Dr Scarlett Gillespie

Post-doctoral Research Fellow

I joined the group as a research assistant following completion of my MRes and PhD at Imperial in 2014. I was excited to join the group due to the investigations in trauma induced coagulopathy (TIC). TIC is a phenomenon that is thought to underlie the inability of trauma patients to produce a sufficient blood clot to stop them bleeding after their initial injury. I am specifically interested in the role of a specific cell type, known as platelets and wish to learn more about how alteration in their function might contribute to the development of TIC.

My main roles with in the group include:

  • Conducting biomarker analysis on international ACITII samples
  • Assisting the recruitment of patients to ACITII
  • Supporting the clinical fellows in their various on-going research projects

I am also currently planning a study to investigate platelet function in trauma patients.

On top of my laboratory based roles within the group I am also been actively involved in organising and attending the trauma teams outreach projects. This has involved events for Big Bang Fairs, British Science Festival and Sevenoaks School Science week. On top of organising our participation in these on-going, established events I am currently putting together an event aimed at engaging local people in different aspects of trauma and its effects on those involved as well as the research we conduct and the science behind it.  

Awards

Schacter Award, BPS

Research interests

I have had an active role in studies to map the coagulatory profile of an international biobank of trauma patient plasma samples. The aim of this is to clarify alterations that may be linked to the coagulopathy known to occur in trauma patients.

I have also been involved in a similar study looking specifically at patients that go on to develop venous thromboembolism (VTE’s). This pathology represents a change in patients from a potentially initial hypocoagulatory state (low clot forming ability) to a hypercoagulatory state (over active clot formation); both of which represent medical problems for different reasons.

These studies both involve investigation into the coagulation system.

I am now currently putting together a new plan aimed at investigating how alteration in platelet function may underlie the pathology seen in TIC. Platelets are the main cell type involved in clot formation and they work together with the coagulation system to make blood clots. By investigating their function, we can develop a better-rounded picture of the physiological problems that may underlie TIC.

Contact

email: s.gillespie@qmul.ac.uk
Tel: +44 (0) 203 594 0731

Gillespie S, Gavins FNE, 2013; Phytochemicals: Countering risk factors and pathological responses associated with ischaemia reperfusion injury, Pharmacology & Therapeutics, Vol:138, ISSN:0163-7258, Pages:38-45

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