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Professor Chris Thiemermann

Professor of Pharmacology, Centre Lead for Translational Medicine & Therapeutics

Chris Thiemermann is the co-lead of the Organ Dysfunction and Protection Research Theme (together with Professor Karim Brohi) within the C4TS. Chris is Professor of Pharmacology and Centre Lead for Translational Medicine & Therapeutics at the William Harvey Research Institute (WHRI) and has 30 years’ experience in sepsis/traumatic shock research.

Supervision

(1) Role of IKK in the activation of NF-kB in sepsis, trauma and acute kidney injury; 

(2) Gender-differences in the response to sepsis and trauma; 

(3) Aging and response to tissue injury and shock; 

(4) Development of translatable interventions aimed at reducing the organ injury/dysfunction in trauma.

Research interests:

Chris has expertise in target discovery and evaluation of the efficacy of drugs in animal models of disease. His specific field of interest encompasses the pathophysiology of shock caused by trauma or sepsis, and reperfusion injury following ischemia (i.e. a restriction in blood supply to tissues, causing a shortage of oxygen and glucose needed to keep tissue alive). Hi research focuses upon the discovery of novel therapeutic targets and interventions that can be translated from the laboratory models of these diseases into the clinic for protection against associated organ injury.

Other research interests include the pathophysiology and treatment of (a) acute and chronic kidney disease and (b) acute myocardial infarction. Chris Thiemermann's lead role within the Organ Failure and Protection Research Theme aligns closely with his research at the William Harvey Research Institute (WHRI). To visit the WHRI's website click here.

Contact

email: c.thiemermann@qmul.ac.uk
Tel: +44 (0) 207 882 2121

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  • Thaventhiran A, Thiemermann C, Brohi K et al. (2021). O1: DISCOVERING NOVEL THERAPEUTICS TO TREAT ACUTE TRAUMATIC COAGULOPATHY (ATC). British Journal of Surgery 108, (Supplement_1) .
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  • Alliouachene S, Kieswich J, Bilanges B et al. (). Uninephrectomy and class II PI3K-C2β inactivation synergistically protect against obesity, insulin resistance and liver steatosis in mice. American Journal of Transplantation .
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  • Praditsuktavorn B, Wall J, Thiemermann C et al. (2020). Rescuing Cardiac Dysfunction Following Traumatic Haemorrhagic Injury. CIRCULATION 142, (24) E496-E497.
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  • VOISIN M, leoni G, WOODFIN A et al. (2019). Neutrophil elastase plays a non-redundant role in remodeling the venular basement membrane and neutrophil diapedesis post ischemia/reperfusion injury. Journal of Pathology 248, (1) 88-102.
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  • Andrikopoulos P, Kieswich J, Pacheco S et al. (2019). The MEK inhibitor trametinib ameliorates kidney fibrosis by suppressing ERK1/2 and mTORC1 signaling. Journal of the American Society of Nephrology 30, (1) 33-49.
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  • Busch D, Kapoor A, Rademann P et al. (2018). Delayed activation of PPAR-β/δ improves long-term survival in mouse sepsis: effects on organ inflammation and coagulation. Innate Immunity 24, (4) 262-273.
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  • Martin L, Thiemermann C (2018). Mitochondrial DNA in acute kidney injury: Chicken or egg?. Shock 49, (3) 352-353.
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  • Tremoleda JL, Watts SA, Reynolds PS et al. (2017). MODELING ACUTE TRAUMATIC HEMORRHAGIC SHOCK INJURY: CHALLENGES AND GUIDELINES FOR PRECLINICAL STUDIES. Shock 48, (6) 610-623.
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  • Purvis GSD, Chiazza F, Chen J et al. (2017). Annexin A1 attenuates microvascular complications through restoration of Akt signalling in a murine model of type 1 diabetes. Diabetologia .
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  • Martin L, Derwall M, Thiemermann C et al. (2017). Heart in sepsis: Molecular mechanisms, diagnosis and therapy of septic cardiomyopathy. Anaesthesist 66, (7) 479-490.
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  • Yamada N, Martin L, Zechendorf E et al. (2017). A NOVEL SYNTHETIC, HOST-DEFENCE PEPTIDE PROTECTS AGAINST ORGAN INJURY/DYSFUNCTION IN A RAT-MODEL OF SEVERE HEMORRHAGIC SHOCK. SHOCK 47, (6) 116-117.
  • Martin L, Chen J, Zechendorf E et al. (2017). ROLE OF THE beta-D-ENDOGLUCURONIDASE HEPARANASE IN SEPTIC CARDIOMYOPATHY. SHOCK 47, (6) 129-129.
  • Osuchowski MF, Thiemermann C, Remick DG (2017). Sepsis-3 on the Block: What Does It Mean for Preclinical Sepsis Modeling?. Shock 47, (5) 658-660.
