Professor Chris Thiemermann

Professor of Pharmacology, Centre Lead for Translational Medicine & Therapeutics

Chris Thiemermann is the co-lead of the Organ Dysfunction and Protection Research Theme (together with Professor Karim Brohi) within the C4TS. Chris is Professor of Pharmacology and Centre Lead for Translational Medicine & Therapeutics at the William Harvey Research Institute (WHRI) and has 30 years’ experience in sepsis/traumatic shock research.

Supervision

(1) Role of IKK in the activation of NF-kB in sepsis, trauma and acute kidney injury; 

(2) Gender-differences in the response to sepsis and trauma; 

(3) Aging and response to tissue injury and shock; 

(4) Development of translatable interventions aimed at reducing the organ injury/dysfunction in trauma.

Research interests:

Chris has expertise in target discovery and evaluation of the efficacy of drugs in animal models of disease. His specific field of interest encompasses the pathophysiology of shock caused by trauma or sepsis, and reperfusion injury following ischemia (i.e. a restriction in blood supply to tissues, causing a shortage of oxygen and glucose needed to keep tissue alive). Hi research focuses upon the discovery of novel therapeutic targets and interventions that can be translated from the laboratory models of these diseases into the clinic for protection against associated organ injury.

Other research interests include the pathophysiology and treatment of (a) acute and chronic kidney disease and (b) acute myocardial infarction. Chris Thiemermann's lead role within the Organ Failure and Protection Research Theme aligns closely with his research at the William Harvey Research Institute (WHRI). To visit the WHRI's website click here.

Contact

email: c.thiemermann@qmul.ac.uk
Tel: +44 (0) 207 882 2121

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    10.1016/j.bbiosy.2022.100047
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    10.3389/fimmu.2022.886421
  • Sheikh MH, Errede M, d'Amati A et al. (2022). Impact of metabolic disorders on the structural, functional, and immunological integrity of the blood-brain barrier: Therapeutic avenues. FASEB Journal 36, (1) .
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    10.3389/fimmu.2022.837180
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  • Mohammad S, Al Zoubi S, Krieg N et al. (2021). A synthetic peptide designed to neutralise lipopolysaccharides attenuates metaflammation and diet-induced metabolic derangements in mice. BRITISH JOURNAL OF PHARMACOLOGY 178, (24) 4998-4999.
  • Peine A, Hallawa A, Bickenbach J et al. (2021). Development and validation of a reinforcement learning algorithm to dynamically optimize mechanical ventilation in critical care. npj Digital Medicine 4, (1) .
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    10.3389/fimmu.2021.701275
  • Thaventhiran A, Thiemermann C, Brohi K et al. (2021). O1: DISCOVERING NOVEL THERAPEUTICS TO TREAT ACUTE TRAUMATIC COAGULOPATHY (ATC). British Journal of Surgery 108, (Supplement_1) .
    10.1093/bjs/znab117.001
  • Todorović Z, Ðurašević S, Stojković M et al. (2021). Lipidomics provides new insight into pathogenesis and therapeutic targets of the ischemia—reperfusion injury. International Journal of Molecular Sciences 22, (6) 1-18.
    10.3390/ijms22062798
  • Mohammad S, Thiemermann C (2021). Role of Metabolic Endotoxemia in Systemic Inflammation and Potential Interventions. Frontiers in Immunology 11.
    10.3389/fimmu.2020.594150
  • Alliouachene S, Kieswich J, Bilanges B et al. (). Uninephrectomy and class II PI3K-C2β inactivation synergistically protect against obesity, insulin resistance and liver steatosis in mice. American Journal of Transplantation .
    10.1111/ajt.16470
  • Praditsuktavorn B, Wall J, Thiemermann C et al. (2020). Rescuing Cardiac Dysfunction Following Traumatic Haemorrhagic Injury. CIRCULATION 142, (24) E496-E497.
  • Zechendorf E, Vaßen P, Zhang J et al. (2020). Corrigendum: Heparan Sulfate Induces Necroptosis in Murine Cardiomyocytes: A Medical-in-Silico Approach Combining In Vitro Experiments and Machine Learning (Front. Immunol, (2018), 9, (393), 10.3389/fimmu.2018.00393). Frontiers in Immunology 11.
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    10.1111/bph.15229
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    10.3389/fimmu.2020.581758
  • Schroth J, Thiemermann C, Henson SM (2020). Senescence and the Aging Immune System as Major Drivers of Chronic Kidney Disease. Frontiers in Cell and Developmental Biology 8564461-564461.
    10.3389/fcell.2020.564461
  • Radermacher P, Billiar TR, Ghezzi P et al. (2020). Editorial: Translational Insights Into Mechanisms and Therapy of Organ Dysfunction in Sepsis and Trauma. Frontiers in Immunology 11.
    10.3389/fimmu.2020.01987
  • Kieswich JE, Chen J, Alliouachene S et al. (2020). Immunohistochemistry of Kidney a-SMA, Collagen 1, and Collagen 3, in A Novel Mouse Model of Reno-cardiac Syndrome. Bio Protoc 10, (18) e3751-.
    10.21769/BioProtoc.3751
  • Chen J, Purvis GSD, Collotta D et al. (2020). RvE1 Attenuates Polymicrobial Sepsis-Induced Cardiac Dysfunction and Enhances Bacterial Clearance. Frontiers in Immunology 112080-2080.
    10.3389/fimmu.2020.02080
  • Collotta D, Hull W, Mastrocola R et al. (2020). Baricitinib counteractsmetaflammation thus protecting against diet-induced metabolic abnormalities in mice. DIABETOLOGIA 63, (SUPPL 1) S241-S242.
  • Aziz Q, Chen J, Moyes AJ et al. (2020). Vascular KATP channels protect from cardiac dysfunction and preserve cardiac metabolism during endotoxemia. Journal of Molecular Medicine .
    10.1007/s00109-020-01946-3
  • Purvis GSD, Collino M, Aranda-Tavio H et al. (2020). Inhibition of Bruton's tyrosine kinase regulates macrophage NF-κB and NLRP3 inflammasome activation in metabolic inflammation. Br J Pharmacol .
    10.1111/bph.15182
  • O'Riordan C, Purvis G, Collotta D et al. (2020). X-LINKED IMMUNE DEFECT MICE ARE PROTECTED AGAINST SEPSIS-INDUCED CARDIAC DYSFUNCTION. SHOCK 5397-97.
  • Bangash MN, Abbott TEF, Patel NSA et al. (2020). The Effect of β2-Adrenoceptor Agonists on Leucocyte-Endothelial Adhesion in a Rodent Model of Laparotomy and Endotoxemia. Frontiers in Immunology 11.
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  • Collotta D, Hull W, Mastrocola R et al. (2020). Baricitinib counteracts metaflammation, thus protecting against diet-induced metabolic abnormalities in mice. Molecular Metabolism 39.
    10.1016/j.molmet.2020.101009
  • Zechendorf E, O'Riordan CE, Stiehler L et al. (2020). Ribonuclease 1 attenuates septic cardiomyopathy and cardiac apoptosis in a murine model of polymicrobial sepsis. JCI Insight 5, (8) .
    10.1172/jci.insight.131571
  • Lopez Tremoleda J, Wall J, Naganathar V et al. (2019). Modelling cardiac dysfunction following traumatic haemorrhage injury: impact on myocardial integrity. Frontiers in Immunology 10.
    10.3389/fimmu.2019.02774
  • O'Riordan CE, Purvis GSD, Collotta D et al. (2019). Bruton's Tyrosine Kinase Inhibition Attenuates the Cardiac Dysfunction Caused by Cecal Ligation and Puncture in Mice. Frontiers in Immunology 10.
