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Professor Adina Michael-Titus

Professor of Neuroscience

I lead the research group investigating new neuroprotective strategies in traumatic brain and spinal cord injury.

I lead the Centre for Neuroscience, Surgery and Trauma, and as a neuroscientist and pharmacologist. I am particularly interested in the development of new therapeutic interventions in traumatic spinal cord injury and brain injury. The Neurotrauma Group that I lead has strong links with clinicians at the Royal London Hospital who are working on brain and spinal cord injury patients, and includes several PhD students, MSc students and post-doctoral researchers. We investigate various aspects of trauma in the central nervous system and peripheral nervous system using experimental models, and more recently we have also become involved in clinical studies in neurotrauma.

I am a Fellow of the British Pharmacological Society and I am also one of the Directors of the International Society for the Study of Fatty Acids and Lipids.

Teaching

I am a Fellow of the Higher Education Academy and teach neuroscience and neuropharmacology in several programmes, at undergraduate and postgraduate level; Lecturer and module convenor for the MBBS degree and Intercalated Neuroscience BSc; Programme Director and lecturer on the MSc in Neuroscience and Translational Medicine; Lecturer on the MSc in Trauma Sciences. In recognition of my activity and results as a teacher, in 2011 I was awarded the Drapers’ Award for Excellence in Teaching and Learning.

Research interests

My main research interest is in the development of new therapeutic strategies for the management of spinal cord injury and brain injury patients. Over the last decade we have developed a large programme of research on a specific polyunsaturated fatty acid which has shown neuroprotective potential in models of spinal cord injury and brain injury and we are at the stage of clinical translation, focused on the development of an optimum formulation, for the first studies in patients. We are also exploring other potential therapeutic targets and diversifying our experimental models and functional endpoints, as well as the assessment of the evolution of the injury using structural and functional imaging, similar to that used in the clinic. Thus, by improving our modelling of neuronal injury, the work in experimental models becomes more relevant to the clinical injury situation.

My group has also started a programme of studies on strategies that could support neurorepair in the chronic phase post-injury, and we have obtained very interesting data with a specialised medical multi-nutrient which has significant potential to enhance neuroplasticity after traumatic injuries. We are also developing a research programme on the link between neurotrauma and neurodegenerative disease.

Current research projects

· Exploration of stable forms of docosahexaenoic acid for acute neuroprotection

· Combinatorial strategies for enhanced recovery after neurotrauma

· The link between traumatic brain injury and brain senescence

· Multiple concussion in the juvenile brain

· Specialised metabolic and nutritional support of white matter in brain ageing and post-injury

