INTRN Publications


Juffermans NP, Wirtz MR, Balvers K, Baksaas-Aasen K, van Dieren S, Gaarder C, Naess PA, Stanworth S, Johansson PI, Stensballe J, Maegele M, Goslings JC, Brohi K; TACTIC partners. Towards patient-specific management of trauma hemorrhage: the effect of resuscitation therapy on parameters of thromboelastometry. J Thromb Haemost. 2019 Mar;17(3):441-448. DOI: 10.1111/jth.14378. Epub 2019 Feb 17.


Baksaas-Aasen K, Van Dieren S, Balvers K, Juffermans NP, Næss PA, Rourke C, Eaglestone S, Ostrowski SR, Stensballe J, Stanworth S, Maegele M, Goslings C, Johansson PI, Brohi K, Gaarder C; TACTIC/INTRN collaborators. Data-driven Development of ROTEM and TEG Algorithms for the Management of Trauma Hemorrhage: A Prospective Observational Multicenter Study (2018) Annals of SurgeryMay 23, 2018 DOI: 10.1097/SLA.0000000000002825

Gall LS, Vulliamy P, Gillespie S, Jones TF, Pierre RSJ, Breukers SE, Gaarder C, Juffermans NP, Maegele M, Stensballe J, Johansson PI, Davenport RA, Brohi K, Targeted Action for Curing Trauma-Induced Coagulopathy (TACTIC) partners. The S100A10 Pathway Mediates an Occult Hyperfibrinolytic Subtype in Trauma Patients. Annals of Surgery (2018) DOI: 10.1097/SLA.0000000000002733 


Balvers K, van Dieren S, Baksaas-Aasen K, Gaarder C, Brohi K, Eaglestone S, Stanworth S, Johansson PI, Ostrowski SR, Stensballe J, Maegele M, Goslings, Juffermans N, TACTIC partners. Combined effect of therapeutic strategies for bleeding injury on early survival, transfusion needs and correction of coagulopathy. The British journal of surgery (2017) 104(3), pp 222-229. DOI 10.1002/bjs.10330 

Baksaas-Aasen K, Gall L, Eaglestone S, Rourke C, Juffermans NP, Goslings JC, Naess PA, van Dieren S, Ostrowski SR, Stensballe J, Maegele M, Stanworth SJ, Gaarder C, Brohi K, Johansson PI. iTACTIC - implementing Treatment Algorithms for the Correction of Trauma-Induced Coagulopathy: study protocol for a multicentre, randomised controlled trial. Trials (2017) 18(1): pp 486. DOI 10.1186/s13063-017-2224-9


Khan S, Davenport R, Raza I, Glasgow S, De'Ath HD, Johansson PI, Curry N, Stanworth S, Gaarder C, Brohi K.  Damage control resuscitation using blood component therapy in standard doses has a limited effect on coagulopathy during trauma haemorrhageIntensive Care Medicine 41(2): 239-247 Feb 2015 DOI: 10.1007/s00134-014-3584-1. Epub 2014 Dec 2.

Schäfer N*, Driessen A*, Fröhlich M, Stürmer EK, Maegele M, TACTIC partners. Diversity in clinical management and protocols for the treatment of major bleeding trauma patients across European level I Trauma Centres. Scandinavian journal of trauma, resuscitation & emergency medicine (2015) 23:74. DOI 10.1186/s13049-015-0147-6


Lord JM, Midwinter MJ, Chen YF, Belli A, Brohi K, Kovacs EJ, Koenderman L, Kubes P, Lilford RJ. The systemic immune response to trauma: An overview of pathophysiology and treatmentThe Lancet 384(9952):1455-1465 Oct 2014

Vivian ME, Torrance HD, Brohi K, Owen HC, Pearse RM Hinds CJ; O’Dwyer MJ. The age of transfused packed red blood cells correlates with the degree of immunosuppression as assessed by gene expression patterns in severely injured trauma patients. Intensive Care Medicine. 40: S20-S20. Sep 2014

Hagemo JS, Stanworth S, Juffermans NP, Brohi K, Cohen M, Johansson PI, Røislien J, Eken T, Næss PA, Gaarder C. Prevalence, predictors and outcome of hypofibrinogenaemia in trauma: a multicentre observational studyCrit Care. 2014 Mar 26;18(2):R52 

Khan S, Brohi K, Chana M, Raza I, Stanworth S, Gaarder C, Davenport R; International Trauma Research Network (INTRN). Hemostatic resuscitation is neither hemostatic nor resuscitative in trauma hemorrhage. J Trauma Acute Care Surg. 2014 Mar;76(3):561-7

Jenkins DH, Rappold JF, Badloe JF, Berséus O, Blackbourne L, Brohi K, Butler FK, Cap AP, Cohen MJ, Davenport R, DePasquale M, Doughty H, Glassberg E, Hervig T, Hooper TJ, Kozar R, Maegele M, Moore EE, Murdock A, Ness PM, Pati S, Rasmussen T, Sailliol A, Schreiber MA, Sunde GA, van de Watering LM, Ward KR, Weiskopf RB, White NJ, Strandenes G, Spinella PC. Trauma hemostasis and oxygenation research position paper on remote damage control resuscitation: Definitions, current practice, and knowledge gapsShock 41(SUPPL. 1):3-12 2014 

