Dr Ross Davenport

Bleeding and Coagulation

I am a Senior Lecturer in Trauma Sciences at C4TS and consultant trauma and vascular surgeon at the Royal London Major Trauma Centre, Bart’s Health NHS Trust.  My research focus is on trauma-induced coagulopathy, acute response to injury and the treatment of major trauma haemorrhage.  I have previously worked in prehospital care for both London and Essex & Herts Air Ambulances.  Currently I am a personal tutor and module lead for the online Masters programme in Trauma Sciences at QMUL.

Research interests

My main research interest is in the global derangement of clotting which occurs after major trauma haemorrhage - Trauma Induced Coagulopathy (TIC) and the earlier endogenous process of Acute Traumatic Coaguloapthy (ATC).  The majority of my PhD thesis was dedicated to the functional and biochemical characterization of the ATC using Rotational Thromboelastometry (ROTEM) and I further demonstrated the importance of the Protein C pathway in this endogenous coagulopathy.  We have shown that ROTEM is able to diagnose ATC within 5 minutes and is a more sensitive marker of massive haemorrhage predication than conventional, laboratory clotting screens.  In addition our work has identified activation of fibrinolysis in almost all severely injured patients and provides some mechanistic evidence for the large RCT evaluating tranexamic acid in trauma haemorrhage (CRASH-2). 

Using our platform study I developed for my PhD - Activation of Coagulation & Inflammation in Trauma (ACIT) -  C4TS are pursuing the wider acute response to injury including the white cell and genomic response to major injury.  My aim is to see this platform developed further for use in prehospital care and austere environment to enable rapid diagnosis of ATC and dysregulated inflammation which may be targeted earlier with novel therapeutics. 

I am currently a co-investigator on the national CRYOSTAT-2 trial evaluating the early use of fibrinogen supplementation (cryoprecipitate) in major trauma haemorrhage.  Previously I have worked on a number of other global RCTs for evaluation of novel and existing therapies for trauma haemorrhage and organ protection – recombinant Factor VIIa (CONTROL), MP4OX (pegylated haemoglobin-based colloid) and the CRYOSTAT (pilot RCT of early cryoprecipitate).

