Professor Adina Michael-Titus

Professor of Neuroscience

I lead the research group investigating new neuroprotective strategies in traumatic brain and spinal cord injury.

I lead the Centre for Neuroscience, Surgery and Trauma, and as a neuroscientist and pharmacologist. I am particularly interested in the development of new therapeutic interventions in traumatic spinal cord injury and brain injury. The Neurotrauma Group that I lead has strong links with clinicians at the Royal London Hospital who are working on brain and spinal cord injury patients, and includes several PhD students, MSc students and post-doctoral researchers. We investigate various aspects of trauma in the central nervous system and peripheral nervous system using experimental models, and more recently we have also become involved in clinical studies in neurotrauma.

I am a Fellow of the British Pharmacological Society and I am also one of the Directors of the International Society for the Study of Fatty Acids and Lipids.

Teaching

I am a Fellow of the Higher Education Academy and teach neuroscience and neuropharmacology in several programmes, at undergraduate and postgraduate level; Lecturer and module convenor for the MBBS degree and Intercalated Neuroscience BSc; Programme Director and lecturer on the MSc in Neuroscience and Translational Medicine; Lecturer on the MSc in Trauma Sciences. In recognition of my activity and results as a teacher, in 2011 I was awarded the Drapers’ Award for Excellence in Teaching and Learning.

Research interests

My main research interest is in the development of new therapeutic strategies for the management of spinal cord injury and brain injury patients. Over the last decade we have developed a large programme of research on a specific polyunsaturated fatty acid which has shown neuroprotective potential in models of spinal cord injury and brain injury and we are at the stage of clinical translation, focused on the development of an optimum formulation, for the first studies in patients. We are also exploring other potential therapeutic targets and diversifying our experimental models and functional endpoints, as well as the assessment of the evolution of the injury using structural and functional imaging, similar to that used in the clinic. Thus, by improving our modelling of neuronal injury, the work in experimental models becomes more relevant to the clinical injury situation.

My group has also started a programme of studies on strategies that could support neurorepair in the chronic phase post-injury, and we have obtained very interesting data with a specialised medical multi-nutrient which has significant potential to enhance neuroplasticity after traumatic injuries. We are also developing a research programme on the link between neurotrauma and neurodegenerative disease.

Current research projects

· Exploration of stable forms of docosahexaenoic acid for acute neuroprotection

· Combinatorial strategies for enhanced recovery after neurotrauma

· The link between traumatic brain injury and brain senescence

· Multiple concussion in the juvenile brain

· Specialised metabolic and nutritional support of white matter in brain ageing and post-injury

