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Professor Karim Brohi

Professor of Trauma Sciences

As head of the Trauma Sciences research team, my time is divided between surgery and science.

As a surgeon, Karim provides care for patients with vascular diseases and traumatic injury. As a scientist, Karim conducts research in the field of Trauma while supervising a range of researchers who are investigating different aspects of traumatic disease. 

In medical practice, trauma specialists use the available evidence to determine and deliver the best patient care. There are many instances where best practice has not been established because medical professionals currently don't fully understand the disease. Karim's aim is to improve the care of trauma patients by increasing our understanding of the disease processes.

Karim studied Medicine at University College Hospital London. At university, Karim also obtained an intercalated BSc in Computer Science and spent a 12-week elective in Trinidad and Tobago. Soon Karim realised that the management of trauma patients in the UK was extremely poor, which fuelled an ambition to improve the standards. Following this, Karim set up the trauma. org resources, which provides education, expert discussion and online support for trauma surgeons worldwide. Having been developed further, AfterTrauma.org has been developed to provide resources and support to patients and their families following a traumatic injury. 

Karim completed several years of training and became qualified in both Anaesthetics and Surgery. Viewed as unusual in many cases, Karim has an extremely useful set of skills for trauma patient management. Karim has worked for the Helicopter Emergency Medical Service (HEMS) in London and spent two years working at a Trauma Hospital in San Francisco. Following this, Karim obtained a Consultant post at The Royal London Hospital and returned to the UK to set up a trauma research department.

Trauma Sciences joined the Centre for Neuroscience in 2008. The centre is housed within the Blizard Institute at Barts and The London School of Medicine and Dentistry. The aim is to improve our understanding of trauma through laboratory experiments and then use those findings to improve patient outcomes by developing new treatment strategies. There collaborations with trauma units within Europe and the USA have been established, along with clinical trials for products designed for use in trauma. Conducting research in emergency surgical conditions is challenging but is essential if we are to make improvements for patients. In the UK, lack of trauma experience and poor organisation of trauma services means that patients are still dying from treatable injuries.

Karim's hope is the future includes specialist trauma centres which provide specialised trauma care from the moment of injury to the end of rehabilitation. Trauma research is an essential component of this process. Karim travels frequently to deliver lectures and teaching. In 2011, he set up an MSc in Trauma Science.

When he is not at work, he enjoys watching movies and enjoying good restaurants. Surgery is a very challenging career but it can also be very rewarding and Karim would encourage anyone who wants to pursue a career in surgery to do so. Trauma has finally been recognised as an important component of surgery in the UK so the future for this specialty is very exciting.

Contact

email: k.brohi@qmul.ac.uk

  • Tucker H, Brohi K, Tan J et al. (2023). Association of red blood cells and plasma transfusion versus red blood cell transfusion only with survival for treatment of major traumatic hemorrhage in prehospital setting in England: a multicenter study. Critical Care 27, (1) .
    10.1186/s13054-022-04279-4
  • Curry NS, Davenport R, Wong H et al. (2023). Traumatic coagulopathy in the older patient: analysis of coagulation profiles from the Activation of Coagulation and Inflammation in Trauma-2 (ACIT-2) observational, multicenter study. Journal of thrombosis and haemostasis : JTH 21, (2) 215-226.
    10.1016/j.jtha.2022.11.005
  • Dujardin RWG, Kisters JEC, Wirtz MR et al. (2022). Shock-Driven Endotheliopathy in Trauma Patients Is Associated with Leucocyte Derived Extracellular Vesicles. International Journal of Molecular Sciences 23, (24) .
    10.3390/ijms232415990
  • Green L, Brohi K, Allen E et al. (2022). UK audit of the management of major bleeding and time taken to deliver blood products. British journal of anaesthesia 129, (5) e111-e114.
    10.1016/j.bja.2022.07.036
  • Vulliamy P, Hancorn K, Glasgow S et al. (2022). Age-related Injury Patterns Resulting from Knife Violence in an Urban Population. Scientific Reports .
    10.1038/s41598-022-17768-x
  • Dujardin RWG, Kleinveld DJB, Gaarder C et al. (2022). Coagulopathy Underlying Rotational Thromboelastometry Derangements in Trauma Patients: A Prospective Observational Multicenter Study. Anesthesiology 137, (2) 232-242.
    10.1097/ALN.0000000000004268
  • Sloos PH, Vulliamy P, van 't Veer C et al. (2022). Platelet dysfunction after trauma: From mechanisms to targeted treatment. Transfusion 62, (S1) S281-S300.
    10.1111/trf.16971
  • Cole E, Aylwin C, Christie R et al. (2022). Multiple Organ Dysfunction in Older Major Trauma Critical Care Patients. Annals of Surgery Open 3, (2) e174-.
    10.1097/as9.0000000000000174
  • Moore L, Bérubé M, Tardif P-A et al. (2022). Quality Indicators Targeting Low-Value Clinical Practices in Trauma Care. JAMA Surg 157, (6) 507-514.
    10.1001/jamasurg.2022.0812
  • Jansen JO, Cochran C, Boyers D et al. (2022). The effectiveness and cost-effectiveness of resuscitative endovascular balloon occlusion of the aorta (REBOA) for trauma patients with uncontrolled torso haemorrhage: study protocol for a randomised clinical trial (the UK-REBOA trial). Trials 23, (1) 384-.
    10.1186/s13063-022-06346-1
  • McElroy L, Robinson L, Battle C et al. (2022). Use of a modified Delphi process to develop research priorities in major trauma. European Journal of Trauma and Emergency Surgery 48, (2) 1453-1461.
    10.1007/s00068-021-01722-z
  • Tallach R, Brohi K (2022). Embracing uncertainty in mass casualty incidents. British Journal of Anaesthesia 128, (2) e79-e82.
    10.1016/j.bja.2021.10.024
  • Tallach R, Einav S, Brohi K et al. (2022). Learning from terrorist mass casualty incidents: a global survey. British Journal of Anaesthesia 128, (2) e168-e179.
    10.1016/j.bja.2021.10.003
  • Brohi K, Tallach R (2022). Mass casualty medicine: time for a 21st century refresh. British Journal of Anaesthesia 128, (2) e65-e67.
    10.1016/j.bja.2021.12.008
  • Byerly S, Nahmias J, Stein DM et al. (2022). A core outcome set for damage control laparotomy via modified Delphi method. Trauma Surgery and Acute Care Open 7, (1) .
    10.1136/tsaco-2021-000821
  • Qasim Z, Butler FK, Holcomb JB et al. (2022). Selective Prehospital Advanced Resuscitative Care-Developing a Strategy to Prevent Prehospital Deaths from Noncompressible Torso Hemorrhage. Shock 57, (1) 7-14.
    10.1097/SHK.0000000000001816
  • Curry N, Davenport R, Lucas J et al. (2022). The CRYOSTAT2 trial: The rationale and study protocol for a multi-Centre, randomised, controlled trial evaluating the effects of early high-dose cryoprecipitate in adult patients with major trauma haemorrhage requiring major haemorrhage protocol activation. Transfusion Medicine .
    10.1111/tme.12932
  • Vigstedt M, Baksaas-Aasen K, Henriksen HH et al. (2022). Thrombelastography (TEG® 6s) early amplitudes predict maximum amplitude in severely injured trauma patients. Scandinavian Journal of Clinical and Laboratory Investigation 82, (6) 508-512.
    10.1080/00365513.2022.2119599
  • Perkins ZB, Yet B, Marsden M et al. (2021). Early Identification of Trauma-induced Coagulopathy Development and Validation of a Multivariable Risk Prediction Model. Annals of Surgery 274, (6) E1119-E1128.
    10.1097/SLA.0000000000003771
  • Roberts DJ, Bobrovitz N, Zygun DA et al. (2021). Evidence for use of damage control surgery and damage control interventions in civilian trauma patients: a systematic review. World Journal of Emergency Surgery 16, (1) .
    10.1186/s13017-021-00352-5
  • Tucker H, Avery P, Brohi K et al. (2021). Outcome measures used in clinical research evaluating prehospital blood component transfusion in traumatically injured bleeding patients: A systematic review. Journal of Trauma and Acute Care Surgery 91, (6) 1018-1024.
    10.1097/TA.0000000000003360
  • Elbourne C, Cole E, Marsh S et al. (2021). At risk child: A contemporary analysis of injured children in London and the South East of England: A prospective, multicentre cohort study. BMJ Paediatrics Open 5, (1) .
    10.1136/bmjpo-2021-001114
  • Rossetto A, Vulliamy P, Lee K et al. (2021). Temporal Transitions In Fibrinolysis After Trauma: Adverse Outcome Is Principally Related To Late Hypofibrinolysis­­­­. Anesthesiology .
    10.1097/ALN.0000000000004036
  • Vulliamy P, Marsden M, Carden R et al. (2021). SP9.1.7 Emergency Laparotomy for Trauma in the United Kingdom and Ireland: a Prospective Multicentre Study. British Journal of Surgery 108, (Supplement_7) .
    10.1093/bjs/znab361.170
  • Kleinveld DJB, Simons DDG, Dekimpe C et al. (2021). Plasma and rhADAMTS13 reduce trauma-induced organ failure by restoring the ADAMTS13-VWF axis. Blood Advances 5, (17) 3478-3491.
    10.1182/BLOODADVANCES.2021004404
  • Johannsen S, Brohi K, Johansson PI et al. (2021). Getting hit by the bus around the world-a global perspective on goal directed treatment of massive hemorrhage in trauma. Current Opinion in Anaesthesiology 34, (4) 537-543.
    10.1097/ACO.0000000000001025
  • Thaventhiran A, Thiemermann C, Brohi K et al. (2021). O1: DISCOVERING NOVEL THERAPEUTICS TO TREAT ACUTE TRAUMATIC COAGULOPATHY (ATC). British Journal of Surgery 108, (Supplement_1) .
    10.1093/bjs/znab117.001
  • Holcomb JB, Moore EE, Sperry JL et al. (2021). Evidence-Based and Clinically Relevant Outcomes for Hemorrhage Control Trauma Trials. Annals of surgery 273, (3) 395-401.
    10.1097/SLA.0000000000004563
  • Vulliamy P, Kornblith LZ, Kutcher ME et al. (2021). Alterations in platelet behavior after major trauma: adaptive or maladaptive?. Platelets 32, (3) 295-304.
