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Professor Karim Brohi

Professor of Trauma Sciences

As head of the Trauma Sciences research team, my time is divided between surgery and science.

As a surgeon, Karim provides care for patients with vascular diseases and traumatic injury. As a scientist, Karim conducts research in the field of Trauma while supervising a range of researchers who are investigating different aspects of traumatic disease. 

In medical practice, trauma specialists use the available evidence to determine and deliver the best patient care. There are many instances where best practice has not been established because medical professionals currently don't fully understand the disease. Karim's aim is to improve the care of trauma patients by increasing our understanding of the disease processes.

Karim studied Medicine at University College Hospital London. At university, Karim also obtained an intercalated BSc in Computer Science and spent a 12-week elective in Trinidad and Tobago. Soon Karim realised that the management of trauma patients in the UK was extremely poor, which fuelled an ambition to improve the standards. Following this, Karim set up the trauma. org resources, which provides education, expert discussion and online support for trauma surgeons worldwide. Having been developed further, AfterTrauma.org has been developed to provide resources and support to patients and their families following a traumatic injury. 

Karim completed several years of training and became qualified in both Anaesthetics and Surgery. Viewed as unusual in many cases, Karim has an extremely useful set of skills for trauma patient management. Karim has worked for the Helicopter Emergency Medical Service (HEMS) in London and spent two years working at a Trauma Hospital in San Francisco. Following this, Karim obtained a Consultant post at The Royal London Hospital and returned to the UK to set up a trauma research department.

Trauma Sciences joined the Centre for Neuroscience in 2008. The centre is housed within the Blizard Institute at Barts and The London School of Medicine and Dentistry. The aim is to improve our understanding of trauma through laboratory experiments and then use those findings to improve patient outcomes by developing new treatment strategies. There collaborations with trauma units within Europe and the USA have been established, along with clinical trials for products designed for use in trauma. Conducting research in emergency surgical conditions is challenging but is essential if we are to make improvements for patients. In the UK, lack of trauma experience and poor organisation of trauma services means that patients are still dying from treatable injuries.

Karim's hope is the future includes specialist trauma centres which provide specialised trauma care from the moment of injury to the end of rehabilitation. Trauma research is an essential component of this process. Karim travels frequently to deliver lectures and teaching. In 2011, he set up an MSc in Trauma Science.

When he is not at work, he enjoys watching movies and enjoying good restaurants. Surgery is a very challenging career but it can also be very rewarding and Karim would encourage anyone who wants to pursue a career in surgery to do so. Trauma has finally been recognised as an important component of surgery in the UK so the future for this specialty is very exciting.

