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June 16, 2015
To acquire a greater insight into the frequency, regulation, and pathophysiological role of neutrophil reverse transendothelial cell migration (rTEM), C4TS has been involved in research that seeks to identify the inflammatory trigger(s) that promote neutrophil rTEM in response to ischemia-reperfusion (I-R) injury.
Previous studies have shown that neutrophil infiltration into interstitial tissues is a critical component of the innate immune response and a hallmark of acute inflammatory reactions. Due to the destructive potential of neutrophils, this response is also intimately associated with the pathogenesis of numerous inflammatory conditions such as (I-R) injury, rheumatoid arthritis, and atherosclerosis
At present, the functional implication of neutrophils undergoing reverse TEM is unclear. It is potentially possible that this phenomenon might have a physiological role such as dampening down a local inflammatory response, and/or reflect a role for neutrophils as cellular sentinels or sirens of inflammation. Alternatively, neutrophil rTEM might play a pathological role such as contributing to turning a local acute inflammatory response into a systemic phenomenon. Although further studies are required, the results of our most recent research support the latter.
For more detail on this study, the findings have now been published in Immunity.
