Dr Ping Yip

Lecturer in Neuroscience

My current role involves basic research in traumatic brain injury and spinal cord injury. I spend my time between in vivo research and in the laboratory doing histology, molecular biology and cell culture. Apart from carrying out research within my own interest, I’m also involved in the supervision of the research carried out by undergraduate, postgraduate and PhD students.  Furthermore, I’m involved in teaching neuroscience to medical, BSc and MSc students from Queen Mary University of London.

Teaching

Provide lecturers and tutorials in neuroscience to medical students and students studying Intercalated BSc Neuroscience and MSc in Neuroscience and Translational Medicine.

Research interests

I have several research interests which include neuroregeneration, neuroplasticity and neuroprotection and the role of microglia in neurotrauma. I am also involved in a collaborative clinical study in the identification of biomarkers in newborn with brain injury.

Contact

email: p.yip@qmul.ac.uk
Tel: +44 (0) 20 7882 2273

  • Bell ZW, Lovell P, Mello CV et al. (2019). Urotensin-related gene transcripts mark developmental emergence of the male forebrain vocal control system in songbirds. Scientific Reports 9, (1) .
    10.1038/s41598-018-37057-w
  • Carrillo-Jimenez A, Deniz Ö, Niklison-Chirou MV et al. (2019). TET2 Regulates the Neuroinflammatory Response in Microglia. Cell Reports 29, (3) 697-713.e8.
    10.1016/j.celrep.2019.09.013
  • Liu ZH, Chen NY, Tu PH et al. (2019). Previous Antithrombotic Therapy, Particularly Anticoagulant, Is Associated with Unfavorable Outcomes in Patients with Primary Spontaneous Intracerebral Hemorrhage Receiving Craniotomy: A Nationwide Population-Based Cohort Study. World Neurosurgery 128e59-e73.
    10.1016/j.wneu.2019.03.269
  • Yip PK, Bowes AL, Hall JCE et al. (2019). Docosahexaenoic acid reduces microglia phagocytic activity via miR-124 and induces neuroprotection in rodent models of spinal cord contusion injury. Human Molecular Genetics 28, (14) 2427-2448.
    10.1093/hmg/ddz073
  • Yip PK, Chapman GE, Sillito RR et al. (2019). Studies on long term behavioural changes in group-housed rat models of brain and spinal cord injury using an automated home cage recording system. Journal of Neuroscience Methods 32149-63.
    10.1016/j.jneumeth.2019.04.005
  • Ponnusamy V, Yip PK (2019). The role of microRNAs in newborn brain development and hypoxic ischaemic encephalopathy. Neuropharmacology 14955-65.
    10.1016/j.neuropharm.2018.11.041
  • Liu ZH, Liu CH, Tu PH et al. (2019). Prior Antiplatelet Therapy, Excluding Phosphodiesterase Inhibitor Is Associated with Poor Outcome in Patients with Spontaneous Intracerebral Haemorrhage. Translational Stroke Research .
    10.1007/s12975-019-00722-x
  • Zubiri I, Lombardi V, Bremang M et al. (2018). Tissue-enhanced plasma proteomic analysis for disease stratification in amyotrophic lateral sclerosis. Molecular neurodegeneration 13, (1) 60-.
    10.1186/s13024-018-0292-2
  • BO XUENONG, GUSHCHINA S, PRYCE G et al. (2018). Increased expression of colony‐stimulating factor‐1 in mouse spinal cord with experimental autoimmune encephalomyelitis correlates with microglial activation and neuronal loss. Glia 66, (10) 2108-2125.
    10.1002/glia.23464
  • Shah DK, Ponnusamy V, Evanson J et al. (2018). Raised plasma neurofilament light protein levels are associated with abnormal MRI outcomes in newborns undergoing therapeutic hypothermia. Frontiers in Neurology 9, (MAR) .
    10.3389/fneur.2018.00086
