Latest News
February 7, 2017
On 1st of February, a Pan London Trauma System prospective observational study called MODET (Multiple Organ Dysfunction in Elderly Trauma) recruited its first patient. Funded by the Dunhill Medical Trust MODET is a two year study which will examine the incidence and impact of Multiple Organ Dysfunction in elderly trauma patients from London’s four Major Trauma Centres (Royal London Hospital, St Marys Hospital, Kings College Hospital and St Georges Hospital).
Chief Investigator Dr Elaine Cole explains the need for the study:
“For the first time there are 11 million people aged 65 or over in the UK and the Office for National Statistics suggests that this is the fastest growing age-group nationally. As people live longer, the number of older people suffering traumatic injury is increasing. In those who survive the initial period after major trauma, a significant proportion goes onto develop adverse events such as multiple organ dysfunction (MODS).”
“MODs occurs as a result of an exaggerated systemic inflammatory response following major tissue trauma, and reports suggest that MODS affects between a third and a half of trauma patients admitted to critical care.”
“Many younger injured people who develop MODS will recover quickly, whereas older patients appear to suffer prolonged organ dysfunction, which is complicated by persistent immunosuppression, infectious episodes and other adverse events. MODS in older people is associated with increased mortality.”
MODET therefore aims to
- Identify the prevalence, severity and patterns of MODS in older patients (compared to younger controls)
- Determine predictors and risk factors of developing MODS for older patients (compared to younger controls)
- Identify age related characteristics that contribute to the development of MODS
- Examine the mode of mortality associated with MODS
- Analyse the relationship between MODS and longer-term recovery and quality of life for older patients (compared to younger controls)
Each London MTC will aim to enrol 130 older patients (>64 years) and 207 younger patients (<64 years).
More information available on our research programme web pages.
