Dr Paul Vulliamy
I am a Senior Clinical Lecturer in Trauma Sciences at the Blizard Institute and Honorary Consultant Trauma Surgeon at the Royal London Hospital. I first joined C4TS as a clinical research fellow and completed my PhD in 2019 under the supervision of Professor Karim Brohi and Professor Tim Warner. I then took up a post as Clinical Lecturer in trauma sciences and Specialist Registrar in general surgery. After completing my higher surgical training and subspecialty training in trauma, I was appointed to my current position where my time is split between clinical and academic commitments.
My primary research focus is on the role of platelets in the pathophysiology of acute traumatic coagulopathy and post-injury organ dysfunction. I have a particular interest in the immunomodulatory roles of platelets, the mechanisms of damage sensing by platelets, and the behaviour of transfused platelets during major haemorrhage.
In addition to my research activities, I co-ordinate medical student placements within the group and I contribute to the Haemorrhage and Coagulopathy module of the Trauma Sciences MSc. I am also co-principal investigator of the ACITII study, our platform observational study, and a founding member of the National trauma research and innovation collaborative (NaTRIC). I participate regularly in our public engagement activities, and run outreach events through the Blizard Institute which support young people from the local community to get involved in scientific and clinical careers. I also have a keen interest in medical art, and was previously awarded the life Sciences Image Award for my work entitled ‘White Blood Cells in Colour’.
Contact
email: p.vulliamy@qmul.ac.uk
Vulliamy P, Gillespie S, Armstrong PC, Allan HE, Warner TD, Brohi K. Histone H4 induces platelet ballooning and microparticle release during trauma hemorrhage. Proc Natl Acad Sci USA. 2019;116(35):17444-17449.
Schofield H, Rossetto A, Armstrong PC, Allan HE, Warner TD, Brohi K, Vulliamy P. Immature platelet dynamics are associated with clinical outcomes after major trauma. J Thromb Haemost. 2023:S1538-7836(23)00865-6. doi: 10.1016/j.jtha.2023.12.002.
Vulliamy P, Armstrong PC. Platelets in haemostasis, thrombosis and inflammation after major trauma. Arterioscler Thromb Vasc Biol. 2024. Jan 18. doi: 10.1161/ATVBAHA.123.318801.
Vulliamy P, Montague SJ, Gillespie S, Chan MV, Coupland LA, Andrews RK, Warner TD, Gardiner EE, Brohi K, Armstrong PC. Loss of GPVI and GPIbα contributes to trauma-induced platelet dysfunction in severely injured patients. Blood Adv. 2020; 4(12):2623-2630.
Gall LS*, Vulliamy P*, Gillespie S, Jones TF, Pierre RSJ, Breukers SE, Gaarder C, Juffermans NP, Maegele M, Stensballe J, Johansson PI, Davenport RA, Brohi K; Targeted Action for Curing Trauma-Induced Coagulopathy (TACTIC) partners. The S100A10 Pathway Mediates an Occult Hyperfibrinolytic Subtype in Trauma Patients. Ann Surg. 2019 Jun;269(6):1184-1191. *Joint first authors.
Vulliamy P, Gillespie S, Gall LS, Green L, Brohi K, Davenport R. Platelet transfusions reduce fibrinolysis but do not restore platelet function during trauma haemorrhage. J Trauma Acute Care Surg. 2017;83(3):388-397.
Vulliamy P, Kornblith LZ, Kutcher ME, Cohen MJ, Brohi K, Neal MD. Alterations in Platelet Behavior After Major Trauma: Adaptive or Maladaptive? Platelets. 2020; 32(3):295-304.
Vulliamy P, Jacob S, Davenport RA. Acute Aorto-Iliac and Mesenteric Arterial Thromboses as Presenting Features of COVID-19. Br J Haematol. 2020; 189(6):1053-1054.
Cole E, Gillespie S, Vulliamy P, Brohi K; Organ Dysfunction in Trauma (ORDIT) study collaborators. Multiple organ dysfunction after trauma. Br J Surg. 2019; 107(4):402-412.