    10.1080/09537104.2020.1718633
  • Curry N, Rourke C, Davenport R et al. (2021). Fibrinogen replacement in trauma haemorrhage. Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine 22, (1) 1-2.
    10.1186/1757-7241-22-S1-A5
  • Baksaas-Aasen K, Gall LS, Stensballe J et al. (2021). Viscoelastic haemostatic assay augmented protocols for major trauma haemorrhage (ITACTIC): a randomized, controlled trial. Intensive Care Medicine 47, (1) 49-59.
    10.1007/s00134-020-06266-1
  • Praditsuktavorn B, Wall J, Thiemermann C et al. (2020). Rescuing Cardiac Dysfunction Following Traumatic Haemorrhagic Injury. CIRCULATION 142, (24) E496-E497.
  • Sohrabi C, Gillespie S, Rossetto A et al. (2020). Circulating levels of platelet factor 4 are elevated in the acute phase after severe traumatic brain injury. BRITISH JOURNAL OF SURGERY 107128-128.
  • Davenport RA, Green L, Brohi K (2020). Cryoprecipitate/Fibrinogen concentrate transfusions. 373-390.
    10.1007/978-3-030-53606-0_22
  • Amezcua-Prieto C, Ross J, Rogozińska E et al. (2020). Maternal trauma due to motor vehicle crashes and pregnancy outcomes: A systematic review and meta-Analysis. BMJ Open 10, (10) .
    10.1136/bmjopen-2019-035562
  • Guerreiro ML, Brohi K (2020). Fibrino(Geno)Lysis: The New Kid in Town for Trauma Care. Journal of the American College of Surgeons 231, (4) s317-s318.
    10.1016/j.jamcollsurg.2020.07.654
  • Busaidi OA, Lee S, Kortbeek JB et al. (2020). Featured articles for CME credit September 2020: Complications of appendectomy and cholecystectomy in acute care surgery: A systematic review and meta-analysis. Journal of Trauma and Acute Care Surgery 89, (3) e89-e91.
    10.1097/TA.0000000000002893
  • Braasch MC, Turco LM, Cole EM et al. (2020). The evolution of initial-hemostatic resuscitation and the void of posthemostatic resuscitation. Journal of Trauma and Acute Care Surgery 89, (3) 597-601.
    10.1097/TA.0000000000002576
  • Braasch MC, Turco LM, Cole EM et al. (2020). The evolution of initial-hemostatic resuscitation and the void of posthemostatic resuscitation. J Trauma Acute Care Surg 89, (3) 597-601.
    10.1097/TA.0000000000002576
  • Vulliamy P, Montague SJ, Gillespie S et al. (2020). Loss of GPVI and GPIbα contributes to trauma-induced platelet dysfunction in severely injured patients. Blood Advances 4, (12) 2623-2630.
    10.1182/bloodadvances.2020001776
  • Tucker H, Brohi K, Cardigan R et al. (2020). A national survey and simulation study of pre-hospital whole blood transfusion: what are the benefits?. BRITISH JOURNAL OF HAEMATOLOGY 189164-165.
  • Gall LS, Vulliamy P, Brohi K et al. (2020). Response to the Comment on "the S100A10 Pathway Mediates an Occult Hyperfibrinolytic Subtype in Trauma Patients". Annals of Surgery 271, (4) E111-E112.
    10.1097/SLA.0000000000003691
  • Moore HB, Gando S, Iba T et al. (2020). Defining trauma-induced coagulopathy with respect to future implications for patient management: Communication from the SSC of the ISTH. Journal of Thrombosis and Haemostasis 18, (3) 740-747.
    10.1111/jth.14690
  • Curry N, Brohi K (2020). Surgery in Traumatic Injury and Perioperative Considerations. Seminars in Thrombosis and Hemostasis 46, (1) 73-82.
    10.1055/s-0039-1697932
  • Pearce AP, Marsden MER, Newell N et al. (2020). Trends in admission timing and mechanism of injury can be used to improve general surgical trauma training. Annals of the Royal College of Surgeons of England 102, (1) 36-42.
    10.1308/rcsann.2019.0135
  • Lopez Tremoleda J, Wall J, Naganathar V et al. (2019). Modelling cardiac dysfunction following traumatic haemorrhage injury: impact on myocardial integrity. Frontiers in Immunology 10.
    10.3389/fimmu.2019.02774
  • Carden R, Lockey D, Brohi K (2019). 034 Early cardiovascular dysfunction drives in-hospital trauma mortality. Emergency Medicine Journal 36, (12) 796-.
    10.1136/emermed-2019-rcem.34
  • COLE ELAINE, Gillespie S, Vulliamy P et al. (). Multiple organ dysfunction after trauma. British Journal of Surgery .
    10.1002/bjs.11361
  • Spyropoulos AC, Brohi K, Caprini J et al. (2019). Scientific and Standardization Committee Communication: Guidance document on the periprocedural management of patients on chronic oral anticoagulant therapy: Recommendations for standardized reporting of procedural/surgical bleed risk and patient-specific thromboembolic risk. Journal of Thrombosis and Haemostasis 17, (11) 1966-1972.
    10.1111/jth.14598
  • Cole E, Weaver A, Gall L et al. (2019). A Decade of Damage Control Resuscitation: New Transfusion Practice, New Survivors, New Directions. Ann Surg .
    10.1097/SLA.0000000000003657
  • Thomas H, Foley C, Lucas J et al. (2019). The challenges of delivering a time-critical intervention in emergency care. TRIALS 20.
  • Vulliamy P, Gillespie S, Armstrong P et al. (2019). Histone H4 induces platelet ballooning and microparticle release during trauma hemorrhage. Proceedings of the National Academy of Sciences .
    10.1073/pnas.1904978116
  • Sordi R, Chiazza F, Collotta D et al. (2019). Resolvin D1 Attenuates the Organ Injury Associated With Experimental Hemorrhagic Shock. Ann Surg .
    10.1097/SLA.0000000000003407
  • Gall LS, Vulliamy P, Gillespie S et al. (2019). The S100A10 Pathway Mediates an Occult Hyperfibrinolytic Subtype in Trauma Patients. Annals of surgery 269, (6) 1184-1191.
    10.1097/SLA.0000000000002733
  • Gall LS, Vulliamy P, Gillespie S et al. (2019). The S100A10 Pathway Mediates an Occult Hyperfibrinolytic Subtype in Trauma Patients. Ann Surg 269, (6) 1184-1191.
    10.1097/SLA.0000000000002733
  • Brohi K, Gruen RL, Holcomb JB (2019). Why are bleeding trauma patients still dying?. Intensive Care Medicine 45, (5) 709-711.
    10.1007/s00134-019-05560-x
  • Schyma BM, Cole E, Wren SM et al. (2019). Delivering trauma mastery with an international trauma masters. Injury 50, (4) 877-882.
    10.1016/j.injury.2019.03.023
  • Rehn M, Weaver A, Brohi K et al. (2019). Effect of Prehospital Red Blood Cell Transfusion on Mortality and Time of Death in Civilian Trauma Patients. Shock 51, (3) 284-288.
    10.1097/SHK.0000000000001166
  • Juffermans NP, Wirtz MR, Balvers K et al. (2019). Towards patient-specific management of trauma hemorrhage: the effect of resuscitation therapy on parameters of thromboelastometry. Journal of Thrombosis and Haemostasis 17, (3) 441-448.
    10.1111/jth.14378
  • Marsden M, Benger J, Brohi K et al. (2019). Coagulopathy, cryoprecipitate and CRYOSTAT-2: realising the potential of a nationwide trauma system for a national clinical trial. British Journal of Anaesthesia 122, (2) 164-169.
    10.1016/j.bja.2018.10.055
  • Crewdson K, Rehn M, Brohi K et al. (2019). Response letter to Voelckel et al. Acta Anaesthesiologica Scandinavica 63, (1) 140-.
    10.1111/aas.13283
  • Crewdson K, Rehn M, Brohi K et al. (2019). Response to Burns et al. Acta Anaesthesiologica Scandinavica 63, (1) 138-.
    10.1111/aas.13281
  • Cabrera CP, Manson J, Shepherd JM et al. (2018). Correction: Signatures of inflammation and impending multiple organ dysfunction in the hyperacute phase of trauma: A prospective cohort study. PLoS Med 15, (10) e1002694-e1002694.
    10.1371/journal.pmed.1002694
  • Glasgow SM, Perkins ZB, Tai NRM et al. (2018). Development of a discrete event simulation model for evaluating strategies of red blood cell provision following mass casualty events. European Journal of Operational Research 270, (1) 362-374.
    10.1016/j.ejor.2018.03.008
  • Virdee J, Pafitanis G, Alamouti R et al. (2018). Mind the gap: 11 years of train-related injuries at the Royal London Hospital Major Trauma Centre. Annals of the Royal College of Surgeons of England 100, (7) 520-528.
    10.1308/rcsann.2018.0089
  • Jones TF, Torrance HDT, Owen HC et al. (2018). MicroRNA profiles are associated with lymphocyte count after a major traumatic injury: a potential role for immunometabolism?. British Journal of Anaesthesia 121, (2) e23-e24.
    10.1016/j.bja.2018.05.027
  • MARSDEN M, CARDEN R, Navaratne L et al. (2018). Outcomes following trauma laparotomy for hypotensive trauma patients: a UK military and civilian perspective. Journal of Trauma and Acute Care Surgery .
    10.1097/TA.0000000000001988
  • Baksaas-Aasen K, Van Dieren S, Balvers K et al. (). Data-driven Development of ROTEM and TEG Algorithms for the Management of Trauma Hemorrhage: A Prospective Observational Multicenter Study. Ann Surg .
    10.1097/SLA.0000000000002825
  • Aswani A, Manson J, Itagaki K et al. (2018). Scavenging circulating mitochondrial DNA as a potential therapeutic option for multiple organ dysfunction in trauma hemorrhage. Frontiers in Immunology 9, (MAY) .
    10.3389/fimmu.2018.00891
  • Crewdson K, Rehn M, Brohi K et al. (2018). Pre-hospital emergency anaesthesia in awake hypotensive trauma patients: beneficial or detrimental?. Acta Anaesthesiologica Scandinavica 62, (4) 504-514.
    10.1111/aas.13059
  • PROWLE JR (2018). Acute Kidney Injury in Trauma Patients Admitted to Critical Care: Development and Validation of a Diagnostic Prediction Model. Scientific Reports .