  • Venero JL, Yip PK, Carrillo-Jimenez A et al. (2017). Galectin-3 acts as an early alarmin orchestrating brain immune response and promoting neurodegeneration after traumatic brain injury. GLIA 65E504-E504.
  • Burguillos MA, Boza A, Yip PK et al. (2017). Immunomodulatory roles of galectin-3 under conditions of neurodegeneration. GLIA 65E15-E15.
  • Liu Z-H, Yip PK, Priestley JV et al. (2017). A Single Dose of Docosahexaenoic Acid Increases the Functional Recovery Promoted by Rehabilitation after Cervical Spinal Cord Injury in the Rat. J Neurotrauma 34, (9) 1766-1777.
    10.1089/neu.2016.4556
  • Yip PK, Carrillo-Jimenez A, King P et al. (2017). Galectin-3 released in response to traumatic brain injury acts as an alarmin orchestrating brain immune response and promoting neurodegeneration. Scientific Reports 741689-41689.
    10.1038/srep41689
  • Tremoleda JL, Thau-Zuchman O, Davies M et al. (). In vivo PET imaging of the neuroinflammatory response in rat spinal cord injury using the TSPO tracer [18F]GE-180 and effect of docosahexaenoic acid. European Journal of Nuclear Medicine and Molecular Imaging .
    10.1007/s00259-016-3391-8
  • Ponnusamy V, Kapellou O, Yip E et al. (2016). A study of microRNAs from dried blood spots in newborns after perinatal asphyxia: A simple and feasible biosampling method. Pediatric Research 79, (5) 799-805.
    10.1038/pr.2015.276
  • Liu ZH, Yip PK, Adams L et al. (2015). A single bolus of docosahexaenoic acid promotes neuroplastic changes in the innervation of spinal cord interneurons and motor neurons and improves functional recovery after spinal cord injury. Journal of Neuroscience 35, (37) 12733-12752.
    10.1523/JNEUROSCI.0605-15.2015
  • Liu ZH, Tu PH, Chen NY et al. (2015). Raised proinflammatory cytokine production within cerebrospinal fluid precedes fever onset in patients with neurosurgery-associated bacterial meningitis. Critical Care Medicine 43, (11) 2416-2428.
    10.1097/CCM.0000000000001188
  • Bowes AL, Yip PK (2014). Modulating inflammatory cell responses to spinal cord injury: all in good time. J Neurotrauma 31, (21) 1753-1766.
    10.1089/neu.2014.3429
  • Hockley JRF, Boundouki G, Cibert-Goton V et al. (2014). Multiple roles for NaV1.9 in the activation of visceral afferents by noxious inflammatory, mechanical, and human disease-derived stimuli. Pain 155, (10) 1962-1975.
    10.1016/j.pain.2014.06.015
  • Paterniti I, Impellizzeri D, Di Paola R et al. (2014). Docosahexaenoic acid attenuates the early inflammatory response following spinal cord injury in mice: in-vivo and in-vitro studies. J Neuroinflammation 116-.
    10.1186/1742-2094-11-6
  • Tsantoulas C, Zhu L, Yip P et al. (2014). Kv2 dysfunction after peripheral axotomy enhances sensory neuron responsiveness to sustained input. Experimental Neurology 251115-126.
    10.1016/j.expneurol.2013.11.011
  • Hockley JRF, Boundouki G, Cibert-Goton V et al. (2014). Multiple roles for NaV1.9 in the activation of visceral afferents by noxious inflammatory, mechanical, and human disease-derived stimuli. Pain 155, (10) 1962-1975.
    10.1016/j.pain.2014.06.015
  • Peluffo H, Foster E, Ahmed SG et al. (2013). Efficient gene expression from integration-deficient lentiviral vectors in the spinal cord. Gene Therapy 20, (6) 645-657.
    10.1038/gt.2012.78
  • Yip PK, Pizzasegola C, Gladman S et al. (2013). The omega-3 fatty acid eicosapentaenoic acid accelerates disease progression in a model of amyotrophic lateral sclerosis. PLoS One 8, (4) e61626-.
    10.1371/journal.pone.0061626
  • Soleman S, Yip PK, Duricki DA et al. (2012). Delayed treatment with chondroitinase ABC promotes sensorimotor recovery and plasticity after stroke in aged rats. BRAIN 1351210-1223.
