ORDIT (Organ Dysfunction in Trauma) is a one month, prospective point prevalence cohort study of all trauma patients (≥16 years) admitted to UK Major Trauma Centre (MTC) adult critical care units.Multiple organ dysfunction syndrome (MODS) is a dysfunctional systemic inflammatory response following major tissue trauma causing significant morbidity and in-hospital mortality.

ORDIT Protocol Summary

REC REFERENCE: England/Wales: 15/LO/1626, South East, 29.10.2015

TITLE: Organ Dysfunction in Trauma: A national prospective point prevalence study

METHODOLOGY AND DURATION: A one month prospective national point prevalence cohort study of trauma patients ≥16 years admitted to an adult critical care unit within a Major Trauma Centre (MTC).

STUDY LEADS: Chief Investigator: Karim Brohi, Professor of Trauma Sciences, Queen Mary University of London; Principal Investigator: Elaine Cole, Trauma Research Fellow, Queen Mary University of London.

PRIMARY OBJECTIVE: To investigate the prevalence of MODS in severely injured patients admitted to MTC critical care units in the UK.

SECONDARY OBJECTIVES: To characterise the severity and temporal variation of MODS in critical care trauma patients; examine the incidence and mode of mortality associated with MODS following trauma; and evaluate the relationship between MODS and other clinical outcomes, length of stay and quality of life.


INCLUSION CRITERIA: All consecutive trauma patients (≥16 years of age) admitted to adult critical care from 08.00 on day one of the study to 07.59 on the final day of the in-hospital study period (one month in total) who subsequently provide informed consent to participate. This includes all trauma patients: direct admissions from the Emergency Department, admissions from the operating theatre or from a ward, transfers from other facilities and readmission to critical care.

EXCLUSION CRITERIA: Any inclusion criteria not met; 

Proposed start date: June 2016

Proposed finish date: June 2017

The study will be formally completed when twelve month follow up for all patients has been obtained and data analysis is complete.

Key documents:

ORDIT Study Protocol

ORDIT Study Synopsis

ORDIT Study Flow Diagram


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