Professor Elaine Cole

Professor in Trauma Sciences, QMUL; Director of Research and Innovation, London Major Trauma System


I am a Professor in Trauma Sciences within the Blizard Institute. I co-lead the MSc in Trauma Sciences, and lead the dissertation year of this programme. This international online MSc provides its multi-professional students with the opportunity to enhance their knowledge about all aspects of trauma care via a distance learning format. Most of the students are also working as clinicians and the virtual MSc provides them with flexibility to study around their working patterns. The MSc also provides students access to many of the global leaders in clinical trauma management.

Within my role I supervise MSc and PhD students, supporting the development of their research, publications and presentations.

I also co-lead the Trauma Sciences and Care of the Injured Patient Programme (TSCIPP).  This undergraduate run-through SSC provides students with the unique opportunity to gain professional experience in trauma care and clinical research through a structured four-year programme. TSCIPP has embedded placements within multidisciplinary teams at Barts Health NHS trust and the Centre for Trauma Sciences, QMUL.



One of my main research interests focus on the drivers and prevalence of poor outcomes after severe injury. This has included investigating the predictors and phenotypes of contemporary multiple organ dysfunction (MODS) after major trauma. I led the first national major trauma study: ORDIT (Organ Dysfunction in Trauma), which involved all Major Trauma Centres in England, Wales and Scotland (ORDIT publication). Following this I was the Chief Investigator for the pan-London Dunhill Medical Trust funded study called MODET. The study was carried out by research teams at the four London Major Trauma Centres investigating the characteristics, predictors and outcomes of MODS in severely injured older patients, compared to younger cohorts. This important research has helped us better understand needs of and plan acute care for an increasing older severely injured population (MODET publication).

I am also the Director of Research and Innovation for the London Major Trauma System (LMTS). Within this role I work with clinical and academic staff within the four major trauma networks and prehospital providers in the London Major Trauma System to support the development of innovation, collaborative research and education across the system. I co-led the evaluation of the London Trauma System (ELOTS) which reported improvements in care quality and patient outcomes following system implementation. In response to increasing numbers of older trauma patients I have led the development of two important sets of guidance to support clinicians in providing the best possible care for this population: Management of older trauma patients and Palliative and End of life care for older trauma.




Investigating the effects of frailty on six-month outcomes in older trauma patients admitted to UK major trauma centres: a multicentre follow up study. Cole E, Crouch R, Baxter, M, Wang C, Sivapathasuntharam D, Peck G, Jennings C, Jarman H.  Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine.  (2024) 32:1,

Factors Associated with delayed Pre-Hospital times during Trauma-Related Mass Casualty Incidents: A Systematic Review. Alruqi F, Aglago EK, Cole E, Brohi K. Disaster Med Public Health Prep. 2023 Nov 10;17:e525. doi: 10.1017/dmp.2023.187.

Prothrombin complex concentrate (PCC) for treatment of trauma-induced coagulopathy: systematic review and meta-analyses. Hannadjas I, James A, Davenport R, Lindsay C, Brohi K, Cole E. Crit Care. 2023 Nov 2;27(1):422. doi: 10.1186/s13054-023-04688-z.

Pre-injury sarcopenia and the association with discharge destination in critical care trauma patients. Badminton R, Christie R, Brohi K, Cole E. Trauma. 2023 Nov. doi:10.1177/14604086231214878

Prothrombin complex concentrate (PCC) for treatment of trauma-induced coagulopathy: systematic review and meta-analyses. Hannadjas I, James A, Davenport R, Lindsay C, Brohi K, Cole E. Crit Care. 2023 Nov 2;27(1):422. doi: 10.1186/s13054-023-04688-z.

Heterogeneity in defining multiple trauma: a systematic review of randomized controlled trials. Jeanmougin T, Cole E, Duceau B, Raux M, James A. Crit Care. 2023 Sep 22;27(1):363. doi: 10.1186/s13054-023-04637-w.

Nationwide analysis of pre-hospital tranexamic acid for trauma demonstrates systematic bias in adherence to treatment guidelines: a retrospective cohort study. Almuwallad A, Cole E, Rossetto A, Brohi K, Perkins Z, Davenport R. Int J Surg. 2023 Sep 18. doi: 10.1097/JS9.0000000000000712. PMID: 37720941

Clinical prediction models for the management of blunt chest trauma in the Emergency Department: a systematic review. Battle C, Cole E, Carter K, Baker E. DOI: 10.1101/2023.06.15.23291429

Soft tissue reconstruction of combat-related injuries affecting the lower limb: is a time target realistic? A systematic review and meta-analysis. Rehman, U., Cole, E., Whiteman, E., Khatib, M., Cavale, N., Giannou, G.Eur J Plast Surg (2023). 