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  • Randall DW, Kieswich J, Swann J et al. (2019). Batch effect exerts a bigger influence on the rat urinary metabolome and gut microbiota than uraemia: A cautionary tale. Microbiome 7, (1) .
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  • Purvis GS, O'Riordan C, Aranda H et al. (2019). Ibrutinib has anti-inflammatory and anti-diabetic effects in a model of HFD-induced insulin resistance and diabetic nephropathy. BRITISH JOURNAL OF PHARMACOLOGY 176, (16) 2997-2997.
  • Sordi R, Chiazza F, Collotta D et al. (2019). Resolvin D1 Attenuates the Organ Injury Associated With Experimental Hemorrhagic Shock. Ann Surg .
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  • Stiehler L, Riordan CO, Zechendorf E et al. (2019). THE ROLE OF RIBONUCLEASE A AS POTENTIAL NEW THERAPEUTIC IN SEPTIC CARDIOMYOPATHY. SHOCK 51, (6) 83-84.
  • SOLITO EGLE, PURVIS G, THIEMERMANN C (2019). Annexin-A1: therapeutic potential in microvascular disease. Frontiers in Immunology .
    10.3389/fimmu.2019.00938
  • VOISIN M, leoni G, WOODFIN A et al. (2019). Neutrophil elastase plays a non-redundant role in remodeling the venular basement membrane and neutrophil diapedesis post ischemia/reperfusion injury. Journal of Pathology 248, (1) 88-102.
    10.1002/path.5234
  • Martin L, Derwall M, Al Zoubi S et al. (2019). Response. Chest 155, (3) 647-648.
    10.1016/j.chest.2018.10.018
  • Martin L, Derwall M, Al Zoubi S et al. (2019). The Septic Heart: Current Understanding of Molecular Mechanisms and Clinical Implications. Chest 155, (2) 427-437.
    10.1016/j.chest.2018.08.1037
  • Purvis GSD, Collino M, Loiola RA et al. (2019). Identification of Annexina1 as an endogenous regulator of RhoA, and its role in the pathophysiology and experimental therapy of type-2 diabetes. Frontiers in Immunology 10, (MAR) .
    10.3389/fimmu.2019.00571
  • Zingarelli B, Coopersmith CM, Drechsler S et al. (2019). Part I: Minimum Quality Threshold in Preclinical Sepsis Studies (MQTiPSS) for Study Design and Humane Modeling Endpoints. Shock 51, (1) 10-22.
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  • Barry SP, Ounzain S, McCormick J et al. (2019). Retraction notice to “Enhanced IL-17 signalling following myocardial ischaemia/reperfusion injury” [Int. J. Cardiol. 163 (2013) 326–334](S0167527311017050)(10.1016/j.ijcard.2011.08.849). International Journal of Cardiology 274404-.
    10.1016/j.ijcard.2018.10.031
  • Andrikopoulos P, Kieswich J, Pacheco S et al. (2019). The MEK inhibitor trametinib ameliorates kidney fibrosis by suppressing ERK1/2 and mTORC1 signaling. Journal of the American Society of Nephrology 30, (1) 33-49.
    10.1681/ASN.2018020209
  • Osuchowski MF, Hellman J, Huber-Lang M et al. (2019). The Response to the Letter to the Editor Titled: " Is Triple Self-plagiarism "OK" If Only Made Transparent? " by Volker R Jacobs, MD, MBA. Shock 51, (1) 140-141.
    10.1097/SHK.0000000000001294
  • Al Zoubi S, Chen J, Murphy C et al. (2018). Linagliptin Attenuates the Cardiac Dysfunction Associated With Experimental Sepsis in Mice With Pre-existing Type 2 Diabetes by Inhibiting NF-κB. Frontiers in Immunology 9.
    10.3389/fimmu.2018.02996
  • Kieswich JE, Chen J, Alliouachene S et al. (2018). A novel model of reno-cardiac syndrome in the C57BL/ 6 mouse strain 11 Medical and Health Sciences 1103 Clinical Sciences 11 Medical and Health Sciences 1102 Cardiorespiratory Medicine and Haematology. BMC Nephrology 19, (1) .
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  • Osuchowski MF, Ayala A, Bahrami S et al. (2018). Correction to: Minimum Quality Threshold in Pre-Clinical Sepsis Studies (MQTiPSS): an international expert consensus initiative for improvement of animal modeling in sepsis (Infection, (2018), 46, 5, (687-691), 10.1007/s15010-018-1183-8). Infection 46, (5) 745-747.
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  • Osuchowski MF, Ayala A, Bahrami S et al. (2018). Minimum quality threshold in pre-clinical sepsis studies (mqtipss): An international expert consensus initiative for improvement of animal modeling in sepsis. Shock 50, (4) 377-380.
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  • Osuchowski MF, Ayala A, Bahrami S et al. (2018). Minimum quality threshold in pre-clinical sepsis studies (MQTiPSS): an international expert consensus initiative for improvement of animal modeling in sepsis. Intensive Care Medicine Experimental 6, (1) 26-26.
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  • Chen J, Hamers AJP, Finsterbusch M et al. (2018). Endogenously generated arachidonate-derived ligands for TRPV1 induce cardiac protection in sepsis. FASEB J fj201701303R-fj201701303R.
    10.1096/fj.201701303R
  • Khan AI, Kapoor A, Chen J et al. (2018). The Antimalarial Drug Artesunate Attenuates Cardiac Injury in A Rodent Model of Myocardial Infarction. Shock 49, (6) 675-681.
    10.1097/SHK.0000000000000963
  • Khan AI, Kapoor A, Chen J et al. (2018). The Antimalarial Drug Artesunate Attenuates Cardiac Injury in A Rodent Model of Myocardial Infarction. Shock 49, (6) 675-681.
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  • Aswani A, Manson J, Itagaki K et al. (2018). Scavenging circulating mitochondrial DNA as a potential therapeutic option for multiple organ dysfunction in trauma hemorrhage. Frontiers in Immunology 9, (MAY) .
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  • Busch D, Kapoor A, Rademann P et al. (2018). Delayed activation of PPAR-β/δ improves long-term survival in mouse sepsis: effects on organ inflammation and coagulation. Innate Immunity 24, (4) 262-273.
    10.1177/1753425918771748
  • Zechendorf E, Vaßen P, Zhang J et al. (2018). Heparan Sulfate Induces Necroptosis in Murine Cardiomyocytes: A Medical-In silico Approach Combining In vitro Experiments and Machine Learning. Front Immunol 9393-393.
    10.3389/fimmu.2018.00393
  • Martin L, Thiemermann C (2018). Mitochondrial DNA in acute kidney injury: Chicken or egg?. Shock 49, (3) 352-353.
    10.1097/SHK.0000000000000966
  • Purvis GSD, Chiazza F, Chen J et al. (2017). Annexin A1 attenuates microvascular complications through restoration of Akt signalling in a murine model of type 1 diabetes. Diabetologia .
    10.1007/s00125-017-4469-y
  • Briegel J, Möhnle P, Vogeser M et al. (2017). Relative adrenal insufficiency in cardiogenic shock: Is there a need for action?. Shock 48, (4) 498-499.
    10.1097/SHK.0000000000000870
  • Sordi R, Nandra KK, Chiazza F et al. (2017). Artesunate Protects Against the Organ Injury and Dysfunction Induced by Severe Hemorrhage and Resuscitation. Ann Surg 265, (2) 408-417.