· Lipidomic signature of the acute phase after brain and spinal cord injur

Contact

email: A.T.Michael-Titus@qmul.ac.uk
Tel: +44 (0) 207 882 2290

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  • Lee WLA, Michael-Titus AT, Shah DK (2017). Hypoxic-Ischaemic Encephalopathy and the Blood-Brain Barrier in Neonates. Developmental Neuroscience 39, (1-4) 49-58.
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  • Michael-Titus AT, Priestley JV (2014). Omega-3 fatty acids and traumatic neurological injury: from neuroprotection to neuroplasticity?. Trends Neurosci 37, (1) 30-38.
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  • Nikolakopoulou Z, Nteliopoulos G, Michael-Titus AT et al. (2013). Omega-3 polyunsaturated fatty acids selectively inhibit growth in neoplastic oral keratinocytes by differentially activating ERK1/2. Carcinogenesis 34, (12) 2716-2725.
    10.1093/carcin/bgt257
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  • Priestley JV, Michael-Titus AT, Tetzlaff W (2012). Limiting spinal cord injury by pharmacological intervention. Handb Clin Neurol 109463-484.
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  • Gladman SJ, Ward RE, Michael-Titus AT et al. (2010). The effect of mechanical strain or hypoxia on cell death in subpopulations of rat dorsal root ganglion neurons in vitro. Neuroscience 171, (2) 577-587.
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  • Jokic N, Yip PK, Michael-Titus A et al. (2010). The human G93A-SOD1 mutation in a pre-symptomatic rat model of amyotrophic lateral sclerosis increases the vulnerability to a mild spinal cord compression. BMC Genomics 11633-633.
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    10.1016/j.neuroscience.2010.04.053
  • Dyall SC, Michael GJ, Michael-Titus AT (2010). Omega-3 fatty acids reverse age-related decreases in nuclear receptors and increase neurogenesis in old rats. J Neurosci Res 88, (10) 2091-2102.
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  • Kiasalari Z, Salehi I, Zhong Y et al. (2010). Identification of Perineal Sensory Neurons Activated by Innocuous Heat. J COMP NEUROL 518, (2) 137-162.
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  • Michael-Titus A, Revest P, Shortland P (2010). 1 ORGANIZATION OF THE NERVOUS SYSTEM. 1-30.
    10.1016/b978-0-7020-3373-5.00001-0
  • Michael-Titus A, Revest P, Shortland P (2010). 10 MOTOR SYSTEMS II THE BASAL GANGLIA. 181-197.
    10.1016/b978-0-7020-3373-5.00010-1
  • Michael-Titus A, Revest P, Shortland P (2010). 11 STROKE AND HEAD INJURY. 199-226.
    10.1016/b978-0-7020-3373-5.00011-3
  • Michael-Titus A, Revest P, Shortland P (2010). 12 INFECTION IN THE CENTRAL NERVOUS SYSTEM. 227-236.
    10.1016/b978-0-7020-3373-5.00012-5
  • Michael-Titus A, Revest P, Shortland P (2010). 13 EPILEPSY. 237-250.
    10.1016/b978-0-7020-3373-5.00013-7
  • Michael-Titus A, Revest P, Shortland P (2010). 14 DEMENTIA. 251-266.
    10.1016/b978-0-7020-3373-5.00014-9
  • Michael-Titus A, Revest P, Shortland P (2010). 15 SCHIZOPHRENIA. 267-279.
    10.1016/b978-0-7020-3373-5.00015-0
  • Michael-Titus A, Revest P, Shortland P (2010). 16 DEPRESSION AND ANXIETY. 281-300.
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  • Michael-Titus A, Revest P, Shortland P (2010). 17 ADDICTION. 301-313.
    10.1016/b978-0-7020-3373-5.00017-4
  • Michael-Titus A, Revest P, Shortland P (2010). 2 ELEMENTS OF CELLULAR AND MOLECULAR NEUROSCIENCE. 31-46.
    10.1016/b978-0-7020-3373-5.00002-2