Scoping review of the literature to ascertain how the STUMBL Score clinical prediction model is used to manage patients with blunt chest wall trauma in emergency care. Battle C, Cole E, Whelan R, Baker E. Injury. 2023 Jul;54(7):110796. doi: 10.1016/j.injury.2023.05.027. Epub 2023 May 7.

Major trauma among E-Scooter and bicycle users: a nationwide cohort study. Clough RA, Platt E, Cole E, Wilson M, Aylwin C. Inj Prev. 2023 Apr;29(2):121-125. doi: 10.1136/ip-2022-044722. Epub 2023 Feb 28.

Establishing the research priorities for major trauma in the United Kingdom: A Delphi study of nurses and allied health professionals. Jarman H, Crouch R, Friend S, Cole E. Int Emerg Nurs. 2023 Mar;67:101265. doi: 10.1016/j.ienj.2023.101265. Epub 2023 Feb 27

Configurations and outcomes of acute hospital care for frail and older patients with moderate to major trauma: a systematic review. Halter M, Jarman H, Moss P, Kulnik ST, Baramova D, Gavalova L, Cole E, Crouch R, Baxter M. BMJ Open. 2023 Feb 21;13(2):e066329. doi: 10.1136/bmjopen-2022-066329.

Provision of acute care pathways for older major trauma patients in the UK. Jarman H, Crouch R, Halter M, Peck G, Cole E.  BMC Geriatr 22, 915 (2022). 

Sex discrimination after injury: is inequity in tranexamic acid administration just the tip of the iceberg? Cole E, Curry N, Davenport R. Br J Anaesth. 2022 Aug;129(2):144-147. doi: 10.1016/j.bja.2022.05.015

The efficacy of weight-based enoxaparin dosing for vte-prophylaxis in trauma patients: a systematic review and meta-analysis. Ebeid A, Cole E, Stallwood-Hall C. J Trauma Acute Care Surg. 2022 Aug 1;93(2):e71-e79. doi: 10.1097/TA.0000000000003707

Multiple Organ Dysfunction in Older Major Trauma Critical Care Patients. A Multi-Center Prospective Observational Study. Cole E, Aylwin C, Christie R, Dillane B, Farrah H, Hopkins P, Ryan C, Woodgate A, Brohi K. Annals of Surgery Open. 3(2):p e174, June 2022. | DOI: 10.1097/AS9.0000000000000174

The national major trauma system within the United Kingdom: inclusive regionalized networks of care. Cole E.  Emergency and Critical Care Medicine 2(2):p 76-79, June 2022. DOI:  10.1097/EC9.0000000000000040

The use of Tranexamic Acid (TXA) in Hip Fracture Surgery – A systematic review and meta-analysis.
Journal of Orthopaedic Trauma. Agius C, Cole E, Mifsud MG, Vasireddy A. J Orthop Trauma. 2020 Jan-Apr;28(1):2309499019887995. doi: 10.1177/2309499019887995

Long term outcomes following rib fracture fixation in patients with major chest trauma. Lucena-Amaro S, Cole E, Zolfaghari P. Injury. 2022 Sep;53(9):2947-2952. doi: 10.1016/j.injury.2022.04.020

Refining mass casualty plans with simulation-based iterative learning. Tallach R, Schyma B, Robinson M, O'Neill B, Edmonds N, Bird R, Sibley M, Leitch A, Cross S, Green L, Weaver A, McLean N, Cemlyn-Jones R, Menon R, Edwards D, Cole E. Br J Anaesth. 2022 Feb;128(2):e180-e189. doi: 10.1016/j.bja.2021.10.004

At risk child: a contemporary analysis of injured children in London and the South East of England: a prospective, multicentre cohort study. Elbourne C, Cole E, Marsh S, Rex D, Makin E, Salter R, Brohi K, Edmonds N, Cleeve S, O'Neill B. BMJ Paediatr Open. 2021 Nov 5;5(1):e001114