    10.1038/s41598-018-21929-2
  • Harris T, Davenport R, Mak M et al. (2018). The Evolving Science of Trauma Resuscitation. Emerg Med Clin North Am 36, (1) 85-106.
    10.1016/j.emc.2017.08.009
  • Brohi K (2018). Shock and blood transfusion. 12-23.
    10.1201/9781315111087-2
  • Vulliamy P, Faulkner M, Kirkwood G et al. (2018). Temporal and geographic patterns of stab injuries in young people: A retrospective cohort study from a UK major trauma centre. BMJ Open 8, (10) .
    10.1136/bmjopen-2018-023114
  • Curry N, Rourke C, Davenport R et al. (2015). Early cryoprecipitate for major haemorrhage in trauma: A randomised controlled feasibility trial. British Journal of Anaesthesia 115, (1) 76-83.
    10.1093/bja/aev134
  • VULLIAMY P, GILLESPIE S, ARMSTRONG P et al. (2017). Platelets Shift Towards a Procoagulant and Proin ammatory Phenotype at the Expense of Aggregation During Trauma Hemorrhage: a Potential Role of Extracellular Histones. Circulation e448-467, (136) .
    10.1161/CIR.0000000000000546
  • Vulliamy P, Gillespie S, Armstrong PC et al. (2017). Platelets Shift Towards a Procoagulant and Proinflammatory Phenotype at the Expense of Aggregation During Trauma Hemorrhage: a Potential Role of Extracellular Histones. CIRCULATION 136, (24) E464-E464.
  • Tremoleda JL, Watts SA, Reynolds PS et al. (2017). MODELING ACUTE TRAUMATIC HEMORRHAGIC SHOCK INJURY: CHALLENGES AND GUIDELINES FOR PRECLINICAL STUDIES. Shock 48, (6) 610-623.
    10.1097/SHK.0000000000000901
  • Nevin DG, Brohi K (2017). Permissive hypotension for active haemorrhage in trauma. Anaesthesia 72, (12) 1443-1448.
    10.1111/anae.14034
  • Brohi K, Eaglestone S (2017). Traumatic coagulopathy and massive transfusion: improving outcomes and saving blood. Programme Grants for Applied Research 5, (19) 1-74.
    10.3310/pgfar05190
  • Baksaas-Aasen K, Gall L, Eaglestone S et al. (2017). iTACTIC - implementing Treatment Algorithms for the Correction of Trauma-Induced Coagulopathy: study protocol for a multicentre, randomised controlled trial. Trials 18, (1) 486-486.
    10.1186/s13063-017-2224-9
  • Wilson NM, Wall J, Naganathar V et al. (2017). Mechanisms Involved in Secondary Cardiac Dysfunction in Animal Models of Trauma and Haemorrhagic Shock. Shock 48, (4) .
    10.1097/SHK.0000000000000882
  • Wilson NM, Wall J, Naganathar V et al. (2017). Mechanisms Involved in Secondary Cardiac Dysfunction in Animal Models of Trauma and Hemorrhagic Shock. Shock 48, (4) 401-410.
    10.1097/SHK.0000000000000882
  • Brohi K, Davenport RA (2017). Acute Traumatic Coagulopathy: Thrombin Is the Driver!: In Reply. Anesthesiology 127, (3) 585-586.
    10.1097/ALN.0000000000001761
  • VULLIAMY P, GILLESPIE S, GALL L et al. (2017). Platelet transfusions reduce fibrinolysis but do not restore platelet function during trauma hemorrhage. Journal of Trauma and Acute Care Surgery 83, (3) 388-397.
    10.1097/TA.0000000000001520.
  • Lockey DJ, Brohi K (2017). Pre-hospital thoracotomy and the evolution of pre-hospital critical care for victims of trauma. Injury 48, (9) 1863-1864.
    10.1016/j.injury.2017.03.034
  • Asehnoune K, Balogh Z, Citerio G et al. (2017). The research agenda for trauma critical care. Intensive Care Medicine 43, (9) 1340-1351.
    10.1007/s00134-017-4895-9
  • CABRERA CP, MANSON J, SHEPHERD JM et al. (2017). Signatures of Inflammation and Impending Multiple Organ Dysfunction in the Hyperacute Phase of Trauma. PLoS Medicine .
    10.1371/journal.pmed.1002352
  • Sordi R, Nandra KK, Chiazza F et al. (2017). Artesunate Protects Against the Organ Injury and Dysfunction Induced by Severe Hemorrhage and Resuscitation. Ann Surg 265, (2) 408-417.
    10.1097/SLA.0000000000001664
  • Heath H, Renney G, Ward M et al. (2017). OC-080 Stat2 is a key mediator of acute pancreatitis. Gut 66, (Suppl 2) a42-.
    10.1136/gutjnl-2017-314472.80
  • Cabrera CP, Manson J, Shepherd JM et al. (2017). Signatures of inflammation and impending multiple organ dysfunction in the hyperacute phase of trauma: A prospective cohort study. PLoS Medicine 14, (7) .
    10.1371/journal.pmed.1002352
  • Brohi K, Schreiber M (2017). The new survivors and a new era for trauma research. PLoS Medicine 14, (7) .
    10.1371/journal.pmed.1002354
  • Yamada N, Martin L, Zechendorf E et al. (2017). A NOVEL SYNTHETIC, HOST-DEFENCE PEPTIDE PROTECTS AGAINST ORGAN INJURY/DYSFUNCTION IN A RAT-MODEL OF SEVERE HEMORRHAGIC SHOCK. SHOCK 47, (6) 116-117.
  • Rourke C, Davenport R, Brohi K (2017). Informed consent in acute trauma resuscitation: experiences of a major trauma centre. TRIALS 18.
  • Balendran CA, Lövgren A, Hansson KM et al. (2017). Prothrombin time is predictive of low plasma prothrombin concentration and clinical outcome in patients with trauma hemorrhage: analyses of prospective observational cohort studies. Scand J Trauma Resusc Emerg Med 25, (1) 30-30.
    10.1186/s13049-016-0332-2
  • Yamada N, Lukas M, Zechendorf E et al. (). Novel Synthetic, Host-defense Peptide Protects Against Organ Injury/Dysfunction in a Rat Model of Severe Hemorrhagic Shock. Annals of Surgery .
    10.1097/SLA.0000000000002186
  • GALL L, BROHI K, DAVENPORT R (2017). Diagnosis And Treatment Of Hyperfibrinolysis In Trauma (A European Perspective). Seminars in Thrombosis and Hemostasis .
    10.1055/s-0036-1598001
  • Balvers K, van Dieren S, Baksaas-Aasen K et al. (2017). Combined effect of therapeutic strategies for bleeding injury on early survival, transfusion needs and correction of coagulopathy. British Journal of Surgery 104, (3) 222-229.
    10.1002/bjs.10330
  • Davenport RA, Guerreiro M, Frith D et al. (2017). Activated Protein C Drives the Hyperfibrinolysis of Acute Traumatic Coagulopathy. Anesthesiology 126, (1) 115-127.
    10.1097/ALN.0000000000001428
  • Moran CG, Webb C, Brohi K et al. (2017). Lessons in planning from mass casualty events in UK. BMJ (Online) 359.
    10.1136/bmj.j4765
  • Vulliamy PE, Perkins ZB, Brohi K et al. (2016). Persistent lymphopenia is an independent predictor of mortality in critically ill emergency general surgical patients. European Journal of Trauma and Emergency Surgery 42, (6) 755-760.
    10.1007/s00068-015-0585-x
  • Perkins ZB, Lendrum RA, Brohi K (2016). Resuscitative endovascular balloon occlusion of the aorta: promise, practice, and progress?. Curr Opin Crit Care 22, (6) 563-571.
    10.1097/MCC.0000000000000367
  • Perkins ZB, Lendrum RA, Brohi K (2016). Resuscitative endovascular balloon occlusion of the aorta: Promise, practice, and progress?. Current Opinion in Critical Care 22, (6) 563-571.
    10.1097/MCC.0000000000000367
  • Shepherd JM, Cole E, Brohi K (2016). Contemporary patterns of multiple organ dysfunction in trauma. Shock .
    10.1097/SHK.0000000000000779
  • De'Ath HD, Oakland K, Brohi K (2016). CT screened arterial calcification as a risk factor for mortality after trauma. Scand J Trauma Resusc Emerg Med 24, (1) 120-120.
    10.1186/s13049-016-0317-1
  • Bos L, Schouten L, van Vught L et al. (2016). ESICM LIVES 2016: part one : Milan, Italy. 1-5 October 2016. Intensive Care Med Exp 4, (Suppl 1) 27-.
    10.1186/s40635-016-0098-x
  • Sivakumar S, Taccone FS, Desai KA et al. (2016). ESICM LIVES 2016: part two : Milan, Italy. 1-5 October 2016. Intensive Care Med Exp 4, (Suppl 1) 30-30.
    10.1186/s40635-016-0099-9
  • Sharples A, Brohi K (2016). Can clinical prediction tools predict the need for computed tomography in blunt abdominal? A systematic review. Injury 47, (8) 1811-1818.
    10.1016/j.injury.2016.05.032
  • Cole E, Lecky F, West A et al. (2016). The impact of a pan-regional inclusive trauma system on quality of care. Annals of Surgery 264, (1) 188-194.
    10.1097/SLA.0000000000001393
  • Manson J, Cole E, De’Ath HD et al. (). Early changes within the lymphocyte population are associated with the development of multiple organ dysfunction syndrome in trauma patients. Critical Care 20, (1) .
    10.1186/s13054-016-1341-2
  • Hoffman KP, Playford DE, Grill E et al. (2016). Minimum data set to measure rehabilitation needs and health outcome after major trauma: application of an international framework. Eur J Phys Rehabil Med 52, (3) 331-346.
  • Heim C, Cole E, West A et al. (2016). Survival prediction algorithms miss significant opportunities for improvement if used for case selection in trauma quality improvement programs. Injury .
    10.1016/j.injury.2016.05.042
  • Klein AA, Arnold P, Bingham RM et al. (). AAGBI guidelines: the use of blood components and their alternatives 2016. Anaesthesia .
    10.1111/anae.13489
  • Davenport RA, Brohi K (2016). Cause of trauma-induced coagulopathy. Current Opinion in Anaesthesiology 29, (2) 212-219.
