Dr Ross Davenport

Bleeding and Coagulation

I am a Senior Lecturer in Trauma Sciences at C4TS and consultant trauma and vascular surgeon at the Royal London Major Trauma Centre, Bart’s Health NHS Trust.  My research focus is on trauma-induced coagulopathy, acute response to injury and the treatment of major trauma haemorrhage.  I have previously worked in prehospital care for both London and Essex & Herts Air Ambulances.  Currently I am a personal tutor and module lead for the online Masters programme in Trauma Sciences at QMUL.

Research interests

My main research interest is in the global derangement of clotting which occurs after major trauma haemorrhage - Trauma Induced Coagulopathy (TIC) and the earlier endogenous process of Acute Traumatic Coaguloapthy (ATC).  The majority of my PhD thesis was dedicated to the functional and biochemical characterization of the ATC using Rotational Thromboelastometry (ROTEM) and I further demonstrated the importance of the Protein C pathway in this endogenous coagulopathy.  We have shown that ROTEM is able to diagnose ATC within 5 minutes and is a more sensitive marker of massive haemorrhage predication than conventional, laboratory clotting screens.  In addition our work has identified activation of fibrinolysis in almost all severely injured patients and provides some mechanistic evidence for the large RCT evaluating tranexamic acid in trauma haemorrhage (CRASH-2). 

Using our platform study I developed for my PhD - Activation of Coagulation & Inflammation in Trauma (ACIT) -  C4TS are pursuing the wider acute response to injury including the white cell and genomic response to major injury.  My aim is to see this platform developed further for use in prehospital care and austere environment to enable rapid diagnosis of ATC and dysregulated inflammation which may be targeted earlier with novel therapeutics. 

I am currently a co-investigator on the national CRYOSTAT-2 trial evaluating the early use of fibrinogen supplementation (cryoprecipitate) in major trauma haemorrhage.  Previously I have worked on a number of other global RCTs for evaluation of novel and existing therapies for trauma haemorrhage and organ protection – recombinant Factor VIIa (CONTROL), MP4OX (pegylated haemoglobin-based colloid) and the CRYOSTAT (pilot RCT of early cryoprecipitate).

Contact

email: ross.davenport@qmul.ac.uk
Tel: +44 (0) 203 594 0731

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