Dr Ross Davenport
Bleeding and Coagulation
Ross is a Reader in Trauma Sciences within the Blizard Institute at Queen Mary University of London, alongside his role as a Consultant Vascular & Trauma Surgeon and Clinical Lead for Trauma Surgery, Royal London Major Trauma Centre, Bart's Health NHS Trust. In addition to these roles, he is the Clinical Director for the North East London & Essex Trauma Network.
Primary research focus is on trauma-induced coagulopathy, acute response to injury and the treatment of major trauma haemorrhage. Previously, Ross has worked in prehospital care for both London and Essex & Herts Air Ambulances. Currently, he is a Personal Tutor and a Module Lead for the online Masters programme in Trauma Sciences at QMUL.
Research interests
My main research interest is in the global derangement of clotting which occurs after major trauma haemorrhage - Trauma Induced Coagulopathy (TIC) and the earlier endogenous process of Acute Traumatic Coaguloapthy (ATC). Active areas of investigation are the importance of the Protein C pathway in this endogenous coagulopathy, fibrinolysis and early detection of ATC with biosensors. We have shown that ROTEM is able to diagnose ATC within 5 minutes and is a more sensitive marker of massive haemorrhage predication than conventional, laboratory clotting screens. In addition our work has identified activation of fibrinolysis in almost all severely injured patients and provides some mechanistic evidence for the large RCT evaluating tranexamic acid in trauma haemorrhage (CRASH-2).
Using our platform study I developed for my PhD in 2008 - Activation of Coagulation & Inflammation in Trauma (ACIT) - it enables C4TS to examine the wider acute response to injury including the white cell and genomic response to major injury in a perpetual prospective cohort study. We have expanded ACIT to a number of centres across the UK and Europe and now enrol in the prehospital phase of care with the London Air Ambulance. If you work within a Major Trauma Centre are interested in joining the study please contact me on the email address below.
I have been PI on a number of clinical trials in trauma haemorrhage and most recently the national CRYOSTAT-2 trial evaluating the early use of fibrinogen supplementation (cryoprecipitate) in major trauma haemorrhage. Previously I have worked on a number of other global RCTs for evaluation of novel and existing therapies for trauma haemorrhage and organ protection – recombinant Factor VIIa (CONTROL), MP4OX (pegylated haemoglobin-based colloid) and the CRYOSTAT (pilot RCT of early cryoprecipitate).
Contact
email: ross.davenport@qmul.ac.uk
Tel: +44 (0) 203 594 0731
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