  • Michael-Titus A, Revest P, Shortland P (2010). 3 CLINICAL EXAMINATION. 47-58.
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  • Michael-Titus A, Revest P, Shortland P (2010). 4 THE SPINAL CORD. 59-78.
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  • Michael-Titus A, Revest P, Shortland P (2010). 5 PAIN AND ANALGESIA. 79-104.
    10.1016/b978-0-7020-3373-5.00005-8
  • Michael-Titus A, Revest P, Shortland P (2010). 6 CRANIAL NERVES AND THE BRAINSTEM. 105-119.
    10.1016/b978-0-7020-3373-5.00006-x
  • Michael-Titus A, Revest P, Shortland P (2010). 7 THE VISUAL SYSTEM. 121-140.
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  • Michael-Titus A, Revest P, Shortland P (2010). 8 HEARING AND BALANCE THE AUDITORY AND VESTIBULAR SYSTEMS. 141-158.
    10.1016/b978-0-7020-3373-5.00008-3
  • Michael-Titus A, Revest P, Shortland P (2010). 9 MOTOR SYSTEMS I DESCENDING PATHWAYS AND CEREBELLUM. 159-180.
    10.1016/b978-0-7020-3373-5.00009-5
  • Wann AK, Mistry J, Michael-Titus A et al. (2010). Eicosapenaenoic acid (EPA) and docasahexaenoic acid (DHA) reduce IL-1β mediated cartilage degradation. European Cells and Materials 20, (SUPPL.2) 6-.
  • Wann AKT, Mistry J, Blain EJ et al. (2010). Eicosapentaenoic acid and docosahexaenoic acid reduce interleukin-1β-mediated cartilage degradation. Arthritis Res Ther 12, (6) R207-.
    10.1186/ar3183
  • Lim S-N, Huang W, Hall JCE et al. (2010). The acute administration of eicosapentaenoic acid is neuroprotective after spinal cord compression injury in rats. Prostaglandins Leukot Essent Fatty Acids 83, (4-6) 193-201.
    10.1016/j.plefa.2010.08.003
  • Nikolakopoulou Z, Michael-Titus AT, Parkinson EK (2009). Abstract B152: The selective effect of omega-3 polyunsaturated fatty acids on normal and neoplastic oral keratinocyte apoptosis. Molecular Cancer Therapeutics 8, (12_Supplement) b152-b152.
    10.1158/1535-7163.targ-09-b152
  • Huang WL, Bhavsar A, Ward RE et al. (2009). Arachidonyl Trifluoromethyl Ketone Is Neuroprotective after Spinal Cord Injury. J NEUROTRAUM 26, (8) 1429-1434.
    10.1089/neu.2008.0835
  • Huang W, Bhavsar A, Ward RE et al. (2009). Arachidonyl trifluoromethyl ketone is neuroprotective after spinal cord injury. J Neurotrauma 26, (8) 1429-1434.
    10.1089/neu.2008.0835
  • Hall JCE, Priestley JV, Perry VH et al. (2009). WINTR VISA AWARD WINNER DOES ACUTE TREATMENT WITH DOCOSAHEXAENOIC OR EICOSAPENTAENOIC ACID AFFECT INFLAMMATORY MARKERS FOLLOWING COMPRESSION SPINAL CORD INJURY?. JOURNAL OF NEUROTRAUMA 26, (8) A45-A45.
  • Michael-Titus AT (2009). Omega-3 fatty acids: their neuroprotective and regenerative potential in traumatic neurological injury. CLIN LIPIDOL 4, (3) 343-353.
    10.2217/CLP.09.19
  • Michael-Titus AT, Albert M, Michael GJ et al. (2008). SONU20176289, a compound combining partial dopamine D(2) receptor agonism with specific serotonin reuptake inhibitor activity, affects neuroplasticity in an animal model for depression. Eur J Pharmacol 598, (1-3) 43-50.
    10.1016/j.ejphar.2008.09.006
  • Hall JCE, Michael-Titus A, Perry VH et al. (2008). The inflammatory response and locomotor recovery following a spinal compression injury. JOURNAL OF NEUROIMMUNOLOGY 197, (2) 172-172.
  • Malaspina A, Michael-Titus AT (2008). Is the modulation of retinoid and retinoid-associated signaling a future therapeutic strategy in neurological trauma and neurodegeneration?. J NEUROCHEM 104, (3) 584-595.
    10.1111/j.1471-4159.2007.05071.x
  • Dyall SC, Michael-Titus AT (2008). Neurological Benefits of Omega-3 Fatty Acids. NEUROMOL MED 10, (4) 219-235.