· Lipidomic signature of the acute phase after brain and spinal cord injur

Contact

email: A.T.Michael-Titus@qmul.ac.uk
Tel: +44 (0) 207 882 2290

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  • Thau-Zuchman O, Ingram R, Harvey GG et al. (2019). A single injection of docosahexaenoic acid induces a pro-resolving lipid mediator profile in the injured tissue and a long-lasting reduction in neurological deficit after traumatic brain injury in mice. J Neurotrauma .
    10.1089/neu.2019.6420
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  • Adolph M, Calder PC, Deutz NE et al. (2018). Commentary on "Fish Oil-Containing Lipid Emulsions in Adult Parenteral Nutrition: A Review of the Evidence" (https://doi.org/10.1177/0148607117721907). JPEN J Parenter Enteral Nutr .
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  • Venero JL, Yip PK, Carrillo-Jimenez A et al. (2017). Galectin-3 acts as an early alarmin orchestrating brain immune response and promoting neurodegeneration after traumatic brain injury. GLIA 65E504-E504.
  • Liu Z-H, Yip PK, Priestley JV et al. (2017). A Single Dose of Docosahexaenoic Acid Increases the Functional Recovery Promoted by Rehabilitation after Cervical Spinal Cord Injury in the Rat. J Neurotrauma 34, (9) 1766-1777.
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  • Yip PK, Carrillo-Jimenez A, King P et al. (2017). Galectin-3 released in response to traumatic brain injury acts as an alarmin orchestrating brain immune response and promoting neurodegeneration. Scientific Reports 741689-41689.
    10.1038/srep41689
  • Lee WLA, Michael-Titus AT, Shah DK (2017). Hypoxic-Ischaemic Encephalopathy and the Blood-Brain Barrier in Neonates. Dev Neurosci 39, (1-4) 49-58.
    10.1159/000467392
  • Tremoleda JL, Thau-Zuchman O, Davies M et al. (). In vivo PET imaging of the neuroinflammatory response in rat spinal cord injury using the TSPO tracer [18F]GE-180 and effect of docosahexaenoic acid. European Journal of Nuclear Medicine and Molecular Imaging .
    10.1007/s00259-016-3391-8
  • Ponnusamy V, Kapellou O, Yip E et al. (2016). A study of microRNAs from dried blood spots in newborns after perinatal asphyxia: a simple and feasible biosampling method. Pediatr Res 79, (5) 799-805.
    10.1038/pr.2015.276
  • Thau-Zuchman O, Pallier PN, Davies M et al. (2016). A specific multi-nutrient intervention, designed to enhance synapse formation and function, improves functional outcome following traumatic brain injury. BRAIN INJURY 30, (5-6) 679-679.
  • Pallier PN, Poddighe L, Zbarsky V et al. (2015). A nutrient combination designed to enhance synapse formation and function improves outcome in experimental spinal cord injury. Neurobiol Dis 82504-515.
    10.1016/j.nbd.2015.09.007
  • Tremoleda JL, Thau-Zuchman O, Davies M et al. (2015). IN VIVO IMAGING OF NEUROINFLAMMATION IN NEUROTRAUMA PRECLINICAL MODELS: POTENTIAL FOR CLINICAL TRANSLATION. SHOCK 4424-25.
  • Tremoleda JL, Thau-Zuchman O, Davies M et al. (2015). T-14: IN VIVO IMAGING OF NEUROINFLAMMATION IN NEUROTRAUMA PRECLINICAL MODELS: POTENTIAL FOR CLINICAL TRANSLATION. Shock 44 Suppl 224-25.
    10.1097/01.shk.0000472079.77136.27
  • Liu Z-H, Yip PK, Adams L et al. (2015). A Single Bolus of Docosahexaenoic Acid Promotes Neuroplastic Changes in the Innervation of Spinal Cord Interneurons and Motor Neurons and Improves Functional Recovery after Spinal Cord Injury. J Neurosci 35, (37) 12733-12752.
    10.1523/JNEUROSCI.0605-15.2015
  • Ward RE, Huang W, Kostusiak M et al. (2014). A characterization of white matter pathology following spinal cord compression injury in the rat. Neuroscience 260227-239.
    10.1016/j.neuroscience.2013.12.024