    10.1097/ACO.0000000000000295
  • Heim C, Steurer MP, Brohi K (2016). Damage Control Resuscitation: More Than Just Transfusion Strategies. Current Anesthesiology Reports 6, (1) 72-78.
    10.1007/s40140-016-0145-x
  • Stanworth SJ, Davenport R, Curry N et al. (2016). Mortality from trauma haemorrhage and opportunities for improvement in transfusion practice. British Journal of Surgery 103, (4) 357-365.
    10.1002/bjs.10052
  • Sordi R, Nandra KK, Chiazza F et al. (2016). Artesunate Protects Against the Organ Injury and Dysfunction Induced by Severe Hemorrhage and Resuscitation. Annals of surgery .
  • Sordi R, Nandra KK, Chiazza F et al. (2016). Artesunate Protects Against the Organ Injury and Dysfunction Induced by Severe Hemorrhage and Resuscitation. Ann Surg .
    10.1097/SLA.0000000000001664
  • Gall L, Davenport R, Brohi K (2016). Effect of early tranexamic acid on the coagulation system in patients with suspected traumatic haemorrhage: a prospective cohort study. The Lancet 387s46-.
    10.1016/s0140-6736(16)00433-5
  • Taccone FS, Bunker N, Waldmann C et al. (2016). Erratum: A new device for the prevention of pulmonary embolism in critically ill patients: Results of the european angel catheter registry (Journal of Trauma and Acute Care Surgery (2015) 79: 3 (456-462)). Journal of Trauma and Acute Care Surgery 80, (2) 355-.
    10.1097/01.ta.0000480705.26372.9d
  • Jenkins DH, Tai NRM, Brohi K (2016). 3 Systems of Care in the Management of Vascular Injury. 21-27.
    10.1016/b978-1-4557-1261-8.00003-5
  • Glen J, Constanti M, Brohi K (2016). Assessment and initial management of major trauma: Summary of NICE guidance. BMJ (Online) 353.
    10.1136/bmj.i3051
  • Roberts DJ, Bobrovitz N, Zygun DA et al. (2016). Indications for use of damage control surgery in civilian trauma patients. A content analysis and expert appropriateness rating study. Annals of Surgery 263, (5) 1018-1027.
    10.1097/SLA.0000000000001347
  • Glasgow S, Vasilakis C, Perkins Z et al. (2016). Managing the surge in demand for blood following mass casualty events: Early automatic restocking may preserve red cell supply. Journal of Trauma and Acute Care Surgery 81, (1) 50-56.
    10.1097/TA.0000000000001101
  • Roberts DJ, Zygun DA, Faris PD et al. (2016). Opinions of Practicing Surgeons on the Appropriateness of Published Indications for Use of Damage Control Surgery in Trauma Patients: An International Cross-Sectional Survey. Journal of the American College of Surgeons 223, (3) 515-529.
    10.1016/j.jamcollsurg.2016.06.002
  • Brohi K (2015). The trials of being a national trauma registry. Emergency Medicine Journal 32, (12) 909-910.
    10.1136/emermed-2015-205424
  • Owen HC, Torrance HDT, Jones TF et al. (2015). Epigenetic regulatory pathways involving microRNAs may modulate the host immune response following major trauma. Journal of Trauma and Acute Care Surgery 79, (5) 766-772.
    10.1097/TA.0000000000000850
  • Glasgow S, Vasilakis C, Perkins Z et al. (2015). DEVELOPING TRANSFUSION BASED STRATEGIES FOR OPTIMISING OUTCOMES FOLLOWING MASS CASUALTY EVENTS USING A DISCRETE EVENT SIMULATION MODELLING APPROACH. SHOCK 445-6.
  • Schäfer N, Driessen A, Fröhlich M et al. (2015). Diversity in clinical management and protocols for the treatment of major bleeding trauma patients across European level I Trauma Centres. Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine 23, (1) .
    10.1186/s13049-015-0147-6
  • Wall JM, Tremoleda JL, Thiemermann C et al. (2015). HEART FATTY ACID BINDING PROTEIN (H-FABP) IS A BIOMARKER OF TRAUMA-INDUCED SECONDARY CARDIAC INJURY IN A PRE-CLINICAL MODEL OF TRAUMA-HAEMORRHAGE. SHOCK 4421-22.
  • Shepherd JM, Cole E, Brohi K (2015). PATTERNS OF MULTI-ORGAN DYSFUNCTION IN SEVERELY INJURED PATIENTS WITH HAEMORRHAGE. SHOCK 4421-21.
  • Vulliamy PE, Perkins ZB, Brohi K et al. (2015). SEVERE LYMPHOPENIA IN EMERGENCY SURGICAL PATIENTS IS ASSOCIATED WITH ILLNESS SEVERITY AND MORTALITY. SHOCK 4410-11.
  • Shepherd JM, Cole E, Brohi K (2015). T-5: PATTERNS OF MULTI-ORGAN DYSFUNCTION IN SEVERELY INJURED PATIENTS WITH HAEMORRHAGE. Shock 44 Suppl 221-.
    10.1097/01.shk.0000472070.23771.ef
  • Torrance HDT, Brohi K, Warnes G et al. (2015). T-helper cell polarisation following severe polytrauma. Intensive Care Medicine Experimental 3.
    10.1186/2197-425X-3-S1-A848
  • Frith D, Wall J, Baptista M et al. (2015). THROMBIN GENERATION POTENTIAL DECLINES DURING TRAUMA HAEMORRHAGE DESPITE HAEMOSTATIC RESUSCITATION. SHOCK 441-2.
  • Gall L, Davenport R, Brohi K (2015). TRANEXAMIC ACID IS ASSOCIATED WITH ENHANCED CLOT STRENGTH, REDUCED FIBRINOLYSIS AND REDUCED ACUTE TRAUMATIC COAGULOPATHY IN BLEEDING TRAUMA PATIENTS. SHOCK 444-4.
  • Sordi R, Nandra KK, Chiazza F et al. (2015). TRAUMA ORGAN PROTECTION WITH ARTESUNATE (TOP-ART): PRECLINICAL EFFICACY OF AN ANTIMALARIAL DRUG WITH EXCELLENT SAFETY PROFILE AND PLANNED PHASE II RCT. SHOCK 441-1.
  • Jones TF, Gillespie S, Gall LS et al. (2015). VENOUS THROMBOEMBOLIC EVENTS AFTER TRAUMATIC INJURY ARE ASSOCIATED WITH EARLY CHANGES TO THE FIBRINOLYTIC SYSTEM. SHOCK 4424-24.
  • Jones TF, Owen HC, Torrance HDT et al. (2015). MicroRNA-mediated regulation of IL-10, IL-12 and TNFα gene expression in severely injured trauma patients. Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine 23, (2) .
    10.1186/1757-7241-23-S2-O5
  • Taccone FS, Bunker N, Waldmann C et al. (2015). A new device for the prevention of pulmonary embolism in critically ill patients: Results of the European Angel Catheter Registry. Journal of Trauma and Acute Care Surgery 79, (3) 456-462.
    10.1097/TA.0000000000000756
  • Taccone FS, Bunker N, Waldmann C et al. (2015). Nonopioid management of acute pain associated with trauma: Focus on pharmacologic options. JOURNAL OF TRAUMA AND ACUTE CARE SURGERY 79, (3) 456-462.
    10.1097/TA.0000000000000756
  • Whitaker J, West A, Brohi K et al. (2015). Reason for Admission and Outcomes for Older Patients Admitted to a Major Trauma Centre. BRITISH JOURNAL OF SURGERY 10286-86.
  • Watts S, Nordmann G, Brohi K et al. (2015). Evaluation of prehospital blood products to attenuate acute coagulopathy of trauma in a model of severe injury and shock in anesthetized pigs. Shock 44138-148.
    10.1097/SHK.0000000000000409
  • Campbell HE, Stokes EA, Bargo DN et al. (2015). Quantifying the healthcare costs of treating severely bleeding major trauma patients: A national study for England. Critical Care 19, (1) .
    10.1186/s13054-015-0987-5
  • Naganathar S, De''Ath HD, Wall J et al. (2015). Admission biomarkers of trauma-induced secondary cardiac injury predict adverse cardiac events and are associated with plasma catecholamine levels. Journal of Trauma and Acute Care Surgery 79, (1) 71-77.
    10.1097/TA.0000000000000694
  • Sordi R, Chiazza F, Johnson FL et al. (2015). Inhibition of IκB kinase attenuates the organ injury and dysfunction associated with hemorrhagic shock. Molecular Medicine 21563-575.
    10.2119/molmed.2015.00049
  • Colom B, Bodkin JV, Beyrau M et al. (2015). Leukotriene B4-Neutrophil Elastase Axis Drives Neutrophil Reverse Transendothelial Cell Migration InVivo. Immunity 42, (6) 1075-1086.
    10.1016/j.immuni.2015.05.010
  • Davenport R, Khan S, Brohi K (2015). Re: Hemostatic resuscitation is neither hemostatic nor resuscitative in trauma hemorrhage: But did they in fact test the effect of hemostatic resuscitation?. Journal of Trauma and Acute Care Surgery 78, (6) 1237-1238.
    10.1097/TA.0000000000000624
  • Hoffman K, Silvester L, Nott P et al. (2015). Evaluation of the value of rehabilitation prescriptions within four major trauma hospitals. Physiotherapy 101e584-.
    10.1016/j.physio.2015.03.3408
  • Torrance HD, Brohi K, Pearse RM et al. (2015). Association between gene expression biomarkers of immunosuppression and blood transfusion in severely injured polytrauma patients. Annals of Surgery 261, (4) 751-759.
    10.1097/SLA.0000000000000653
  • Torrance HD, Brohi K, Pearse RM et al. (2015). Association between gene expression biomarkers of immunosuppression and blood transfusion in severely injured polytrauma patients. Ann Surg 261, (4) 751-759.
    10.1097/SLA.0000000000000653
  • Perkins ZB, Yet B, Glasgow S et al. (2015). Meta-analysis of prognostic factors for amputation following surgical repair of lower extremity vascular trauma. British Journal of Surgery 102, (5) 436-450.
    10.1002/bjs.9689
  • Hagemo JS, Christiaans SC, Stanworth SJ et al. (2015). Detection of acute traumatic coagulopathy and massive transfusion requirements by means of rotational thromboelastometry: An international prospective validation study. Critical Care 19, (1) .
