Dr Paul Vulliamy

I joined C4TS in October 2015 as a clinical research fellow and PhD student, taking time out of my training in general surgery. I am now a clinical lecturer in trauma sciences and specialist registrar in general surgery. I took up my current position after completing my PhD in the group in 2018.

My primary research focus is on the role of platelets in the pathophysiology of acute traumatic coagulopathy and post-injury organ dysfunction. I have a particular interest in the immunomodulatory roles of platelets, the mechanisms of damage sensing by platelets, and the behaviour of transfused platelets during major haemorrhage.

In addition to my research activities, I co-ordinate medical student placements within the group and I am the co-lead of the Haemorrhage and Coagulopathy module of the Trauma Sciences MSc. I am also co-principal investigator of the ACITII study, our platform observational study, and a founding member of the National trauma research and innovation collaborative (NaTRIC). I participate regularly in our public engagement activities, and run outreach events through the Blizard Institute which support young people from the local community to get involved in scientific and clinical careers.

Contact

email: p.vulliamy@qmul.ac.uk

Vulliamy P, Gillespie S, Armstrong PC, Allan HE, Warner TD, Brohi K. Histone H4 induces platelet ballooning and microparticle release during trauma hemorrhage. Proc Natl Acad Sci U S A. 2019 Aug 27;116(35):17444-17449. doi: 10.1073/pnas.1904978116.

Cole E, Gillespie S, Vulliamy P, Brohi K; Organ Dysfunction in Trauma (ORDIT) study collaborators. Multiple organ dysfunction after trauma. Br J Surg. 2019 Nov 6. doi: 10.1002/bjs.11361.

Sordi R, Chiazza F, Collotta D, Migliaretti G, Colas RA, Vulliamy P, Brohi K, Dalli J, Collino M, Thiemermann C. Resolvin D1 Attenuates the Organ Injury Associated With Experimental Hemorrhagic Shock. Ann Surg. 2019 Jun 7. doi: 10.1097/SLA.0000000000003407

Vulliamy P, Thaventhiran AJ, Davenport RA. What's new for trauma haemorrhage management? Br J Hosp Med (Lond). 2019 May 2;80(5):268-273. doi: 10.12968/hmed.2019.80.5.268.

Vulliamy P, Faulkner M, Kirkwood G, West A, O’Neill B, Griffiths MP, Moore F, Brohi K.   Temporal and geographic patterns of stab injuries in young people: a retrospective cohort study from a UK major trauma centre. BMJ Open. 2018 Nov 6;8(10):e023114. doi: 10.1136/bmjopen-2018-023114.

Gall LS*, Vulliamy P*, Gillespie S, Jones TF, Pierre RSJ, Breukers SE, Gaarder C, Juffermans NP, Maegele M, Stensballe J, Johansson PI, Davenport RA, Brohi K; Targeted Action for Curing Trauma-Induced Coagulopathy (TACTIC) partners. The S100A10 Pathway Mediates an Occult Hyperfibrinolytic Subtype in Trauma Patients. Ann Surg. 2019 Jun;269(6):1184-1191. doi: 10.1097/SLA.0000000000002733 *Joint first authors

Vulliamy P, Gillespie S, Gall LS, Green L, Brohi K, Davenport RA. Platelet transfusions reduce fibrinolysis but do not restore platelet function during trauma haemorrhage. J Trauma Acute Care Surg (In press)

Symons N, Moorthy K, Vincent C, Arora S, Vulliamy P, Davenport R, Theodoropoulou K. Reliability in the process of care during emergency general surgical admission. Int J Surg 2016;32:143-9)

Manson J, Cole E, De’Ath H, Vulliamy P, Meier U, Pennington D, Brohi K. Early changes within the lymphocyte population are associated with the development of multiple organ failure in trauma patients: an observational cohort study. Crit Care. 2016 Jun 7;20(1):176.

Vulliamy P, McCluney S, Ashby L, Mukherjee S, Amalesh T. Post-operative Elevation of the Neutrophil:Lymphocyte Ratio Predicts Complications Following Oesophageal Resection. World J Surg 2016; 40(6):1397-403

Vulliamy P, McCluney S, Raouf S, Banerjee S. Urgent Referrals for Suspected Colorectal Cancer. Annals of the Royal College of Surgeons of England. 2016 Aug 23:1-4

Vulliamy P, Perkins Z, Brohi K, Manson j. Persistent Lymphopenia is an Independent Predictor of Mortality in Critically Ill Emergency Surgical Patients. Eur J Tr Em Surg 2015 Oct 26 (epub ahead of print)

Abukar A, Leung P, Vulliamy P, Cheatle T. An unusual cause of abdominal pain. BMJ Case Reports 2015 Aug 9

Vulliamy P, Junaid I. Peer-Mentoring Junior Surgical Trainees in the United Kingdom.: A Pilot Program. Med Educ Online. 2013;18:1-3

Vulliamy P, Hariharan V, Gutmann J, Mukherjee D. Superior mesenteric artery syndrome and the ‘nutcracker phenomenon.’ BMJ Case Rep 2013 Mar 21

Vulliamy P, Berner AM, Farooq MS, Srilekha A. Near-fatal small bowel ischaemia secondary to sacrocolpopexy mesh. BMJ Case Rep. 2013 Jan 25

Vulliamy P, Lau K, Wood AJ. Vanishing Lung Syndrome. BMJ 2012;344:e2876

Vulliamy P, McCormack DJ, Szczeklik MS, Lall K. Coarctation Repair Mimicking Acute Aortic Dissection. Eur J Cardiothorac Surg. 2012 Dec;42(6):1055.

De’Ath H, Vulliamy P, Davies C, Uppal R. A Large Ventricular Septal Defect Complicating Resuscitation After Blunt Trauma. J Emerg Trauma Shock. 2012 Oct;5(4):350-2.

Vulliamy P, Srilekha A, Fotiadis N, Kyriakides C. Operative Repair of a Giant Hepatic Artery Aneurysm. Journal of Surgical Case Reports 2011 3:1.

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