    10.1007/s12017-008-8036-z
  • Jokic N, Ling YY, Ward RE et al. (2007). Retinoid receptors in chronic degeneration of the spinal cord: observations in a rat model of amyotrophic lateral sclerosis. J Neurochem 103, (5) 1821-1833.
    10.1111/j.1471-4159.2007.04893.x
  • Huang WL, King VR, Curran OE et al. (2007). A combination of intravenous and dietary docosahexaenoic acid significantly improves outcome after spinal cord injury. Brain 130, (Pt 11) 3004-3019.
    10.1093/brain/awm223
  • King VR, Averill SA, Hewazy D et al. (2007). Erythropoietin and carbamylated erythropoietin are neuroprotective following spinal cord hemisection in the rat. Eur J Neurosci 26, (1) 90-100.
    10.1111/j.1460-9568.2007.05635.x
  • Dyall SC, Michael GJ, Whelpton R et al. (2007). Dietary enrichment with omega-3 polyunsaturated fatty acids reverses age-related decreases in the GluR2 and NR2B glutamate receptor subunits in rat forebrain. Neurobiol Aging 28, (3) 424-439.
    10.1016/j.neurobiolaging.2006.01.002
  • Makwana M, Raivich G, Dyall S et al. (2007). Effect of docosahexaenoic acid in a mouse facial nerve injury model. OCL - Oleagineux Corps Gras Lipides 14, (3-4) 233-.
    10.1051/ocl.2007.0233
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    10.1051/ocl.2007.0234
  • Michael-Titus AT (2007). Omega-3 fatty acids and neurological injury. Prostaglandins Leukot Essent Fatty Acids 77, (5-6) 295-300.
    10.1016/j.plefa.2007.10.021
  • Dyall SC, Michael GJ, Michael-Titus AT (2007). Omega-3 polyunsaturated fatty acids reverse age-related decreases in retinoic acid receptors, retinoid x receptors and peroxisome-proliferator-activated receptors in rat forebrain. OCL - Oleagineux Corps Gras Lipides 14, (3-4) 232-.
    10.1051/ocl.2007.0232
  • King VR, Huang WL, Dyall SC et al. (2006). Omega-3 fatty acids improve recovery, whereas omega-6 fatty acids worsen outcome, after spinal cord injury in the adult rat. J Neurosci 26, (17) 4672-4680.
    10.1523/JNEUROSCI.5539-05.2006
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  • Nazir S, Michael GJ, Michael-Titus AT (2002). Distribution of NMDA and AMPA glutamate receptor subunits in rat prefrontal cortex and the effect of chronic imipramine treatment on the GluR2 subunit. BRIT J PHARMACOL 135.
  • Hawkins A, McCune L, Whelpton R et al. (2002). Effect of noradrenaline and 5-HT on excitatory amino acid release in rat prefrontal cortex. BRIT J PHARMACOL 135.
  • Whelpton R, Michael-Titus AT, Fox A (2002). Bioanalysis of temoporfin, a new pharmacodynamic therapy agent. CHROMATOGRAPHIA 55S177-S181.
    10.1007/BF02493376
  • Michael-Titus AT, Fernandes K, Setty H et al. (2002). In vivo metabolism and clearance of substance P and co-expressed tachykinins in rat striatum. Neuroscience 110, (2) 277-286.
    10.1016/s0306-4522(01)00530-9
  • Toner CC, Connell K, Whelpton R et al. (2001). Effects of sevoflurane on dopamine, glutamate and aspartate release in an in vitro model of cerebral ischaemia. BRIT J ANAESTH 86, (4) 550-554.
    10.1093/bja/86.4.550
  • Khan S, Whelpton R, Michael-Titus AT (2000). Substance P modulation of striatal dopamine outflow is determined by M1 and M2 muscarinic receptors in male Wistar rats. Neuroscience Letters 293, (3) 179-182.
    10.1016/S0304-3940(00)01529-9
  • Michael-Titus AT, Bains S, Jeetle J et al. (2000). Imipramine and phenelzine decrease glutamate overflow in the prefrontal cortex - A possible mechanism of neuroprotection in major depression?. Neuroscience 100, (4) 681-684.
