Below is an abridged list of recent and seminal publications produced through our Bleeding and Coagulation research programme. A full list of publications can be found attached to the relevant researchers, accessed via the Staff pages.
Gunn F, Stevenson R, Almuwallad A, Rossetto A, Vulliamy P, Brohi K, Davenport R. A comparative analysis of tranexamic acid dosing strategies in traumatic major hemorrhage. J Trauma Acute Care Surg. 2024 Feb 1;96(2):216-224. doi: 10.1097/TA.0000000000004177. Epub 2023 Oct 24. PMID: 37872678.
Schofield H, Rossetto A, Armstrong PC, Allan HE, Warner TD, Brohi K, Vulliamy P. Immature platelet dynamics are associated with clinical outcomes after major trauma. J Thromb Haemost. 2024 Apr;22(4):926-935. doi: 10.1016/j.jtha.2023.12.002. Epub 2023 Dec 13. PMID: 38101576.
Rossetto A, Torres T, Platton S, Vulliamy P, Curry N, Davenport R. A new global fibrinolysis capacity assay for the sensitive detection of hyperfibrinolysis and hypofibrinogenemia in trauma patients. J Thromb Haemost. 2023 Oct;21(10):2759-2770. doi: 10.1016/j.jtha.2023.05.005. Epub 2023 May 17. PMID: 37207863
Rossetto A, Wohlgemut JM, Brohi K, Davenport R. Sonorheometry versus rotational thromboelastometry in trauma: a comparison of diagnostic and prognostic performance. J Thromb Haemost. 2023 Aug;21(8):2114-2125. doi: 10.1016/j.jtha.2023.04.031. Epub 2023 May 8. PMID: 37164268
Curry NS, Davenport R, Wong H, Gaarder C, Johansson P, Juffermans NP, Maegele M, Stensballe J, Brohi K, Laffan M, Stanworth SJ. Traumatic coagulopathy in the older patient: analysis of coagulation profiles from the Activation of Coagulation and Inflammation in Trauma-2 (ACIT-2) observational, multicenter study. J Thromb Haemost. 2023 Feb;21(2):215-226. doi: 10.1016/j.jtha.2022.11.005. Epub 2022 Dec 22. PMID: 36700506
Dujardin RWG, Kisters JEC, Wirtz MR, Hajji N, Tuip-de Boer AM, Stensballe J, Johansson PI, Brohi K, Davenport RA, Gaarder C, Stanworth S, Maegele M, Nieuwland R, van der Pol E, Juffermans NP. Shock-Driven Endotheliopathy in Trauma Patients Is Associated with Leucocyte Derived Extracellular Vesicles. Int J Mol Sci. 2022 Dec 15;23(24):15990. doi: 10.3390/ijms232415990. PMID: 36555630; PMCID: PMC9782606
Dujardin RWG, Kleinveld DJB, Gaarder C, Brohi K, Davenport RA, Curry N, Stanworth S, Johansson PI, Stensballe J, Maegele M, Juffermans NP. Coagulopathy Underlying Rotational Thromboelastometry Derangements in Trauma Patients: A Prospective Observational Multicenter Study. Anesthesiology. 2022 Aug 1;137(2):232-242. doi: 10.1097/ALN.0000000000004268. PMID: 35544678.
Rossetto A, Vulliamy P, Lee KM, Brohi K, Davenport R. Temporal Transitions in Fibrinolysis after Trauma: Adverse Outcome Is Principally Related to Late Hypofibrinolysis. Anesthesiology. 2022 Jan 1;136(1):148-161. doi: 10.1097/ALN.0000000000004036. PMID: 34724559
Baksaas-Aasen K, Gall LS, Stensballe J, Juffermans NP, Curry N, Maegele M, Brooks A, Rourke C, Gillespie S, Murphy J, Maroni R, Vulliamy P, Henriksen HH, Pedersen KH, Kolstadbraaten KM, Wirtz MR, Kleinveld DJB, Schäfer N, Chinna S, Davenport RA, Naess PA, Goslings JC, Eaglestone S, Stanworth S, Johansson PI, Gaarder C, Brohi K. Viscoelastic haemostatic assay augmented protocols for major trauma haemorrhage (ITACTIC): a randomized, controlled trial. Intensive Care Med. 2021 Jan;47(1):49-59. doi: 10.1007/s00134-020-06266-1. Epub 2020 Oct 13. PMID: 33048195; PMCID: PMC7550843.