    10.1097/SHK.0000000000000775
  • Purvis GSD, Chiazza F, Collino M et al. (2017). Endogenous Annexin-A1 is a Protective Determinant in HFD-induced Insulin Resistance and Diabetic Nephropathy. FASEB JOURNAL 31.
  • Kalbitz M, Waller C, Huber-Lang M et al. (2017). OXYGEN in the HEART: HOW MUCH IS TOO MUCH?. Shock 47, (4) 531-532.
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  • Yamada N, Lukas M, Zechendorf E et al. (). Novel Synthetic, Host-defense Peptide Protects Against Organ Injury/Dysfunction in a Rat Model of Severe Hemorrhagic Shock. Annals of Surgery .
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  • Purvis GSD, Chiazza F, Solito E et al. (2017). Endogenous annexin-A1 is a protective determinant in high-fat diet (HFD)-induced insulin resistance and diabetic nephropathy. DIABETIC MEDICINE 3426-26.
    10.1111/dme.42_13304
  • Davenport RA, Guerreiro M, Frith D et al. (2017). Activated Protein C Drives the Hyperfibrinolysis of Acute Traumatic Coagulopathy. Anesthesiology 126, (1) 115-127.
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  • Chen J, Kieswich JE, Chiazza F et al. (2017). IκB Kinase Inhibitor Attenuates Sepsis-Induced Cardiac Dysfunction in CKD. Journal of the American Society of Nephrology : JASN 28, (1) 94-105.
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  • Martin L, Horst K, Chiazza F et al. (2016). The synthetic antimicrobial peptide 19-2.5 attenuates septic cardiomyopathy and prevents down-regulation of SERCA2 in polymicrobial sepsis. Scientific Reports 6.
    10.1038/srep37277
  • Yamada N, Martin L, Sordi R et al. (2016). A NOVEL SYNTHETIC PEPTIDE PROTECTS AGAINST ORGAN INJURY IN A RAT-MODEL OF SEVERE HAEMORRHAGIC SHOCK. SHOCK 46, (4) 34-35.
  • Chen J, Hamers AJP, Finsterbusch M et al. (2016). ACTIVATION OF TRPV1 BY 12(S)-HPETE AND 20-HETE RELEASES CGRP AND PROTECTS THE HEART AGAINST THE CARDIAC DYSFUNCTION CAUSED BY LPS. SHOCK 46, (4) 31-32.
  • Martin LB, Zechendorf E, Chen J et al. (2016). THE SYNTHETIC ANTIMICROBIAL PEPTIDE 19-2.5 ATTENUATES SEPTIC CARDIOMYOPATHY IN A MURINE MODEL OF POLYMICROBIAL SEPSIS. SHOCK 46, (4) 31-31.
  • Asfar P, Thiemermann C, Radermacher P (2016). Norepinephrine, the Intensivist's Swiss Army Knife for Circulatory Shock?. Shock 46, (1) 106-107.
    10.1097/SHK.0000000000000590
  • Coldewey SM, Benetti E, Collino M et al. (2016). Elevation of serum sphingosine-1-phosphate attenuates impaired cardiac function in experimental sepsis. Scientific Reports 627594-27594.
    10.1038/srep27594
  • Chen J, Thiemermann C (2016). Selenium and niacin for sepsis therapy: The sum is greater than its parts. Critical Care Medicine 44, (6) 1256-1257.
    10.1097/CCM.0000000000001493
  • Sordi R, Chiazza F, Collino M et al. (2016). Neuronal Nitric Oxide Synthase is Involved in Vascular Hyporeactivity and Multiple Organ Dysfunction Associated with Hemorrhagic Shock. SHOCK 45, (5) 525-533.
    10.1097/SHK.0000000000000533
  • Gaffney VJ, Mota-Filipe H, Pinto RA et al. (2016). Chemical and biochemical characterization and in vivo safety evaluation of pharmaceuticals in drinking water. Environmental toxicology and chemistry / SETAC .
    10.1002/etc.3451
  • Chen J, Hamers AJP, Finsterbusch M et al. (2016). Activation of TRPV1 by 12(s)-HpETE and 20-HETE Releases CGRP and Protects the Heart Against the Cardiac Dysfunction Caused by LPS. FASEB JOURNAL 30.
  • Sordi R, Nandra KK, Chiazza F et al. (2016). Artesunate Protects Against the Organ Injury and Dysfunction Induced by Severe Hemorrhage and Resuscitation. Annals of surgery .
  • Sordi R, Nandra KK, Chiazza F et al. (2016). Artesunate Protects Against the Organ Injury and Dysfunction Induced by Severe Hemorrhage and Resuscitation. Ann Surg .
    10.1097/SLA.0000000000001664
  • Madalli S, Beyrau M, Whiteford J et al. (2015). Sex-specific regulation of chemokine Cxcl5/6 controls neutrophil recruitment and tissue injury in acute inflammatory states. Biology of Sex Differences 6, (1) .
