Professor Karim Brohi

Professor of Trauma Sciences

As head of the Trauma Sciences research team, my time is divided between surgery and science.

As a surgeon I provide care for patients with vascular diseases and traumatic injury. As a scientist, I conduct my own work and supervise 15 researchers who are investigating different aspects of traumatic disease.

 In medical practice, we use available evidence to determine and deliver the best patient care.There are many instances where best practice has not been established because we don't fully understand the disease. My aim is to improve the care of trauma patients by increasing our understanding of the disease processes.

I studied Medicine at University College Hospital London. At university I also obtained an intercalated BSc in Computer Science and spent my 12-week elective in Trinidad and Tobago. Once I started work, I realised that the management of trauma patients in the UK was extremely poor and this fuelled an ambition to improve the standards. I set up trauma.org, a non-profit making, web forum which provides education, expert discussion and online support for trauma surgeons worldwide.

I completed several years of training and became qualified in both Anaesthetics and Surgery. This was a little unusual but has given me an extremely useful set of skills for trauma patient management. I worked for the Helicopter Emergency Medical Service (HEMS) in London and spent two years working at a Trauma Hospital in San Francisco. I obtained a Consultant post at The Royal London Hospital and returned to the UK to set up a trauma research department.

Trauma Sciences joined the Centre for Neuroscience in 2008. Our centre is housed within the Blizard Institute at Barts and The London School of Medicine and Dentistry. Our aim is to improve our understanding of trauma through laboratory experiments and then use those findings to improve patient outcomes by developing new treatment strategies. We have established collaborations with trauma units within Europe and the USA and we also conduct clinical trials for products designed for use in trauma. Conducting research in emergency surgical conditions is challenging but is essential if we are to make improvements for patients. In the UK, lack of trauma experience and poor organisation of trauma services means that patients are still dying from treatable injuries.

I hope for a future where specialist trauma centres provide specialised trauma care from the moment of injury to the end of rehabilitation. Trauma research is an essential component of this process. I travel frequently to deliver lectures and teaching. In 2011 I set up an MSc in Trauma Science.

When I am not at work I like to watch movies and eat at good restaurants. Surgery is a very challenging career but it can also be very rewarding and I would encourage anyone who wants to pursue a career in surgery to do so. Trauma has finally been recognised as an important component of surgery in the UK so the future for this specialty is very exciting.