Evaluation of elderly specific pre-hospital trauma triage criteria: a systematic review. Boulton AJ, Peel D, Rahman U, Cole E. Scand J Trauma Resusc Emerg Med. 2021 Aug 30;29(1):127. doi: 10.1186/s13049-021-00940-z

The Impact of Pre-Hospital TXA on Mortality among Bleeding Trauma Patients: A Systematic Review and Meta-Analysis. Almuwallad A, Cole E, Ross J, Perkins Z, Davenport R. J Trauma Acute Care Surg. 2021 May 1;90(5):901-907. doi: 10.1097/TA.0000000000003120

Feasibility and accuracy of ED frailty identification in older trauma patients: a multi-centre study.  Jarman H, Crouch R, Baxter M, Wang C, Peck G, Sivapathasuntharam D, Jennings C, Cole E. Scand J Trauma Resusc Emerg Med. 2021 Mar 30;29(1):54. doi: 10.1186/s13049-021-00868-4

Acute compartment syndrome (ACS) - a case of delayed diagnosis. Agius C, Cole E. Int J Orthop Trauma Nurs. 021 Jul;42:100845. doi: 10.1016/j.ijotn.2021.100845

Multiple organ dysfunction after trauma. Cole E, Gillespie S, Vulliamy P, Brohi K; Organ Dysfunction in Trauma (ORDIT) study collaborators. Br J Surg. 2020 Mar;107(4):402-412. doi: 10.1002/bjs.11361.

Major Trauma Centre Lead Clinicians: An evaluation of current practice in major trauma centres in England. Sabin EJ, Cole E. Trauma. 29 Nov 2020

Frailty in major trauma study (FRAIL-T): A study protocol to determine the feasibility of nurse-led frailty assessment in elderly trauma and the impact on outcome in patients with major trauma. Jarman H, Crouch R, Baxter M, Cole E, Dillane B, Wang C. BMJ Open 10(8) 05 Aug 2020

Do pre-hospital physicians improve mortality in major trauma patients? A systematic review. Morgan O, Yarham E, Hudson A, Cole E. Trauma Sept 2020.

Effectiveness of Surgical Airway Training Laboratory and Assessment of Skill and Knowledge Fade in Surgical Airway Establishment Among Prehospital Providers. Luckey-Smith K, High K, Cole E. Air Med J 39(5):369-373 Sep 2020.

The Evolution of Initial-Hemostatic Resuscitation and the Void of Post-Hemostatic Resuscitation.  Braasch MC, Turco LM, Cole E, Brohi K, Winfield RD. J Trauma Acute Care Surg. 2020 Sep;89(3):597-601. doi: 10.1097/TA.0000000000002576

Targeted prevention of road traffic deaths in Greece: a multifactorial 5-year census-based study. Anagnostou E, Cole E. Eur J Trauma Emerg Surg. 2020 Jan 2. doi: 10.1007/s00068-019-01290-3

Developing Undergraduate Trauma Education Through a Student Led Co-Curriculum Model. Ledbury K, Holdsworth L, Robathan M, Sultan S, Cole E, Baptista A, Goodsman D, Davenport R. Br J Surg. 2019 106: 130-130.

The Changing Epidemiology of Serious Trauma in the Elderly Population: An Increasing Concern of a Tertiary Hospital in Singapore. Go KT, Cheng JY, Seah X, Goh MH, Teo LT, Cole E. Ann Acad Med Singap. 2019 Nov;48(11):354-362

A Decade of Damage Control Resuscitation: New Transfusion Practice, New Survivors, New Directions.  Cole E, Weaver A, Gall L, West A, Nevin D, Tallach R, O’Neill B, Lahiri S, Allard S, Tai N, Davenport R, Green L, Brohi K.  Ann Surg. 2021 Jun 1;273(6):1215-1220. doi: 10.1097/SLA.0000000000003657

Timing and methods of frailty assessments in geriatric trauma patients: A Systematic Review. Cubitt M, Downie E, Shakerian R, Lange PW, Cole E. Injury. 2019 Nov;50(11):1795-1808. doi: 10.1016/j.injury.2019.07.026

Delivering trauma mastery with an international trauma masters. Schyma BM, Cole E, Wren SM, Brohi K, Brundage SI. Injury. 2019 Apr;50(4):877-882. doi: 10.1016/j.injury.2019.03.023