  • Paterniti I, Impellizzeri D, Di Paola R et al. (2014). Docosahexaenoic acid attenuates the early inflammatory response following spinal cord injury in mice: in-vivo and in-vitro studies. J Neuroinflammation 116-.
    10.1186/1742-2094-11-6
  • Michael-Titus AT, Priestley JV (2014). Omega-3 fatty acids and traumatic neurological injury: from neuroprotection to neuroplasticity?. Trends Neurosci 37, (1) 30-38.
    10.1016/j.tins.2013.10.005
  • Nikolakopoulou Z, Nteliopoulos G, Michael-Titus AT et al. (2013). Omega-3 polyunsaturated fatty acids selectively inhibit growth in neoplastic oral keratinocytes by differentially activating ERK1/2. Carcinogenesis 34, (12) 2716-2725.
    10.1093/carcin/bgt257
  • Nikolakopoulou Z, Shaikh MH, Dehlawi H et al. (2013). The induction of apoptosis in pre-malignant keratinocytes by omega-3 polyunsaturated fatty acids docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) is inhibited by albumin. Toxicol Lett 218, (2) 150-158.
    10.1016/j.toxlet.2013.01.021
  • Lim S-N, Gladman SJ, Dyall SC et al. (2013). Transgenic mice with high endogenous omega-3 fatty acids are protected from spinal cord injury. Neurobiol Dis 51104-112.
    10.1016/j.nbd.2012.10.021
  • Lim S-N, Huang W, Hall JCE et al. (2013). Improved outcome after spinal cord compression injury in mice treated with docosahexaenoic acid. Exp Neurol 23913-27.
    10.1016/j.expneurol.2012.09.015
  • Yip PK, Pizzasegola C, Gladman S et al. (2013). The omega-3 fatty acid eicosapentaenoic acid accelerates disease progression in a model of amyotrophic lateral sclerosis. PLoS One 8, (4) e61626-.
    10.1371/journal.pone.0061626
  • Hall JCE, Priestley JV, Perry VH et al. (2012). Docosahexaenoic acid, but not eicosapentaenoic acid, reduces the early inflammatory response following compression spinal cord injury in the rat. J Neurochem 121, (5) 738-750.
    10.1111/j.1471-4159.2012.07726.x
  • Gladman SJ, Huang W, Lim S-N et al. (2012). Improved outcome after peripheral nerve injury in mice with increased levels of endogenous ω-3 polyunsaturated fatty acids. J Neurosci 32, (2) 563-571.
    10.1523/JNEUROSCI.3371-11.2012
  • Priestley JV, Michael-Titus AT, Tetzlaff W (2012). Limiting spinal cord injury by pharmacological intervention. Handb Clin Neurol 109463-484.
    10.1016/B978-0-444-52137-8.00029-2
  • Gladman S, Lim SN, Dyall S et al. (2011). Omega-3 fatty acids and acute neurological trauma: A perspective on clinical translation. OCL - Oleagineux Corps Gras Lipides 18, (6) 317-323.
    10.1684/ocl.2011.0421
  • Wann AKT, Mistry J, Blain EJ et al. (2011). Eicosapenaenoic acid (EPA) and docasahexaenoic acid (DHA) reduce IL-1 beta mediated cartilage degradation. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY 92, (3) A11-A12.
  • Gladman SJ, Ward RE, Michael-Titus AT et al. (2010). The effect of mechanical strain or hypoxia on cell death in subpopulations of rat dorsal root ganglion neurons in vitro. Neuroscience 171, (2) 577-587.
    10.1016/j.neuroscience.2010.07.009
  • Jokic N, Yip PK, Michael-Titus A et al. (2010). The human G93A-SOD1 mutation in a pre-symptomatic rat model of amyotrophic lateral sclerosis increases the vulnerability to a mild spinal cord compression. BMC Genomics 11633-633.
    10.1186/1471-2164-11-633
  • Ward RE, Huang W, Curran OE et al. (2010). Docosahexaenoic acid prevents white matter damage after spinal cord injury. J Neurotrauma 27, (10) 1769-1780.
    10.1089/neu.2010.1348
  • Lim S-N, Huang W, Hall JCE et al. (2010). The acute administration of eicosapentaenoic acid is neuroprotective after spinal cord compression injury in rats. Prostaglandins Leukot Essent Fatty Acids 83, (4-6) 193-201.