    10.1186/s13054-015-0823-y
  • Balvers K, Wirtz M, Rourke C et al. (2015). Effect of the haemoglobin level on neurologic outcome in patients with severe traumatic brain injury. Critical Care 19, (Suppl 1) p335-.
    10.1186/cc14415
  • Brohi K (2015). Make the bleeding stop. Science Translational Medicine 7, (277) .
    10.1126/scitranslmed.aaa6555
  • Khan S, Davenport R, Raza I et al. (2015). Damage control resuscitation using blood component therapy in standard doses has a limited effect on coagulopathy during trauma hemorrhage. Intensive Care Medicine 41, (2) 239-247.
    10.1007/s00134-014-3584-1
  • Cole E, Davenport R, Willett K et al. (2015). Tranexamic acid use in severely injured civilian patients and the effects on outcomes: a prospective cohort study. Ann Surg 261, (2) 390-394.
    10.1097/SLA.0000000000000717
  • Torrance HD, Vivian ME, Brohi K et al. (2015). Changes in gene expression following trauma are related to the age of transfused packed red blood cells. J Trauma Acute Care Surg 78, (3) 535-542.
    10.1097/TA.0000000000000534
  • Roberts DJ, Bobrovitz N, Zygun DA et al. (2015). Indications for use of thoracic, abdominal, pelvic, and vascular damage control interventions in trauma patients: A content analysis and expert appropriateness rating study. Journal of Trauma and Acute Care Surgery 79, (4) 568-579.
    10.1097/TA.0000000000000821
  • Frith D, Brohi K (2015). Massive transfusion in trauma. 101-119.
    10.1007/978-3-319-08735-1_11
  • Perkins ZB, Yet B, Glasgow S et al. (2015). Meta-analysis of prognostic factors for amputation following surgical repair of lower extremity vascular trauma. British Journal of Surgery .
    10.1002/bjs.9689
  • Heim C, Brohi K (2015). Perioperative hemostasis in trauma. 311-330.
    10.1007/978-3-642-55004-1_18
  • Jenkins DH, Tai NRM, Brohi K (2015). Systems of Care in the Management of Vascular Injury. 21-27.
    10.1016/B978-1-4557-1261-8.00003-5
  • Owen HC, Torrance HDT, Barnes MR et al. (2015). The role of micrornas in the development of hospital acquired infection in polytrauma patients. Intensive Care Medicine Experimental 3.
    10.1186/2197-425X-3-S1-A35
  • Bird R, Lawless J, Davenport R et al. (2014). Rotational thromboelastometry (ROTEM) – The future of haemostatic resuscitation in major trauma centres. International Journal of Surgery 12s89-.
    10.1016/j.ijsu.2014.08.191
  • Lord JM, Midwinter MJ, Chen YF et al. (2014). The systemic immune response to trauma: An overview of pathophysiology and treatment. The Lancet 384, (9952) 1455-1465.
    10.1016/S0140-6736(14)60687-5
  • Asehnoune K, Faraoni D, Brohi K (2014). What’s new in management of traumatic coagulopathy?. Intensive Care Medicine 40, (11) 1727-1730.
    10.1007/s00134-014-3388-3
  • Sivapathasuntharam D, Whitaker J, West A et al. (2014). P532: Reason for admission and outcomes for older patients presenting to a major trauma centre. European Geriatric Medicine 5s251-.
    10.1016/s1878-7649(14)70695-3
  • Vivian M, Torrance HDT, Pearse R et al. (2014). THE AGE OF TRANSFUSED PACKED RED BLOOD CELLS CORRELATES WITH THE DEGREE OF IMMUNOSUPPRESSION AS ASSESSED BY GENE EXPRESSION PATTERNS IN SEVERELY INJURED TRAUMA PATIENTS. INTENSIVE CARE MEDICINE 40S20-S20.
  • Perkins ZB, Maytham GD, Koers L et al. (2014). Impact on outcome of a targeted performance improvement programme in haemodynamically unstable patients with a pelvic fracture. Bone Joint J 96-B, (8) 1090-1097.
    10.1302/0301-620X.96B8.33383
  • Asehnoune K, Faraoni D, Brohi K (2014). What's new in management of traumatic coagulopathy?. Intensive Care Medicine .
    10.1007/s00134-014-3388-3
  • Torrance HDT, Brohi K, Pearse RM et al. (2014). Association between gene expression biomarkers of immunosuppression and blood transfusion in severely injured polytrauma patients. Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine 22, (1) .
    10.1186/1757-7241-22-S1-O7
  • Guerreiro M, Tremoleda JL, Frith D et al. (2014). Reduction of the natural Activated protein C pathway activity significantly prevents coagulopathy in a murine model of acute traumatic coagulopathy. Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine 22, (1) .
    10.1186/1757-7241-22-S1-O6
  • Perkins ZB, Yet B, Glasgow S et al. (2014). Prognostic Factors for Amputation Following Surgical Repair of Lower Extremity Vascular Trauma: A Systematic Review and Meta-Analysis of Observational Studies. JOURNAL OF VASCULAR SURGERY 59, (6) 75S-75S.
    10.1016/j.jvs.2014.03.167
  • Guerreiro ML, Tremoleda JL, Thiemermann C et al. (2014). REDUCTION OF NATURAL ACTIVATED PROTEIN C PREVENTS COAGULOPATHY IN A PRECLINICAL ANIMAL MODEL OF ACUTE TRAUMATIC COAGULOPATHY. SHOCK 4151-51.
  • Colom B, Bodkin JV, Beyrau M et al. (2014). Leukotriene B4-Neutrophil Elastase Axis Drives Neutrophil Reverse Transendothelial Cell Migration InVivo. Immunity .
    10.1016/j.immuni.2015.05.010
  • Jenkins DH, Rappold JF, Badloe JF et al. (2014). Trauma hemostasis and oxygenation research position paper on remote damage control resuscitation: definitions, current practice, and knowledge gaps. Shock 41 Suppl 1, (0 1) 3-12.
    10.1097/SHK.0000000000000140
  • Hagemo JS, Stanworth S, Juffermans NP et al. (2014). Prevalence, predictors and outcome of hypofibrinogenaemia in trauma: A multicentre observational study. Critical Care 18, (2) .
    10.1186/cc13798
  • Khan S, Brohi K, Chana M et al. (2014). Hemostatic resuscitation is neither hemostatic nor resuscitative in trauma hemorrhage. Journal of Trauma and Acute Care Surgery 76, (3) 561-568.
    10.1097/TA.0000000000000146
  • Cole E, Davenport R, Willett K et al. (2014). The burden of infection in severely injured trauma patients and the relationship with admission shock severity. Journal of Trauma and Acute Care Surgery 76, (3) 730-735.
    10.1097/TA.0b013e31829fdbd7
  • Cole E, Davenport R, Willett K et al. (2014). The burden of infection in severely injured trauma patients and the relationship with admission shock severity. J Trauma Acute Care Surg 76, (3) 730-735.
    10.1097/TA.0b013e31829fdbd7
  • Dua A, Frith D, Wade CE et al. (2014). The Effect of Aging on Acute Traumatic Coagulopathy. Journal of Surgical Research 186, (2) 687-.
    10.1016/j.jss.2013.11.1003
  • Owen HC, Torrance HD, Brohi K et al. (2014). 1068. MicroRNA-regulated immunosuppression in severely injured polytrauma patients. Intensive Care Medicine Experimental 2.
    10.1186/2197-425X-2-S1-P84
  • Hoffman K, Cole E, Playford ED et al. (2014). Health outcome after major trauma: what are we measuring?. PLoS One 9, (7) e103082-.
    10.1371/journal.pone.0103082
  • Khan S, Brohi K, Chana M et al. (2014). Hemostatic resuscitation is neither hemostatic nor resuscitative in trauma hemorrhage. Journal of Trauma and Acute Care Surgery 76, (3) 561-568.
    10.1097/TA.0000000000000146
  • Perkins ZB, Maytham GD, Koers L et al. (2014). Impact on outcome of a targeted performance improvement programme in haemodynamically unstable patients with a pelvic fracture. Bone and Joint Journal 96 B, (8) 1090-1097.
    10.1302/0301-620X.96B8.33383
  • Müller MCA, Balvers K, Binnekade JM et al. (2014). Thromboelastometry and organ failure in trauma patients: a prospective cohort study. Critical care (London, England) 18, (6) 687-.
    10.1186/s13054-014-0687-6
  • Abrams ST, Manson J, Liu T et al. (2013). Acute phase proteins reduce histone-induced platelet aggregation and coagulation activation. JOURNAL OF THROMBOSIS AND HAEMOSTASIS 1122-22.
  • Torrance HDT, Brohi K, Pearse RM et al. (2013). BLOOD TRANSFUSION FOLLOWING SEVERE TRAUMA IS ASSOCIATED WITH THE DEVELOPMENT OF AN EARLY ANTI-INFLAMMATORY RESPONSE. INTENSIVE CARE MEDICINE 39S386-S387.
  • Davenport R, Brohi K (2013). Fibrinogen depletion in trauma: early, easy to estimate and central to trauma-induced coagulopathy. Crit Care 17, (5) 190-.
    10.1186/cc13021
  • Glasgow S, Davenport R, Perkins Z et al. (2013). A comprehensive review of blood product use in civilian mass casualty events. J Trauma Acute Care Surg 75, (3) 468-474.
    10.1097/TA.0b013e318298efb9
  • Davenport R, Frith D, Geurreiro M et al. (2013). ACTIVATED PROTEIN C IS CENTRAL TO SYSTEMIC FIBRINOLYSIS BUT NOT ANTICOAGULATION IN ACUTE TRAUMATIC COAGULOPATHY. SHOCK 4024-24.
  • Raza I, Khan S, Rourke C et al. (2013). ACUTE TRAUMATIC COAGULOPATHY HAS MULTIPLE IMPORTANT PATTERNS OF COAGULATION SYSTEM DERANGEMENT. SHOCK 4034-34.
  • Perkins Z, Yet B, Glasgow S et al. (2013). EARLY PREDICTION OF TRAUMATIC COAGULOPATHY USING ADMISSION CLINICAL VARIABLES. SHOCK 4025-25.
  • Khan S, Raza I, Davenport R et al. (2013). MAJOR HEMORRHAGE PROTOCOLS HAVE A LIMITED EFFECT ON TRAUMA-INDUCED COAGULOPATHY. SHOCK 4034-34.