    10.1097/SLA.0000000000001664
  • Johnson FL, Patel NSA, Purvis GSD et al. (2017). Inhibition of IκB Kinase at 24 Hours After Acute Kidney Injury Improves Recovery of Renal Function and Attenuates Fibrosis. J Am Heart Assoc 6, (7) .
    10.1161/JAHA.116.005092
  • Martin L, Derwall M, Thiemermann C et al. (2017). Heart in sepsis: Molecular mechanisms, diagnosis and therapy of septic cardiomyopathy. Anaesthesist 66, (7) 479-490.
    10.1007/s00101-017-0329-x
  • Martin L, Gombert A, Chen J et al. (2017). The β-d-Endoglucuronidase Heparanase Is a Danger Molecule That Drives Systemic Inflammation and Correlates with Clinical Course after Open and Endovascular Thoracoabdominal Aortic Aneurysm Repair: Lessons Learnt from Mice and Men. Front Immunol 8681-681.
    10.3389/fimmu.2017.00681
  • Yamada N, Martin L, Zechendorf E et al. (2017). A NOVEL SYNTHETIC, HOST-DEFENCE PEPTIDE PROTECTS AGAINST ORGAN INJURY/DYSFUNCTION IN A RAT-MODEL OF SEVERE HEMORRHAGIC SHOCK. SHOCK 47, (6) 116-117.
  • Martin L, Chen J, Zechendorf E et al. (2017). ROLE OF THE beta-D-ENDOGLUCURONIDASE HEPARANASE IN SEPTIC CARDIOMYOPATHY. SHOCK 47, (6) 129-129.
  • Tremoleda JL, Watts SA, Reynolds PS et al. (2017). Modelling Acute Traumatic Haemorrhagic Shock Injury: Challenges and Guidelines for Preclinical Studies. Shock .
    10.1097/SHK.0000000000000901
  • Osuchowski MF, Thiemermann C, Remick DG (2017). Sepsis-3 on the Block: What Does It Mean for Preclinical Sepsis Modeling?. Shock 47, (5) 658-660.
    10.1097/SHK.0000000000000775
  • Purvis GSD, Chiazza F, Collino M et al. (2017). Endogenous Annexin-A1 is a Protective Determinant in HFD-induced Insulin Resistance and Diabetic Nephropathy. FASEB JOURNAL 31.
  • Kalbitz M, Waller C, Huber-Lang M et al. (2017). OXYGEN in the HEART: HOW MUCH IS TOO MUCH?. Shock 47, (4) 531-532.
    10.1097/SHK.0000000000000760
  • Yamada N, Lukas M, Zechendorf E et al. (). Novel Synthetic, Host-defense Peptide Protects Against Organ Injury/Dysfunction in a Rat Model of Severe Hemorrhagic Shock. Annals of Surgery .
    10.1097/SLA.0000000000002186
  • Purvis GSD, Chiazza F, Solito E et al. (2017). Endogenous annexin-A1 is a protective determinant in high-fat diet (HFD)-induced insulin resistance and diabetic nephropathy. DIABETIC MEDICINE 3426-26.
    10.1111/dme.42_13304
  • Davenport RA, Guerreiro M, Frith D et al. (2017). Activated Protein C Drives the Hyperfibrinolysis of Acute Traumatic Coagulopathy. Anesthesiology 126, (1) 115-127.
    10.1097/ALN.0000000000001428
  • Chen J, Kieswich JE, Chiazza F et al. (2017). IκB Kinase Inhibitor Attenuates Sepsis-Induced Cardiac Dysfunction in CKD. Journal of the American Society of Nephrology : JASN 28, (1) 94-105.
    10.1681/asn.2015060670
  • Martin L, Horst K, Chiazza F et al. (2016). The synthetic antimicrobial peptide 19-2.5 attenuates septic cardiomyopathy and prevents down-regulation of SERCA2 in polymicrobial sepsis. Scientific Reports 6.
    10.1038/srep37277
  • Yamada N, Martin L, Sordi R et al. (2016). A NOVEL SYNTHETIC PEPTIDE PROTECTS AGAINST ORGAN INJURY IN A RAT-MODEL OF SEVERE HAEMORRHAGIC SHOCK. SHOCK 46, (4) 34-35.
  • Chen J, Hamers AJP, Finsterbusch M et al. (2016). ACTIVATION OF TRPV1 BY 12(S)-HPETE AND 20-HETE RELEASES CGRP AND PROTECTS THE HEART AGAINST THE CARDIAC DYSFUNCTION CAUSED BY LPS. SHOCK 46, (4) 31-32.
  • Martin LB, Zechendorf E, Chen J et al. (2016). THE SYNTHETIC ANTIMICROBIAL PEPTIDE 19-2.5 ATTENUATES SEPTIC CARDIOMYOPATHY IN A MURINE MODEL OF POLYMICROBIAL SEPSIS. SHOCK 46, (4) 31-31.
  • Asfar P, Thiemermann C, Radermacher P (2016). Norepinephrine, the Intensivist's Swiss Army Knife for Circulatory Shock?. Shock 46, (1) 106-107.
    10.1097/SHK.0000000000000590
  • Coldewey SM, Benetti E, Collino M et al. (2016). Elevation of serum sphingosine-1-phosphate attenuates impaired cardiac function in experimental sepsis. Scientific Reports 627594-27594.
    10.1038/srep27594
  • Chen J, Thiemermann C (2016). Selenium and niacin for sepsis therapy: The sum is greater than its parts. Critical Care Medicine 44, (6) 1256-1257.
    10.1097/CCM.0000000000001493
  • Sordi R, Chiazza F, Collino M et al. (2016). Neuronal Nitric Oxide Synthase is Involved in Vascular Hyporeactivity and Multiple Organ Dysfunction Associated with Hemorrhagic Shock. SHOCK 45, (5) 525-533.
    10.1097/SHK.0000000000000533
  • Gaffney VJ, Mota-Filipe H, Pinto RA et al. (2016). Chemical and biochemical characterization and in vivo safety evaluation of pharmaceuticals in drinking water. Environmental toxicology and chemistry / SETAC .
    10.1002/etc.3451
  • Chen J, Hamers AJP, Finsterbusch M et al. (2016). Activation of TRPV1 by 12(s)-HpETE and 20-HETE Releases CGRP and Protects the Heart Against the Cardiac Dysfunction Caused by LPS. FASEB JOURNAL 30.
  • Sordi R, Nandra KK, Chiazza F et al. (2016). Artesunate Protects Against the Organ Injury and Dysfunction Induced by Severe Hemorrhage and Resuscitation. Annals of surgery .
  • Sordi R, Nandra KK, Chiazza F et al. (2016). Artesunate Protects Against the Organ Injury and Dysfunction Induced by Severe Hemorrhage and Resuscitation. Ann Surg .
    10.1097/SLA.0000000000001664
  • Coldewey SM, Benetti E, Collino M et al. (2015). Enhanced sphingosine-1-phosphate levels ameliorate murine septic cardiomyopathy. Intensive Care Med Exp 3, (Suppl 1) A615-.
    10.1186/2197-425X-3-S1-A615
  • Madalli S, Beyrau M, Whiteford J et al. (2015). Sex-specific regulation of chemokine Cxcl5/6 controls neutrophil recruitment and tissue injury in acute inflammatory states. Biology of Sex Differences 6, (1) .
    10.1186/s13293-015-0047-5
  • Chiazza F, Couturier-Maillard A, Benetti E et al. (2015). Targeting the NLRP3 inflammasome to reduce diet-induced metabolic abnormalities in mice. Molecular Medicine 211025-1037.
