Cohort Observation study of Pain in Extremity Trauma
This is a multicentre study of early and persistent pain after tibial injuries.
Chief Investigator: Mr Shehan Hettiaratchy, Sponsored by Imperial College Healthcare NHS Trust.
Pain after severe injury can limit patients’ recovery and has been raised as a concern by patient groups. Chronic pain can have a major personal impact whilst at a societal level it poses a significant socioeconomic burden. This study aims to determine the incidence, impact and describe the nature of chronic pain after lower leg trauma, using fractures of the tibial diaphysis (shaft) as a model.
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TITLE |
A Multicentre Cohort Observational Study of Pain in Extremity Trauma (COPET) |
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DESIGN |
Observational cohort study |
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AIMS |
To determine the incidence and natural history nerve dysfunction and chronic pain in extremity trauma |
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OUTCOME MEASURES |
Incidence of peripheral nerve dysfunction Incidence and severity of acute nociceptive and neuropathic pain Incidence and severity of chronic nociceptive and neuropathic pain Participant recruitment feasibility |
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POPULATION |
Adults over 16 years old with fractures of the tibial diaphysis (AO classification 42 A-C 1-3) with or without soft tissue injury. |
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ELIGIBILITY |
Age ≥16 year. Adequate understanding of English for comprehension of study questionnaires. Isolated open or closed fracture of the tibial diaphysis (shaft) meeting AO classification 42 (A1-3, B1-3, C1-3) with or without soft tissue injury. Within 48 hours of arrival in hospital. |
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Duration |
6 months recruitment, 12 months follow up |
Trial status
- Closed to recruitment Feb 2019 across all sites
- Recruited 66 participants (target 60)
- Initial data being collated from sites
Pre-work leading to study has been published here. Reference: Prinsloo F, Flynn C, Prime M, Wickham A & Hettiaratchy S. The incidence of chronic pain following tibial diaphyseal fracture. J Trauma Crit Care 2019;3(1): 6-11.
For more information email COPETStudy@gmail.com