    10.1093/brain/aws027
  • Yip PK, Malaspina A (2012). Spinal cord trauma and the molecular point of no return. Mol Neurodegener 76-.
    10.1186/1750-1326-7-6
  • Marchand F, D'Mello R, Yip PK et al. (2011). Specific involvement of atypical PKCζ/PKMζ in spinal persistent nociceptive processing following peripheral inflammation in rat. Molecular Pain 7.
    10.1186/1744-8069-7-86
  • Jokic N, Yip PK, Michael-Titus A et al. (2010). The human G93A-SOD1 mutation in a pre-symptomatic rat model of amyotrophic lateral sclerosis increases the vulnerability to a mild spinal cord compression. BMC Genomics 11633-.
    10.1186/1471-2164-11-633
  • Malaspina A, Ngoh SFA, Ward RE et al. (2010). Activation transcription factor-3 activation and the development of spinal cord degeneration in a rat model of amyotrophic lateral sclerosis. Neuroscience 169, (2) 812-827.
    10.1016/j.neuroscience.2010.04.053
  • Yip PK, Wong LF, Sears TA et al. (2010). Cortical overexpression of neuronal calcium sensor-1 induces functional plasticity in spinal cord following unilateral pyramidal tract injury in rat. PLoS Biology 8, (6) .
    10.1371/journal.pbio.1000399
  • Kaan TKY, Yip PK, Grist J et al. (2010). Endogenous purinergic control of bladder activity via presynaptic P2X 3 and P2X2/3 receptors in the spinal cord. Journal of Neuroscience 30, (12) 4503-4507.
    10.1523/JNEUROSCI.6132-09.2010
  • Soleman S, Yip P, Leasure JL et al. (2010). Sustained sensorimotor impairments after endothelin-1 induced focal cerebral ischemia (stroke) in aged rats. Exp Neurol 222, (1) 13-24.
    10.1016/j.expneurol.2009.11.007
  • Goncalves MB, Williams E-J, Yip P et al. (2010). The COX-2 inhibitors, meloxicam and nimesulide, suppress neurogenesis in the adult mouse brain. Br J Pharmacol 159, (5) 1118-1125.
    10.1111/j.1476-5381.2009.00618.x
  • Agudo M, Yip P, Davies M et al. (2010). A retinoic acid receptor beta agonist (CD2019) overcomes inhibition of axonal outgrowth via phosphoinositide 3-kinase signalling in the injured adult spinal cord. Neurobiol Dis 37, (1) 147-155.
    10.1016/j.nbd.2009.09.018
  • Kaan TKY, Yip PK, Patel S et al. (2010). Systemic blockade of P2X3 and P2X2/3 receptors attenuates bone cancer pain behaviour in rats. Brain 133, (9) 2549-2564.
    10.1093/brain/awq194
  • Yip PK, Kaan TKY, Fenesan D et al. (2009). Rapid isolation and culture of primary microglia from adult mouse spinal cord. Journal of Neuroscience Methods 183, (2) 223-237.
    10.1016/j.jneumeth.2009.07.002
  • Clark AK, Yip PK, Malcangio M (2009). The liberation of fractalkine in the dorsal horn requires microglial cathepsin S. Journal of Neuroscience 29, (21) 6945-6954.
    10.1523/JNEUROSCI.0828-09.2009
  • Thacker MA, Clark AK, Bishop T et al. (2009). CCL2 is a key mediator of microglia activation in neuropathic pain states. European Journal of Pain 13, (3) 263-272.
    10.1016/j.ejpain.2008.04.017
  • Starkey ML, Davies M, Yip PK et al. (2009). Expression of the regeneration-associated protein SPRR1A in primary sensory neurons and spinal cord of the adult mouse following peripheral and central injury. J Comp Neurol 513, (1) 51-68.
    10.1002/cne.21944
  • Goncalves MB, Suetterlin P, Yip P et al. (2008). A diacylglycerol lipase-CB2 cannabinoid pathway regulates adult subventricular zone neurogenesis in an age-dependent manner. Mol Cell Neurosci 38, (4) 526-536.
    10.1016/j.mcn.2008.05.001
  • Bishop T, Hewson DW, Yip PK et al. (2007). Characterisation of ultraviolet-B-induced inflammation as a model of hyperalgesia in the rat. Pain 131, (1-2) 70-82.