  • Willink M, Khan S, Cole E et al. (2013). OUTCOMES FOLLOWING TRAUMA HEMORRHAGE. SHOCK 4028-29.
  • Raza I, Khan S, Rourke C et al. (2013). THE RELATIVE CONTRIBUTIONS OF PAI-1, TAFI, AND FACTOR XI IN ACUTE TRAUMATIC COAGULOPATHY. SHOCK 4022-22.
  • Cole E, Davenport R, Glasgow S et al. (2013). TRANEXAMIC ACID USE IN SHOCKED SEVERELY INJURED PATIENTS AND THE EFFECTS ON OUTCOMES. SHOCK 4021-21.
  • Brockamp T, Maegele M, Gaarder C et al. (2013). Comparison of the predictive performance of the BIG, TRISS, and PS09 score in anadult trauma population derived from multiple international trauma registries. Critical Care 17, (4) .
    10.1186/cc12813
  • Abrams ST, Manson J, Liu T et al. (2013). Circulating histone-induced thrombosis leads to circulatory and respiratory failure. JOURNAL OF THROMBOSIS AND HAEMOSTASIS 11128-128.
  • Hunt BJ, Raza I, Brohi K (2013). The incidence and magnitude of fibrinolytic activation in trauma patients: A reply to a rebuttal. Journal of Thrombosis and Haemostasis 11, (7) 1437-1438.
    10.1111/jth.12296
  • Abrams S, Manson J, Liu T et al. (2013). EXTRACELLULAR HISTONES-INDUCE MICROCIRCULATORY THROMBOSIS AND ACUTE RESPIRATORY FAILURE. HAEMATOLOGICA 98259-259.
  • Perkins Z, Maytham G, Koers L et al. (2013). A targeted performance improvement programme reduces mortality in exsanguinating pelvic trauma. Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine 21, (Suppl 1) s28-.
    10.1186/1757-7241-21-s1-s28
  • Glasgow SM, Perkins ZB, Davenport R et al. (2013). A 100 year review of blood use in civilian mass casualty events - how best to predict future needs. BRITISH JOURNAL OF SURGERY 10031-31.
  • Khan S, Allard S, Weaver A et al. (2013). A major haemorrhage protocol improves the delivery of blood component therapy and reduces waste in trauma massive transfusion. Injury 44, (5) 587-592.
    10.1016/j.injury.2012.09.029
  • Khan S, Allard S, Weaver A et al. (2013). A major haemorrhage protocol improves the delivery of blood component therapy and reduces waste in trauma massive transfusion. Injury 44, (5) 587-592.
    10.1016/j.injury.2012.09.029
  • Perkins ZB, Glasgow S, Brohi K et al. (2013). A systematic review and meta-analysis of prognostic variables for secondary amputation following surgical repair of lower extremity vascular trauma. BRITISH JOURNAL OF SURGERY 10051-51.
  • Hagemo JS, Næss PA, Johansson P et al. (2013). Evaluation of TEG® and RoTEM® inter-changeability in trauma patients. Injury 44, (5) 600-605.
    10.1016/j.injury.2012.11.016
  • Vulliamy P, Manson J, Brohi K (2013). The admission differential white cell count in trauma - relationship with shock, injury severity and outcome. BRITISH JOURNAL OF SURGERY 10030-30.
  • Oakland K, De'Ath H, Brohi K (2013). The incidence of calcified atherosclerosis and association with in-hospital mortality in trauma. BRITISH JOURNAL OF SURGERY 10030-30.
  • De'Ath HD, Manson J, Davenport R et al. (2013). Trauma-induced secondary cardiac injury is associated with hyperacute elevations in inflammatory cytokines. Shock 39, (5) 415-420.
    10.1097/SHK.0b013e31828ded41
  • Abrams ST, Manson J, Liu T et al. (2013). Pro-thrombotic properties of circulating histones cause microcirculatory obstruction and acute respiratory failure. BRITISH JOURNAL OF HAEMATOLOGY 161, (SI, Suplement 1) 6-6.
  • Torrance H, Brohi K, Hinds C et al. (2013). Cytokine gene expression can predict infectious complications following severe trauma. Critical Care 17, (Suppl 2) p27-.
    10.1186/cc11965
  • Raza I, Davenport R, Rourke C et al. (2013). The incidence and magnitude of fibrinolytic activation in trauma patients. J Thromb Haemost 11, (2) 307-314.
    10.1111/jth.12078
  • Abrams ST, Zhang N, Manson J et al. (2013). Circulating histones are mediators of trauma-associated lung injury. American Journal of Respiratory and Critical Care Medicine 187, (2) 160-169.
    10.1164/rccm.201206-1037OC
  • Cole EM, West A, Davenport R et al. (2013). Can residents be effective trauma team leaders in a major trauma centre?. Injury 44, (1) 18-22.
    10.1016/j.injury.2011.09.020
  • Cole E, Davenport R, De'Ath H et al. (2013). Coagulation system changes associated with susceptibility to infection in trauma patients. J Trauma Acute Care Surg 74, (1) 51-57.
    10.1097/TA.0b013e3182788b0f
  • Hoffman K, West A, Nott P et al. (2013). Measuring acute rehabilitation needs in trauma: Preliminary evaluation of the Rehabilitation Complexity Scale. Injury 44, (1) 104-109.
    10.1016/j.injury.2011.11.001
  • Hoffman K, West A, Nott P et al. (2013). Measuring acute rehabilitation needs in trauma: preliminary evaluation of the Rehabilitation Complexity Scale. Injury 44, (1) 104-109.
    10.1016/j.injury.2011.11.001
  • Frith D, Lima-Baptista M, Davenport R et al. (2013). Thromboelastometry diagnosed Acute Traumatic Coagulopathy (ATC) identifies trauma patients with poor clinical outcomes better than Disseminated Intravascular Coagulation (DIC) scoring. Scandinavian journal of trauma, resuscitation and emergency medicine 21, (Suppl 1) S30-S30.
    10.1186/1757-7241-21-s1-s30
  • Frith D, Brohi K (2012). The pathophysiology of trauma-induced coagulopathy. Curr Opin Crit Care 18, (6) 631-636.
    10.1097/MCC.0b013e3283599ab9
  • Davenport R, Brohi K (2012). HYPOPERFUSION & ACTIVATION OF PROTEIN C IN TRAUMA. SHOCK 38, (4) 1-1.
  • Gruen RL, Brohi K, Schreiber M et al. (2012). Haemorrhage control in severely injured patients. Lancet 380, (9847) 1099-1108.
    10.1016/S0140-6736(12)61224-0
  • Harris T, Thomas GOR, Brohi K (2012). Early fluid resuscitation in severe trauma. BMJ 345e5752-.
    10.1136/bmj.e5752
  • Roberts I, Perel P, Prieto-Merino D et al. (2012). Effect of tranexamic acid on mortality in patients with traumatic bleeding: prespecified analysis of data from randomised controlled trial. BMJ-BRITISH MEDICAL JOURNAL 345.
    10.1136/bmj.e5839
  • Adams A, Fotiadis N, Chin JY et al. (2012). A pictorial review of traumatic pericardial injuries. Insights Imaging 3, (4) 307-311.
    10.1007/s13244-012-0177-9
  • Perkins ZB, De'Ath HD, Aylwin C et al. (2012). Epidemiology and outcome of vascular trauma at a British Major Trauma Centre. Eur J Vasc Endovasc Surg 44, (2) 203-209.
    10.1016/j.ejvs.2012.05.013
  • Rourke C, Curry N, Khan S et al. (2012). Fibrinogen levels during trauma hemorrhage, response to replacement therapy, and association with patient outcomes. J Thromb Haemost 10, (7) 1342-1351.
    10.1111/j.1538-7836.2012.04752.x
  • De'Ath HD, Rourke C, Davenport R et al. (2012). Clinical and biomarker profile of trauma-induced secondary cardiac injury. British Journal of Surgery 99, (6) 789-797.
    10.1002/bjs.8728
  • De'Ath HD, Rourke C, Davenport R et al. (2012). Clinical and biomarker profile of trauma-induced secondary cardiac injury. Br J Surg 99, (6) 789-797.
    10.1002/bjs.8728
  • Frith D, Cohen MJ, Brohi K (2012). Animal models of trauma-induced coagulopathy. Thromb Res 129, (5) 551-556.
    10.1016/j.thromres.2011.11.053
  • Khan S, Allard S, Weaver A et al. (2012). A trauma major haemorrhage protocol reduces waste and improves the delivery of blood component therapy. BRITISH JOURNAL OF SURGERY 9944-44.
  • Frith D, Davenport R, Brohi K (2012). Acute traumatic coagulopathy. Curr Opin Anaesthesiol 25, (2) 229-234.
    10.1097/ACO.0b013e3283509675
  • Cohen MJ, Call M, Nelson M et al. (2012). Critical role of activated protein C in early coagulopathy and later organ failure, infection and death in trauma patients. Ann Surg 255, (2) 379-385.
    10.1097/SLA.0b013e318235d9e6
  • Fuller G, Bouamra O, Woodford M et al. (2012). Recent massive blood transfusion practice in England and Wales: view from a trauma registry. Emerg Med J 29, (2) 118-123.
    10.1136/emj.2010.104349
  • Brohi K (2012). A strategy for future trauma research. Br J Surg 99 Suppl 14-5.
    10.1002/bjs.7791
  • Harris T, Thomas GO, Brohi K (2012). Authors' reply to Wiles and Chitnavis. BMJ 345e7266-.
    10.1136/bmj.e7266
  • Frith D, Guerreiro M, Pearse R et al. (2012). EXPERIMENTAL ACUTE TRAUMATIC COAGULOPATHY IS ASSOCIATED WITH MODERATE IMPAIRMENT OF THROMBIN GENERATION AND DYSFIBRINOGENEMIA. SHOCK 3734-34.
  • Harris T, Thomas GOR, Brohi K (2012). Early fluid resuscitation in severe trauma. BMJ: British Medical Journal 345.
    10.1136/bmj.e7266
  • Hagemo JS, Næss PA, Johansson P et al. (2012). Evaluation of TEG® and RoTEM® inter-changeability in trauma patients. Injury .
    10.1016/j.injury.2012.11.016
  • Oakland K, De'Ath H, Brohi K (2012). Mesenteric Vessel Calcification Predicts Mortality in Older Trauma Patients. BRITISH JOURNAL OF SURGERY 9939-39.