Torrance HD, Brohi K, Pearse RM, Mein CA, Wozniak E, Prowle JR, Hinds CJ, OʼDwyer MJ. al. Association between gene expression biomarkers of immunosuppression and blood transfusion in severely injured polytrauma patientsAnnals of Surgery 25 Mar 2014

Driessen A, Schäfer N, Albrecht V, Schenk M, Fröhlich M, Stürmer EK, Maegele M, TACTIC partners. Infrastructure and clinical practice for the detection and management of trauma-associated haemorrhage and coagulopathy. European Journal of Trauma and Emergency Surgery (2014) 41, pp 413–420. *Equal contributors


Davenport R, Brohi K. Fibrinogen depletion in trauma: early, easy to estimate and central to trauma-induced coagulopathyCrit Care. 2013 Sep 24;17(5):190

Brockamp T, Maegele M, Gaarder C, Goslings JC, Cohen MJ, Lefering R, Joosse P, Naess PA, Skaga NO, Groat T, Eaglestone S, Borgman MA, Spinella PC, Schreiber MA, Brohi K. Comparison of the predictive performance of the BIG, TRISS, and PS09 score in an adult trauma population derived from multiple international trauma registries. Crit Care. 2013 Jul 11;17(4):R134.

Hagemo JS, Næss PA, Johansson P, Windeløv NA, Cohen MJ, Røislien J, Brohi K, Heier HE, Hestnes M, Gaarder C. Evaluation of TEG(®) and RoTEM(®) inter-changeability in trauma patients. Injury. 2013 May;44(5):600-5

Khan S, Allard S, Weaver A, Barber C, Davenport R, Brohi K. A major haemorrhage protocol improves the delivery of blood component therapy and reduces waste in trauma massive transfusion. Injury. 2013 May;44(5):587-92

Raza I, Davenport R, Rourke C, Platton S, Manson J, Spoors C, Khan S, De'Ath HD, Allard S, Hart DP, Pasi KJ, Hunt BJ, Stanworth S, MacCallum PK, Brohi K. The incidence and magnitude of fibrinolytic activation in trauma patients. J Thromb Haemost. 2013 Feb;11(2):307-14.

Cole E, Davenport R, De'Ath H, Manson J, Brockamp T, Brohi K. . Coagulation system changes associated with susceptibility to infection in trauma patients.  J Trauma Acute Care Surg. 2013 Jan;74(1):51-7 


Frith D, Brohi K. The pathophysiology of trauma-induced coagulopathy. Curr Opin Crit Care. 2012 Dec;18(6):631-6

Gruen RL, Brohi K, Schreiber M, Balogh ZJ, Pitt V, Narayan M, Maier al. Haemorrhage control in severely injured patientsLancet. 2012 Sep 22;380(9847):1099-108

Rourke C, Curry N, Khan S, Taylor R, Raza I, Davenport R, Stanworth S, Brohi K. Fibrinogen levels during trauma hemorrhage, response to replacement therapy, and association with patient outcomes. J Thromb Haemost. 2012 Jul;10(7):1342-51

Frith D, Davenport R, Brohi K. Acute traumatic coagulopathyCurr Opin Anaesthesiol. 2012 Apr;25(2):229-34.

Cohen MJ, Call M, Nelson M, Calfee CS, Esmon CT, Brohi K, Pittet JF. Critical role of activated protein C in early coagulopathy and later organ failure, infection and death in trauma patientsAnn Surg. 2012 Feb;255(2):379-85. 


Davenport R, Manson J, De'Ath H, Platton S, Coates A, Allard S, Hart D, Pearse R, Pasi KJ, MacCallum P, Stanworth S, Brohi K. Functional definition and characterization of acute traumatic coagulopathyCrit Care Med 2011; 39: 1–7. 

Curry, NS; Rourke, C; Khan, S; Kingsland, SA; Allard, S; Pasi, J; Brohi, K; Stanworth, S. Fibrinogen replacement for major haemorrhage in trauma – an in-vitro study. Br J Haematol 2011; 153: S2.

Davenport R, Curry N, Manson J, De'ath H, Coates A, Rourke C, Pearse R, Stanworth S, Brohi K. Hemostatic effects of fresh frozen plasma may be maximal at red cell ratios of 1:2J Trauma 2011; 70: 90-95.


Frith D, Goslings JC, Gaarder C, Maegele M, Cohen MJ, Allard S, Johansson PI, Stanworth S, Thiemermann C, Brohi K. Definition and drivers of acute traumatic coagulopathy: clinical and experimental investigations. J Thromb Haemost 2010; 8: 1919–25

Stanworth SJ, Morris TP, Gaarder C, Goslings JC, Maegele M, Cohen MJ, Konig TC, Davenport RA, Pittet JF, Johansson PI, Allard S, Johnson T, Brohi K. Reappraising the concept of massive transfusion in trauma. Crit Care 2010; 14: R239.


Cohen MJ, Bir N, Rahn P, Dotson R, Brohi K, Chesebro BB, Mackersie R, Carles M, Wiener-Kronish J, Pittet JF. Protein C depletion early after trauma increases the risk of ventilator-associated pneumoniaJ Trauma 2009; 67: 1176-1181.


Share this page