    10.1186/s13293-015-0047-5
  • Chiazza F, Couturier-Maillard A, Benetti E et al. (2015). Targeting the NLRP3 inflammasome to reduce diet-induced metabolic abnormalities in mice. Molecular Medicine 211025-1037.
    10.2119/molmed.2015.00104
  • Coldewey SM, Benetti E, Collino M et al. (2015). ENHANCED SPHINGOSINE-1-PHOSPHATE LEVELS ATTENUATE CARDIAC DYSFUNCTION IN EXPERIMENTAL SEPTIC CARDIOMYOPATHY. SHOCK 4417-17.
  • Coldewey SM, Benetti E, Collino M et al. (2015). Enhanced sphingosine-1-phosphate levels ameliorate murine septic cardiomyopathy. Intensive Care Medicine Experimental 3.
    10.1186/2197-425X-3-S1-A615
  • Wall JM, Tremoleda JL, Thiemermann C et al. (2015). HEART FATTY ACID BINDING PROTEIN (H-FABP) IS A BIOMARKER OF TRAUMA-INDUCED SECONDARY CARDIAC INJURY IN A PRE-CLINICAL MODEL OF TRAUMA-HAEMORRHAGE. SHOCK 4421-22.
  • Chen J, Kieswich J, Chiazza F et al. (2015). THE CARDIAC DYSFUNCTION CAUSED BY SEPSIS IN ANIMALS WITH CHRONIC KIDNEY DISEASE IS ATTENUATED BY INHIBITING I kappa B KINASE. SHOCK 4416-16.
  • Johnson F, Patel N, Collino M et al. (2015). THE LATE INHIBITION OF INHIBITOR OF IKB KINASE ATTENUATES ACUTE KIDNEY INJURY AND THE SUBSEQUENT DEVELOPMENT OF FIBROSIS IN A RAT MODEL OF ISCHAEMIA REPERFUSION INJURY. SHOCK 4410-10.
  • Sordi R, Nandra KK, Chiazza F et al. (2015). TRAUMA ORGAN PROTECTION WITH ARTESUNATE (TOP-ART): PRECLINICAL EFFICACY OF AN ANTIMALARIAL DRUG WITH EXCELLENT SAFETY PROFILE AND PLANNED PHASE II RCT. SHOCK 441-1.
  • Hache G, Osuchowski M, Thiemermann C (2015). Does Insulin Protect the Brain in Mice and Man with Sepsis?. Shock 44, (3) 287-.
    10.1097/SHK.0000000000000423
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  • Hide E, Piper J, Nev P et al. (1995). Cardioprotective effects of prostaglandin E1 in the rabbit are abolished by a blocker of ATP-sensitive potassium channels. Pharmacological Research 3178-.
    10.1016/1043-6618(95)86570-5
  • Akarasereenont P, Bakhle YS, Thiemermann C et al. (1995). Cytokine‐mediated induction of cyclo‐oxygenase‐2 by activation of tyrosine kinase in bovine endothelial cells stimulated by bacterial lipopolysaccharide. British Journal of Pharmacology 115, (3) 401-408.
    10.1111/j.1476-5381.1995.tb16347.x
  • De Kimpe SJ, Hunter ML, Bryant CE et al. (1995). Delayed circulatory failure due to the induction of nitric oxide synthase by lipoteichoic acid from Staphylococcus aureus in anaesthetized rats. British Journal of Pharmacology 114, (6) 1317-1323.
    10.1111/j.1476-5381.1995.tb13349.x
  • Perretti M, Szabó C, Thiemermann C (1995). Effect of interleukin‐4 and interleukin‐10 on leucocyte migration and nitric oxide production in the mouse. British Journal of Pharmacology 116, (4) 2251-2257.
    10.1111/j.1476-5381.1995.tb15061.x
  • Klemm P, Thiemermann C, Winklmaier G et al. (1995). Effects of nitric oxide synthase inhibition combined with nitric oxide inhalation in a porcine model of endotoxin shock. British Journal of Pharmacology 114, (2) 363-368.
    10.1111/j.1476-5381.1995.tb13235.x
  • Kengatharan M, Battistini B, Warner TD et al. (1995). Endothelin-1 mediates the increase in ex vivo coronary vascular resistance induced by hemorrhagic shock in the anesthetized rat. Journal of Cardiovascular Pharmacology 26S422-S424.
    10.1097/00005344-199526003-00124
  • Hide EJ, Piper J, Thiemermann C (1995). Endothelin‐1 ‐induced reduction of myocardial infarct size by activation of ATP‐sensitive potassium channels in a rabbit model of myocardial ischaemia and reperfusion. British Journal of Pharmacology 116, (6) 2597-2602.
    10.1111/j.1476-5381.1995.tb17213.x
  • Wu C, Thiemermann C, Vane JR (1995). Glibenclamide‐induced inhibition of the expression of inducible nitric oxide synthase in cultured macrophages and in the anaesthetized rat. British Journal of Pharmacology 114, (6) 1273-1281.