Contact

email: k.brohi@qmul.ac.uk

  • Tucker H, Brohi K, Tan J et al. (2023). Association of red blood cells and plasma transfusion versus red blood cell transfusion only with survival for treatment of major traumatic hemorrhage in prehospital setting in England: a multicenter study. Critical Care 27, (1) .
    10.1186/s13054-022-04279-4
  • Simpson R, Praditsuktavorn B, Wall J et al. (2023). Myocardial alterations following traumatic hemorrhagic injury. J Trauma Acute Care Surg 95, (4) 481-489.
    10.1097/TA.0000000000003987
  • Almuwallad A, Cole E, Rossetto A et al. (2023). Nationwide analysis of pre-hospital tranexamic acid for trauma demonstrates systematic bias in adherence to treatment guidelines: a retrospective cohort study. Int J Surg .
    10.1097/JS9.0000000000000712
  • Dicker R, Brohi K (2023). Violence and surgeons. The British journal of surgery 110, (10) 1247-1248.
    10.1093/bjs/znad246
  • Shepherd JM, Ross J, Anton L et al. (2023). Safety and efficacy of artesunate treatment in severely injured patients with traumatic hemorrhage. The TOP-ART randomized clinical trial. Intensive Care Medicine 49, (8) 922-933.
    10.1007/s00134-023-07135-3
  • Rossetto A, Wohlgemut JM, Brohi K et al. (2023). Sonorheometry versus rotational thromboelastometry in trauma: a comparison of diagnostic and prognostic performance. Journal of Thrombosis and Haemostasis 21, (8) 2114-2125.
    10.1016/j.jtha.2023.04.031
  • Curry N, Davenport R, Lucas J et al. (2023). The CRYOSTAT2 trial: The rationale and study protocol for a multi-Centre, randomised, controlled trial evaluating the effects of early high-dose cryoprecipitate in adult patients with major trauma haemorrhage requiring major haemorrhage protocol activation. Transfusion Medicine 33, (2) 123-131.
    10.1111/tme.12932
  • Curry NS, Davenport R, Wong H et al. (2023). Traumatic coagulopathy in the older patient: analysis of coagulation profiles from the Activation of Coagulation and Inflammation in Trauma-2 (ACIT-2) observational, multicenter study. Journal of Thrombosis and Haemostasis 21, (2) 215-226.
    10.1016/j.jtha.2022.11.005
  • Brohi K (2023). Shock, haemorrhage and transfusion. 11-23.
    10.1201/9781003106852-3
  • Dujardin RWG, Kisters JEC, Wirtz MR et al. (2022). Shock-Driven Endotheliopathy in Trauma Patients Is Associated with Leucocyte Derived Extracellular Vesicles. International Journal of Molecular Sciences 23, (24) .
    10.3390/ijms232415990
  • Green L, Brohi K, Allen E et al. (2022). UK audit of the management of major bleeding and time taken to deliver blood products. British Journal of Anaesthesia 129, (5) e111-e114.
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  • Thaventhiran A, Thiemermann C, Brohi K et al. (2021). O1: DISCOVERING NOVEL THERAPEUTICS TO TREAT ACUTE TRAUMATIC COAGULOPATHY (ATC). British Journal of Surgery 108, (Supplement_1) .
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    10.1007/978-3-030-53606-0_22
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  • Guerreiro ML, Brohi K (2020). Fibrino(Geno)Lysis: The New Kid in Town for Trauma Care. Journal of the American College of Surgeons 231, (4) s317-s318.
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  • Busaidi OA, Lee S, Kortbeek JB et al. (2020). Featured articles for CME credit September 2020: Complications of appendectomy and cholecystectomy in acute care surgery: A systematic review and meta-analysis. Journal of Trauma and Acute Care Surgery 89, (3) e89-e91.
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  • Braasch MC, Turco LM, Cole EM et al. (2020). The evolution of initial-hemostatic resuscitation and the void of posthemostatic resuscitation. Journal of Trauma and Acute Care Surgery 89, (3) 597-601.
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    10.1182/bloodadvances.2020001776
  • Gall LS, Vulliamy P, Brohi K et al. (2020). Response to the Comment on "the S100A10 Pathway Mediates an Occult Hyperfibrinolytic Subtype in Trauma Patients". Annals of Surgery 271, (4) E111-E112.
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    10.1111/jth.14690
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    10.1055/s-0039-1697932
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  • Spyropoulos AC, Brohi K, Caprini J et al. (2019). Scientific and Standardization Committee Communication: Guidance document on the periprocedural management of patients on chronic oral anticoagulant therapy: Recommendations for standardized reporting of procedural/surgical bleed risk and patient-specific thromboembolic risk. Journal of Thrombosis and Haemostasis 17, (11) 1966-1972.
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  • Brohi K, Gruen RL, Holcomb JB (2019). Why are bleeding trauma patients still dying?. Intensive Care Medicine 45, (5) 709-711.
    10.1007/s00134-019-05560-x
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  • Marsden M, Benger J, Brohi K et al. (2019). Coagulopathy, cryoprecipitate and CRYOSTAT-2: realising the potential of a nationwide trauma system for a national clinical trial. British Journal of Anaesthesia 122, (2) 164-169.
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  • Brohi K, Eaglestone S (). Traumatic coagulopathy and massive transfusion: improving outcomes and saving blood. Programme Grants for Applied Research 5, (19) 1-74.
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  • Brohi K, Schreiber M (2017). The new survivors and a new era for trauma research. PLoS Medicine 14, (7) .
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  • Rourke C, Davenport R, Brohi K (2017). Informed consent in acute trauma resuscitation: experiences of a major trauma centre. TRIALS 18.
  • Moran CG, Webb C, Brohi K et al. (2017). Lessons in planning from mass casualty events in UK. BMJ (Online) 359.
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