    10.1016/S0306-4522(00)00390-0
  • Michael-Titus AT, Blackburn D, Connolly Y et al. (1999). N-and C-terminal substance P fragments: Differential effects on striatal [3H]substance P binding and NK1 receptor internalization. NeuroReport 10, (10) 2209-2213.
    10.1097/00001756-199907130-00038
  • Whelpton R, Michael-Titus AT, Stephens SM et al. (1998). Identification of substance P metabolites using a combination of reversed-phase high-performance liquid chromatography and capillary electrophoresis. Journal of Chromatography B: Biomedical Applications 716, (1-2) 95-106.
    10.1016/S0378-4347(98)00334-X
  • Khan S, Sandhu J, Whelpton R et al. (1998). Substance P fragments and striatal endogenous dopamine outflow: Interaction with substance P. Neuropeptides 32, (6) 519-526.
    10.1016/S0143-4179(98)90080-4
  • MichaelTitus AT, Whelpton R, Stephens SM et al. (1997). Metabolism of substance P in rat striatum studies using a combination of high performance liquid chromatography (HPLC) and capillary electrophoresis (CE). BRIT J PHARMACOL 122P79-P79.
  • Khan S, Sandhu J, Whelpton R et al. (1996). Substance fragments, SP1-9 and SP6-11, modulate endogenous dopamine outflow in rat striatum. BRIT J PHARMACOL 119P175-P175.
  • Khan S, Whelpton R, Michael-Titus AT (1996). Evidence for modulatory effects of substance P fragments (1-4) and (8-11) on endogenous dopamine outflow in rat striatal slices. Neuroscience Letters 205, (1) 33-36.
    10.1016/0304-3940(96)12363-6
  • Whelpton R, Michael-Titus AT, Jamdar RP et al. (1996). Distribution and excretion of radiolabeled temoporfin in a murine tumor model. Photochemistry and Photobiology 63, (6) 885-891.
    10.1111/j.1751-1097.1996.tb09646.x
  • Khan S, Grogan E, Whelpton R et al. (1996). N- and C-terminal substance P fragments modulate striatal dopamine outflow through a cholinergic link mediated by muscarinic receptors. Neuroscience 73, (4) 919-927.
    10.1016/0306-4522(96)00119-4
  • KHAN S, GROGAN E, WHELPTON R et al. (1995). SUBSTANCE-P AND ITS FRAGMENT-(1-7) AND FRAGMENT-(5-11) MODULATE STRIATAL DOPAMINE OUTFLOW VIA A CHOLINERGIC LINK MEDIATED BY MUSCARINIC RECEPTORS. BRIT J PHARMACOL 116P96-P96.
  • Khan S, Brooks N, Whelpton R et al. (1995). Substance P-(1-7) and substance P-(5-11) locally modulate dopamine release in rat striatum. European Journal of Pharmacology 282, (1-3) 229-233.
    10.1016/0014-2999(95)00342-I
  • KHAN S, WHELPTON R, MICHAEL-TITUS A (1995). ENDOGENOUS DOPAMINE OUTFLOW FROM RAT STRIATAL SLICES IN STATIC AND DYNAMIC CONDITIONS. NEUROSCI RES COMMUN 16, (3) 145-153.
  • IRAVANI MM, KHAN S, MICHAELTITUS A et al. (1995). EFFECTS OF 6-HYDROXYDOPAMINE LESIONS IN THE VENTRAL TEGMENTAL AREA OR SUBSTANTIA-NIGRA ON DOPAMINE RELEASE IN SUBREGIONS OF THE RAT STRIATUM. BRIT J PHARMACOL 114P337-P337.
  • WHELPTON R, MICHAELTITUS AT, YAQUB Z (1995). TEMOPORFIN BINDING TO HUMAN SERUM-LIPOPROTEINS. BRIT J PHARMACOL 114P265-P265.
  • Michael‐Titus A, Whelpton R, Yaqub Z (1995). Binding of temoporfin to the lipoprotein fractions of human serum. British Journal of Clinical Pharmacology 40, (6) 594-597.
    10.1111/j.1365-2125.1995.tb05805.x
  • Whelpton R, Michael‐Titus AT, Basra SS et al. (1995). DISTRIBUTION OF TEMOPORFIN, A NEW PHOTOSENSITIZER FOR THE PHOTODYNAMIC THERAPY OF CANCER, IN A MURINE TUMOR MODEL. Photochemistry and Photobiology 61, (4) 397-401.
    10.1111/j.1751-1097.1995.tb08629.x