    10.1016/j.pain.2006.12.014
  • Clark AK, Yip PK, Grist J et al. (2007). Inhibition of spinal microglial cathepsin S for the reversal of neuropathic pain. Proceedings of the National Academy of Sciences of the United States of America 104, (25) 10655-10660.
    10.1073/pnas.0610811104
  • Yip PK, Wong LF, Pattinson D et al. (2006). Lentiviral vector expressing retinoic acid receptor β2 promotes recovery of function after corticospinal tract injury in the adult rat spinal cord. Human Molecular Genetics 15, (21) 3107-3118.
    10.1093/hmg/ddl251
  • Barritt AW, Davies M, Marchand F et al. (2006). Chondroitinase ABC promotes sprouting of intact and injured spinal systems after spinal cord injury. J Neurosci 26, (42) 10856-10867.
    10.1523/JNEUROSCI.2980-06.2006
  • So PL, Yip PK, Bunting S et al. (2006). Interactions between retinoic acid, nerve growth factor and sonic hedgehog signalling pathways in neurite outgrowth. Developmental Biology 298, (1) 167-175.
    10.1016/j.ydbio.2006.06.027
  • Wong LF, Yip PK, Battaglia A et al. (2006). Retinoic acid receptor β2 promotes functional regeneration of sensory axons in the spinal cord. Nature Neuroscience 9, (2) 243-250.
    10.1038/nn1622
  • Starkey ML, Barritt AW, Yip PK et al. (2005). Assessing behavioural function following a pyramidotomy lesion of the corticospinal tract in adult mice. Experimental Neurology 195, (2) 524-539.
    10.1016/j.expneurol.2005.06.017
  • Cockayne DA, Dunn PM, Zhong Y et al. (2005). P2X2 knockout mice and P2X2/P2X3 double knockout mice reveal a role for the P2X2 receptor subunit in mediating multiple sensory effects of ATP. J Physiol 567, (Pt 2) 621-639.
    10.1113/jphysiol.2005.088435
  • Lever I, Cunningham J, Grist J et al. (2003). Release of BDNF and GABA in the dorsal horn of neuropathic rats. European Journal of Neuroscience 18, (5) 1169-1174.
    10.1046/j.1460-9568.2003.02848.x
  • Chapman AG, Talebi A, Yip PK et al. (2001). Anticonvulsant activity of a mGlu receptor selective agonist, (1S,3R,4S)-1-aminocyclopentane-1,2,4-tricarboxylic acid. European Journal of Pharmacology 424, (2) 107-113.
    10.1016/S0014-2999(01)01013-5
  • Yip PK, Meldrum BS, Rattray M (2001). Elevated levels of group-III metabotropic glutamate receptors in the inferior colliculus of genetically epilepsy-prone rats following intracollicular administration of L-serine-O-phosphate. Journal of Neurochemistry 78, (1) 13-23.
    10.1046/j.1471-4159.2001.00418.x
  • Chapman AG, Nanan K, Yip P et al. (1999). Anticonvulsant activity of a metabotropic glutamate receptor 8 preferential agonist, (R,S)-4-phosphonophenylglycine. Eur J Pharmacol 383, (1) 23-27.
    10.1016/s0014-2999(99)00615-9
  • Chapman AG, Yip PK, Yap JS et al. (1999). Anticonvulsant actions of LY 367385 ((+)-2-methyl-4-carboxyphenylglycine) and AIDA ((RS)-1-aminoindan-1,5-dicarboxylic acid). European Journal of Pharmacology 368, (1) 17-24.
    10.1016/S0014-2999(99)00014-X
  • Tang E, Yip PK, Chapman AG et al. (1997). Prolonged anticonvulsant action of glutamate metabotropic receptor agonists in inferior colliculus of genetically epilepsy-prone rats. European Journal of Pharmacology 327, (2-3) 109-115.
    10.1016/s0014-2999(97)89649-5
  • Smith SE, Man CM, Yip PK et al. (1996). Anticonvulsant effects of 7-nitroindazole in rodents with reflex epilepsy may result from L-arginine accumulation or a reduction in nitric oxide or L-citrulline formation. British Journal of Pharmacology 119, (1) 165-173.
    10.1111/j.1476-5381.1996.tb15690.x

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