    10.1111/j.1476-5381.1995.tb13343.x
  • Klemm P, Hecker M, Stockhausen H et al. (1995). Inhibition by N‐acetyl‐5‐hydroxytryptamine of nitric oxide synthase expression in cultured cells and in the anaesthetized rat. British Journal of Pharmacology 115, (7) 1175-1181.
    10.1111/j.1476-5381.1995.tb15021.x
  • De Kimpe SJ, Thiemermann C, Vane JR (1995). Intracellular release of PAF contributes to the induction of nitric oxide synthase in a model of gram-positive shock. Pharmacological Research 31305-.
    10.1016/1043-6618(95)87480-1
  • Southan GJ, Szabó C, Thiemermann C (1995). Isothioureas: potent inhibitors of nitric oxide synthases with variable isoform selectivity. British Journal of Pharmacology 114, (2) 510-516.
    10.1111/j.1476-5381.1995.tb13256.x
  • Bryant CE, Tomlinson A, Mitchell JA et al. (1995). Nitric oxide synthase in the rat fallopian tube is regulated during the oestrous cycle. Journal of Endocrinology 146, (1) 149-157.
    10.1677/joe.0.1460149
  • Hide EJ, Ney P, Piper J et al. (1995). Reduction by prostaglandin E1 or prostaglandin E0 of myocardial infarct size in the rabbit by activation of ATP‐sensitive potassium channels. British Journal of Pharmacology 116, (5) 2435-2440.
    10.1111/j.1476-5381.1995.tb15092.x
  • Szabó C, Thiemermann C (1995). Regulation of the Expression of the Inducible Isoform of Nitric Oxide Synthase. Advances in Pharmacology 34, (C) 113-153.
    10.1016/S1054-3589(08)61083-2
  • De Kimpe SJ, Thiemermann C, Vane JR (1995). Role for intracellular platelet‐activating factor in the circulatory failure in a model of Gram‐positive shock. British Journal of Pharmacology 116, (8) 3191-3198.
    10.1111/j.1476-5381.1995.tb15123.x
  • Kengatharan M, De Kimpe SJ, Thiemermann C et al. (1995). Role of tyrosine kinase and NFκB in the induction of nitric oxide synthase by lipoteichoic acid in cultured murine macrophages. Pharmacological Research 3165-.
    10.1016/1043-6618(95)86521-7
  • Thiemermann C (1995). Selective inhibition of the activity of inducible nitric oxide synthase in septic shock. Progress in clinical and biological research 392383-392.
  • Hohlfeld T, Klemm P, Thiemermann C et al. (1995). The contribution of tumour necrosis factor‐α and endothelin‐1 to the increase of coronary resistance in hearts from rats treated with endotoxin. British Journal of Pharmacology 116, (8) 3309-3315.
    10.1111/j.1476-5381.1995.tb15140.x
  • Akarasereenont P, Hide E, Ney P et al. (1995). The induction of cyclooxygenase-2 elicited by endotoxin in endothelial cells and macrophages is inhibited by prostaglandin E1 and 13,14-dihydro prostaglandin E1. Agents and Actions 45, (SUPPL. I) 59-64.
    10.1007/978-3-0348-7346-8_9
  • Thiemermann C, Ruetten H, Wu C et al. (1995). The multiple organ dysfunction syndrome caused by endotoxin in the rat: attenuation of liver dysfunction by inhibitors of nitric oxide synthase. British Journal of Pharmacology 116, (7) 2845-2851.
    10.1111/j.1476-5381.1995.tb15935.x
  • Bakhle YS, Akarasereenont PA, Thiemermann C et al. (1995). Tyrosine kinase is essential for induction of COX-2 in endothelial cells by LPS or inflammatory cytokines. Pharmacological Research 31312-.
    10.1016/1043-6618(95)87506-9
  • Szabó C, Southan GJ, Thiemermann C (1994). Beneficial effects and improved survival in rodent models of septic shock with S-methylisothiourea sulfate, a potent and selective inhibitor of inducible nitric oxide synthase. Proceedings of the National Academy of Sciences of the United States of America 91, (26) 12472-12476.
    10.1073/pnas.91.26.12472
  • Wood PJ, Sansom JM, Butler SA et al. (1994). Induction of hypoxia in experimental murine tumors by the nitric oxide synthase inhibitor, NG-nitro-L-arginine. Cancer Res 54, (24) 6458-6463.
  • Southan GJ, Szabó C, Thiemermann C (1994). Inhibition of the induction of nitric oxide synthase by spermine is modulated by aldehyde dehydrogenase. Biochemical and Biophysical Research Communications 203, (3) 1638-1644.
    10.1006/bbrc.1994.2374
  • McMurdo L, Thiemermann C, Vane JR (1994). The endothelin ETB receptor agonist, IRL 1620, causes vasodilation and inhibits ex vivo platelet aggregation in the anaesthetised rabbit. European Journal of Pharmacology 259, (1) 51-55.