    10.1016/j.plefa.2010.08.003
  • Malaspina A, Ngoh SFA, Ward RE et al. (2010). Activation transcription factor-3 activation and the development of spinal cord degeneration in a rat model of amyotrophic lateral sclerosis. Neuroscience 169, (2) 812-827.
    10.1016/j.neuroscience.2010.04.053
  • Dyall SC, Michael GJ, Michael-Titus AT (2010). Omega-3 fatty acids reverse age-related decreases in nuclear receptors and increase neurogenesis in old rats. J Neurosci Res 88, (10) 2091-2102.
    10.1002/jnr.22390
  • Robson LG, Dyall S, Sidloff D et al. (2010). Omega-3 polyunsaturated fatty acids increase the neurite outgrowth of rat sensory neurones throughout development and in aged animals. Neurobiol Aging 31, (4) 678-687.
    10.1016/j.neurobiolaging.2008.05.027
  • Kiasalari Z, Salehi I, Zhong Y et al. (2010). Identification of Perineal Sensory Neurons Activated by Innocuous Heat. J COMP NEUROL 518, (2) 137-162.
    10.1002/cne.22187
  • Wann AK, Mistry J, Michael-Titus A et al. (2010). Eicosapenaenoic acid (EPA) and docasahexaenoic acid (DHA) reduce IL-1β mediated cartilage degradation. European Cells and Materials 20, (SUPPL.2) 6-.
  • Wann AKT, Mistry J, Blain EJ et al. (2010). Eicosapentaenoic acid and docosahexaenoic acid reduce interleukin-1β-mediated cartilage degradation. Arthritis Res Ther 12, (6) R207-.
    10.1186/ar3183
  • Huang WL, Bhavsar A, Ward RE et al. (2009). Arachidonyl Trifluoromethyl Ketone Is Neuroprotective after Spinal Cord Injury. J NEUROTRAUM 26, (8) 1429-1434.
    10.1089/neu.2008.0835
  • Huang W, Bhavsar A, Ward RE et al. (2009). Arachidonyl trifluoromethyl ketone is neuroprotective after spinal cord injury. J Neurotrauma 26, (8) 1429-1434.
    10.1089/neu.2008.0835
  • Hall JCE, Priestley JV, Perry VH et al. (2009). WINTR VISA AWARD WINNER DOES ACUTE TREATMENT WITH DOCOSAHEXAENOIC OR EICOSAPENTAENOIC ACID AFFECT INFLAMMATORY MARKERS FOLLOWING COMPRESSION SPINAL CORD INJURY?. JOURNAL OF NEUROTRAUMA 26, (8) A45-A45.
  • Michael-Titus AT (2009). Omega-3 fatty acids: their neuroprotective and regenerative potential in traumatic neurological injury. CLIN LIPIDOL 4, (3) 343-353.
    10.2217/CLP.09.19
  • Michael-Titus AT, Albert M, Michael GJ et al. (2008). SONU20176289, a compound combining partial dopamine D(2) receptor agonism with specific serotonin reuptake inhibitor activity, affects neuroplasticity in an animal model for depression. Eur J Pharmacol 598, (1-3) 43-50.
    10.1016/j.ejphar.2008.09.006
  • Hall JCE, Michael-Titus A, Perry VH et al. (2008). The inflammatory response and locomotor recovery following a spinal compression injury. JOURNAL OF NEUROIMMUNOLOGY 197, (2) 172-172.
  • Malaspina A, Michael-Titus AT (2008). Is the modulation of retinoid and retinoid-associated signaling a future therapeutic strategy in neurological trauma and neurodegeneration?. J NEUROCHEM 104, (3) 584-595.
    10.1111/j.1471-4159.2007.05071.x
  • Dyall SC, Michael-Titus AT (2008). Neurological Benefits of Omega-3 Fatty Acids. NEUROMOL MED 10, (4) 219-235.
    10.1007/s12017-008-8036-z
  • Jokic N, Ling YY, Ward RE et al. (2007). Retinoid receptors in chronic degeneration of the spinal cord: observations in a rat model of amyotrophic lateral sclerosis. J Neurochem 103, (5) 1821-1833.
    10.1111/j.1471-4159.2007.04893.x
  • Huang WL, King VR, Curran OE et al. (2007). A combination of intravenous and dietary docosahexaenoic acid significantly improves outcome after spinal cord injury. Brain 130, (Pt 11) 3004-3019.
    10.1093/brain/awm223
  • Michael-Titus AT (2007). Omega-3 fatty acids and neurological injury. Prostaglandins Leukot Essent Fatty Acids 77, (5-6) 295-300.
