory failure and multiple organ injury in haemorrhagic shock in the anaesthetised rat. BRIT J PHARMACOL 133U63-U63.
  • Abdelrahman M, McDonald MC, Cuzzocrea S et al. (2001). Effects of tyrphostin AG126 on the multiple organ failure caused by severe haemorrhage and resuscitation in the anaesthetised rat. BRIT J PHARMACOL 133U63-U63.
  • Thiemermann C (2001). Inhaled CO: Deadly gas or novel therapeutic?. NAT MED 7, (5) 534-535.
    10.1038/87853
  • Jorgensen PF, Wang JE, Almlof M et al. (2001). Peptidoglycan and lipoteichoic acid modify monocyte phenotype in human whole blood. CLIN DIAGN LAB IMMUN 8, (3) 515-521.
    10.1128/CDLI.8.3.515-521.2001
  • Zacharowski K, Frank S, Thiemermann C (2001). Role of nitric oxide on the delayed cardioprotection afforded by lipopolysaccharide in the rat heart in vivo. BRIT J PHARMACOL 133.
  • Chatterjee PK, Pedersen H, Chatterjee BE et al. (2001). The poly(ADP-ribose) polymerase inhibitor 5-aminoisoquinoline reduces oxidative stress-mediated renal dysfunction in the rat in vivo and in vitro. BRIT J PHARMACOL 133U65-U65.
  • Patel N, Chatterjee PK, Chatterjee BE et al. (2001). The stable nitroxyl radical tempone reduces oxidative stress-mediated renal dysfunction in the rat in vivo and in vitro. BRIT J PHARMACOL 133U9-U9.
  • Zacharowski K, Blackburn B, Thiemermann C (2001). Ranolazine, a partial fatty acid oxidation inhibitor, reduces myocardial infarct size and cardiac troponin T release in the rat. Eur J Pharmacol 418, (1-2) 105-110.
    10.1016/S0014-2999(01)00920-7
  • Cuzzocrea S, McDonald MC, Mazzon E et al. (2001). Calpain inhibitor I reduces colon injury caused by dinitrobenzene sulphonic acid in the rat. GUT 48, (4) 478-488.
    10.1136/gut.48.4.478
  • Wray GM, Foster SJ, Hinds CJ et al. (2001). A cell wall component from pathogenic and non-pathogenic gram-positive bacteria (peptidoglycan) synergises with endotoxin to cause the release of tumour necrosis factor-alpha, nitric oxide production, shock, and multiple organ injury/dysfunction in the rat. Shock 15, (2) 135-142.
    10.1097/00024382-200115020-00010
  • Jørgensen PF, Wang JE, Solberg R et al. (2001). Procalcitonin does not influence the surface expression of inflammatory receptors on whole blood leukocytes. Intensive Care Med 27, (2) 430-433.
    10.1007/s001340000821
  • Jorgensen PF, Wang JE, Almlof M et al. (2001). Sirolimus interferes with the innate response to bacterial products in human whole blood by attenuation of IL-10 production. SCAND J IMMUNOL 53, (2) 184-191.
    10.1046/j.1365-3083.2001.00862.x
  • Cuzzocrea S, McDonald MC, Mazzon E et al. (2001). Beneficial effects of tempol, a membrane-permeable radical scavenger, on the multiple organ failure induced by zymosan in the rat. CRIT CARE MED 29, (1) 102-111.
    10.1097/00003246-200101000-00022
  • McDonald MC, Mota-Filipe H, Paul A et al. (2001). Calpain inhibitor I reduces the activation of nuclear factor-kappaB and organ injury/dysfunction in hemorrhagic shock. FASEB J 15, (1) 171-186.
    10.1096/fj.99-0645com
  • Thiemermann C (2001). Nitric oxide and circulatory shock: An update. NITRIC OXIDE 317117-125.
  • Thiemermann C, McDonald MC, Cuzzocrea S (2001). The stable nitroxide, tempol, attenuates the effects of peroxynitrite and oxygen-derived free radicals. CRIT CARE MED 29, (1) 223-224.
    10.1097/00003246-200101000-00055
  • Cuzzocrea S, McDonald MC, Mazzon E et al. (2000). Beneficial effects of tempol, a membrane-permeable radical scavenger, in a rodent model of splanchnic artery occlusion and reperfusion. SHOCK 14, (2) 150-156.
    10.1097/00024382-200014020-00013
  • Thiemermann C (2000). Inhibition of the activity of poly (ADP-ribose) polymerase in ischemia-reperfusion injury - Editorial comment. SHOCK 14, (2) 142-143.
    10.1097/00024382-200014020-00011
  • SOLITO E, Purvis GSD, Chiazza F et al. (). Annexin A1 attenuates microvascular complications through restoration of Akt signalling in a murine model of type 1 diabetes. Diabetologia .
    10.1007/s00125-017-4469-y
  • SOLITO E, Purvis GSD, Chiazza, et al. (). Annexin A1 attenuates microvascular complications through restoration of Akt signalling in a murine model of type 1 diabetes. Diabetologia .
    10.1007/s00125-017-4469-y
  • Purvis GSD, Chiazza F, Chen J et al. (). Treatment with Annexin A1 attenuates the development of diabetic nephropathy and cardiomyopathy, in murine type 1 diabetes, through restoration of AKT signalling. Diabetologia .
    10.1007/s00125-017-4469-y

Share this page