    10.2119/molmed.2015.00104
  • Coldewey SM, Benetti E, Collino M et al. (2015). ENHANCED SPHINGOSINE-1-PHOSPHATE LEVELS ATTENUATE CARDIAC DYSFUNCTION IN EXPERIMENTAL SEPTIC CARDIOMYOPATHY. SHOCK 4417-17.
  • Wall JM, Tremoleda JL, Thiemermann C et al. (2015). HEART FATTY ACID BINDING PROTEIN (H-FABP) IS A BIOMARKER OF TRAUMA-INDUCED SECONDARY CARDIAC INJURY IN A PRE-CLINICAL MODEL OF TRAUMA-HAEMORRHAGE. SHOCK 4421-22.
  • Chen J, Kieswich J, Chiazza F et al. (2015). THE CARDIAC DYSFUNCTION CAUSED BY SEPSIS IN ANIMALS WITH CHRONIC KIDNEY DISEASE IS ATTENUATED BY INHIBITING I kappa B KINASE. SHOCK 4416-16.
  • Johnson F, Patel N, Collino M et al. (2015). THE LATE INHIBITION OF INHIBITOR OF IKB KINASE ATTENUATES ACUTE KIDNEY INJURY AND THE SUBSEQUENT DEVELOPMENT OF FIBROSIS IN A RAT MODEL OF ISCHAEMIA REPERFUSION INJURY. SHOCK 4410-10.
  • Sordi R, Nandra KK, Chiazza F et al. (2015). TRAUMA ORGAN PROTECTION WITH ARTESUNATE (TOP-ART): PRECLINICAL EFFICACY OF AN ANTIMALARIAL DRUG WITH EXCELLENT SAFETY PROFILE AND PLANNED PHASE II RCT. SHOCK 441-1.
  • Hache G, Osuchowski M, Thiemermann C (2015). Does Insulin Protect the Brain in Mice and Man with Sepsis?. Shock 44, (3) 287-.
    10.1097/SHK.0000000000000423
  • Sordi R, Chiazza F, Johnson FL et al. (2015). Inhibition of IκB kinase attenuates the organ injury and dysfunction associated with hemorrhagic shock. Molecular Medicine 21563-575.
    10.2119/molmed.2015.00049
  • Chen J, Kieswich J, Chiazza F et al. (2015). THE CARDIAC DYSFUNCTION CAUSED BY SEPSIS IN ANIMALS WITH CHRONIC KIDNEY DISEASE IS ATTENUATED BY INHIBITING I kappa B KINASE. SHOCK 43, (6) 92-93.
  • Collino M, Thiemermann C, Cerami A et al. (2015). Flipping the molecular switch for innate protection and repair of tissues: Long-lasting effects of a non-erythropoietic small peptide engineered from erythropoietin. Pharmacology and Therapeutics 15132-40.
    10.1016/j.pharmthera.2015.02.005
  • Lilley E, Armstrong R, Clark N et al. (2015). Refinement of animal models of sepsis and septic shock. Shock 43, (4) 304-316.
    10.1097/SHK.0000000000000318
  • Sordi R, Chiazza F, Patel NSA et al. (2015). 'Preconditioning' with low dose lipopolysaccharide aggravates the organ injury/dysfunction caused by hemorrhagic shock in rats. PLoS ONE 10, (4) .
    10.1371/journal.pone.0122096
  • Sand CA, Starr A, Wilder CDE et al. (2015). Quantification of microcirculatory blood flow: A sensitive and clinically relevant prognostic marker in murine models of sepsis. Journal of Applied Physiology 118, (3) 344-354.
    10.1152/japplphysiol.00793.2014
  • Gobbetti T, Coldewey SM, Chen J et al. (2014). Nonredundant protective properties of FPR2/ALX in polymicrobial murine sepsis. Proceedings of the National Academy of Sciences of the United States of America 111, (52) 18685-18690.
    10.1073/pnas.1410938111
  • McCafferty K, Forbes S, Thiemermann C et al. (2014). The challenge of translating ischemic conditioning from animal models to humans: The role of comorbidities. DMM Disease Models and Mechanisms 7, (12) 1321-1333.
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  • Bowes J, Piper J, Thiemermann C (1998). Inhibitors of the activity of poly (ADP-ribose) synthetase reduce the cell death caused by hydrogen peroxide in human cardiac myoblasts. British Journal of Pharmacology 124, (8) 1760-1766.
    10.1038/sj.bjp.0702009
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    10.1159/000025571
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    10.1097/00024382-199802000-00006
  • Wray GM, Hinds CJ, Thiemermann C (1998). Cell wall fragments from Gram positive and Gram negative bacteria synergize to cause organ failure in the rat. British Journal of Anaesthesia 80, (4) 542-543.
  • Wray GM, Hinds CJ, Thiemermann C (1998). Effects of inhibitors of poly(ADP-ribose) synthetase activity on hypotension and multiple organ dysfunction caused by endotoxin. Shock 10, (1) 13-19.
    10.1097/00024382-199807000-00003
  • Bowes J, Thiemermann C (1998). Effects of inhibitors of the activity of poly (ADP-ribose) synthetase on the liver injury caused by ischaemia-reperfusion: A comparison with radical scavengers. British Journal of Pharmacology 124, (6) 1254-1260.
    10.1038/sj.bjp.0701930
  • Chatterjee PK, Thiemermann C (1998). Inhibitors of poly (ADP-ribose) synthetase protect rat renal proximal tubular cells against oxidant stress. Biochemical Society Transactions 26, (4) .
    10.1042/bst026s318
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    10.1097/00024382-199805000-00003
  • Thiemermann C (1998). The Use of Selective Inhibitors of Inducible Nitric Oxide Synthase in Septic Shock. Sepsis 1, (2) 123-129.
    10.1023/A:1009780509335
  • Ruetten H, Thiemermann C (1997). Combination immunotherapy which neutralises the effects of TNFα and IL- 1β attenuates the circulatory failure and multiple organ dysfunction caused by endotoxin in the rat. Journal of Physiology and Pharmacology 48, (4) 605-621.
  • Ruetten H, Thiemermann C (1997). Endothelin-1 stimulates the biosynthesis of tumour necrosis factor in macrophages: ET-receptors, signal transduction and inhibition by dexamethasone. Journal of Physiology and Pharmacology 48, (4) 675-688.
  • Ruetten H, Thiemermann C (1997). Effects of tyrphostins and genistein on the circulatory failure and organ dysfunction caused by endotoxin in the rat: A possible role for protein tyrosine kinase. British Journal of Pharmacology 122, (1) 59-70.
    10.1038/sj.bjp.0701345
  • Millar CGM, Thiemermann C (1997). Intrarenal haemodynamics and renal dysfunction in endotoxaemia: Effects of nitric oxide synthase inhibition. British Journal of Pharmacology 121, (8) 1824-1830.
    10.1038/sj.bjp.0701335
  • Thiemermann C (1997). Nitric oxide and septic shock. General Pharmacology 29, (2) 159-166.
    10.1016/S0306-3623(96)00410-7
  • Ruetten H, Thiemermann C (1997). Effect of calpain inhibitor I, an inhibitor of the proteolysis of IκB, on the circulatory failure and multiple organ dysfunction caused by endotoxin in the rat. British Journal of Pharmacology 121, (4) 695-704.
    10.1038/sj.bjp.0701180
  • Hattor Y, Kasai K, Akimoto K et al. (1997). Induction of NO synthesis by lipoteichoic acid from Staphylococcus aureus in J774 macrophages: Involvement of a CD14-dependent pathway. Biochemical and Biophysical Research Communications 233, (2) 375-379.