Contact

email: k.brohi@qmul.ac.uk

  • Tremoleda JL, Watts SA, Reynolds PS et al. (2017). Modeling Acute Traumatic Hemorrhagic Shock Injury: Challenges and Guidelines for Preclinical Studies. Shock 48, (6) 610-623.
    10.1097/SHK.0000000000000901
  • Nevin DG, Brohi K (2017). Permissive hypotension for active haemorrhage in trauma. Anaesthesia 72, (12) 1443-1448.
    10.1111/anae.14034
  • Baksaas-Aasen K, Gall L, Eaglestone S et al. (2017). iTACTIC - implementing Treatment Algorithms for the Correction of Trauma-Induced Coagulopathy: study protocol for a multicentre, randomised controlled trial. Trials 18, (1) 486-.
    10.1186/s13063-017-2224-9
  • Wilson NM, Wall J, Naganathar V et al. (2017). Mechanisms Involved in Secondary Cardiac Dysfunction in Animal Models of Trauma and Hemorrhagic Shock. Shock 48, (4) 401-410.
    10.1097/SHK.0000000000000882
  • Brohi K, Davenport RA (2017). In Reply. Anesthesiology 127, (3) 585-586.
    10.1097/ALN.0000000000001761
  • Asehnoune K, Balogh Z, Citerio G et al. (2017). The research agenda for trauma critical care. Intensive Care Med 43, (9) 1340-1351.
    10.1007/s00134-017-4895-9
  • Cabrera CP, Manson J, Shepherd JM et al. (2017). Signatures of inflammation and impending multiple organ dysfunction in the hyperacute phase of trauma: A prospective cohort study. PLoS Med 14, (7) e1002352-.
    10.1371/journal.pmed.1002352
  • Brohi K, Schreiber M (2017). The new survivors and a new era for trauma research. PLoS Med 14, (7) e1002354-.
    10.1371/journal.pmed.1002354
  • Yamada N, Martin L, Zechendorf E et al. (2017). A NOVEL SYNTHETIC, HOST-DEFENCE PEPTIDE PROTECTS AGAINST ORGAN INJURY/DYSFUNCTION IN A RAT-MODEL OF SEVERE HEMORRHAGIC SHOCK. SHOCK 47, (6) 116-117.
  • Rourke C, Davenport R, Brohi K (2017). Informed consent in acute trauma resuscitation: experiences of a major trauma centre. TRIALS 18.
  • Wilson NM, Wall J, Naganathar V et al. (2017). Mechanisms Involved in Secondary Cardiac Dysfunction in Animal Models of Trauma and Haemorrhagic Shock. Shock .
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  • Balendran CA, Lövgren A, Hansson KM et al. (2017). Prothrombin time is predictive of low plasma prothrombin concentration and clinical outcome in patients with trauma hemorrhage: analyses of prospective observational cohort studies. Scand J Trauma Resusc Emerg Med 25, (1) 30-.
    10.1186/s13049-016-0332-2
  • GALL L, BROHI K, DAVENPORT R (2017). Diagnosis And Treatment Of Hyperfibrinolysis In Trauma (A European Perspective). Seminars in Thrombosis and Hemostasis .
    10.1055/s-0036-1598001
  • Sordi R, Nandra KK, Chiazza F et al. (2017). Artesunate Protects Against the Organ Injury and Dysfunction Induced by Severe Hemorrhage and Resuscitation. Ann Surg 265, (2) 408-417.
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  • Balvers K, van Dieren S, Baksaas-Aasen K et al. (2017). Combined effect of therapeutic strategies for bleeding injury on early survival, transfusion needs and correction of coagulopathy. Br J Surg 104, (3) 222-229.
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  • Davenport RA, Guerreiro M, Frith D et al. (2017). Activated Protein C Drives the Hyperfibrinolysis of Acute Traumatic Coagulopathy. Anesthesiology 126, (1) 115-127.
    10.1097/ALN.0000000000001428
  • Vulliamy PE, Perkins ZB, Brohi K et al. (2016). Persistent lymphopenia is an independent predictor of mortality in critically ill emergency general surgical patients. Eur J Trauma Emerg Surg 42, (6) 755-760.
    10.1007/s00068-015-0585-x
  • Perkins ZB, Lendrum RA, Brohi K (2016). Resuscitative endovascular balloon occlusion of the aorta: promise, practice, and progress?. Curr Opin Crit Care 22, (6) 563-571.
    10.1097/MCC.0000000000000367
  • Perkins ZB, Lendrum RA, Brohi K (2016). Resuscitative endovascular balloon occlusion of the aorta: promise, practice, and progress?. Curr Opin Crit Care .
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  • Shepherd JM, Cole E, Brohi K (2016). Contemporary patterns of multiple organ dysfunction in trauma. Shock .
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  • De'Ath HD, Oakland K, Brohi K (2016). CT screened arterial calcification as a risk factor for mortality after trauma. Scand J Trauma Resusc Emerg Med 24, (1) 120-120.