    10.1016/0014-2999(94)90156-2
  • Wood PJ, Sansom JM, Stratford IJ et al. (1994). Modification of metabolism of transplantable and spontaneous murine tumors by the nitric oxide synthase inhibitor, nitro-L-arginine. International Journal of Radiation Oncology, Biology, Physics 29, (3) 443-447.
    10.1016/0360-3016(94)90435-9
  • Wu CC, Szabó C, Chen SJ et al. (1994). Activation of soluble guanylyl cyclase by a factor other than nitric oxide or carbon monoxide contributes to the vascular hyporeactivity to vasoconstrictor agents in the aorta of rats treated with endotoxin. Biochemical and Biophysical Research Communications 201, (1) 436-442.
    10.1006/bbrc.1994.1720
  • Szabó C, Thiemermann C, Wu CC et al. (1994). Attenuation of the induction of nitric oxide synthase by endogenous glucocorticoids accounts for endotoxin tolerance in vivo. Proceedings of the National Academy of Sciences of the United States of America 91, (1) 271-275.
    10.1073/pnas.91.1.271
  • Wellings RP, Corder R, Warner TD et al. (1994). Evidence from receptor antagonists of an important role for ETB receptor‐mediated vasoconstrictor effects of endothelin‐1 in the rat kidney. British Journal of Pharmacology 111, (2) 515-520.
    10.1111/j.1476-5381.1994.tb14767.x
  • Szabó C, Southan GJ, Wood E et al. (1994). Inhibition by spermine of the induction of nitric oxide synthase in J774.2 macrophages: requirement of a serum factor. British Journal of Pharmacology 112, (2) 355-356.
    10.1111/j.1476-5381.1994.tb13078.x
  • SzabÓ C, Thiemermann C (1994). Invited opinion: Role of nitric oxide in hemorrhagic, traumatic, and anaphylactic shock and thermal injury. Shock 2, (2) 145-154.
    10.1097/00024382-199408000-00011
  • Akarasereenont P, Mitchell JA, Appleton I et al. (1994). Involvement of tyrosine kinase in the induction of cyclo‐oxygenase and nitric oxide synthase by endotoxin in cultured cells. British Journal of Pharmacology 113, (4) 1522-1528.
    10.1111/j.1476-5381.1994.tb17169.x
  • Thiemermann C (1994). The Role of the L-Arginine: Nitric Oxide Pathway in Circulatory Shock. 2845-79.
    10.1016/S1054-3589(08)60493-7
  • McMurdo L, Thiemermann C, Vane JR (1994). The effects of the endothelin ETA receptor antagonist, FR 139317, on infarct size in a rabbit model of acute myocardial ischaemia and reperfusion. British Journal of Pharmacology 112, (1) 75-80.
    10.1111/j.1476-5381.1994.tb13032.x
  • Szabó C, Southan GJ, Thiemermann C et al. (1994). The mechanism of the inhibitory effect of polyamines on the induction of nitric oxide synthase: role of aldehyde metabolites. British Journal of Pharmacology 113, (3) 757-766.
    10.1111/j.1476-5381.1994.tb17058.x
  • Mitchell JA, Akarasereenont P, Thiemermann C et al. (1993). Selectivity of nonsteroidal antiinflammatory drugs as inhibitors of constitutive and inducible cyclooxygenase. Proceedings of the National Academy of Sciences of the United States of America 90, (24) 11693-11697.
    10.1073/pnas.90.24.11693
  • Szabó C, Wu CC, Gross SS et al. (1993). Interleukin-1 contributes to the induction of nitric oxide synthase by endotoxin in vivo. European Journal of Pharmacology 250, (1) 157-160.
    10.1016/0014-2999(93)90634-T
  • Szabo C, Mitchell JA, Gross SS et al. (1993). Nifedipine inhibits the induction of nitric oxide synthase by bacterial lipopolysaccharide. Journal of Pharmacology and Experimental Therapeutics 265, (2) 674-680.
  • Szabó C, Thiemermann C, Vane JR (1993). Dihydropyridine Antagonists and Agonists of Calcium Channels Inhibit the Induction of Nitric Oxide Synthase by Endotoxin in Cultured Macrophages. Biochemical and Biophysical Research Communications 196, (2) 825-830.
    10.1006/bbrc.1993.2323
  • McMurdo L, Sessa WC, Thiemermann C et al. (1993). Ischaemia and reperfusion enhances the coronary vasoconstrictor effects of endothelin-1 in the rat isolated perfused heart. Pharmacology Communications 3, (2) 183-192.
  • Wood PJ, Stratford IJ, Adams GE et al. (1993). Modification of energy metabolism and radiation response of a murine tumor by changes in nitric oxide availability. Biochemical and Biophysical Research Communications 192, (2) 505-510.
    10.1006/bbrc.1993.1444
  • Thiemermann C, Szabo C, Mitchell JA et al. (1993). Vascular hyporeactivity to vasoconstrictor agents and hemodynamic decompensation in hemorrhagic shock is mediated by nitric oxide. Proceedings of the National Academy of Sciences of the United States of America 90, (1) 267-271.