  • Das D, Rogers J, Michael-Titus AT (1994). Comparative study of the effects of mu, delta and kappa opioid agonists on 3H-dopamine uptake in rat striatum and nucleus accumbens. Neuropharmacology 33, (2) 221-226.
    10.1016/0028-3908(94)90012-4
  • Dourmap N, Michael‐Titus A, Costentin J (1992). Differential Effect of Intrastriatal Kainic Acid on the Modulation of Dopamine Release by μ‐ and δ‐Opioid Peptides: A Microdialysis Study. Journal of Neurochemistry 58, (2) 709-713.
    10.1111/j.1471-4159.1992.tb09775.x
  • Bousselmame R, Michael-Titus A, Costentin J (1991). Desensitization of μ-opioid receptors does not modify the analgesia induced by an enkephalinase inhibitor. European Journal of Pharmacology 203, (2) 295-297.
    10.1016/0014-2999(91)90728-9
  • Bousselmame R, Eustache M, Michael-Titus A et al. (1991). Chronic inhibition of enkephalinase induces changes in the antinociceptive and locomotor effects of the enkephalinase inhibitor acetorphan in rats. Neuropharmacology 30, (8) 865-870.
    10.1016/0028-3908(91)90120-Z
  • Michael-Titus A, Bousselmame R, Costentin J (1990). Stimulation of dopamine D2 receptors induces an analgesia involving an opiodergic but non enkephalinergic link. European Journal of Pharmacology 187, (2) 201-207.
    10.1016/0014-2999(90)90007-S
  • Dourmap N, Michael-Titus A, Costentin J (1990). Local enkephalins tonically modulate dopamine release in the striatum: a microdialysis study. Brain Research 524, (1) 153-155.
    10.1016/0006-8993(90)90505-6
  • Dourmap N, Michael‐Titus A, Costentin J (1990). Acetorphan, an Enkephalinase Inhibitor, Modulates Dopaminergic Transmission in Rat Olfactory Tubercle, but not in the Nucleus Accumbens and Striatum. European Journal of Neuroscience 2, (9) 783-787.
    10.1111/j.1460-9568.1990.tb00469.x
  • Costentin J, Duterte-Boucher D, Panissaud C et al. (1990). Dopamine D1 and D2 receptors mediate opposite effects of apomorphine on the body temperature of reserpinized mice. Neuropharmacology 29, (1) 31-35.
    10.1016/0028-3908(90)90080-B
  • Michael-Titus A, Dourmap N, Costentin J et al. (1990). Role of delta opioid receptors in the effects of inhibitors of enkephalin-degrading peptidases on the horizontal and vertical components of locomotion in mice. Neuropeptides 15, (2) 89-100.
    10.1016/0143-4179(90)90044-Y
  • Michael-Titus A, Dourmap N, Costentin J (1989). MU and delta opioid receptors control differently the horizontal and vertical components of locomotor activity in mice. Neuropeptides 13, (4) 235-242.
    10.1016/0143-4179(89)90076-0
  • Michael-Titus A, Dourmap N, Caline H et al. (1989). Role of endogenous enkephalins in locomotion and nociception studied with peptidase inhibitors in two inbred strains of mice (C57BL/6J AND DBA/2J). Neuropharmacology 28, (2) 117-122.
    10.1016/0028-3908(89)90046-4
  • Duterte-Eoucher D, Panissaud C, Michael-Titus A et al. (1989). Stimulation of central D1 dopamine receptors reverses reserpine-induced hypothermia in mice. Neuropharmacology 28, (4) 419-421.
    10.1016/0028-3908(89)90039-7
  • Michael-Titus A, Preterre P, Giros B et al. (1987). Role of endogenous enkephalins in locomotion evidenced by acetorphan, an 'enkephalinase' inhibitor. Journal of Pharmacology and Experimental Therapeutics 243, (3) 1062-1066.
  • Michael-Titus A, Costentin J (1987). Analgesic effects of metapramine and evidence against the involvement of endogenous enkephalins in the analgesia induced by tricyclic antidepressants. Pain 31, (3) 391-400.
    10.1016/0304-3959(87)90167-9

 

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