    10.1006/bbrc.1997.6462
  • Thiemermann C, Bowes J, Myint FP et al. (1997). Inhibition of the activity of poly(ADP ribose) synthetase reduces ischemia-reperfusion injury in the heart and skeletal muscle. Proceedings of the National Academy of Sciences of the United States of America 94, (2) 679-683.
    10.1073/pnas.94.2.679
  • Ruetten H, Thiemermann C (1997). Interleukin-13 is a more potent inhibitor of the expression of inducible nitric oxide synthase in smooth muscle cells than in macrophages: A comparison with interleukin-4 and interleukin-10. Shock 8, (6) 409-414.
    10.1097/00024382-199712000-00003
  • Thiemermann C (1996). The role of nitric oxide for the regulation of vascular tone in health and disease. Korean Journal of Physiology 30, (2) 187-195.
  • Ruetten H, Thiemermann C (1996). Prevention of the expression of inducible nitric oxide synthase by aminoguanidine or aminoethyl-isothiourea in macrophages and in the rat. Biochemical and Biophysical Research Communications 225, (2) 525-530.
    10.1006/bbrc.1996.1206
  • Hide EJ, Thiemermann C (1996). Limitation of myocardial infarct size in the rabbit by ischaemic preconditioning is abolished by sodium 5-hydroxydecanoate. Cardiovascular Research 31, (6) 941-946.
    10.1016/0008-6363(96)00041-7
  • Wu CC, Ruetten H, Thiemermann C (1996). Comparison of the effects of aminoguanidine and Nω-nitro-L-arginine methyl ester on the multiple organ dysfunction caused by endotoxaemia in the rat. European Journal of Pharmacology 300, (1-2) 99-104.
    10.1016/0014-2999(95)00877-2
  • Akarasereenont P, Thiemermann C (1996). The induction of cyclo-oxygenase-2 in human pulmonary epithelial cell culture (A549) activated by IL-1β is inhibited by tyrosine kinase inhibitors. Biochemical and Biophysical Research Communications 220, (1) 181-185.
    10.1006/bbrc.1996.0377
  • Kengatharan M, De Kimpe SJ, Thiemermann C (1996). Analysis of the signal transduction in the induction of nitric oxide synthase by lipoteichoic acid in macrophages. British Journal of Pharmacology 117, (6) 1163-1170.
    10.1111/j.1476-5381.1996.tb16711.x
  • Ruetten H, Southan GJ, Abate A et al. (1996). Attenuation of endotoxin-induced multiple organ dysfunction by 1-amino-2-hydroxy-guanidine, a potent inhibitor of inducible nitric oxide synthase. British Journal of Pharmacology 118, (2) 261-270.
    10.1111/j.1476-5381.1996.tb15397.x
  • Wu CC, Thiemermann C (1996). Biological control and inhibition of induction of nitric oxide synthase. Methods in Enzymology 268408-420.
    10.1016/s0076-6879(96)68043-4
  • Wood PJ, Sansom JM, Stratford IJ et al. (1996). Changes in energy metabolism and X-ray sensitivity in murine tumours by the nitric oxide donor SIN-1. British Journal of Cancer 74, (SUPPL. XXVII) .
  • Ruetten H, Thiemermann C (1996). Effect of selective blockade of endothelin ET(B) receptors on the liver dysfunction and injury caused by endotoxaemia in the rat. British Journal of Pharmacology 119, (3) 479-486.
    10.1111/j.1476-5381.1996.tb15697.x
  • Ruetten H, Thiemermann C, Vane JR (1996). Effects of the endothelin receptor antagonist, SB 209670, on circulatory failure and organ injury in endotoxic shock in the anaesthetized rat. British Journal of Pharmacology 118, (1) 198-204.
    10.1111/j.1476-5381.1996.tb15386.x
  • Cristol JP, Thiemermann C, Guerin MC et al. (1996). L-Arginine infusion after ischaemia-reperfusion of rat kidney enhances lipid peroxidation. Journal of Lipid Mediators and Cell Signalling 13, (1) 9-17.
    10.1016/0929-7855(95)00010-0
  • Millar CGM, Baxter GF, Thiemermann C (1996). Protection of the myocardium by ischaemic preconditioning: Mechanisms and therapeutic implications. Pharmacology and Therapeutics 69, (2) 143-151.
    10.1016/0163-7258(95)02055-1
  • Ogata H, Luo XX, Szabo C et al. (1996). Role of nitric oxide in hemorrhagic shock. Anesthesia and Resuscitation 32, (1) 19-27.
  • Kengatharan KM, De Kimpe SJ, Thiemermann C (1996). Role of nitric oxide in the circulatory failure and organ injury in a rodent model of Gram-positive shock. British Journal of Pharmacology 119, (7) 1411-1421.
    10.1111/j.1476-5381.1996.tb16053.x
  • Hide EJ, Thiemermann C (1996). Sulprostone-induced reduction of myocardial infarct size in the rabbit by activation of ATP-sensitive potassium channels. British Journal of Pharmacology 118, (6) 1409-1414.
    10.1111/j.1476-5381.1996.tb15553.x
  • Thiemermann C (1995). Inhibition of nitric oxide synthase activity in circulatory shock: Friend or foe?. Medecine/Sciences 11, (12) 1643-1651.
  • Southan GJ, Szabó C, O'Connor MP et al. (1995). Amidines are potent inhibitors of nitric oxide synthases: preferential inhibition of the inducible isoform. European Journal of Pharmacology: Molecular Pharmacology 291, (3) 311-318.
    10.1016/0922-4106(95)90071-3
  • De Kimpe SJ, Kengatharan M, Thiemermann C et al. (1995). The cell wall components peptidoglycan and lipoteichoic acid from Staphylococcus aureus act in synergy to cause shock and multiple organ failure. Proceedings of the National Academy of Sciences of the United States of America 92, (22) 10359-10363.
    10.1073/pnas.92.22.10359
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    10.1016/0922-4106(95)90128-0
  • Wu CC, Croxtall JD, Perretti M et al. (1995). Lipocortin 1 mediates the inhibition by dexamethasone of the induction by endotoxin of nitric oxide synthase in the rat. Proceedings of the National Academy of Sciences of the United States of America 92, (8) 3473-3477.
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  • Akarasereenont P, Mitchell JA, Bakhle YS et al. (1995). Comparison of the induction of cyclooxygenase and nitric oxide synthase by endotoxin in endothelial cells and macrophages. European Journal of Pharmacology 273, (1-2) 121-128.
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  • Wu C, Chen S, Szabó C et al. (1995). Aminoguanidine attenuates the delayed circulatory failure and improves survival in rodent models of endotoxic shock. British Journal of Pharmacology 114, (8) 1666-1672.
    10.1111/j.1476-5381.1995.tb14955.x
  • Akarasereenont P, Bakhle YS, Thiemermann C et al. (1995). Cytokine‐mediated induction of cyclo‐oxygenase‐2 by activation of tyrosine kinase in bovine endothelial cells stimulated by bacterial lipopolysaccharide. British Journal of Pharmacology 115, (3) 401-408.
    10.1111/j.1476-5381.1995.tb16347.x
  • De Kimpe SJ, Hunter ML, Bryant CE et al. (1995). Delayed circulatory failure due to the induction of nitric oxide synthase by lipoteichoic acid from Staphylococcus aureus in anaesthetized rats. British Journal of Pharmacology 114, (6) 1317-1323.
    10.1111/j.1476-5381.1995.tb13349.x
  • Perretti M, Szabó C, Thiemermann C (1995). Effect of interleukin‐4 and interleukin‐10 on leucocyte migration and nitric oxide production in the mouse. British Journal of Pharmacology 116, (4) 2251-2257.
