Dr Scarlett Gillespie

Clinical Trial Manager and Postdoctoral Researcher

Over the last 5 years, my work and input to C4TS was been multifaceted. I have contributed to various projects supporting the lab work underpinning teams understanding of acute traumatic coagulopathy and platelet function after Trauma. As part of the C4TS clinical trials teams, I have supported management of ACITII study  and I have also been the Trial Site Co-ordinator for iTACTIC, eFIT, ORDIT and CryostatII.

Alongside these roles I head our Public Engagement events such as taking the team along to Big Bang festivals and the local QMUL Festival of Communities. I have also become more involved in the Patient and Public involvement (PPI) in our research and clinical trials to ensure of work has an active PPI voice. I am looking into ways of taking this online. I also work with Elaine Cole and Ross Davenport to support the TSCIPP programme and act as mentor for the 2nd year Public Engagement module.

My main roles with in the group include:

  • Conducting biomarker analysis on international ACITII samples
  • Assisting the recruitment of patients to ACITII
  • Supporting the clinical fellows in their various on-going research projects

I am also currently planning a study to investigate platelet function in trauma patients.

On top of my laboratory based roles within the group I am also been actively involved in organising and attending the trauma teams outreach projects. This has involved events for Big Bang Fairs, British Science Festival and Sevenoaks School Science week. On top of organising our participation in these on-going, established events I am currently putting together an event aimed at engaging local people in different aspects of trauma and its effects on those involved as well as the research we conduct and the science behind it.  


Schachter Award, British Pharmacological Society

Research interests

I have had an active role in studies to map the coagulatory profile of an international biobank of trauma patient plasma samples. The aim of this is to clarify alterations that may be linked to the coagulopathy known to occur in trauma patients.

I have also been involved in a similar study looking specifically at patients that go on to develop venous thromboembolism (VTE’s). This pathology represents a change in patients from a potentially initial hypocoagulatory state (low clot forming ability) to a hypercoagulatory state (over active clot formation); both of which represent medical problems for different reasons.

These studies both involve investigation into the coagulation system.

I am now currently putting together a new plan aimed at investigating how alteration in platelet function may underlie the pathology seen in TIC. Platelets are the main cell type involved in clot formation and they work together with the coagulation system to make blood clots. By investigating their function, we can develop a better-rounded picture of the physiological problems that may underlie TIC.


email: s.gillespie@qmul.ac.uk
Tel: +44 (0) 203 594 0731 

Vulliamy P, Gillespie S, et al. Platelet transfusions reduce fibrinolysis but do not restore platelet function during trauma hemorrhage. J Trauma Acute Care Surg. 2017

Vulliamy P, Gillespie S, et al. Histone H4 induces platelet ballooning and microparticle release during trauma hemorrhage.
Proc Natl Acad Sci U S A. 2019

Gall LS, Vulliamy P, Gillespie S et al.​ The S100A10 Pathway Mediates an Occult Hyperfibrinolytic Subtype in Trauma Patients.
Ann Surg. 2019​

Vulliamy P, Montague SJ, Gillespie S, et al. Loss of GPVI and GPIbα contributes to trauma-induced platelet dysfunction in severely injured patients. Blood Adv. 2020​

Cole E, Gillespie S et al. Multiple organ dysfunction after trauma. Br J Surg. 2020

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