Functional inclusivity of trauma networks: a pilot study of the North West London Trauma Network. Wohlgemut JM, Davies J, Aylwin C, Morrison JJ, Cole E, Batrick N, Brundage SI, Jansen JO. J Surg Res. 2018 Nov;231:201-209. doi: 10.1016/j.jss.2018.05.045

Evaluating the ability of a trauma team activation tool to identify severe injury: a multicenter cohort study. Vinjevoll OP, Uleberg O, Cole E. Scand J Trauma Resusc Emerg Med. 2018 Aug 10; 26(1):63.doi: 10.1186/s13049-018-0533-y

Beliefs and expectations of rural hospital practitioners towards a developing trauma system: A qualitative case study. Adams RDF, Cole E, Brundage SI, Morrison Z, Jansen JO. Injury. 2018 Mar 22. pii: S0020-1383(18)30137-2. doi: 10.1016/j.injury.2018.03.025.

Contemporary patterns of multiple organ dysfunction in trauma. Shepherd JM, Cole E, Brohi K.  Shock. 2017 Apr; 47(4):429-435. doi: 10.1097/SHK.0000000000000779.

Survival prediction algorithms miss significant opportunities for improvement if used for case selection in trauma quality improvement programs. Heim C, Cole E, West A, Tai N, Brohi K. Injury. 2016 Sep; 47(9):1960-5. doi: 10.1016/j.injury.2016.05.042.

Early changes within the lymphocyte population are associated with the development of multiple organ dysfunction syndrome in trauma patients. Manson J, Cole E, De'Ath HD, Vulliamy P, Meier U, Pennington D, Brohi K. Crit Care. 2016 Jun 7; 20(1):176. doi: 10.1186/s13054-016-1341-2.

The impact of a pan-regional inclusive trauma system on quality of care. Cole E, Lecky F, West A, Smith N, Brohi K, Davenport R.  Ann Surg. 2016 Jul; 264(1):188-94. doi: 10.1097/SLA.0000000000001393.

Meta-analysis of prognostic factors for amputation following surgical repair of lower extremity vascular trauma. Perkins ZB, Yet B, Glasgow S, Cole E, Marsh W, Brohi K, Rasmussen TE, Tai NR. Br J Surg. 2015 Apr; 102(5):436-50. doi: 10.1002/bjs.9689. Epub 2015 Feb 23

Tranexamic acid use in severely injured civilian patients and the effects on outcomes. Cole E, Davenport R, Willett K, Brohi K. Ann Surg, 2014 Feb; 261(2):390-4

Health outcome after major trauma: what are we measuring? Hoffman K, Cole E, Playford ED, Grill E, Soberg HL, Brohi K.  PLoS One. 2014 Jul 22; 9(7):e103082. doi: 10.1371/journal.pone.0103082. eCollection

The burden of infection and the relationship with admission shock in severely injured patients. Cole E, Davenport R, Willett K, Brohi K.  J Trauma Acute Care Surg. 2014; 76(3):730-735

Coagulation system changes associated with susceptibility to infection in trauma patients. Cole E, Davenport R, De'Ath H, Manson J, Brockamp T, Brohi K.  J Trauma Acute Care Surg. 2013; 74(1):51-7

Measuring acute rehabilitation needs in trauma: Preliminary evaluation of the Rehabilitation Complexity Scale. Hoffman K, West A, Nott P, Cole E, Playford D, Liu C, Brohi K. Injury. 2013; 44(1):104-109

Major trauma and urban cyclists: physiological status and injury profile. Manson J, Cooper S, West A, Foster E, Cole E, Tai N. Emerg Med J. 2013; 30(1):32-37

Improving outcomes in the early phases after major trauma. Brohi K, Cole E, Hoffman K. Curr Opin Crit Care. 2011; 17 (5):515-9.

Can residents be effective trauma team leaders in a major trauma centre? Cole E, West A, Davenport R, Naganathar S, Kanzara T, Carey M, Brohi K.  Injury. 2011; 44(1):18-22

Older people and major trauma. Bridges J, Cole E, Lynch A, West A.  Reviews in Clinical Gerontology. 2009; 19, 77-85

Human factors – the culture of a trauma team. Cole E, Crichton N. J Clinical Nursing. 2006; 15(10) 1257-1266

Implications of cultural diversity in do not attempt resuscitation ‘DNAR’ decision-making. Cox C L, Cole E, Reynolds T, Wandrag M, Breckenridge S, Dingle M. J Multicultural Nursing and Health.  2006; 12 (1) 20-28






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