    10.1073/pnas.90.1.267
  • Thiemermann C (1993). Drugs which modulate nitric oxide homeostasis are likely to provide therapeutic benefit in cardiovascular disease. Cardiovascular Research 27, (12) 2104-.
    10.1093/cvr/27.12.2104
  • Thiemermann C, Mitchell JA, Ferns GAA (1993). Eicosanoids and atherosclerosis. Current Opinion in Lipidology 4, (5) 401-406.
    10.1097/00041433-199310000-00009
  • McMurdo L, Lidbury PS, Corder R et al. (1993). Heterogeneous receptors mediate endothelin-1-induced changes in blood pressure, hematocrit, and platelet aggregation. Journal of Cardiovascular Pharmacology 22, (SUPPL. 8) .
    10.1097/00005344-199322008-00050
  • McMurdo L, Corder R, Thiemermann C et al. (1993). Incomplete inhibition of the pressor effects of endothelin‐1 and related peptides in the anaesthetized rat with BQ‐123 provides evidence for more than one vasoconstrictor receptor. British Journal of Pharmacology 108, (2) 557-561.
    10.1111/j.1476-5381.1993.tb12840.x
  • Szabo C, Thiemermann C, Vane JR (1993). Inhibition of the production of nitric oxide and vasodilator prostaglandins attenuates the cardiovascular response to bacterial endotoxin in adrenalectomized rats. Proceedings of the Royal Society B: Biological Sciences 253, (1338) 233-238.
    10.1098/rspb.1993.0108
  • McMurdo L, Thiemermann C, Vane JR (1993). Ischaemia and Reperfusion Enhances the Vasoconstrictor Effects of Endothelin-1 in the Isolated Perfused Heart of the Rat. 187-188.
    10.1007/978-1-4615-2437-3_38
  • McMurdo L, Lidbury PS, Thiemermann C et al. (1993). Mediation of endothelin‐1‐induced inhibition of platelet aggregation via the ETB receptor. British Journal of Pharmacology 109, (2) 530-534.
    10.1111/j.1476-5381.1993.tb13602.x
  • Cristol J, Warner TD, Thiemermann C et al. (1993). Mediation via different receptors of the vasoconstrictor effects of endothelins and sarafotoxins in the systemic circulation and renal vasculature of the anaesthetized rat. British Journal of Pharmacology 108, (3) 776-779.
    10.1111/j.1476-5381.1993.tb12877.x
  • Szabó C, Mitchell JA, Thiemermann C et al. (1993). Nitric oxide‐mediated hyporeactivity to noradrenaline precedes the induction of nitric oxide synthase in endotoxin shock. British Journal of Pharmacology 108, (3) 786-792.
    10.1111/j.1476-5381.1993.tb12879.x
  • Szabó C, Wu CC, Mitchell JA et al. (1993). Platelet-activating factor contributes to the induction of nitric oxide synthase by bacterial lipopolysaccharide. Circulation Research 73, (6) 991-999.
    10.1161/01.RES.73.6.991
  • Thiemermann C, Wu C, Szabó C et al. (1993). Role of tumour necrosis factor in the induction of nitric oxide synthase in a rat model of endotoxin shock. British Journal of Pharmacology 110, (1) 177-182.
    10.1111/j.1476-5381.1993.tb13789.x
  • Cristol JP, Thiemermann C, Mitchell JA et al. (1993). Support of renal blood flow after ischaemic‐reperfusion injury by endogenous formation of nitric oxide and of cyclo‐oxygenase vasodilator metabolites. British Journal of Pharmacology 109, (1) 188-194.
    10.1111/j.1476-5381.1993.tb13552.x
  • Wellings RP, Warner TD, Thiemermann C et al. (1993). Vasoconstriction in the rat kidney induced by endothelin-1 is blocked by PD 145065. Journal of Cardiovascular Pharmacology 22, (SUPPL. 8) .
    10.1097/00005344-199322008-00028
  • Thiemermann C, Corder R (1992). Is endothelin-1 the regulator of myofibroblast contraction during wound healing?. Laboratory Investigation 67, (6) 677-679.
  • CRISTOL JP, WARNER TD, THIEMERMANN C et al. (1992). THE VASOCONSTRICTOR EFFECTS OF ENDOTHELINS AND SARAFOTOXINS IN THE SYSTEMIC CIRCULATION AND RENAL VASCULATURE ARE MEDIATED VIA DIFFERENT RECEPTORS. BRITISH JOURNAL OF PHARMACOLOGY 107P278-P278.
  • Tettamanti R, Bianchi G, Vitte PA et al. (1992). A novel insight into the mechanism of the antithrombotic action of defibrotide. Life Sciences 51, (19) 1545-1555.
    10.1016/0024-3205(92)90565-7
  • Huneidi AHS, Thiemermann C, Lidbury PS et al. (1992). Do Endothelin-1 (ET-1) and human big-endothelin (b-ET) cause subarachnoid haemorrhage?. Journal of Neurology Neurosurgery and Psychiatry 55, (1) 77-.