Contact

email: ross.davenport@qmul.ac.uk
Tel: +44 (0) 203 594 0731

  • Brohi K, Davenport RA (2017). In Reply. Anesthesiology 127, (3) 585-586.
    10.1097/ALN.0000000000001761
  • Rourke C, Davenport R, Brohi K (2017). Informed consent in acute trauma resuscitation: experiences of a major trauma centre. TRIALS 18.
  • DAVENPORT R (2017). Strategies for use of blood products for major bleeding in trauma. CochraneDatabase of Systematic Reviews 2017, (Issue 4) .
    10.1002/14651858.CD012635
  • GALL L, BROHI K, DAVENPORT R (2017). Diagnosis And Treatment Of Hyperfibrinolysis In Trauma (A European Perspective). Seminars in Thrombosis and Hemostasis .
    10.1055/s-0036-1598001
  • Davenport RA, Guerreiro M, Frith D et al. (2017). Activated Protein C Drives the Hyperfibrinolysis of Acute Traumatic Coagulopathy. Anesthesiology 126, (1) 115-127.
    10.1097/ALN.0000000000001428
  • Cole E, Lecky F, West A et al. (2016). The Impact of a Pan-regional Inclusive Trauma System on Quality of Care. Ann Surg 264, (1) 188-194.
    10.1097/SLA.0000000000001393
  • Davenport RA, Brohi K (2016). Cause of trauma-induced coagulopathy. Current Opinion in Anaesthesiology 29, (2) 212-219.
    10.1097/ACO.0000000000000295
  • Stanworth SJ, Davenport R, Curry N et al. (2016). Mortality from trauma haemorrhage and opportunities for improvement in transfusion practice. Br J Surg 103, (4) 357-365.
    10.1002/bjs.10052
  • Gall L, Davenport R, Brohi K (2016). Effect of early tranexamic acid on the coagulation system in patients with suspected traumatic haemorrhage: a prospective cohort study. LANCET 38746-46.
  • Maegele M, Inaba K, Rizoli S et al. (2015). Early viscoelasticity-based coagulation therapy for severely injured bleeding patients: Report of the consensus group on the consensus conference 2014 for formulation of S2k guidelines. Notfall und Rettungsmedizin 18, (6) 510-526.
    10.1007/s10049-015-0071-3
  • Gall L, Davenport R, Brohi K (2015). TRANEXAMIC ACID IS ASSOCIATED WITH ENHANCED CLOT STRENGTH, REDUCED FIBRINOLYSIS AND REDUCED ACUTE TRAUMATIC COAGULOPATHY IN BLEEDING TRAUMA PATIENTS. SHOCK 444-4.
  • Maegele M, Inaba K, Rizoli S et al. (2015). [Early viscoelasticity-based coagulation therapy for severely injured bleeding patients: Report of the consensus group on the consensus conference 2014 for formulation of S2k guidelines]. Anaesthesist 64, (10) 778-794.
    10.1007/s00101-015-0040-8
  • Zinchenko R, Cole E, Glasgow S et al. (2015). Mild, moderate or severe lung injury after trauma: What are the early predictors?. Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine .
    10.1186/1757-7241-23-S2-A8
  • Maegele M, Inaba K, Rizoli S et al. (2015). Early viscoelasticity-based coagulation therapy for severely injured bleeding patients: Report of the consensus group on the consensus conference 2014 for formulation of S2k guidelines. Notfall und Rettungsmedizin .
    10.1007/s10049-015-0071-3
  • Curry N, Rourke C, Davenport R et al. (2015). Early cryoprecipitate for major haemorrhage in trauma: a randomised controlled feasibility trial. Br J Anaesth 115, (1) 76-83.
    10.1093/bja/aev134
  • Inaba K, Rizoli S, Veigas PV et al. (2015). 2014 Consensus conference on viscoelastic test-based transfusion guidelines for early trauma resuscitation: Report of the panel. J Trauma Acute Care Surg 78, (6) 1220-1229.
    10.1097/TA.0000000000000657
  • Davenport R, Khan S, Brohi K (2015). Re: Hemostatic resuscitation is neither hemostatic nor resuscitative in trauma hemorrhage: But did they in fact test the effect of hemostatic resuscitation?. J Trauma Acute Care Surg 78, (6) 1237-1238.
    10.1097/TA.0000000000000624
  • Khan S, Davenport R, Raza I et al. (2015). Damage control resuscitation using blood component therapy in standard doses has a limited effect on coagulopathy during trauma hemorrhage. Intensive Care Med 41, (2) 239-247.
    10.1007/s00134-014-3584-1
  • Cole E, Davenport R, Willett K et al. (2015). Tranexamic acid use in severely injured civilian patients and the effects on outcomes: a prospective cohort study. Ann Surg 261, (2) 390-394.
    10.1097/SLA.0000000000000717
  • Cole E, Davenport R (2015). Early tranexamic acid use in trauma haemorrhage: Why do we give it and which patients benefit most?. International Emergency Nursing 23, (1) 38-41.
    10.1016/j.ienj.2014.03.004
  • Cole E, Davenport R (2015). Early tranexamic acid use in trauma haemorrhage: why do we give it and which patients benefit most?. Int Emerg Nurs 23, (1) 38-41.