    10.1111/j.1476-5381.1995.tb15061.x
  • Klemm P, Thiemermann C, Winklmaier G et al. (1995). Effects of nitric oxide synthase inhibition combined with nitric oxide inhalation in a porcine model of endotoxin shock. British Journal of Pharmacology 114, (2) 363-368.
    10.1111/j.1476-5381.1995.tb13235.x
  • Kengatharan M, Battistini B, Warner TD et al. (1995). Endothelin-1 mediates the increase in ex vivo coronary vascular resistance induced by hemorrhagic shock in the anesthetized rat. Journal of Cardiovascular Pharmacology 26S422-S424.
    10.1097/00005344-199526003-00124
  • Hide EJ, Piper J, Thiemermann C (1995). Endothelin‐1 ‐induced reduction of myocardial infarct size by activation of ATP‐sensitive potassium channels in a rabbit model of myocardial ischaemia and reperfusion. British Journal of Pharmacology 116, (6) 2597-2602.
    10.1111/j.1476-5381.1995.tb17213.x
  • Wu C, Thiemermann C, Vane JR (1995). Glibenclamide‐induced inhibition of the expression of inducible nitric oxide synthase in cultured macrophages and in the anaesthetized rat. British Journal of Pharmacology 114, (6) 1273-1281.
    10.1111/j.1476-5381.1995.tb13343.x
  • Klemm P, Hecker M, Stockhausen H et al. (1995). Inhibition by N‐acetyl‐5‐hydroxytryptamine of nitric oxide synthase expression in cultured cells and in the anaesthetized rat. British Journal of Pharmacology 115, (7) 1175-1181.
    10.1111/j.1476-5381.1995.tb15021.x
  • Southan GJ, Szabó C, Thiemermann C (1995). Isothioureas: potent inhibitors of nitric oxide synthases with variable isoform selectivity. British Journal of Pharmacology 114, (2) 510-516.
    10.1111/j.1476-5381.1995.tb13256.x
  • Bryant CE, Tomlinson A, Mitchell JA et al. (1995). Nitric oxide synthase in the rat fallopian tube is regulated during the oestrous cycle. Journal of Endocrinology 146, (1) 149-157.
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    10.1111/j.1476-5381.1995.tb15092.x
  • Szabó C, Thiemermann C (1995). Regulation of the Expression of the Inducible Isoform of Nitric Oxide Synthase. Advances in Pharmacology 34, (C) 113-153.
    10.1016/S1054-3589(08)61083-2
  • De Kimpe SJ, Thiemermann C, Vane JR (1995). Role for intracellular platelet‐activating factor in the circulatory failure in a model of Gram‐positive shock. British Journal of Pharmacology 116, (8) 3191-3198.
    10.1111/j.1476-5381.1995.tb15123.x
  • Thiemermann C (1995). Selective inhibition of the activity of inducible nitric oxide synthase in septic shock. Progress in clinical and biological research 392383-392.
  • Hohlfeld T, Klemm P, Thiemermann C et al. (1995). The contribution of tumour necrosis factor‐α and endothelin‐1 to the increase of coronary resistance in hearts from rats treated with endotoxin. British Journal of Pharmacology 116, (8) 3309-3315.
    10.1111/j.1476-5381.1995.tb15140.x
  • Akarasereenont P, Hide E, Ney P et al. (1995). The induction of cyclooxygenase-2 elicited by endotoxin in endothelial cells and macrophages is inhibited by prostaglandin E1 and 13,14-dihydro prostaglandin E1. Agents and Actions 45, (SUPPL. I) 59-64.
    10.1007/978-3-0348-7346-8_9
  • Thiemermann C, Ruetten H, Wu C et al. (1995). The multiple organ dysfunction syndrome caused by endotoxin in the rat: attenuation of liver dysfunction by inhibitors of nitric oxide synthase. British Journal of Pharmacology 116, (7) 2845-2851.
    10.1111/j.1476-5381.1995.tb15935.x
  • Szabó C, Southan GJ, Thiemermann C (1994). Beneficial effects and improved survival in rodent models of septic shock with S-methylisothiourea sulfate, a potent and selective inhibitor of inducible nitric oxide synthase. Proceedings of the National Academy of Sciences of the United States of America 91, (26) 12472-12476.
    10.1073/pnas.91.26.12472
  • Southan GJ, Szabó C, Thiemermann C (1994). Inhibition of the induction of nitric oxide synthase by spermine is modulated by aldehyde dehydrogenase. Biochemical and Biophysical Research Communications 203, (3) 1638-1644.
    10.1006/bbrc.1994.2374
  • McMurdo L, Thiemermann C, Vane JR (1994). The endothelin ETB receptor agonist, IRL 1620, causes vasodilation and inhibits ex vivo platelet aggregation in the anaesthetised rabbit. European Journal of Pharmacology 259, (1) 51-55.
    10.1016/0014-2999(94)90156-2
  • Wood PJ, Sansom JM, Stratford IJ et al. (1994). Modification of metabolism of transplantable and spontaneous murine tumors by the nitric oxide synthase inhibitor, nitro-L-arginine. International Journal of Radiation Oncology, Biology, Physics 29, (3) 443-447.
    10.1016/0360-3016(94)90435-9
  • Wu CC, Szabó C, Chen SJ et al. (1994). Activation of soluble guanylyl cyclase by a factor other than nitric oxide or carbon monoxide contributes to the vascular hyporeactivity to vasoconstrictor agents in the aorta of rats treated with endotoxin. Biochemical and Biophysical Research Communications 201, (1) 436-442.
    10.1006/bbrc.1994.1720
  • Szabó C, Thiemermann C, Wu CC et al. (1994). Attenuation of the induction of nitric oxide synthase by endogenous glucocorticoids accounts for endotoxin tolerance in vivo. Proceedings of the National Academy of Sciences of the United States of America 91, (1) 271-275.
    10.1073/pnas.91.1.271
  • Wellings RP, Corder R, Warner TD et al. (1994). Evidence from receptor antagonists of an important role for ETB receptor‐mediated vasoconstrictor effects of endothelin‐1 in the rat kidney. British Journal of Pharmacology 111, (2) 515-520.
    10.1111/j.1476-5381.1994.tb14767.x
  • Szabó C, Southan GJ, Wood E et al. (1994). Inhibition by spermine of the induction of nitric oxide synthase in J774.2 macrophages: requirement of a serum factor. British Journal of Pharmacology 112, (2) 355-356.
    10.1111/j.1476-5381.1994.tb13078.x
  • SzabÓ C, Thiemermann C (1994). Invited opinion: Role of nitric oxide in hemorrhagic, traumatic, and anaphylactic shock and thermal injury. Shock 2, (2) 145-154.
    10.1097/00024382-199408000-00011
  • Akarasereenont P, Mitchell JA, Appleton I et al. (1994). Involvement of tyrosine kinase in the induction of cyclo‐oxygenase and nitric oxide synthase by endotoxin in cultured cells. British Journal of Pharmacology 113, (4) 1522-1528.
    10.1111/j.1476-5381.1994.tb17169.x
  • Thiemermann C (1994). The Role of the L-Arginine: Nitric Oxide Pathway in Circulatory Shock. 2845-79.
    10.1016/S1054-3589(08)60493-7
  • McMurdo L, Thiemermann C, Vane JR (1994). The effects of the endothelin ETA receptor antagonist, FR 139317, on infarct size in a rabbit model of acute myocardial ischaemia and reperfusion. British Journal of Pharmacology 112, (1) 75-80.