  • Sprague RS, Thiemermann C, Vane JR (1992). Endogenous endothelium-derived relaxing factor opposes hypoxic pulmonary vasoconstriction and supports blood flow to hypoxic alveoli in anesthetized rabbits. Proceedings of the National Academy of Sciences of the United States of America 89, (18) 8711-8715.
    10.1073/pnas.89.18.8711
  • Walder CE, Thiemermann C, Vane JR (1992). NG‐hydroxy‐L‐arginine prevents the haemodynamic effects of nitric oxide synthesis inhibition in the anaesthetized rat. British Journal of Pharmacology 107, (2) 476-480.
    10.1111/j.1476-5381.1992.tb12770.x
  • Thiemermann C (1991). Biosynthesis and interaction of endothelium-derived vasoactive mediators. Eicosanoids 4, (4) 187-202.
  • Thiemermann C, Al-Damluji S, Hecker M et al. (1991). FMRF-amide and L-Arg-L-Phe increase blood pressure and heart rate in the anaesthetised rat by central stimulation of the sympathetic nervous system. Biochemical and Biophysical Research Communications 175, (1) 318-324.
    10.1016/S0006-291X(05)81237-9
  • Huneidi AHS, Thiemermann C, Lidbury PS et al. (1991). Endothelin-1 and big endothelin cause subarachnoid hemorrhage in the anesthetized rabbit. Journal of Cardiovascular Pharmacology 17S492-S495.
    10.1097/00005344-199100177-00140
  • Walder CE, Thiemermann C, Vane JR (1991). Inhibition of EDRF Synthesis Reduces the Pentagastrin-Induced Hyperaemia of the Rat Gastric Mucosa. 293-293.
    10.1007/978-1-4615-3736-6_62
  • Thiemermann C, Mustafa M, Mester PA et al. (1991). Inhibition of the release of endothelium‐derived relaxing factor in vitro and in vivo by dipeptides containing NG‐nitro‐l‐arginine. British Journal of Pharmacology 104, (1) 31-38.
    10.1111/j.1476-5381.1991.tb12380.x
  • Walder CE, Thiemermann C, Vane JR (1991). The involvement of endothelium‐derived relaxing factor in the regulation of renal cortical blood flow in the rat. British Journal of Pharmacology 102, (4) 967-973.
    10.1111/j.1476-5381.1991.tb12285.x
  • Lidbury PS, Thiemermann C, Korbut R et al. (1990). Endothelins release tissue plasminogen activator and prostanoids. European Journal of Pharmacology 186, (2-3) 205-212.
    10.1016/0014-2999(90)90435-9
  • Thiemermann C, Vane J (1990). Inhibition of nitric oxide synthesis reduces the hypotension induced by bacterial lipopolysaccharides in the rat in vivo. European Journal of Pharmacology 182, (3) 591-595.
    10.1016/0014-2999(90)90062-B
  • Hecker M, Mitchell JA, Harris HJ et al. (1990). Endothelial cells metabolize NG-monomethyl-L-arginine to L-citrulline and subsequently to L-arginine. Biochemical and Biophysical Research Communications 167, (3) 1037-1043.
    10.1016/0006-291X(90)90627-Y
  • Walder CE, Thiemermann C, Vane JR (1990). EDRF-mediation of the pentagastrin-induced hyperaemia in the gastric mucosa of the anaesthetized rat in vivo. Journal of Physiology 425.
  • Thiemermann C, May GR, Page CP et al. (1990). Endothelin-1 inhibits platelet aggregation in vivo: a study with 111indium-labelled platelets. British Journal of Pharmacology 99, (2) 303-308.
    10.1111/j.1476-5381.1990.tb14699.x
  • Walder CE, Thiemermann C, Vane JR (1990). Endothelium-derived relaxing factor participates in the increased blood flow in response to pentagastrin in the rat stomach mucosa. Proceedings of the Royal Society B: Biological Sciences 241, (1302) 195-200.
    10.1098/rspb.1990.0085
  • Hecker M, Mitchell JA, Harris HJ et al. (1990). N(G)-monomethyl-L-arginine but not N(ω)-nitro-L-arginine is metabolized by endothelial cells to L-citrulline. European Journal of Pharmacology 183, (2) 648-649.
    10.1016/0014-2999(90)93576-C
  • Thomas GR, Walder CE, Thiemermann C et al. (1990). Regional vascular resistance and haemodynamics in the spontaneously hypertensive rat: The effects of bradykinin. Journal of Cardiovascular Pharmacology 15, (2) 211-217.
    10.1097/00005344-199002000-00006
  • Schror K, Thiemermann C (1989). Eicosanoids in myocardial ischemia. Biomedica Biochimica Acta 48, (10) 729-734.