Perkins ZB, Yet B, Marsden M, Glasgow S, Marsh W, Davenport R, Brohi K, Tai NRM. Early Identification of Trauma-induced Coagulopathy: Development and Validation of a Multivariable Risk Prediction Model. Ann Surg. 2021 Dec 1;274(6):e1119-e1128. doi: 10.1097/SLA.0000000000003771. PMID: 31972649
Gall L, Brohi K, Davenport R (2017). Diagnosis And Treatment Of Hyperfibrinolysis In Trauma (A European Perspective). Seminars in Thrombosis and Hemostasis .
10.1055/s-0036-1598001
Sordi R, Nandra KK, Chiazza F et al. (2017). Artesunate Protects Against the Organ Injury and Dysfunction Induced by Severe Hemorrhage and Resuscitation. Ann Surg 265, (2) 408-417.
10.1097/SLA.0000000000001664
Davenport RA, Guerreiro M, Frith D et al. (2017). Activated Protein C Drives the Hyperfibrinolysis of Acute Traumatic Coagulopathy. Anesthesiology 126, (1) 115-127.
10.1097/ALN.0000000000001428
Perkins ZB, Lendrum RA, Brohi K (2016). Resuscitative endovascular balloon occlusion of the aorta: promise, practice, and progress?. Curr Opin Crit Care 22, (6) 563-571.
10.1097/MCC.0000000000000367
Davenport RA, Brohi K (2016). Cause of trauma-induced coagulopathy. Current Opinion in Anaesthesiology 29, (2) 212-219.
10.1097/ACO.0000000000000295
Stanworth SJ, Davenport R, Curry N et al. (2016). Mortality from trauma haemorrhage and opportunities for improvement in transfusion practice. Br J Surg 103, (4) 357-365.
10.1002/bjs.10052
Watts S, Nordmann G, Brohi K et al. (2015). Evaluation of Prehospital Blood Products to Attenuate Acute Coagulopathy of Trauma in a Model of Severe Injury and Shock in Anesthetized Pigs. Shock 44 Suppl 1138-148.
10.1097/SHK.0000000000000409
Campbell HE, Stokes EA, Bargo DN et al. (2015). Quantifying the healthcare costs of treating severely bleeding major trauma patients: a national study for England. Crit Care 19276-.
10.1186/s13054-015-0987-5
Curry N, Rourke C, Davenport R et al. (2015). Early cryoprecipitate for major haemorrhage in trauma: a randomised controlled feasibility trial. Br J Anaesth 115, (1) 76-83.
10.1093/bja/aev134
Davenport R, Khan S, Brohi K (2015). Re: Hemostatic resuscitation is neither hemostatic nor resuscitative in trauma hemorrhage: But did they in fact test the effect of hemostatic resuscitation?. J Trauma Acute Care Surg 78, (6) 1237-1238.
10.1097/TA.0000000000000624
Hagemo JS, Christiaans SC, Stanworth SJ et al. (2015). Detection of acute traumatic coagulopathy and massive transfusion requirements by means of rotational thromboelastometry: an international prospective validation study. Crit Care 1997-.
10.1186/s13054-015-0823-y
Cole E, Davenport R, Willett K et al. (2015). Tranexamic acid use in severely injured civilian patients and the effects on outcomes: a prospective cohort study. Ann Surg 261, (2) 390-394.
10.1097/SLA.0000000000000717
Perkins ZB, Maytham GD, Koers L et al. (2014). Impact on outcome of a targeted performance improvement programme in haemodynamically unstable patients with a pelvic fracture. Bone Joint J 96-B, (8) 1090-1097.