    10.1186/s13049-016-0317-1
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  • Sivakumar S, Taccone FS, Desai KA et al. (2016). ESICM LIVES 2016: part two : Milan, Italy. 1-5 October 2016. Intensive Care Med Exp 4, (Suppl 1) 30-30.
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  • Roberts DJ, Zygun DA, Faris PD et al. (2016). Opinions of Practicing Surgeons on the Appropriateness of Published Indications for Use of Damage Control Surgery in Trauma Patients: An International Cross-Sectional Survey. J Am Coll Surg 223, (3) 515-529.
    10.1016/j.jamcollsurg.2016.06.002
  • Sharples A, Brohi K (2016). Can clinical prediction tools predict the need for computed tomography in blunt abdominal? A systematic review. Injury 47, (8) 1811-1818.
    10.1016/j.injury.2016.05.032
  • Cole E, Lecky F, West A et al. (2016). The Impact of a Pan-regional Inclusive Trauma System on Quality of Care. Ann Surg 264, (1) 188-194.
    10.1097/SLA.0000000000001393
  • Glen J, Constanti M, Brohi K et al. (2016). Assessment and initial management of major trauma: summary of NICE guidance. BMJ 353i3051-.
    10.1136/bmj.i3051
  • Hoffman KP, Playford DE, Grill E et al. (2016). Minimum data set to measure rehabilitation needs and health outcome after major trauma: application of an international framework. Eur J Phys Rehabil Med 52, (3) 331-346.
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    10.1097/SLA.0000000000001347
  • Davenport RA, Brohi K (2016). Cause of trauma-induced coagulopathy. Current Opinion in Anaesthesiology 29, (2) 212-219.
    10.1097/ACO.0000000000000295
  • Stanworth SJ, Davenport R, Curry N et al. (2016). Mortality from trauma haemorrhage and opportunities for improvement in transfusion practice. Br J Surg 103, (4) 357-365.
    10.1002/bjs.10052
  • Gall L, Davenport R, Brohi K (2016). Effect of early tranexamic acid on the coagulation system in patients with suspected traumatic haemorrhage: a prospective cohort study. LANCET 38746-46.
  • Sordi R, Nandra KK, Chiazza F et al. (2016). Artesunate Protects Against the Organ Injury and Dysfunction Induced by Severe Hemorrhage and Resuscitation. Annals of surgery .
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  • Torrance H, Brohi K, Warnes G et al. (2015). T-helper cell polarisation following severe polytrauma. Intensive Care Med Exp 3, (Suppl 1) A848-.
    10.1186/2197-425X-3-S1-A848
  • Owen HC, Torrance H, Barnes MR et al. (2015). The Role of Micrornas in The Development of Hospital Acquired Infection in Polytrauma Patients. Intensive Care Med Exp 3, (Suppl 1) A35-.
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  • Brohi K (2015). The trials of being a national trauma registry. Emerg Med J 32, (12) 909-910.
    10.1136/emermed-2015-205424
  • Glasgow S, Vasilakis C, Perkins Z et al. (2015). DEVELOPING TRANSFUSION BASED STRATEGIES FOR OPTIMISING OUTCOMES FOLLOWING MASS CASUALTY EVENTS USING A DISCRETE EVENT SIMULATION MODELLING APPROACH. SHOCK 445-6.
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  • Wall JM, Tremoleda JL, Thiemermann C et al. (2015). HEART FATTY ACID BINDING PROTEIN (H-FABP) IS A BIOMARKER OF TRAUMA-INDUCED SECONDARY CARDIAC INJURY IN A PRE-CLINICAL MODEL OF TRAUMA-HAEMORRHAGE. SHOCK 4421-22.
  • Roberts DJ, Bobrovitz N, Zygun DA et al. (2015). Indications for use of thoracic, abdominal, pelvic, and vascular damage control interventions in trauma patients: A content analysis and expert appropriateness rating study. J Trauma Acute Care Surg 79, (4) 568-579.
    10.1097/TA.0000000000000821
  • Shepherd JM, Cole E, Brohi K (2015). PATTERNS OF MULTI-ORGAN DYSFUNCTION IN SEVERELY INJURED PATIENTS WITH HAEMORRHAGE. SHOCK 4421-21.
  • Vulliamy PE, Perkins ZB, Brohi K et al. (2015). SEVERE LYMPHOPENIA IN EMERGENCY SURGICAL PATIENTS IS ASSOCIATED WITH ILLNESS SEVERITY AND MORTALITY. SHOCK 4410-11.
  • Shepherd JM, Cole E, Brohi K (2015). T-5: PATTERNS OF MULTI-ORGAN DYSFUNCTION IN SEVERELY INJURED PATIENTS WITH HAEMORRHAGE. Shock 44 Suppl 221-.
    10.1097/01.shk.0000472070.23771.ef