  • Lidbury PS, Thiemermann C, Roger Thomas G et al. (1989). Endothelin-3: selectivity as an anti-aggregatory peptide in vivo. European Journal of Pharmacology 166, (2) 335-338.
    10.1016/0014-2999(89)90079-4
  • Thiemermann C, Thomas GR, Vane JR (1989). Defibrotide reduces infarct size in a rabbit model of experimental myocardial ischaemia and reperfusion. British Journal of Pharmacology 97, (2) 401-408.
    10.1111/j.1476-5381.1989.tb11967.x
  • Thiemermann C, Thomas GR, Vane JR (1989). Effects of defibrotide on infarct size and regional myocardial blood flow on the ischaemic reperfused rabbit heart. Progress in clinical and biological research 301131-135.
  • Thiemermann C, Lidbury PS, Roger Thomas G et al. (1989). Endothelin-1 releases prostacyclin and inhibits ex vivo platelet aggregation in the anesthetized rabbit. Journal of Cardiovascular Pharmacology 13S138-S141.
    10.1097/00005344-198900135-00034
  • Hohlfeld T, Thiemermann C, Schrör K (1989). Protection from myocardial ischemic injury in cats and pigs by defibrotide--different mode of action?. Progress in clinical and biological research 301137-141.
  • Schrör K, Thiemermann C, Löbel P (1989). Stimulation of Vascular Prostacyclin Formation by Defibrotide: A New Strategy for Treatment of Acute Myocardial Ischaemia. 83-93.
    10.1007/978-3-642-73585-1_12
  • Walder CE, Roger Thomas G, Thiemermann C et al. (1989). The hemodynamic effects of endothelin-1 in the pithed rat. Journal of Cardiovascular Pharmacology 13S93-S97.
    10.1097/00005344-198900135-00023
  • Thiemermann C, Lidbury P, Thomas R et al. (1988). Endothelin inhibits ex vivo platelet aggregation in the rabbit. European Journal of Pharmacology 158, (1-2) 181-182.
    10.1016/0014-2999(88)90273-7
  • Thiemermann C, Ney P, Schror K (1988). Protection of the ischaemic myocardium from reperfusion injury by defibrotide and its possible mechanism of action. Biomedica Biochimica Acta 47, (10-11) .
  • Thiemermann C, Ney P, Schrör K (1988). The thromboxane receptor antagonist, daltroban, protects the myocardium from ischaemic injury resulting in suppression of leukocytosis. European Journal of Pharmacology 155, (1-2) 57-67.
    10.1016/0014-2999(88)90402-5
  • Thiemermann C, Schrör K (1988). Kardioprotektive Wirkung von Prostaglandin E1 auf das reperfundierte ischämische Myokard im Tierversuch. 34-44.
    10.1007/978-3-642-73943-9_4
  • Schrör K, Thiemermann C, Ney P (1988). Protection of the ischemic myocardium from reperfusion injury by prostaglandin E1 inhibition of ischemia-induced neutrophil activation. Naunyn-Schmiedeberg's Archives of Pharmacology 338, (3) 268-274.
    10.1007/BF00173399
  • Thomas GR, Thiemermann C, Walder C et al. (1988). The effects of endothelium‐dependent vasodilators on cardiac output and their distribution in the anaesthetized rat: a comparison with sodium nitroprusside. British Journal of Pharmacology 95, (3) 986-992.
    10.1111/j.1476-5381.1988.tb11729.x
  • Thiemermann C, Smith EF, Schrör K (1986). Successful treatment of acute myocardial ischaemia with teopranitol-a novel organic nitrate. European Heart Journal 7, (5) 418-424.
    10.1093/oxfordjournals.eurheartj.a062083
  • Schrör K, Thiemermann C (1986). Treatment of acute myocardial ischaemia with a selective antagonist of thromboxane receptors (BM 13.177). British Journal of Pharmacology 87, (4) 631-637.
    10.1111/j.1476-5381.1986.tb14579.x
  • Thiemermann C, Löbel P, Schrör K (1985). Usefulness of defibrotide in protecting ischemic myocardium from early reperfusion damage. The American Journal of Cardiology 56, (15) 978-982.
    10.1016/0002-9149(85)90416-3
  • Thiemermann C, Schror K (1984). Comparison of the thromboxane synthetase inhibitor dazoxiben and the prostacyclin mimetic iloprost in an animal model of acute ischaemia and reperfusion. Biomedica Biochimica Acta 43, (8-9) .
  • Thiemermann C, Steinhagen-Thiessen E, Schrör K (1984). Inhibition of oxygen-centered free radical formation by the stable prostacyclin-mimetic iloprost (ZK 36 374) in acute myocardial ischemia. Journal of Cardiovascular Pharmacology 6, (2) 365-366.
    10.1097/00005344-198403000-00025
  • Thiemermann C, Smith EF, Schrör K (1984). Kardioprotektive Wirkung von Teopranitol (KC 046) bei akuter myokardialer Ischämie im Tierversuch. 34-40.
    10.1007/978-3-642-85341-8_4

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