    10.1016/j.plefa.2007.10.021
  • King VR, Averill SA, Hewazy D et al. (2007). Erythropoietin and carbamylated erythropoietin are neuroprotective following spinal cord hemisection in the rat. Eur J Neurosci 26, (1) 90-100.
    10.1111/j.1460-9568.2007.05635.x
  • Dyall SC, Michael GJ, Whelpton R et al. (2007). Dietary enrichment with omega-3 polyunsaturated fatty acids reverses age-related decreases in the GluR2 and NR2B glutamate receptor subunits in rat forebrain. Neurobiol Aging 28, (3) 424-439.
    10.1016/j.neurobiolaging.2006.01.002
  • Ward RE, Huang W, Hall JCE et al. (2007). Effect of docosahexaenoic acid on axonal damage after spinal cord injury. OCL - Oleagineux Corps Gras Lipides 14, (3-4) 234-.
    10.1051/ocl.2007.0234
  • King VR, Huang WL, Dyall SC et al. (2006). Omega-3 fatty acids improve recovery, whereas omega-6 fatty acids worsen outcome, after spinal cord injury in the adult rat. J Neurosci 26, (17) 4672-4680.
    10.1523/JNEUROSCI.5539-05.2006
  • Penschuck S, Flagstad P, Didriksen M et al. (2006). Decrease in parvalbumin-expressing neurons in the hippocampus and increased phencyclidine-induced locomotor activity in the rat methylazoxymethanol (MAM) model of schizophrenia. EUR J NEUROSCI 23, (1) 279-284.
    10.1111/j.1460-9568.2005.04536.x
  • Flagstad P, Mørk A, Glenthøj BY et al. (2004). Disruption of neurogenesis on gestational day 17 in the rat causes behavioral changes relevant to positive and negative schizophrenia symptoms and alters amphetamine-induced dopamine release in nucleus accumbens. Neuropsychopharmacology 29, (11) 2052-2064.
    10.1038/sj.npp.1300516
  • Nazir S, Michael GJ, Michael-Titus AT (2002). Distribution of NMDA and AMPA glutamate receptor subunits in rat prefrontal cortex and the effect of chronic imipramine treatment on the GluR2 subunit. BRIT J PHARMACOL 135.
  • Hawkins A, McCune L, Whelpton R et al. (2002). Effect of noradrenaline and 5-HT on excitatory amino acid release in rat prefrontal cortex. BRIT J PHARMACOL 135.
  • Whelpton R, Michael-Titus AT, Fox A (2002). Bioanalysis of temoporfin, a new pharmacodynamic therapy agent. CHROMATOGRAPHIA 55S177-S181.
    10.1007/BF02493376
  • Michael-Titus AT, Fernandes K, Setty H et al. (2002). In vivo metabolism and clearance of substance P and co-expressed tachykinins in rat striatum. Neuroscience 110, (2) 277-286.
    10.1016/S0306-4522(01)00530-9
  • Toner CC, Connell K, Whelpton R et al. (2001). Effects of sevoflurane on dopamine, glutamate and aspartate release in an in vitro model of cerebral ischaemia. BRIT J ANAESTH 86, (4) 550-554.
    10.1093/bja/86.4.550
  • MichaelTitus AT, Whelpton R, Stephens SM et al. (1997). Metabolism of substance P in rat striatum studies using a combination of high performance liquid chromatography (HPLC) and capillary electrophoresis (CE). BRIT J PHARMACOL 122P79-P79.
  • Khan S, Sandhu J, Whelpton R et al. (1996). Substance fragments, SP1-9 and SP6-11, modulate endogenous dopamine outflow in rat striatum. BRIT J PHARMACOL 119P175-P175.
  • KHAN S, GROGAN E, WHELPTON R et al. (1995). SUBSTANCE-P AND ITS FRAGMENT-(1-7) AND FRAGMENT-(5-11) MODULATE STRIATAL DOPAMINE OUTFLOW VIA A CHOLINERGIC LINK MEDIATED BY MUSCARINIC RECEPTORS. BRIT J PHARMACOL 116P96-P96.
  • IRAVANI MM, KHAN S, MICHAELTITUS A et al. (1995). EFFECTS OF 6-HYDROXYDOPAMINE LESIONS IN THE VENTRAL TEGMENTAL AREA OR SUBSTANTIA-NIGRA ON DOPAMINE RELEASE IN SUBREGIONS OF THE RAT STRIATUM. BRIT J PHARMACOL 114P337-P337.
  • WHELPTON R, MICHAELTITUS AT, YAQUB Z (1995). TEMOPORFIN BINDING TO HUMAN SERUM-LIPOPROTEINS. BRIT J PHARMACOL 114P265-P265.

 

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