    10.1016/j.ienj.2014.03.004
  • Curry N, Rourke C, Davenport R et al. (2014). Fibrinogen replacement in trauma haemorrhage. Scand J Trauma Resusc Emerg Med 22, (1) 764-.
    10.1186/1757-7241-22-S1-A5
  • Davenport R (2014). Haemorrhage control of the pre-hospital trauma patient. Scand J Trauma Resusc Emerg Med 22, (1) 763-.
    10.1186/1757-7241-22-S1-A4
  • Haddow JB, Adwan H, Clark SE et al. (2014). Use of the surgical Apgar score to guide postoperative care. Ann R Coll Surg Engl 96, (5) 352-358.
    10.1308/003588414X13946184900840
  • Davenport R (2014). Coagulopathy following major trauma hemorrhage: Lytic, lethal and a lack of fibrinogen. Critical Care 18, (3) .
    10.1186/cc13923
  • Jenkins DH, Rappold JF, Badloe JF et al. (2014). Trauma hemostasis and oxygenation research position paper on remote damage control resuscitation: definitions, current practice, and knowledge gaps. Shock 41 Suppl 13-12.
    10.1097/SHK.0000000000000140
  • Khan S, Brohi K, Chana M et al. (2014). Hemostatic resuscitation is neither hemostatic nor resuscitative in trauma hemorrhage. Journal of Trauma and Acute Care Surgery 76, (3) 561-568.
    10.1097/TA.0000000000000146
  • Cole E, Davenport R, Willett K et al. (2014). The burden of infection in severely injured trauma patients and the relationship with admission shock severity. Journal of Trauma and Acute Care Surgery 76, (3) 730-735.
    10.1097/TA.0b013e31829fdbd7
  • Cole E, Davenport R, Willett K et al. (2014). The burden of infection in severely injured trauma patients and the relationship with admission shock severity. J Trauma Acute Care Surg 76, (3) 730-735.
    10.1097/TA.0b013e31829fdbd7
  • Khan S, Davenport R, Raza I et al. (2014). Damage control resuscitation using blood component therapy in standard doses has a limited effect on coagulopathy during trauma hemorrhage. Intensive Care Medicine 41, (2) 239-247.
    10.1007/s00134-014-3584-1
  • Khan S, Brohi K, Chana M et al. (2014). Hemostatic resuscitation is neither hemostatic nor resuscitative in trauma hemorrhage. Journal of Trauma and Acute Care Surgery 76, (3) 561-568.
    10.1097/TA.0000000000000146
  • Davenport R, Brohi K (2013). Fibrinogen depletion in trauma: early, easy to estimate and central to trauma-induced coagulopathy. Crit Care 17, (5) 190-.
    10.1186/cc13021
  • Glasgow S, Davenport R, Perkins Z et al. (2013). A comprehensive review of blood product use in civilian mass casualty events. J Trauma Acute Care Surg 75, (3) 468-474.
    10.1097/TA.0b013e318298efb9
  • Davenport R, Frith D, Geurreiro M et al. (2013). ACTIVATED PROTEIN C IS CENTRAL TO SYSTEMIC FIBRINOLYSIS BUT NOT ANTICOAGULATION IN ACUTE TRAUMATIC COAGULOPATHY. SHOCK 4024-24.
  • Raza I, Khan S, Rourke C et al. (2013). ACUTE TRAUMATIC COAGULOPATHY HAS MULTIPLE IMPORTANT PATTERNS OF COAGULATION SYSTEM DERANGEMENT. SHOCK 4034-34.
  • Khan S, Raza I, Davenport R et al. (2013). MAJOR HEMORRHAGE PROTOCOLS HAVE A LIMITED EFFECT ON TRAUMA-INDUCED COAGULOPATHY. SHOCK 4034-34.
  • Willink M, Khan S, Cole E et al. (2013). OUTCOMES FOLLOWING TRAUMA HEMORRHAGE. SHOCK 4028-29.
  • Raza I, Khan S, Rourke C et al. (2013). THE RELATIVE CONTRIBUTIONS OF PAI-1, TAFI, AND FACTOR XI IN ACUTE TRAUMATIC COAGULOPATHY. SHOCK 4022-22.
  • Cole E, Davenport R, Glasgow S et al. (2013). TRANEXAMIC ACID USE IN SHOCKED SEVERELY INJURED PATIENTS AND THE EFFECTS ON OUTCOMES. SHOCK 4021-21.
  • Glasgow SM, Perkins ZB, Davenport R et al. (2013). A 100 year review of blood use in civilian mass casualty events - how best to predict future needs. BRITISH JOURNAL OF SURGERY 10031-31.
  • Khan S, Allard S, Weaver A et al. (2013). A major haemorrhage protocol improves the delivery of blood component therapy and reduces waste in trauma massive transfusion. Injury 44, (5) 587-592.
    10.1016/j.injury.2012.09.029
  • Khan S, Allard S, Weaver A et al. (2013). A major haemorrhage protocol improves the delivery of blood component therapy and reduces waste in trauma massive transfusion. Injury 44, (5) 587-592.
    10.1016/j.injury.2012.09.029
  • De'Ath HD, Manson J, Davenport R et al. (2013). Trauma-induced secondary cardiac injury is associated with hyperacute elevations in inflammatory cytokines. Shock 39, (5) 415-420.
    10.1097/SHK.0b013e31828ded41
  • Raza I, Davenport R, Rourke C et al. (2013). The incidence and magnitude of fibrinolytic activation in trauma patients. J Thromb Haemost 11, (2) 307-314.