Rossetto A, Vulliamy P, Lee KM, Brohi K, Davenport R. Temporal Transitions in Fibrinolysis after Trauma: Adverse Outcome Is Principally Related to Late Hypofibrinolysis. Anesthesiology. 2021 Nov 1.
Marsden MER, Vulliamy P, Carden R, Naumann DN, Davenport RA; National Trauma Research and Innovation Collaborative (NaTRIC). Trauma Laparotomy in the UK: A Prospective National Service Evaluation. J Am Coll Surg. 2021; 233(3):383-394.e1.
Sordi R, Chiazza F, Collotta D, Migliaretti G, Colas RA, Vulliamy P, Brohi K, Dalli J, Collino M, Thiemermann C. Resolvin D1 Attenuates the Organ Injury Associated With Experimental Hemorrhagic Shock. Ann Surg. 2019 Jun 7. doi: 10.1097/SLA.0000000000003407
Vulliamy P, Thaventhiran AJ, Davenport RA. What's new for trauma haemorrhage management? Br J Hosp Med (Lond). 2019 May 2;80(5):268-273. doi: 10.12968/hmed.2019.80.5.268.
Vulliamy P, Faulkner M, Kirkwood G, West A, O’Neill B, Griffiths MP, Moore F, Brohi K. Temporal and geographic patterns of stab injuries in young people: a retrospective cohort study from a UK major trauma centre. BMJ Open. 2018 Nov 6;8(10):e023114. doi: 10.1136/bmjopen-2018-023114.
Symons N, Moorthy K, Vincent C, Arora S, Vulliamy P, Davenport R, Theodoropoulou K. Reliability in the process of care during emergency general surgical admission. Int J Surg 2016;32:143-9)
Manson J, Cole E, De’Ath H, Vulliamy P, Meier U, Pennington D, Brohi K. Early changes within the lymphocyte population are associated with the development of multiple organ failure in trauma patients: an observational cohort study. Crit Care. 2016 Jun 7;20(1):176.
Vulliamy P, McCluney S, Ashby L, Mukherjee S, Amalesh T. Post-operative Elevation of the Neutrophil:Lymphocyte Ratio Predicts Complications Following Oesophageal Resection. World J Surg 2016; 40(6):1397-403
Vulliamy P, McCluney S, Raouf S, Banerjee S. Urgent Referrals for Suspected Colorectal Cancer. Annals of the Royal College of Surgeons of England. 2016 Aug 23:1-4
Vulliamy P, Perkins Z, Brohi K, Manson J. Persistent Lymphopenia is an Independent Predictor of Mortality in Critically Ill Emergency Surgical Patients. Eur J Tr Em Surg 2015 Oct 26 (epub ahead of print)
Abukar A, Leung P, Vulliamy P, Cheatle T. An unusual cause of abdominal pain. BMJ Case Reports 2015 Aug 9
Vulliamy P, Junaid I. Peer-Mentoring Junior Surgical Trainees in the United Kingdom.: A Pilot Program. Med Educ Online. 2013;18:1-3
Vulliamy P, Hariharan V, Gutmann J, Mukherjee D. Superior mesenteric artery syndrome and the ‘nutcracker phenomenon.’ BMJ Case Rep 2013 Mar 21
Vulliamy P, Berner AM, Farooq MS, Srilekha A. Near-fatal small bowel ischaemia secondary to sacrocolpopexy mesh. BMJ Case Rep. 2013 Jan 25
Vulliamy P, Lau K, Wood AJ. Vanishing Lung Syndrome. BMJ 2012;344:e2876
Vulliamy P, McCormack DJ, Szczeklik MS, Lall K. Coarctation Repair Mimicking Acute Aortic Dissection. Eur J Cardiothorac Surg. 2012 Dec;42(6):1055.
De’Ath H, Vulliamy P, Davies C, Uppal R. A Large Ventricular Septal Defect Complicating Resuscitation After Blunt Trauma. J Emerg Trauma Shock. 2012 Oct;5(4):350-2.
Vulliamy P, Srilekha A, Fotiadis N, Kyriakides C. Operative Repair of a Giant Hepatic Artery Aneurysm. Journal of Surgical Case Reports 2011 3:1.