  • Frith D, Wall J, Baptista M et al. (2015). THROMBIN GENERATION POTENTIAL DECLINES DURING TRAUMA HAEMORRHAGE DESPITE HAEMOSTATIC RESUSCITATION. SHOCK 441-2.
  • Gall L, Davenport R, Brohi K (2015). TRANEXAMIC ACID IS ASSOCIATED WITH ENHANCED CLOT STRENGTH, REDUCED FIBRINOLYSIS AND REDUCED ACUTE TRAUMATIC COAGULOPATHY IN BLEEDING TRAUMA PATIENTS. SHOCK 444-4.
  • Sordi R, Nandra KK, Chiazza F et al. (2015). TRAUMA ORGAN PROTECTION WITH ARTESUNATE (TOP-ART): PRECLINICAL EFFICACY OF AN ANTIMALARIAL DRUG WITH EXCELLENT SAFETY PROFILE AND PLANNED PHASE II RCT. SHOCK 441-1.
  • Jones TF, Gillespie S, Gall LS et al. (2015). VENOUS THROMBOEMBOLIC EVENTS AFTER TRAUMATIC INJURY ARE ASSOCIATED WITH EARLY CHANGES TO THE FIBRINOLYTIC SYSTEM. SHOCK 4424-24.
  • Jones TF, Owen HC, Torrance HDT et al. (2015). MicroRNA-mediated regulation of IL-10, IL-12 and TNFα gene expression in severely injured trauma patients. Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine 23, (2) .
    10.1186/1757-7241-23-S2-O5
  • Taccone FS, Bunker N, Waldmann C et al. (2015). A new device for the prevention of pulmonary embolism in critically ill patients: Results of the European Angel Catheter Registry. J Trauma Acute Care Surg 79, (3) 456-462.
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  • Whitaker J, West A, Brohi K et al. (2015). Reason for Admission and Outcomes for Older Patients Admitted to a Major Trauma Centre. BRITISH JOURNAL OF SURGERY 10286-86.
  • Watts S, Nordmann G, Brohi K et al. (2015). Evaluation of Prehospital Blood Products to Attenuate Acute Coagulopathy of Trauma in a Model of Severe Injury and Shock in Anesthetized Pigs. Shock 44 Suppl 1138-148.
    10.1097/SHK.0000000000000409
  • Campbell HE, Stokes EA, Bargo DN et al. (2015). Quantifying the healthcare costs of treating severely bleeding major trauma patients: a national study for England. Crit Care 19276-.
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  • Naganathar S, De''Ath HD, Wall J et al. (2015). Admission biomarkers of trauma-induced secondary cardiac injury predict adverse cardiac events and are associated with plasma catecholamine levels. Journal of Trauma and Acute Care Surgery 79, (1) 71-77.
    10.1097/TA.0000000000000694
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  • Davenport R, Khan S, Brohi K (2015). Re: Hemostatic resuscitation is neither hemostatic nor resuscitative in trauma hemorrhage: But did they in fact test the effect of hemostatic resuscitation?. J Trauma Acute Care Surg 78, (6) 1237-1238.
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  • Torrance HD, Brohi K, Pearse RM et al. (2015). Association between gene expression biomarkers of immunosuppression and blood transfusion in severely injured polytrauma patients. Annals of Surgery 261, (4) 751-759.
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    10.1097/SLA.0000000000000653
  • Perkins ZB, Yet B, Glasgow S et al. (2015). Meta-analysis of prognostic factors for amputation following surgical repair of lower extremity vascular trauma. Br J Surg 102, (5) 436-450.
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  • Brohi K (2015). Make the bleeding stop. Sci Transl Med 7, (277) 277fs10-.
    10.1126/scitranslmed.aaa6555
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  • Torrance HD, Vivian ME, Brohi K et al. (2015). Changes in gene expression following trauma are related to the age of transfused packed red blood cells. J Trauma Acute Care Surg 78, (3) 535-542.
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  • Frith D, Brohi K (2015). Massive transfusion in trauma. 101-119.
    10.1007/978-3-319-08735-1_11
  • Perkins ZB, Yet B, Glasgow S et al. (2015). Meta-analysis of prognostic factors for amputation following surgical repair of lower extremity vascular trauma. British Journal of Surgery 102, (5) 436-450.
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  • Heim C, Brohi K (2015). Perioperative hemostasis in trauma. 311-330.
    10.1007/978-3-642-55004-1_18
  • Müller MCA, Balvers K, Binnekade JM et al. (2014). Thromboelastometry and organ failure in trauma patients: a prospective cohort study. Crit Care 18, (6) 687-.