10.1302/0301-620X.96B8.33383
Hagemo JS, Stanworth S, Juffermans NP et al. (2014). Prevalence, predictors and outcome of hypofibrinogenaemia in trauma: A multicentre observational study. Critical Care 18, (2) .
10.1186/cc13798
Glasgow S, Davenport R, Perkins Z et al. (2013). A comprehensive review of blood product use in civilian mass casualty events. J Trauma Acute Care Surg 75, (3) 468-474.
10.1097/TA.0b013e318298efb9
Khan S, Allard S, Weaver A et al. (2013). A major haemorrhage protocol improves the delivery of blood component therapy and reduces waste in trauma massive transfusion. Injury 44, (5) 587-592.
10.1016/j.injury.2012.09.029
Raza I, Davenport R, Rourke C et al. (2013). The incidence and magnitude of fibrinolytic activation in trauma patients. J Thromb Haemost 11, (2) 307-314.
10.1111/jth.12078
Gruen RL, Brohi K, Schreiber M et al. (2012). Haemorrhage control in severely injured patients. Lancet 380, (9847) 1099-1108.
10.1016/S0140-6736(12)61224-0
Rourke C, Curry N, Khan S et al. (2012). Fibrinogen levels during trauma hemorrhage, response to replacement therapy, and association with patient outcomes. J Thromb Haemost 10, (7) 1342-1351.
10.1111/j.1538-7836.2012.04752.x
Frith D, Cohen MJ, Brohi K (2012). Animal models of trauma-induced coagulopathy. Thromb Res 129, (5) 551-556.
10.1016/j.thromres.2011.11.053
Cohen MJ, Call M, Nelson M et al. (2012). Critical role of activated protein C in early coagulopathy and later organ failure, infection and death in trauma patients. Ann Surg 255, (2) 379-385.
10.1097/SLA.0b013e318235d9e6
Curry N, Stanworth S, Hopewell S et al. (2011). Trauma-Induced Coagulopathy-A Review of the Systematic Reviews: Is There Sufficient Evidence to Guide Clinical Transfusion Practice?. TRANSFUS MED REV 25, (3) 217-231.
10.1016/j.tmrv.2011.01.001
Roberts I, Shakur H, Afolabi A et al. (2011). The importance of early treatment with tranexamic acid in bleeding trauma patients: an exploratory analysis of the CRASH-2 randomised controlled trial. LANCET 377, (9771) 1096-1101.
10.1016/S0140-6736(11)60278-X
Davenport R, Curry N, Manson J et al. (2011). Hemostatic effects of fresh frozen plasma may be maximal at red cell ratios of 1:2. J Trauma 70, (1) 90-95.
10.1097/TA.0b013e318202e486
Curry N, Hopewell S, Doree C et al. (2011). The acute management of trauma hemorrhage: a systematic review of randomized controlled trials. CRIT CARE 15, (2) .
10.1186/cc10096
Frith D, Goslings JC, Gaarder C et al. (2010). Definition and drivers of acute traumatic coagulopathy: clinical and experimental investigations. J Thromb Haemost 8, (9) 1919-1925.
10.1111/j.1538-7836.2010.03945.x
Stanworth SJ, Morris TP, Gaarder C et al. (2010). Reappraising the concept of massive transfusion in trauma. CRIT CARE 14, (6) .
10.1186/cc9394
Brohi K, Cohen MJ, Ganter MT et al. (2008). Acute coagulopathy of trauma: Hypoperfusion induces systemic anticoagulation and hyperfibrinolysis. JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE 64, (5) 1211-1217.
10.1097/TA.0b013e318169cd3c
Brohi K, Cohen MJ, Ganter MT et al. (2007). Acute traumatic coagulopathy: Initiated by hypoperfusion - Modulated through the protein C pathway?. ANN SURG 245, (5) 812-818.
10.1097/01.sla.0000256862.79374.31