  • Chana MS, Manson J, Davenport R et al. (2012). Time course of lactate clearance in trauma and its relevance to outcomes. Scandinavian journal of trauma, resuscitation and emergency medicine 20, (Suppl 1) O9-O9.
    10.1186/1757-7241-20-s1-o9
  • Manson J, Thiemermann C, Brohi K (2012). Trauma alarmins as activators of damage-induced inflammation. Br J Surg 99 Suppl 112-20.
    10.1002/bjs.7717
  • Davenport R, Manson J, De'Ath H et al. (2011). Functional definition and characterization of acute traumatic coagulopathy. Crit Care Med 39, (12) 2652-2658.
    10.1097/CCM.0b013e3182281af5
  • Brohi K, Cole E, Hoffman K (2011). Improving outcomes in the early phases after major trauma. Curr Opin Crit Care 17, (5) 515-519.
    10.1097/MCC.0b013e32834a9353
  • Brohi K (2011). Prediction of acute traumatic coagulopathy and massive transfusion - Is this the best we can do?. Resuscitation 82, (9) 1128-1129.
    10.1016/j.resuscitation.2011.06.022
  • De' Ath HD, Rourke C, Manson J et al. (2011). Trauma induced secondary cardiac injury. EUROPEAN HEART JOURNAL 32726-726.
  • Khan S, Brohi K, Davenport R et al. (2011). A major haemorrhage protocol improves blood product administration and wastage compared to traditional massive transfusion protocols. JOURNAL OF THROMBOSIS AND HAEMOSTASIS 9691-692.
  • Davenport R, Rourke C, Manson J et al. (2011). Activated protein C is a principle mediator of acute traumatic coagulopathy. J THROMB HAEMOST 951-52.
  • Rourke C, Curry NS, Khan S et al. (2011). Characterization of fibrinogen depletion and response to replacement therapy in bleeding trauma patients. J THROMB HAEMOST 9121-121.
  • Raza I, Davenport R, Brohi K et al. (2011). Dilutional coagulopathy following blood transfusion in trauma. JOURNAL OF THROMBOSIS AND HAEMOSTASIS 9692-693.
  • Frith D, Baptista ML, Cohen M et al. (2011). Experimental acute traumatic coagulopathy is due to systemic activation of protein c during hypoperfusion. JOURNAL OF THROMBOSIS AND HAEMOSTASIS 9481-481.
  • Curry NS, Rourke C, Khan S et al. (2011). Fibrinogen replacement in traumatic bleeding. JOURNAL OF THROMBOSIS AND HAEMOSTASIS 9938-938.
  • Raza I, Davenport R, Rourke C et al. (2011). Occult activation of fibrinolysis in trauma. JOURNAL OF THROMBOSIS AND HAEMOSTASIS 9848-848.
  • Spoors CM, Davenport R, De'Ath H et al. (2011). Platelet function in trauma measured by multiple electrode aggregometry. JOURNAL OF THROMBOSIS AND HAEMOSTASIS 9799-799.
  • Curry NS, Raja A, Brohi K et al. (2011). Procoagulant microvesicles are elevated in acute traumatic injury. JOURNAL OF THROMBOSIS AND HAEMOSTASIS 9895-895.
  • Curry N, Stanworth S, Hopewell S et al. (2011). Trauma-Induced Coagulopathy-A Review of the Systematic Reviews: Is There Sufficient Evidence to Guide Clinical Transfusion Practice?. TRANSFUS MED REV 25, (3) 217-231.
    10.1016/j.tmrv.2011.01.001
  • Manson J, Davenport R, Coates A et al. (2011). TRAUMATIC TISSUE DAMAGE: THE SEARCH FOR TRAUMA ALARMINS. INFLAMMATION RESEARCH 60160-160.
  • Manson J, Abrams S, Wang G et al. (2011). Circulating nucleosomes suggest that cell death occurs during hypoperfusion after trauma. BRITISH JOURNAL OF SURGERY 9816-16.
  • De'Ath HDI, Rourke C, Davenport R et al. (2011). Cardiac dysfunction after trauma: A real and present danger. BRITISH JOURNAL OF SURGERY 987-8.
  • Curry NS, Rourke C, Khan S et al. (2011). Fibrinogen replacement for major haemorrhage in trauma - an in-vitro study. BRITISH JOURNAL OF HAEMATOLOGY 1532-2.
  • Davenport R, Manson J, De'Ath H et al. (2011). Point of care diagnostics for the rapid identification of acute traumatic coagulopathy and prediction of massive trauma haemorrhage. BRITISH JOURNAL OF SURGERY 987-7.
  • Spoors C, Rourke C, Manson J et al. (2011). Rotem indices of platelet function in acute traumatic coagulopathy. BRITISH JOURNAL OF SURGERY 988-8.
  • Manson J, Davenport R, Coates A et al. (2011). Trauma: Characterising the cytokine response to tissue damage. BRITISH JOURNAL OF SURGERY 9822-22.
  • Roberts I, Shakur H, Afolabi A et al. (2011). The importance of early treatment with tranexamic acid in bleeding trauma patients: an exploratory analysis of the CRASH-2 randomised controlled trial. LANCET 377, (9771) 1096-1101.
    10.1016/S0140-6736(11)60278-X
  • Stannard A, Brohi K, Tai N (2011). Vascular injury in the United Kingdom. Perspectives in Vascular Surgery and Endovascular Therapy 23, (1) 27-33.
    10.1177/1531003511409055
  • Manson J, Davenport R, Coates A et al. (2011). DEMONSTRATING THE HUMAN CYTOKINE RESPONSE TO TISSUE DAMAGE AFTER TRAUMATIC INJURY. SHOCK 3623-23.
  • Frith D, Baptista ML, Cohen MJ et al. (2011). EXPERIMENTAL ACUTE TRAUMATIC COAGULOPATHY: INITIATED BY HYPOPERFUSION, MODULATED BY THE PROTEIN C PATHWAY. SHOCK 3616-17.
  • Davenport R, Curry N, Manson J et al. (2011). Hemostatic effects of fresh frozen plasma may be maximal at red cell ratios of 1:2. J Trauma 70, (1) 90-95.
    10.1097/TA.0b013e318202e486
  • Chana MS, Manson J, Davenport R et al. (2011). TIME COURSE OF LACTATE CLEARANCE IN TRAUMA AND ITS RELEVANCE TO OUTCOMES. SHOCK 3610-11.
  • De'Ath H, Manson J, Rourke C et al. (2011). TRAUMA INDUCED SECONDARY CARDIAC INJURY IS ASSOCIATED WITH ACUTE INFLAMMATION. SHOCK 3612-12.
  • Curry N, Hopewell S, Doree C et al. (2011). The acute management of trauma hemorrhage: a systematic review of randomized controlled trials. CRIT CARE 15, (2) .
    10.1186/cc10096
  • De' Ath HD, Rourke C, Manson J et al. (2011). Trauma induced secondary cardiac injury. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE 183726-726.
  • Brohi K, Plani F, Moeng M et al. (2010). MULTICENTER RANDOMIZED CONTROLLED TRIAL TRA-204 TO EVALUATE THE SAFETY AND EFFICACY OF MP4OX IN LACTATE CLEARANCE FOLLOWING TRAUMA HEMORRHAGE. CRITICAL CARE MEDICINE 38, (12) U227-U227.
  • Frith D, Stanworth S, Gaarder C et al. (2010). Acute traumatic coagulopathy is dependent upon injury load and shock. BRITISH JOURNAL OF SURGERY 9739-40.
  • Thomas D, Wee M, Clyburn P et al. (2010). Blood transfusion and the anaesthetist: Management of massive haemorrhage. Anaesthesia 65, (11) 1153-1161.
    10.1111/j.1365-2044.2010.06538.x
  • Duchesne JC, McSwain NE, Cotton BA et al. (2010). Damage control resuscitation: the new face of damage control. J Trauma 69, (4) 976-990.
    10.1097/TA.0b013e3181f2abc9
  • Frith D, Goslings JC, Gaarder C et al. (2010). Definition and drivers of acute traumatic coagulopathy: clinical and experimental investigations. J Thromb Haemost 8, (9) 1919-1925.
    10.1111/j.1538-7836.2010.03945.x
  • Cohen MJ, Carles M, Brohi K et al. (2010). Early Release of Soluble Receptor for Advanced Glycation Endproducts After Severe Trauma in Humans. JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE 68, (6) 1273-1278.
    10.1097/TA.0b013e3181db323e
  • Frith D, Brohi K (2010). The acute coagulopathy of trauma shock: clinical relevance. Surgeon 8, (3) 159-163.
    10.1016/j.surge.2009.10.022
  • Curry N, Raja A, Hughes T et al. (2010). A prospective observational study evaluating changes in coagulation parameters in trauma admissions. BRITISH JOURNAL OF HAEMATOLOGY 14910-10.
  • Zhang Q, Raoof M, Chen Y et al. (2010). Circulating mitochondrial DAMPs cause inflammatory responses to injury. Nature 464, (7285) 104-107.
    10.1038/nature08780
  • Davenport RA, Tai N, West A et al. (2010). A major trauma centre is a specialty hospital not a hospital of specialties. Br J Surg 97, (1) 109-117.
    10.1002/bjs.6806
  • Bouillon B, Brohi K, Hess JR et al. (2010). Educational initiative on critical bleeding in trauma: Chicago, July 11-13, 2008. J Trauma 68, (1) 225-230.
    10.1097/TA.0b013e3181c42815
  • Konig TC, Davenport R, Sapsford W et al. (2010). Emergent Thoracotomy for Blunt Trauma-Is the Outcome so Bad?. International Journal of Surgery 8, (7) 575-.
    10.1016/j.ijsu.2010.07.270
  • Stanworth SJ, Morris TP, Gaarder C et al. (2010). Reappraising the concept of massive transfusion in trauma. CRIT CARE 14, (6) .
    10.1186/cc9394
  • Frith D, Cohen M, Pearse R et al. (2010). Rodent coagulation responses to trauma and haemorrhagic shock. INFLAMMATION RESEARCH 59S26-S27.
  • Mossadegh S, Leahman H, Brohi K et al. (2010). Splenic injury in a major British trauma centre: evolution in therapy over time. BRITISH JOURNAL OF SURGERY 9765-65.
  • Durai R, Agrawal R, Piper K et al. (2009). Wegener's granulomatosis presenting as an abdominal aortic aneurysm: a case report. Cases J 29346-.