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  • Perkins ZB, Yet B, Glasgow S et al. (2014). Prognostic Factors for Amputation Following Surgical Repair of Lower Extremity Vascular Trauma: A Systematic Review and Meta-Analysis of Observational Studies. JOURNAL OF VASCULAR SURGERY 59, (6) 75S-75S.
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  • Khan S, Davenport R, Raza I et al. (2014). Damage control resuscitation using blood component therapy in standard doses has a limited effect on coagulopathy during trauma hemorrhage. Intensive Care Medicine 41, (2) 239-247.
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  • Hoffman K, Cole E, Playford ED et al. (2014). Health outcome after major trauma: what are we measuring?. PLoS One 9, (7) e103082-.
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  • Khan S, Brohi K, Chana M et al. (2014). Hemostatic resuscitation is neither hemostatic nor resuscitative in trauma hemorrhage. Journal of Trauma and Acute Care Surgery 76, (3) 561-568.
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  • Perkins ZB, Maytham GD, Koers L et al. (2014). Impact on outcome of a targeted performance improvement programme in haemodynamically unstable patients with a pelvic fracture. Bone and Joint Journal 96 B, (8) 1090-1097.
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  • Abrams ST, Manson J, Liu T et al. (2013). Acute phase proteins reduce histone-induced platelet aggregation and coagulation activation. JOURNAL OF THROMBOSIS AND HAEMOSTASIS 1122-22.
  • Torrance HDT, Brohi K, Pearse RM et al. (2013). BLOOD TRANSFUSION FOLLOWING SEVERE TRAUMA IS ASSOCIATED WITH THE DEVELOPMENT OF AN EARLY ANTI-INFLAMMATORY RESPONSE. INTENSIVE CARE MEDICINE 39S386-S387.
  • Davenport R, Brohi K (2013). Fibrinogen depletion in trauma: early, easy to estimate and central to trauma-induced coagulopathy. Crit Care 17, (5) 190-.
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  • Glasgow S, Davenport R, Perkins Z et al. (2013). A comprehensive review of blood product use in civilian mass casualty events. J Trauma Acute Care Surg 75, (3) 468-474.
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  • Khan S, Raza I, Davenport R et al. (2013). MAJOR HEMORRHAGE PROTOCOLS HAVE A LIMITED EFFECT ON TRAUMA-INDUCED COAGULOPATHY. SHOCK 4034-34.
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  • Raza I, Khan S, Rourke C et al. (2013). THE RELATIVE CONTRIBUTIONS OF PAI-1, TAFI, AND FACTOR XI IN ACUTE TRAUMATIC COAGULOPATHY. SHOCK 4022-22.
  • Cole E, Davenport R, Glasgow S et al. (2013). TRANEXAMIC ACID USE IN SHOCKED SEVERELY INJURED PATIENTS AND THE EFFECTS ON OUTCOMES. SHOCK 4021-21.
  • Brockamp T, Maegele M, Gaarder C et al. (2013). Comparison of the predictive performance of the BIG, TRISS, and PS09 score in anadult trauma population derived from multiple international trauma registries. Critical Care 17, (4) .
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  • Abrams ST, Manson J, Liu T et al. (2013). Circulating histone-induced thrombosis leads to circulatory and respiratory failure. JOURNAL OF THROMBOSIS AND HAEMOSTASIS 11128-128.
  • Hunt BJ, Raza I, Brohi K (2013). The incidence and magnitude of fibrinolytic activation in trauma patients: A reply to a rebuttal. Journal of Thrombosis and Haemostasis 11, (7) 1437-1438.
    10.1111/jth.12296
  • Glasgow SM, Perkins ZB, Davenport R et al. (2013). A 100 year review of blood use in civilian mass casualty events - how best to predict future needs. BRITISH JOURNAL OF SURGERY 10031-31.
  • Khan S, Allard S, Weaver A et al. (2013). A major haemorrhage protocol improves the delivery of blood component therapy and reduces waste in trauma massive transfusion. Injury 44, (5) 587-592.
    10.1016/j.injury.2012.09.029
  • Khan S, Allard S, Weaver A et al. (2013). A major haemorrhage protocol improves the delivery of blood component therapy and reduces waste in trauma massive transfusion. Injury 44, (5) 587-592.
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  • Perkins ZB, Glasgow S, Brohi K et al. (2013). A systematic review and meta-analysis of prognostic variables for secondary amputation following surgical repair of lower extremity vascular trauma. BRITISH JOURNAL OF SURGERY 10051-51.
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