    10.1111/jth.12078
  • Cole EM, West A, Davenport R et al. (2013). Can residents be effective trauma team leaders in a major trauma centre?. Injury 44, (1) 18-22.
    10.1016/j.injury.2011.09.020
  • Cole E, Davenport R, De'Ath H et al. (2013). Coagulation system changes associated with susceptibility to infection in trauma patients. J Trauma Acute Care Surg 74, (1) 51-57.
    10.1097/TA.0b013e3182788b0f
  • Davenport R (2013). Pathogenesis of acute traumatic coagulopathy. Transfusion 53 Suppl 123S-27S.
    10.1111/trf.12032
  • Davenport R, Brohi K (2012). HYPOPERFUSION & ACTIVATION OF PROTEIN C IN TRAUMA. SHOCK 38, (4) 1-1.
  • Harris T, Davenport R, Hurst T et al. (2012). Improving outcome in severe trauma: what's new in ABC? Imaging, bleeding and brain injury. Postgrad Med J 88, (1044) 595-603.
    10.1136/postgradmedj-2011-130285
  • Curry NS, Davenport RA, Hunt BJ et al. (2012). Transfusion strategies for traumatic coagulopathy. Blood Reviews 26, (5) 223-232.
    10.1016/j.blre.2012.06.004
  • Rourke C, Curry N, Khan S et al. (2012). Fibrinogen levels during trauma hemorrhage, response to replacement therapy, and association with patient outcomes. J Thromb Haemost 10, (7) 1342-1351.
    10.1111/j.1538-7836.2012.04752.x
  • De'Ath HD, Rourke C, Davenport R et al. (2012). Clinical and biomarker profile of trauma-induced secondary cardiac injury. British Journal of Surgery 99, (6) 789-797.
    10.1002/bjs.8728
  • De'Ath HD, Rourke C, Davenport R et al. (2012). Clinical and biomarker profile of trauma-induced secondary cardiac injury. Br J Surg 99, (6) 789-797.
    10.1002/bjs.8728
  • Khan S, Allard S, Weaver A et al. (2012). A trauma major haemorrhage protocol reduces waste and improves the delivery of blood component therapy. BRITISH JOURNAL OF SURGERY 9944-44.
  • Frith D, Davenport R, Brohi K (2012). Acute traumatic coagulopathy. Curr Opin Anaesthesiol 25, (2) 229-234.
    10.1097/ACO.0b013e3283509675
  • Newton N, Davenport R, Tai NRM (2011). Extremity compartment syndrome with Sickle Cell Trait. J R Army Med Corps 157, (4) 418-.
  • Davenport R, Manson J, De'Ath H et al. (2011). Functional definition and characterization of acute traumatic coagulopathy. Crit Care Med 39, (12) 2652-2658.
    10.1097/CCM.0b013e3182281af5
  • Davenport R, Khan S (2011). Management of major trauma haemorrhage: treatment priorities and controversies. Br J Haematol 155, (5) 537-548.
    10.1111/j.1365-2141.2011.08885.x
  • Davenport R, Rourke C, Manson J et al. (2011). Activated protein C is a principle mediator of acute traumatic coagulopathy. J THROMB HAEMOST 951-52.
  • Manson J, Davenport R, Coates A et al. (2011). TRAUMATIC TISSUE DAMAGE: THE SEARCH FOR TRAUMA ALARMINS. INFLAMMATION RESEARCH 60160-160.
  • Davenport R, Manson J, De'Ath H et al. (2011). Point of care diagnostics for the rapid identification of acute traumatic coagulopathy and prediction of massive trauma haemorrhage. BRITISH JOURNAL OF SURGERY 987-7.
  • Davenport R, Curry N, Manson J et al. (2011). Hemostatic effects of fresh frozen plasma may be maximal at red cell ratios of 1:2. J Trauma 70, (1) 90-95.
    10.1097/TA.0b013e318202e486
  • Davenport RA, Tai N, West A et al. (2010). A major trauma centre is a specialty hospital not a hospital of specialties. Br J Surg 97, (1) 109-117.
    10.1002/bjs.6806
  • Stanworth SJ, Morris TP, Gaarder C et al. (2010). Reappraising the concept of massive transfusion in trauma. CRIT CARE 14, (6) .
    10.1186/cc9394
  • Davenport R, Tai N, Walsh M (2009). Vascular trauma. Surgery 27, (8) 331-336.
    10.1016/j.mpsur.2009.06.008
  • Davenport RA, Brohi K (2009). Coagulopathy in trauma patients: importance of thrombocyte function?. Curr Opin Anaesthesiol 22, (2) 261-266.
    10.1097/ACO.0b013e328325a6d9
  • Davenport R, Coates A, Allard S et al. (2009). TRAUMA HAEMORRHAGE: EVOLVING ROLE OF ROTEM FOR PREDICTING TRANSFUSION REQUIREMENTS. SHOCK 3215-15.
  • Brohi K, Cohen MJ, Davenport RA (2007). Acute coagulopathy of trauma: mechanism, identification and effect. Curr Opin Crit Care 13, (6) 680-685.
    10.1097/MCC.0b013e3282f1e78f
  • VULLIAMY P, GILLESPIE S, GALL L et al. (). Platelet transfusions reduce fibrinolysis but do not restore platelet function during trauma hemorrhage. Journal of Trauma and Acute Care Surgery .
    10.1097/TA.0000000000001520

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