    10.1186/1757-1626-2-9346
  • O'reilly D, Brohi K (2009). Effects of terrorism on the healthcare community. 45-58.
    10.1007/978-0-387-09412-0_4
  • Chesebro BB, Rahn P, Carles M et al. (2009). Increase in activated protein C mediates acute traumatic coagulopathy in mice. Shock 32, (6) 659-665.
    10.1097/SHK.0b013e3181a5a632
  • Cohen MJ, Bir N, Rahn P et al. (2009). Protein C Depletion Early After Trauma Increases the Risk of Ventilator-Associated Pneumonia. JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE 67, (6) 1176-1181.
    10.1097/TA.0b013e3181c1c1bc
  • Brohi K (2009). Trauma induced coagulopathy. J R Army Med Corps 155, (4) 320-322.
    10.1136/jramc-155-04-15
  • Brohi K (2009). Diagnosis and management of coagulopathy after major trauma. Br J Surg 96, (9) 963-964.
    10.1002/bjs.6691
  • Bent CL, Fotiadis N, Renfrew I et al. (2009). Total percutaneous aortic repair: midterm outcomes. Cardiovasc Intervent Radiol 32, (3) 449-454.
    10.1007/s00270-009-9537-3
  • Davenport RA, Brohi K (2009). Coagulopathy in trauma patients: importance of thrombocyte function?. Curr Opin Anaesthesiol 22, (2) 261-266.
    10.1097/ACO.0b013e328325a6d9
  • König TC, Morris T, Gaarder C et al. (2009). Redefining massive transfusion. Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine 17, (Suppl 1) o1-.
    10.1186/1757-7241-17-s1-o1
  • Frith D, Chesebro B, Pittet JF et al. (2009). ACUTE TRAUMATIC COAGULOPATHY IS DRIVEN BY SYSTEMIC HYPOPERFUSION INDEPENDENT OF HYPOTENSION AND HAEMORRHAGE VOLUME. SHOCK 329-9.
  • Band RA, Bilski TR, Bowyer MW et al. (2009). Contributeurs. xiv-xx.
    10.1016/b978-2-8101-0087-3.00068-2
  • Cohen MJ, Brohi K, Calfee CS et al. (2009). Early release of high mobility group box nuclear protein 1 after severe trauma in humans: role of injury severity and tissue hypoperfusion. CRIT CARE 13, (6) .
    10.1186/cc8152
  • Davenport R, Coates A, Allard S et al. (2009). TRAUMA HAEMORRHAGE: EVOLVING ROLE OF ROTEM FOR PREDICTING TRANSFUSION REQUIREMENTS. SHOCK 3215-15.
  • Davenport RA, Tai N, West A et al. (2009). The Trauma Centre: a specialty hospital, not a hospital of specialties. Scandinavian journal of trauma, resuscitation and emergency medicine 17, (Suppl 1) O3-O3.
    10.1186/1757-7241-17-s1-o3
  • Greaves P, Konig T, Barber C et al. (2009). Use of 'massive transfusion packs' at a major trauma centre. BRITISH JOURNAL OF HAEMATOLOGY 14580-80.
  • Hess JR, Brohi K, Dutton RP et al. (2008). The Coagulopathy of Trauma: A Review of Mechanisms. J TRAUMA 65, (4) 748-754.
    10.1097/TA.0b013e181877a9c
  • Parr MJ, Bouillon B, Brohi K et al. (2008). Traumatic Coagulopathy: Where are the Good Experimental Models?. J TRAUMA 65, (4) 766-771.
    10.1097/TA.0b013e31818606d2
  • Brohi K (2008). The Utstein template for uniform reporting of data following major trauma: a valuable tool for establishing a pan-European dataset. Scand J Trauma Resusc Emerg Med 168-.
    10.1186/1757-7241-16-8
  • Kortbeek JB, Al Turki SA, Ali J et al. (2008). Advanced Trauma Life Support, 8th edition, the evidence for change. J TRAUMA 64, (6) 1638-1650.
    10.1097/TA.0b013e3181744b03
  • Davenport R, Aylwin C, Ward E et al. (2008). A performance improvement programme aids analysis of potentially preventable death from trauma: A UK inner-city hospital experience. Injury extra. 39, (5) 157-.
    10.1016/j.injury.2007.11.293
  • Brohi K, Cohen MJ, Ganter MT et al. (2008). Acute coagulopathy of trauma: Hypoperfusion induces systemic anticoagulation and hyperfibrinolysis. JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE 64, (5) 1211-1217.
    10.1097/TA.0b013e318169cd3c
  • Davies E, Davenport R, Brohi K et al. (2008). Anatomy and mechanism of injury of fatal vascular trauma: An inner city hospital's experience. Injury extra. 39, (5) 160-.
    10.1016/j.injury.2007.11.301
  • Ganter MT, Cohen MJ, Brohi K et al. (2008). Angiopoietin-2, marker and mediator of endothelial activation with prognostic significance early after trauma?. ANN SURG 247, (2) 320-326.
    10.1097/SLA.0b013e318162d616
  • Aylwin CJ, Brohi K, Davies GD et al. (2008). Pre-hospital and in-hospital thoracostomy: indications and complications. Ann R Coll Surg Engl 90, (1) 54-57.
    10.1308/003588408X242286
  • Brohi K (2008). Shock and blood transfusion. 13-23.
  • Frith D, Chesebro B, Patel N et al. (2008). Towards a mouse model for acute coagulopathy of trauma/shock. SHOCK 296-6.
  • Brohi K, Cohen MJ, Davenport RA (2007). Acute coagulopathy of trauma: mechanism, identification and effect. Curr Opin Crit Care 13, (6) 680-685.
    10.1097/MCC.0b013e3282f1e78f
  • Bent CL, Matson MB, Sobeh M et al. (2007). Endovascular management of acute blunt traumatic thoracic aortic injury: a single center experience. J Vasc Surg 46, (5) 920-927.
    10.1016/j.jvs.2007.07.032
  • Brohi K (2007). Trauma care: The future and how to get there. Australasian Emergency Care 10, (4) 216-.
    10.1016/j.aenj.2007.09.076
  • Ganter MT, Brohi K, Cohen MJ et al. (2007). Role of the alternative pathway in the early complement activation following major trauma. SHOCK 28, (1) 29-34.
    10.1097/shk.0b013e3180342439
  • Brohi K (2007). Trauma specialist centres. ANN ROY COLL SURG 89, (5) 252-253.
    10.1308/147363507x216681
  • Flint LM, Kheirabadi BS, Moore FA et al. (2007). Discussion. Journal of Trauma - Injury, Infection and Critical Care 62, (6) 1359-1361.
    10.1097/TA.0b013e318047b805
  • Brohi K, Cohen MJ, Ganter MT et al. (2007). Acute traumatic coagulopathy: Initiated by hypoperfusion - Modulated through the protein C pathway?. ANN SURG 245, (5) 812-818.
    10.1097/01.sla.0000256862.79374.31
  • Davenport R, West A, Walsh M et al. (2007). A dedicated trauma service reduces hospital stay in critically injured patients. Injury extra. 38, (4) 108-.
    10.1016/j.injury.2006.12.048
  • Bhatti M, Matson M, Renfrew I et al. (2007). Endovascular management of extremity vascular injuries. Injury extra. 38, (4) 142-.
    10.1016/j.injury.2006.12.114
  • Cohen MJ, Brohi K, Ganter MT et al. (2007). Early coagulopathy after traumatic brain injury: the role of hypoperfusion and the protein c pathway. Journal of Trauma 63, (6) 1254-1262.
    10.1097/TA.0b013e318156ee4c
  • Aylwin CJ, König TC, Brennan NW et al. (2006). Reduction in critical mortality in urban mass casualty incidents: analysis of triage, surge, and resource use after the London bombings on July 7, 2005. Lancet 368, (9554) 2219-2225.
    10.1016/S0140-6736(06)69896-6
  • Rickard MJFX, Brohi K, Bautz PC (2005). Pancreatic and duodenal injuries: Keep it simple. ANZ J SURG 75, (7) 581-586.
    10.1111/j.1445-2197.2005.03351.x
  • Brohi K, Healy M, Fotheringham T et al. (2005). Helical computed tomographic scanning for the evaluation of the cervical spine in the unconscious, intubated trauma patient. J Trauma 58, (5) 897-901.
    10.1097/01.ta.0000171984.25699.35
  • Brohi K, Singh J, Heron M et al. (2003). Acute traumatic coagulopathy. J TRAUMA 54, (6) 1127-1130.
    10.1097/01.TA.0000069184.82147.06
  • Walsh M, Brohi K, Cord-Udy C (2003). Splenectomy after major trauma: could more spleens be saved?. ANN ROY COLL SURG 85, (3) 221-222.
    10.1308/003588403321661541
  • Kyriakides C, Bicknell CD, Walsh M et al. (2003). Minimal-access aortic surgery: techniques and early experience. BRITISH JOURNAL OF SURGERY 90, (4) 495-496.
  • Oakley P, Brohi K, Wilson A et al. (2003). Guidelines for initial management and assessment of spinal injury British Trauma Society, 2002. Injury 34, (6) 405-425.
    10.1016/S0020-1383(02)00354-6
  • Brohi K (2003). Use of the internet to improve trauma care. Trauma 5, (2) 117-122.
    10.1191/1460408603ta276oa
  • Henderson KIM, Coats TJ, Hassan TB et al. (2000). Audit of time to emergency trauma laparotomy. British Journal of Surgery 87, (4) 472-476.
    10.1046/j.1365-2168.2000.01392.x
  • Brohi K, Wilson-Macdonald J (2000). Evaluation of unstable cervical spine injury: A 6-year experience. Journal of Trauma - Injury, Infection and Critical Care 49, (1) 76-80.
    10.1097/00005373-200007000-00011
  • Brohi K, Dhadly P, Mauger J (1999). The role of prehospital surgical cricothyroidotomy and methods of tracheal intubation. The Journal of trauma 46, (4) 745-.
    10.1097/00005373-199904000-00043
  • Fackler ML, Mason RT, Ross RT et al. (1999). Letter to the editor (multiple letters). Journal of Trauma - Injury, Infection and Critical Care 46, (4) 741-746.
    10.1097/00005373-199904000-00037
  • Ravalia A, Brohi K (1995). Fractured neck of femur in a patient with a complicated medical condition. British Journal of Hospital Medicine 53, (11) 588-.

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