    10.1111/j.1476-5381.1994.tb13032.x
  • Szabó C, Southan GJ, Thiemermann C et al. (1994). The mechanism of the inhibitory effect of polyamines on the induction of nitric oxide synthase: role of aldehyde metabolites. British Journal of Pharmacology 113, (3) 757-766.
    10.1111/j.1476-5381.1994.tb17058.x
  • Mitchell JA, Akarasereenont P, Thiemermann C et al. (1993). Selectivity of nonsteroidal antiinflammatory drugs as inhibitors of constitutive and inducible cyclooxygenase. Proceedings of the National Academy of Sciences of the United States of America 90, (24) 11693-11697.
    10.1073/pnas.90.24.11693
  • Szabó C, Wu CC, Gross SS et al. (1993). Interleukin-1 contributes to the induction of nitric oxide synthase by endotoxin in vivo. European Journal of Pharmacology 250, (1) 157-160.
    10.1016/0014-2999(93)90634-T
  • Szabo C, Mitchell JA, Gross SS et al. (1993). Nifedipine inhibits the induction of nitric oxide synthase by bacterial lipopolysaccharide. Journal of Pharmacology and Experimental Therapeutics 265, (2) 674-680.
  • Szabó C, Thiemermann C, Vane JR (1993). Dihydropyridine Antagonists and Agonists of Calcium Channels Inhibit the Induction of Nitric Oxide Synthase by Endotoxin in Cultured Macrophages. Biochemical and Biophysical Research Communications 196, (2) 825-830.
    10.1006/bbrc.1993.2323
  • McMurdo L, Sessa WC, Thiemermann C et al. (1993). Ischaemia and reperfusion enhances the coronary vasoconstrictor effects of endothelin-1 in the rat isolated perfused heart. Pharmacology Communications 3, (2) 183-192.
  • Wood PJ, Stratford IJ, Adams GE et al. (1993). Modification of energy metabolism and radiation response of a murine tumor by changes in nitric oxide availability. Biochemical and Biophysical Research Communications 192, (2) 505-510.
    10.1006/bbrc.1993.1444
  • Thiemermann C, Szabo C, Mitchell JA et al. (1993). Vascular hyporeactivity to vasoconstrictor agents and hemodynamic decompensation in hemorrhagic shock is mediated by nitric oxide. Proceedings of the National Academy of Sciences of the United States of America 90, (1) 267-271.
    10.1073/pnas.90.1.267
  • Thiemermann C (1993). Drugs which modulate nitric oxide homeostasis are likely to provide therapeutic benefit in cardiovascular disease. Cardiovascular Research 27, (12) 2104-.
    10.1093/cvr/27.12.2104
  • Thiemermann C, Mitchell JA, Ferns GAA (1993). Eicosanoids and atherosclerosis. Current Opinion in Lipidology 4, (5) 401-406.
    10.1097/00041433-199310000-00009
  • McMurdo L, Lidbury PS, Corder R et al. (1993). Heterogeneous receptors mediate endothelin-1-induced changes in blood pressure, hematocrit, and platelet aggregation. Journal of Cardiovascular Pharmacology 22, (SUPPL. 8) .
    10.1097/00005344-199322008-00050
  • McMurdo L, Corder R, Thiemermann C et al. (1993). Incomplete inhibition of the pressor effects of endothelin‐1 and related peptides in the anaesthetized rat with BQ‐123 provides evidence for more than one vasoconstrictor receptor. British Journal of Pharmacology 108, (2) 557-561.
    10.1111/j.1476-5381.1993.tb12840.x
  • Szabo C, Thiemermann C, Vane JR (1993). Inhibition of the production of nitric oxide and vasodilator prostaglandins attenuates the cardiovascular response to bacterial endotoxin in adrenalectomized rats. Proceedings of the Royal Society B: Biological Sciences 253, (1338) 233-238.
    10.1098/rspb.1993.0108
  • McMurdo L, Lidbury PS, Thiemermann C et al. (1993). Mediation of endothelin‐1‐induced inhibition of platelet aggregation via the ETB receptor. British Journal of Pharmacology 109, (2) 530-534.
    10.1111/j.1476-5381.1993.tb13602.x
  • Cristol J, Warner TD, Thiemermann C et al. (1993). Mediation via different receptors of the vasoconstrictor effects of endothelins and sarafotoxins in the systemic circulation and renal vasculature of the anaesthetized rat. British Journal of Pharmacology 108, (3) 776-779.
    10.1111/j.1476-5381.1993.tb12877.x
  • Szabó C, Mitchell JA, Thiemermann C et al. (1993). Nitric oxide‐mediated hyporeactivity to noradrenaline precedes the induction of nitric oxide synthase in endotoxin shock. British Journal of Pharmacology 108, (3) 786-792.
    10.1111/j.1476-5381.1993.tb12879.x
  • Szabó C, Wu CC, Mitchell JA et al. (1993). Platelet-activating factor contributes to the induction of nitric oxide synthase by bacterial lipopolysaccharide. Circulation Research 73, (6) 991-999.
    10.1161/01.RES.73.6.991
  • Thiemermann C, Wu C, Szabó C et al. (1993). Role of tumour necrosis factor in the induction of nitric oxide synthase in a rat model of endotoxin shock. British Journal of Pharmacology 110, (1) 177-182.
    10.1111/j.1476-5381.1993.tb13789.x
  • Cristol JP, Thiemermann C, Mitchell JA et al. (1993). Support of renal blood flow after ischaemic‐reperfusion injury by endogenous formation of nitric oxide and of cyclo‐oxygenase vasodilator metabolites. British Journal of Pharmacology 109, (1) 188-194.
    10.1111/j.1476-5381.1993.tb13552.x
  • Wellings RP, Warner TD, Thiemermann C et al. (1993). Vasoconstriction in the rat kidney induced by endothelin-1 is blocked by PD 145065. Journal of Cardiovascular Pharmacology 22, (SUPPL. 8) .
    10.1097/00005344-199322008-00028
  • Thiemermann C, Corder R (1992). Is endothelin-1 the regulator of myofibroblast contraction during wound healing?. Laboratory Investigation 67, (6) 677-679.
  • Tettamanti R, Bianchi G, Vitte PA et al. (1992). A novel insight into the mechanism of the antithrombotic action of defibrotide. Life Sciences 51, (19) 1545-1555.
    10.1016/0024-3205(92)90565-7
  • Huneidi AHS, Thiemermann C, Lidbury PS et al. (1992). Do Endothelin-1 (ET-1) and human big-endothelin (b-ET) cause subarachnoid haemorrhage?. Journal of Neurology Neurosurgery and Psychiatry 55, (1) 77-.
  • Sprague RS, Thiemermann C, Vane JR (1992). Endogenous endothelium-derived relaxing factor opposes hypoxic pulmonary vasoconstriction and supports blood flow to hypoxic alveoli in anesthetized rabbits. Proceedings of the National Academy of Sciences of the United States of America 89, (18) 8711-8715.
    10.1073/pnas.89.18.8711
  • Walder CE, Thiemermann C, Vane JR (1992). NG‐hydroxy‐L‐arginine prevents the haemodynamic effects of nitric oxide synthesis inhibition in the anaesthetized rat. British Journal of Pharmacology 107, (2) 476-480.
    10.1111/j.1476-5381.1992.tb12770.x
  • Thiemermann C (1991). Biosynthesis and interaction of endothelium-derived vasoactive mediators. Eicosanoids 4, (4) 187-202.
  • Thiemermann C, Al-Damluji S, Hecker M et al. (1991). FMRF-amide and L-Arg-L-Phe increase blood pressure and heart rate in the anaesthetised rat by central stimulation of the sympathetic nervous system. Biochemical and Biophysical Research Communications 175, (1) 318-324.
    10.1016/S0006-291X(05)81237-9
  • Huneidi AHS, Thiemermann C, Lidbury PS et al. (1991). Endothelin-1 and big endothelin cause subarachnoid hemorrhage in the anesthetized rabbit. Journal of Cardiovascular Pharmacology 17S492-S495.
    10.1097/00005344-199100177-00140
  • Thiemermann C, Mustafa M, Mester PA et al. (1991). Inhibition of the release of endothelium‐derived relaxing factor in vitro and in vivo by dipeptides containing NG‐nitro‐l‐arginine. British Journal of Pharmacology 104, (1) 31-38.
    10.1111/j.1476-5381.1991.tb12380.x
  • Walder CE, Thiemermann C, Vane JR (1991). The involvement of endothelium‐derived relaxing factor in the regulation of renal cortical blood flow in the rat. British Journal of Pharmacology 102, (4) 967-973.
    10.1111/j.1476-5381.1991.tb12285.x
  • Lidbury PS, Thiemermann C, Korbut R et al. (1990). Endothelins release tissue plasminogen activator and prostanoids. European Journal of Pharmacology 186, (2-3) 205-212.
    10.1016/0014-2999(90)90435-9
  • Thiemermann C, Vane J (1990). Inhibition of nitric oxide synthesis reduces the hypotension induced by bacterial lipopolysaccharides in the rat in vivo. European Journal of Pharmacology 182, (3) 591-595.
    10.1016/0014-2999(90)90062-B
  • Hecker M, Mitchell JA, Harris HJ et al. (1990). Endothelial cells metabolize NG-monomethyl-L-arginine to L-citrulline and subsequently to L-arginine. Biochemical and Biophysical Research Communications 167, (3) 1037-1043.
    10.1016/0006-291X(90)90627-Y
  • Walder CE, Thiemermann C, Vane JR (1990). EDRF-mediation of the pentagastrin-induced hyperaemia in the gastric mucosa of the anaesthetized rat in vivo. Journal of Physiology 425.
  • Thiemermann C, May GR, Page CP et al. (1990). Endothelin-1 inhibits platelet aggregation in vivo: a study with 111indium-labelled platelets. British Journal of Pharmacology 99, (2) 303-308.
    10.1111/j.1476-5381.1990.tb14699.x
  • Walder CE, Thiemermann C, Vane JR (1990). Endothelium-derived relaxing factor participates in the increased blood flow in response to pentagastrin in the rat stomach mucosa. Proceedings of the Royal Society B: Biological Sciences 241, (1302) 195-200.
    10.1098/rspb.1990.0085
  • Hecker M, Mitchell JA, Harris HJ et al. (1990). N(G)-monomethyl-L-arginine but not N(ω)-nitro-L-arginine is metabolized by endothelial cells to L-citrulline. European Journal of Pharmacology 183, (2) 648-649.
    10.1016/0014-2999(90)93576-C
  • Thomas GR, Walder CE, Thiemermann C et al. (1990). Regional vascular resistance and haemodynamics in the spontaneously hypertensive rat: The effects of bradykinin. Journal of Cardiovascular Pharmacology 15, (2) 211-217.
    10.1097/00005344-199002000-00006
  • Schror K, Thiemermann C (1989). Eicosanoids in myocardial ischemia. Biomedica Biochimica Acta 48, (10) 729-734.
  • Lidbury PS, Thiemermann C, Roger Thomas G et al. (1989). Endothelin-3: selectivity as an anti-aggregatory peptide in vivo. European Journal of Pharmacology 166, (2) 335-338.
    10.1016/0014-2999(89)90079-4
  • Thiemermann C, Thomas GR, Vane JR (1989). Defibrotide reduces infarct size in a rabbit model of experimental myocardial ischaemia and reperfusion. British Journal of Pharmacology 97, (2) 401-408.
    10.1111/j.1476-5381.1989.tb11967.x
  • Thiemermann C, Thomas GR, Vane JR (1989). Effects of defibrotide on infarct size and regional myocardial blood flow on the ischaemic reperfused rabbit heart. Progress in clinical and biological research 301131-135.
  • Thiemermann C, Lidbury PS, Roger Thomas G et al. (1989). Endothelin-1 releases prostacyclin and inhibits ex vivo platelet aggregation in the anesthetized rabbit. Journal of Cardiovascular Pharmacology 13S138-S141.
    10.1097/00005344-198900135-00034
  • Hohlfeld T, Thiemermann C, Schrör K (1989). Protection from myocardial ischemic injury in cats and pigs by defibrotide--different mode of action?. Progress in clinical and biological research 301137-141.
  • Walder CE, Roger Thomas G, Thiemermann C et al. (1989). The hemodynamic effects of endothelin-1 in the pithed rat. Journal of Cardiovascular Pharmacology 13S93-S97.
    10.1097/00005344-198900135-00023
  • Thiemermann C, Lidbury P, Thomas R et al. (1988). Endothelin inhibits ex vivo platelet aggregation in the rabbit. European Journal of Pharmacology 158, (1-2) 181-182.
    10.1016/0014-2999(88)90273-7
  • Thiemermann C, Ney P, Schror K (1988). Protection of the ischaemic myocardium from reperfusion injury by defibrotide and its possible mechanism of action. Biomedica Biochimica Acta 47, (10-11) .
  • Thiemermann C, Ney P, Schrör K (1988). The thromboxane receptor antagonist, daltroban, protects the myocardium from ischaemic injury resulting in suppression of leukocytosis. European Journal of Pharmacology 155, (1-2) 57-67.
    10.1016/0014-2999(88)90402-5
  • Schrör K, Thiemermann C, Ney P (1988). Protection of the ischemic myocardium from reperfusion injury by prostaglandin E1 inhibition of ischemia-induced neutrophil activation. Naunyn-Schmiedeberg's Archives of Pharmacology 338, (3) 268-274.
    10.1007/BF00173399
  • Thomas GR, Thiemermann C, Walder C et al. (1988). The effects of endothelium‐dependent vasodilators on cardiac output and their distribution in the anaesthetized rat: a comparison with sodium nitroprusside. British Journal of Pharmacology 95, (3) 986-992.
    10.1111/j.1476-5381.1988.tb11729.x
  • Thiemermann C, Smith EF, Schrör K (1986). Successful treatment of acute myocardial ischaemia with teopranitol-a novel organic nitrate. European Heart Journal 7, (5) 418-424.
    10.1093/oxfordjournals.eurheartj.a062083
  • Schrör K, Thiemermann C (1986). Treatment of acute myocardial ischaemia with a selective antagonist of thromboxane receptors (BM 13.177). British Journal of Pharmacology 87, (4) 631-637.
    10.1111/j.1476-5381.1986.tb14579.x
  • Thiemermann C, Löbel P, Schrör K (1985). Usefulness of defibrotide in protecting ischemic myocardium from early reperfusion damage. The American Journal of Cardiology 56, (15) 978-982.
    10.1016/0002-9149(85)90416-3
  • Thiemermann C, Schror K (1984). Comparison of the thromboxane synthetase inhibitor dazoxiben and the prostacyclin mimetic iloprost in an animal model of acute ischaemia and reperfusion. Biomedica Biochimica Acta 43, (8-9) .
  • Thiemermann C, Steinhagen-Thiessen E, Schrör K (1984). Inhibition of oxygen-centered free radical formation by the stable prostacyclin-mimetic iloprost (ZK 36 374) in acute myocardial ischemia. Journal of Cardiovascular Pharmacology 6, (2) 365-366.
    10.1097/00005344-198403000-00025

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